{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:46:45Z","timestamp":1788860805053,"version":"build-2803163510"},"reference-count":125,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["LY22B070007"],"award-info":[{"award-number":["LY22B070007"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["31902178"],"award-info":[{"award-number":["31902178"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["LY22B070007"],"award-info":[{"award-number":["LY22B070007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31902178"],"award-info":[{"award-number":["31902178"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Peptide transporter 2 (PepT2) in mammals plays essential roles in the reabsorption and conservation of peptide-bound amino acids in the kidney and in maintaining neuropeptide homeostasis in the brain. It is also of significant medical and pharmacological significance in the absorption and disposing of peptide-like drugs, including angiotensin-converting enzyme inhibitors, \u03b2-lactam antibiotics and antiviral prodrugs. Understanding the structure, function and regulation of PepT2 is of emerging interest in nutrition, medical and pharmacological research. In this review, we provide a comprehensive overview of the structure, substrate preferences and localization of PepT2 in mammals. As PepT2 is expressed in various organs, its function in the liver, kidney, brain, heart, lung and mammary gland has also been addressed. Finally, the regulatory factors that affect the expression and function of PepT2, such as transcriptional activation and posttranslational modification, are also discussed.<\/jats:p>","DOI":"10.3390\/cells11182874","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T20:50:45Z","timestamp":1663188645000},"page":"2874","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Biology of Peptide Transporter 2 in Mammals: New Insights into Its Function, Structure and Regulation"],"prefix":"10.3390","volume":"11","author":[{"given":"Caihong","family":"Wang","sequence":"first","affiliation":[{"name":"College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China"},{"name":"Department of Bioinformatics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China"},{"name":"Zhejiang Conba Pharmaceutical Limited Company, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu","family":"Chu","sequence":"additional","affiliation":[{"name":"College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Ji","sequence":"additional","affiliation":[{"name":"College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoliang","family":"Luo","sequence":"additional","affiliation":[{"name":"Zhejiang Conba Pharmaceutical Limited Company, Hangzhou 310052, China"},{"name":"Zhejiang Institute of Modern Chinese Medicine and Natural Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunling","family":"Xu","sequence":"additional","affiliation":[{"name":"Zhejiang Conba Pharmaceutical Limited Company, Hangzhou 310052, China"},{"name":"Zhejiang Institute of Modern Chinese Medicine and Natural Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houhong","family":"He","sequence":"additional","affiliation":[{"name":"Zhejiang Conba Pharmaceutical Limited Company, Hangzhou 310052, China"},{"name":"Zhejiang Institute of Modern Chinese Medicine and Natural Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbiao","family":"Yao","sequence":"additional","affiliation":[{"name":"Zhejiang Conba Pharmaceutical Limited Company, Hangzhou 310052, China"},{"name":"Zhejiang Institute of Modern Chinese Medicine and Natural Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wu","sequence":"additional","affiliation":[{"name":"Zhejiang Conba Pharmaceutical Limited Company, Hangzhou 310052, China"},{"name":"Zhejiang Institute of Modern Chinese Medicine and Natural Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangning","family":"Hu","sequence":"additional","affiliation":[{"name":"Zhejiang Conba Pharmaceutical Limited Company, Hangzhou 310052, China"},{"name":"Zhejiang Institute of Modern Chinese Medicine and Natural Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanxiang","family":"Jin","sequence":"additional","affiliation":[{"name":"College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1469-7793.1997.169bf.x","article-title":"Electrophysiological analysis of the function of the mammalian renal peptide transporter expressed in Xenopus laevis oocytes","volume":"504","author":"Amasheh","year":"1997","journal-title":"J. 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