{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:38:02Z","timestamp":1790678282479,"version":"4.1.0"},"reference-count":170,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T00:00:00Z","timestamp":1664668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH\/NIDCD","award":["R01 DC015781"],"award-info":[{"award-number":["R01 DC015781"]}]},{"name":"NIH\/NIDCD","award":["R01-DC010844"],"award-info":[{"award-number":["R01-DC010844"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Pericytes (PCs), as a central component of the neurovascular unit, contribute to the regenerative potential of the central nervous system (CNS) and peripheral nervous system (PNS) by virtue of their role in blood flow regulation, angiogenesis, maintenance of the BBB, neurogenesis, and neuroprotection. Emerging evidence indicates that PCs also have a role in mediating cell-to-cell communication through the secretion of extracellular vesicles (EVs). Extracellular vesicles are cell-derived, micro- to nano-sized vesicles that transport cell constituents such as proteins, nucleic acids, and lipids from a parent originating cell to a recipient cell. PC-derived EVs (PC-EVs) play a crucial homeostatic role in neurovascular disease, as they promote angiogenesis, maintain the integrity of the blood-tissue barrier, and provide neuroprotection. The cargo carried by PC-EVs includes growth factors such as endothelial growth factor (VEGF), connecting tissue growth factors (CTGFs), fibroblast growth factors, angiopoietin 1, and neurotrophic growth factors such as brain-derived neurotrophic growth factor (BDNF), neuron growth factor (NGF), and glial-derived neurotrophic factor (GDNF), as well as cytokines such as interleukin (IL)-6, IL-8, IL-10, and MCP-1. The PC-EVs also carry miRNA and circular RNA linked to neurovascular health and the progression of several vascular and neuronal diseases. Therapeutic strategies employing PC-EVs have potential in the treatment of vascular and neurodegenerative diseases. This review discusses current research on the characteristic features of EVs secreted by PCs and their role in neuronal and vascular health and disease.<\/jats:p>","DOI":"10.3390\/cells11193108","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T01:52:21Z","timestamp":1665193941000},"page":"3108","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["The Emerging Role of Pericyte-Derived Extracellular Vesicles in Vascular and Neurological Health"],"prefix":"10.3390","volume":"11","author":[{"given":"Kushal","family":"Sharma","sequence":"first","affiliation":[{"name":"Oregon Hearing Research Center, Department of Otolaryngology\/Head & Neck Surgery, Oregon Health & Science University, Portland, OR 97239, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5254-796X","authenticated-orcid":false,"given":"Yunpei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Oregon Hearing Research Center, Department of Otolaryngology\/Head & Neck Surgery, Oregon Health & Science University, Portland, OR 97239, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3591-2080","authenticated-orcid":false,"given":"Keshav Raj","family":"Paudel","sequence":"additional","affiliation":[{"name":"Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW 2007, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Kachelmeier","sequence":"additional","affiliation":[{"name":"Oregon Hearing Research Center, Department of Otolaryngology\/Head & Neck Surgery, Oregon Health & Science University, Portland, OR 97239, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4741-3035","authenticated-orcid":false,"given":"Philip M.","family":"Hansbro","sequence":"additional","affiliation":[{"name":"Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW 2007, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorui","family":"Shi","sequence":"additional","affiliation":[{"name":"Oregon Hearing Research Center, Department of Otolaryngology\/Head & Neck Surgery, Oregon Health & Science University, Portland, OR 97239, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1038\/nn.2946","article-title":"Central nervous system pericytes in health and disease","volume":"14","author":"Winkler","year":"2011","journal-title":"Nat. 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