{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:47:48Z","timestamp":1790552868097,"version":"4.1.0"},"reference-count":146,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T00:00:00Z","timestamp":1665273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea (NRF)","award":["2018R1A6A1A03023718"],"award-info":[{"award-number":["2018R1A6A1A03023718"]}]},{"name":"National Research Foundation of Korea (NRF)","award":["2019R1A2C1008619"],"award-info":[{"award-number":["2019R1A2C1008619"]}]},{"name":"National Research Foundation of Korea (NRF)","award":["2019H1A2A1076925"],"award-info":[{"award-number":["2019H1A2A1076925"]}]},{"name":"National Research Foundation of Korea (NRF)","award":["HN21C0952"],"award-info":[{"award-number":["HN21C0952"]}]},{"name":"Ministry of Education, Science, and Technology","award":["2018R1A6A1A03023718"],"award-info":[{"award-number":["2018R1A6A1A03023718"]}]},{"name":"Ministry of Education, Science, and Technology","award":["2019R1A2C1008619"],"award-info":[{"award-number":["2019R1A2C1008619"]}]},{"name":"Ministry of Education, Science, and Technology","award":["2019H1A2A1076925"],"award-info":[{"award-number":["2019H1A2A1076925"]}]},{"name":"Ministry of Education, Science, and Technology","award":["HN21C0952"],"award-info":[{"award-number":["HN21C0952"]}]},{"name":"Ministry of Science and ICT","award":["2018R1A6A1A03023718"],"award-info":[{"award-number":["2018R1A6A1A03023718"]}]},{"name":"Ministry of Science and ICT","award":["2019R1A2C1008619"],"award-info":[{"award-number":["2019R1A2C1008619"]}]},{"name":"Ministry of Science and ICT","award":["2019H1A2A1076925"],"award-info":[{"award-number":["2019H1A2A1076925"]}]},{"name":"Ministry of Science and ICT","award":["HN21C0952"],"award-info":[{"award-number":["HN21C0952"]}]},{"name":"Ministry of Trade, Industry, and Energy","award":["2018R1A6A1A03023718"],"award-info":[{"award-number":["2018R1A6A1A03023718"]}]},{"name":"Ministry of Trade, Industry, and Energy","award":["2019R1A2C1008619"],"award-info":[{"award-number":["2019R1A2C1008619"]}]},{"name":"Ministry of Trade, Industry, and Energy","award":["2019H1A2A1076925"],"award-info":[{"award-number":["2019H1A2A1076925"]}]},{"name":"Ministry of Trade, Industry, and Energy","award":["HN21C0952"],"award-info":[{"award-number":["HN21C0952"]}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["2018R1A6A1A03023718"],"award-info":[{"award-number":["2018R1A6A1A03023718"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["2019R1A2C1008619"],"award-info":[{"award-number":["2019R1A2C1008619"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["2019H1A2A1076925"],"award-info":[{"award-number":["2019H1A2A1076925"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HN21C0952"],"award-info":[{"award-number":["HN21C0952"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Histone deacetylase 8 (HDAC8) is a class I HDAC that catalyzes the deacetylation of histone and non-histone proteins. As one of the best-characterized isoforms, numerous studies have identified interacting partners of HDAC8 pertaining to diverse molecular mechanisms. Consequently, deregulation and overexpression of HDAC8 give rise to diseases. HDAC8 is especially involved in various aspects of cancer progression, such as cancer cell proliferation, metastasis, immune evasion, and drug resistance. HDAC8 is also associated with the development of non-cancer diseases such as Cornelia de Lange Syndrome (CdLS), infectious diseases, cardiovascular diseases, pulmonary diseases, and myopathy. Therefore, HDAC8 is an attractive therapeutic target and various HDAC8 selective inhibitors (HDAC8is) have been developed. Here, we address the pathological function of HDAC8 in cancer and other diseases, as well as illustrate several HDAC8is that have shown anti-cancer effects.<\/jats:p>","DOI":"10.3390\/cells11193161","type":"journal-article","created":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T04:00:02Z","timestamp":1665288002000},"page":"3161","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Pathological Role of HDAC8: Cancer and Beyond"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5354-164X","authenticated-orcid":false,"given":"Ji Yoon","family":"Kim","sequence":"first","affiliation":[{"name":"College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayoung","family":"Cho","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung","family":"Yoo","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go Woon","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Hyun","family":"Jeon","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Wu","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3753-4415","authenticated-orcid":false,"given":"So Hee","family":"Kwon","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1146\/annurev-bioeng-071516-044720","article-title":"Epigenetic Regulation: A New Frontier for Biomedical Engineers","volume":"19","author":"Chen","year":"2017","journal-title":"Annu. 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