{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:29:15Z","timestamp":1789784955580,"version":"4.0.1"},"reference-count":95,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The National Natural Science Foundation of China","award":["81830032"],"award-info":[{"award-number":["81830032"]}]},{"name":"The National Natural Science Foundation of China","award":["82071421"],"award-info":[{"award-number":["82071421"]}]},{"name":"The National Natural Science Foundation of China","award":["31872779"],"award-info":[{"award-number":["31872779"]}]},{"name":"The National Natural Science Foundation of China","award":["81901289"],"award-info":[{"award-number":["81901289"]}]},{"name":"The National Natural Science Foundation of China","award":["202007030008"],"award-info":[{"award-number":["202007030008"]}]},{"name":"The National Natural Science Foundation of China","award":["2021ZT09Y007"],"award-info":[{"award-number":["2021ZT09Y007"]}]},{"name":"The National Natural Science Foundation of China","award":["2020B121201006"],"award-info":[{"award-number":["2020B121201006"]}]},{"name":"The National Natural Science Foundation of China","award":["2018B030337001"],"award-info":[{"award-number":["2018B030337001"]}]},{"name":"Guangzhou Key Research Program on Brain Science","award":["81830032"],"award-info":[{"award-number":["81830032"]}]},{"name":"Guangzhou Key Research Program on Brain Science","award":["82071421"],"award-info":[{"award-number":["82071421"]}]},{"name":"Guangzhou Key Research Program on Brain Science","award":["31872779"],"award-info":[{"award-number":["31872779"]}]},{"name":"Guangzhou Key Research Program on Brain Science","award":["81901289"],"award-info":[{"award-number":["81901289"]}]},{"name":"Guangzhou Key Research Program on Brain Science","award":["202007030008"],"award-info":[{"award-number":["202007030008"]}]},{"name":"Guangzhou Key Research Program on Brain Science","award":["2021ZT09Y007"],"award-info":[{"award-number":["2021ZT09Y007"]}]},{"name":"Guangzhou Key Research Program on Brain Science","award":["2020B121201006"],"award-info":[{"award-number":["2020B121201006"]}]},{"name":"Guangzhou Key Research Program on Brain Science","award":["2018B030337001"],"award-info":[{"award-number":["2018B030337001"]}]},{"name":"Department of Science and Technology of Guangdong Province","award":["81830032"],"award-info":[{"award-number":["81830032"]}]},{"name":"Department of Science and Technology of Guangdong Province","award":["82071421"],"award-info":[{"award-number":["82071421"]}]},{"name":"Department of Science and Technology of Guangdong Province","award":["31872779"],"award-info":[{"award-number":["31872779"]}]},{"name":"Department of Science and Technology of Guangdong Province","award":["81901289"],"award-info":[{"award-number":["81901289"]}]},{"name":"Department of Science and Technology of Guangdong Province","award":["202007030008"],"award-info":[{"award-number":["202007030008"]}]},{"name":"Department of Science and Technology of Guangdong Province","award":["2021ZT09Y007"],"award-info":[{"award-number":["2021ZT09Y007"]}]},{"name":"Department of Science and Technology of Guangdong Province","award":["2020B121201006"],"award-info":[{"award-number":["2020B121201006"]}]},{"name":"Department of Science and Technology of Guangdong Province","award":["2018B030337001"],"award-info":[{"award-number":["2018B030337001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Huntington\u2019s disease (HD) is an autosomal-dominant inherited progressive neurodegenerative disorder. It is caused by a CAG repeat expansion in the Huntingtin gene that is translated to an expanded polyglutamine (PolyQ) repeat in huntingtin protein. HD is characterized by mood swings, involuntary movement, and cognitive decline in the late disease stage. HD patients often die 15\u201320 years after disease onset. Currently, there is no cure for HD. Due to the striking neuronal loss in HD, most studies focused on the investigation of the predominantly neuronal degeneration in specific brain regions. However, the pathology of the white matter area in the brains of HD patients was also reported by clinical imaging studies, which showed white matter abnormalities even before the clinical onset of HD. Since oligodendrocytes form myelin sheaths around the axons in the brain, white matter lesions are likely attributed to alterations in myelin and oligodendrocyte-associated changes in HD. In this review, we summarized the evidence for white matter, myelin, and oligodendrocytes alterations that were previously observed in HD patients and animal models. We also discussed potential mechanisms for white matter changes and possible treatment to prevent glial dysfunction in HD.<\/jats:p>","DOI":"10.3390\/cells11213381","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T11:53:51Z","timestamp":1666785231000},"page":"3381","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Insights into White Matter Defect in Huntington\u2019s Disease"],"prefix":"10.3390","volume":"11","author":[{"given":"Yize","family":"Sun","sequence":"first","affiliation":[{"name":"Guangdong Key Laboratory of Non-Human Primate Research, Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huichun","family":"Tong","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Non-Human Primate Research, Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqi","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Non-Human Primate Research, Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Non-Human Primate Research, Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jiang","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Non-Human Primate Research, Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihua","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Non-Human Primate Research, Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/ng0893-398","article-title":"The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington\u2019s disease","volume":"4","author":"Andrew","year":"1993","journal-title":"Nat. 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