{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T06:19:06Z","timestamp":1762064346334,"version":"build-2065373602"},"reference-count":113,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Deutsche Forschungsgemeinschaft","award":["SFB 1181\/2-B02"],"award-info":[{"award-number":["SFB 1181\/2-B02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Gut-related diseases like ulcerative colitis, Crohn\u2019s disease, or colorectal cancer affect millions of people worldwide. It is an ongoing process finding causes leading to the development and manifestation of those disorders. This is highly relevant since understanding molecular processes and signalling pathways offers new opportunities in finding novel ways to interfere with and apply new pharmaceuticals. Memory T cells (mT cells) and their pro-inflammatory properties have been proven to play an important role in gastrointestinal diseases and are therefore increasingly spotlighted. This review focuses on mT cells and their subsets in the context of disease pathogenesis and maintenance. It illustrates the network of regulatory proteins and metabolites connecting mT cells with other cell types and tissue compartments. Furthermore, the crosstalk with various microbes will be a subject of discussion. Characterizing mT cell interactions will help to further elucidate the sophisticated molecular and cellular networking system in the intestine and may present new ideas for future research approaches to control gut-related diseases.<\/jats:p>","DOI":"10.3390\/cells11182780","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T20:52:51Z","timestamp":1662497571000},"page":"2780","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Memory T Cell \u201cCommunication Web\u201d in Context with Gastrointestinal Disorders\u2014How Memory T Cells Affect Their Surroundings and How They Are Influenced by It"],"prefix":"10.3390","volume":"11","author":[{"given":"Annkathrin","family":"Knauss","sequence":"first","affiliation":[{"name":"Medical Clinic 1, Research Campus, University Hospital Erlangen, Hartmannstr. 14, 91052 Erlangen, Germany"},{"name":"Medical Immunology Campus Erlangen, Friedrich-Alexander Universit\u00e4t Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Gabel","sequence":"additional","affiliation":[{"name":"Medical Clinic 1, Research Campus, University Hospital Erlangen, Hartmannstr. 14, 91052 Erlangen, Germany"},{"name":"Medical Immunology Campus Erlangen, Friedrich-Alexander Universit\u00e4t Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus F.","family":"Neurath","sequence":"additional","affiliation":[{"name":"Medical Clinic 1, University Hospital Erlangen, Ulmenweg 18, 91054 Erlangen, Germany"},{"name":"Deutsches Zentrum Immuntherapie (DZI), 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2398-0844","authenticated-orcid":false,"given":"Benno","family":"Weigmann","sequence":"additional","affiliation":[{"name":"Medical Clinic 1, Research Campus, University Hospital Erlangen, Hartmannstr. 14, 91052 Erlangen, Germany"},{"name":"Medical Immunology Campus Erlangen, Friedrich-Alexander Universit\u00e4t Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S2468-1253(19)30333-4","article-title":"The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990\u20132017: A systematic analysis for the Global Burden of Disease Study 2017","volume":"5","author":"Alatab","year":"2020","journal-title":"Lancet Gastroenterol. 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