{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T06:19:39Z","timestamp":1762064379425,"version":"build-2065373602"},"reference-count":168,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education","award":["2020R1I1A2066868","2020R1A5A2019413"],"award-info":[{"award-number":["2020R1I1A2066868","2020R1A5A2019413"]}]},{"name":"National Research Foundation of Korea (NRF) grant funded by the Korea government","award":["2020R1I1A2066868","2020R1A5A2019413"],"award-info":[{"award-number":["2020R1I1A2066868","2020R1A5A2019413"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Medical health systems continue to be challenged due to newly emerging COVID-19, and there is an urgent need for alternative approaches for treatment. An increasing number of clinical observations indicate cytokine storms to be associated with COVID-19 severity and also to be a significant cause of death among COVID-19 patients. Cytokine storm involves the extensive proliferative and hyperactive activity of T and macrophage cells and the overproduction of pro-inflammatory cytokines. Stem cells are the type of cell having self-renewal properties and giving rise to differentiated cells. Currently, stem cell therapy is an exciting and promising therapeutic approach that can treat several diseases that were considered incurable in the past. It may be possible to develop novel methods to treat various diseases by identifying stem cells\u2019 growth and differentiation factors. Treatment with mesenchymal stem cells (MSCs) in medicine is anticipated to be highly effective. The present review article is organized to put forward the positive arguments and implications in support of mesenchymal stem cell therapy as an alternative therapy to cytokine storms, to combat COVID-19. Using the immunomodulatory potential of the MSCs, it is possible to fight against COVID-19 and counterbalance the cytokine storm.<\/jats:p>","DOI":"10.3390\/cells11172686","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T21:01:31Z","timestamp":1661806891000},"page":"2686","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Potential Therapeutic Role of Mesenchymal-Derived Stem Cells as an Alternative Therapy to Combat COVID-19 through Cytokines Storm"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2551-9779","authenticated-orcid":false,"given":"Tarun Kumar","family":"Upadhyay","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Parul Institute of Applied Sciences and Animal Cell Culture and Immunobiochemistry Lab, Centre of Research for Development, Parul University, Vadodara 391760, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashmi","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Parul Institute of Applied Sciences and Animal Cell Culture and Immunobiochemistry Lab, Centre of Research for Development, Parul University, Vadodara 391760, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3449-7978","authenticated-orcid":false,"given":"Fahad","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Noida Institute of Engineering & Technology, Greater Noida 201306, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7029-8517","authenticated-orcid":false,"given":"Pratibha","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Noida Institute of Engineering & Technology, Greater Noida 201306, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6630-5999","authenticated-orcid":false,"given":"Amit Baran","family":"Sharangi","sequence":"additional","affiliation":[{"name":"Department of Plantation, Spices, Medicinal & Aromatic Crops, BCKV-Agricultural University, Mohanpur 741252, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3904-7343","authenticated-orcid":false,"given":"Harsh","family":"Goel","sequence":"additional","affiliation":[{"name":"Department of Laboratory Oncology, All India Institute of Medical Sciences, New Delhi 110023, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3443-386X","authenticated-orcid":false,"given":"Mohd","family":"Saeed","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Sciences, University of Hail, Hail 34464, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9276-3894","authenticated-orcid":false,"given":"Moon Nyeo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Korean Medicine, Kyung Hee University, Seoul 05254, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8678-156X","authenticated-orcid":false,"given":"Bonglee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"unstructured":"World Health Organization (WHO) (2020, April 01). 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