{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:52:20Z","timestamp":1790729540420,"version":"4.1.0"},"reference-count":280,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Canadian Institutes for Health Research (CIHR)"},{"name":"Fonds de Recherche en Sant\u00e9 du Qu\u00e9bec (FRQS)"},{"name":"Fonds de Recherche en Ophtalmologie de l\u2019Universit\u00e9 de Montr\u00e9al (FROUM)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The TGF-\u03b2 signaling pathway plays a crucial role in several key aspects of development and tissue homeostasis. TGF-\u03b2 ligands and their mediators have been shown to be important regulators of ocular physiology and their dysregulation has been described in several eye pathologies. TGF-\u03b2 signaling participates in regulating several key developmental processes in the eye, including angiogenesis and neurogenesis. Inadequate TGF-\u03b2 signaling has been associated with defective angiogenesis, vascular barrier function, unfavorable inflammatory responses, and tissue fibrosis. In addition, experimental models of corneal neovascularization, diabetic retinopathy, proliferative vitreoretinopathy, glaucoma, or corneal injury suggest that aberrant TGF-\u03b2 signaling may contribute to the pathological features of these conditions, showing the potential of modulating TGF-\u03b2 signaling to treat eye diseases. This review highlights the key roles of TGF-\u03b2 family members in ocular physiology and in eye diseases, and reviews approaches targeting the TGF-\u03b2 signaling as potential treatment options.<\/jats:p>","DOI":"10.3390\/cells11152336","type":"journal-article","created":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T21:49:02Z","timestamp":1659304142000},"page":"2336","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["TGF-\u03b2 Superfamily Signaling in the Eye: Implications for Ocular Pathologies"],"prefix":"10.3390","volume":"11","author":[{"given":"Soumaya","family":"Hachana","sequence":"first","affiliation":[{"name":"Maisonneuve-Rosemont Hospital Research Center, Montreal, QC H1T 2M4, Canada"},{"name":"Department of Ophthalmology, Universit\u00e9 de Montr\u00e9al, Montreal, QC H3C 3J7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1388-3108","authenticated-orcid":false,"given":"Bruno","family":"Larriv\u00e9e","sequence":"additional","affiliation":[{"name":"Maisonneuve-Rosemont Hospital Research Center, Montreal, QC H1T 2M4, Canada"},{"name":"Department of Ophthalmology, Universit\u00e9 de Montr\u00e9al, Montreal, QC H3C 3J7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/978-3-030-27378-1_2","article-title":"A Review of Pathogenic Drivers of Age-Related Macular Degeneration, Beyond Complement, with a Focus on Potential Endpoints for Testing Therapeutic Interventions in Preclinical Studies","volume":"1185","author":"Choudhary","year":"2019","journal-title":"Adv. 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