{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T23:19:34Z","timestamp":1769555974663,"version":"3.49.0"},"reference-count":47,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T00:00:00Z","timestamp":1663977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea (NRF) grant","award":["NRF-2020R1A2C1004517"],"award-info":[{"award-number":["NRF-2020R1A2C1004517"]}]},{"name":"National Research Foundation of Korea (NRF) grant","award":["NRF-2020R1F1A1075199"],"award-info":[{"award-number":["NRF-2020R1F1A1075199"]}]},{"name":"Korean government (Ministry of Science and ICT)","award":["NRF-2020R1A2C1004517"],"award-info":[{"award-number":["NRF-2020R1A2C1004517"]}]},{"name":"Korean government (Ministry of Science and ICT)","award":["NRF-2020R1F1A1075199"],"award-info":[{"award-number":["NRF-2020R1F1A1075199"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Cross-talk between astrocytes and microglia plays an important role in neuroinflammation and central sensitization, but the manner in which glial cells interact remains less well-understood. Herein, we investigated the role of dual immunoglobulin domain-containing cell adhesion molecules (DICAM) in the glial cell interaction during neuroinflammation. DICAM knockout (KO) mice revealed enhanced nociceptive behaviors and glial cell activation of the tibia fracture with a cast immobilization model of complex regional pain syndrome (CRPS). DICAM was selectively secreted in reactive astrocytes, mainly via extracellular vesicles (EVs), and contributed to the regulation of neuroinflammation through the M2 polarization of microglia, which is dependent on the suppression of p38 MAPK signaling. In conclusion, DICAM secreted from reactive astrocytes through EVs was involved in the suppression of microglia activation and subsequent attenuation of neuroinflammation during central sensitization.<\/jats:p>","DOI":"10.3390\/cells11192977","type":"journal-article","created":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T21:14:28Z","timestamp":1664140468000},"page":"2977","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["DICAM in the Extracellular Vesicles from Astrocytes Attenuates Microglia Activation and Neuroinflammation"],"prefix":"10.3390","volume":"11","author":[{"given":"Jin","family":"Han","sequence":"first","affiliation":[{"name":"Laboratory for Arthritis and Cartilage Biology, Research Institute of Aging and Metabolism, Kyungpook National University, Daegu 41404, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Jung","family":"Cho","sequence":"additional","affiliation":[{"name":"Laboratory for Arthritis and Bone Biology, Fatima Research Institute, Daegu Fatima Hospital, Daegu 41404, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghwi","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 44521, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1614-7635","authenticated-orcid":false,"given":"Seungwoo","family":"Han","sequence":"additional","affiliation":[{"name":"Laboratory for Arthritis and Cartilage Biology, Research Institute of Aging and Metabolism, Kyungpook National University, Daegu 41404, Korea"},{"name":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 41404, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e12137","DOI":"10.1111\/jabr.12137","article-title":"The neurobiology of central sensitization","volume":"23","author":"Harte","year":"2018","journal-title":"J. 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