{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:28:37Z","timestamp":1791808117676,"version":"4.3.4"},"reference-count":155,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["845110"],"award-info":[{"award-number":["845110"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Spinal cord injury (SCI) is a significant cause of disability, and treatment alternatives that generate beneficial outcomes and have no side effects are urgently needed. SCI may be treatable if intervention is initiated promptly. Therefore, several treatment proposals are currently being evaluated. Inflammation is part of a complex physiological response to injury or harmful stimuli induced by mechanical, chemical, or immunological agents. Neuroinflammation is one of the principal secondary changes following SCI and plays a crucial role in modulating the pathological progression of acute and chronic SCI. This review describes the main inflammatory events occurring after SCI and discusses recently proposed potential treatments and therapeutic agents that regulate inflammation after insult in animal models.<\/jats:p>","DOI":"10.3390\/cells11172692","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T21:01:31Z","timestamp":1661806891000},"page":"2692","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":210,"title":["Inflammation: A Target for Treatment in Spinal Cord Injury"],"prefix":"10.3390","volume":"11","author":[{"given":"Ximena","family":"Freyermuth-Trujillo","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Neurol\u00f3gicas, Hospital de Especialidades Dr. Bernardo Sep\u00falveda, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City CP 06720, Mexico"},{"name":"Posgrado en Ciencias Biol\u00f3gicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City CP 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0676-5667","authenticated-orcid":false,"given":"Julia J.","family":"Segura-Uribe","sequence":"additional","affiliation":[{"name":"Subdirecci\u00f3n de Gesti\u00f3n de la Investigaci\u00f3n, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, Secretar\u00eda de Salud, Mexico City CP 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0715-9263","authenticated-orcid":false,"given":"Hermelinda","family":"Salgado-Ceballos","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Neurol\u00f3gicas, Hospital de Especialidades Dr. Bernardo Sep\u00falveda, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City CP 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3989-1205","authenticated-orcid":false,"given":"Carlos E.","family":"Orozco-Barrios","sequence":"additional","affiliation":[{"name":"CONACyT-Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Neurol\u00f3gicas, Hospital de Especialidades Dr. Bernardo Sep\u00falveda, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City CP 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7007-9509","authenticated-orcid":false,"given":"Ang\u00e9lica","family":"Coyoy-Salgado","sequence":"additional","affiliation":[{"name":"CONACyT-Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Neurol\u00f3gicas, Hospital de Especialidades Dr. Bernardo Sep\u00falveda, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City CP 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1800529","DOI":"10.1002\/advs.201800529","article-title":"Regulation of inflammatory cytokines for spinal cord injury repair through local delivery of therapeutic agent","volume":"5","author":"Ren","year":"2018","journal-title":"Adv. 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