{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:22:10Z","timestamp":1761218530408,"version":"build-2065373602"},"reference-count":54,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH\/NIAID\/NIA","doi-asserted-by":"publisher","award":["R01AI132695","RF1AG059321","MNIRGD-12-243075"],"award-info":[{"award-number":["R01AI132695","RF1AG059321","MNIRGD-12-243075"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH\/NIA","doi-asserted-by":"publisher","award":["R01AI132695","RF1AG059321","MNIRGD-12-243075"],"award-info":[{"award-number":["R01AI132695","RF1AG059321","MNIRGD-12-243075"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer\u2019s Association","doi-asserted-by":"publisher","award":["R01AI132695","RF1AG059321","MNIRGD-12-243075"],"award-info":[{"award-number":["R01AI132695","RF1AG059321","MNIRGD-12-243075"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Extensive experimental and human-derived evidence suggest that misfolded A\u03b2 particles spread similarly to infectious prions. Moreover, peripheral administration of A\u03b2 seeds accelerates brain amyloidosis in both susceptible experimental animals and humans. The mechanisms and elements governing the transport of misfolded A\u03b2 from the periphery to the brain are not fully understood, although circulation and retrograde axonal transport have been proposed. Here, we demonstrate that injection of A\u03b2 seeds in the tongue, a highly innervated organ, substantially accelerates the appearance of plaques in Tg2576 mice. In addition, the extra-nasal exposure of A\u03b2 aggregates increased amyloid pathology in the olfactory bulb. Our results show that exposing highly innervated tissues to A\u03b2 seeds accelerates AD-like pathological features, and suggest that A\u03b2 seeds can be transported from peripheral compartments to the brain by retrograde axonal transport. Research in this direction may be relevant on different fronts, including disease mechanisms, diagnosis, and risk-evaluation of potential iatrogenic transmission of A\u03b2 misfolding.<\/jats:p>","DOI":"10.3390\/cells11213442","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T23:26:32Z","timestamp":1667258792000},"page":"3442","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Altering Brain Amyloidosis by Intra-Lingual and Extra-Nasal Exposure of A\u03b2 Aggregates"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6847-7735","authenticated-orcid":false,"given":"Nazaret","family":"Gamez","sequence":"first","affiliation":[{"name":"Department of Neurology, The University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX 77030, USA"},{"name":"Dpto. Biolog\u00eda Celular, Gen\u00e9tica y Fisiolog\u00eda, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga-IBIMA, Facultad de Ciencias, Universidad of Malaga, 29010 Malaga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javiera","family":"Bravo-Alegria","sequence":"additional","affiliation":[{"name":"Department of Neurology, The University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX 77030, USA"},{"name":"Universidad de los Andes, Facultad de Medicina, Av. San Carlos de Apoquindo 2200, Las Condes, Santiago 7620001, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3052-3796","authenticated-orcid":false,"given":"Yumeng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson","family":"Perez-Urrutia","sequence":"additional","affiliation":[{"name":"Department of Neurology, The University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX 77030, USA"},{"name":"Facultad de Ciencias de la Salud, Universidad San Sebastian, Lientur 1456, Concepcion 4080871, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepa","family":"Dongarwar","sequence":"additional","affiliation":[{"name":"Department of Neurology, The University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Soto","sequence":"additional","affiliation":[{"name":"Department of Neurology, The University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7766-5770","authenticated-orcid":false,"given":"Rodrigo","family":"Morales","sequence":"additional","affiliation":[{"name":"Department of Neurology, The University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX 77030, USA"},{"name":"Centro Integrativo de Biologia y Quimica Aplicada (CIBQA), Universidad Bernardo O\u2019Higgins, Santiago 8370993, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Alzheimer Disease","volume":"7","author":"Knopman","year":"2021","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Alzheimer\u2019s Disease","volume":"28","author":"Querfurth","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Twohig, D., and Nielsen, H.M. (2019). \u03b1-Synuclein in the Pathophysiology of Alzheimer\u2019s Disease. Mol. Neurodegener., 14.","DOI":"10.1186\/s13024-019-0320-x"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer\u2019s Disease: The Amyloid Cascade Hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The Amyloid Hypothesis of Alzheimer\u2019s Disease at 25 Years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","article-title":"The Amyloid-\u03b2 Pathway in Alzheimer\u2019s Disease","volume":"26","author":"Hampel","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/hmg\/ddh019","article-title":"Mutant Presenilins Specifically Elevate the Levels of the 42 Residue \u03b2-Amyloid Peptide in Vivo: Evidence for Augmentation of a 42-Specific \u03b3 Secretase","volume":"13","author":"Jankowsky","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal Beta-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer\u2019s Disease Mutations: Potential Factors in Amyloid Plaque Formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1126\/science.274.5284.99","article-title":"Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice","volume":"274","author":"Hsiao","year":"1996","journal-title":"Science"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"9349","DOI":"10.1038\/srep09349","article-title":"Titration of Biologically Active Amyloid-\u03b2 Seeds in a Transgenic Mouse Model of Alzheimer\u2019s Disease","volume":"5","author":"Morales","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.1523\/JNEUROSCI.20-10-03606.2000","article-title":"Evidence for Seeding of \u03b2-Amyloid by Intracerebral Infusion of Alzheimer Brain Extracts in \u03b2-Amyloid Precursor Protein-Transgenic Mice","volume":"20","author":"Kane","year":"2000","journal-title":"J. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5690","DOI":"10.1038\/s41380-021-01150-w","article-title":"Transmission of Cerebral Amyloid Pathology by Peripheral Administration of Misfolded A\u03b2 Aggregates","volume":"26","author":"Morales","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1126\/science.1131864","article-title":"Exogenous Induction of Cerebral Beta-Amyloidogenesis Is Governed by Agent and Host","volume":"313","author":"Coomaraswamy","year":"2006","journal-title":"Science"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"a024398","DOI":"10.1101\/cshperspect.a024398","article-title":"The Prion-Like Properties of Amyloid-\u03b2 Assemblies: Implications for Alzheimer\u2019s Disease","volume":"6","author":"Walker","year":"2016","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"13363","DOI":"10.1073\/pnas.95.23.13363","article-title":"Prions","volume":"95","author":"Prusiner","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.neuro.24.1.519","article-title":"Prion Diseases of Humans and Animals: Their Causes and Molecular Basis","volume":"24","author":"Collinge","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1146\/annurev.pathmechdis.3.121806.154326","article-title":"Molecular Mechanisms of Prion Pathogenesis","volume":"3","author":"Aguzzi","year":"2008","journal-title":"Annu. Rev. Pathol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.virusres.2014.12.031","article-title":"Prion-like Features of Misfolded A\u03b2 and Tau Aggregates","volume":"207","author":"Morales","year":"2015","journal-title":"Virus Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.cell.2012.05.007","article-title":"Transmissible Proteins: Expanding the Prion Heresy","volume":"149","author":"Soto","year":"2012","journal-title":"Cell"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1001\/jamaneurol.2013.1933","article-title":"Evaluation of Potential Infectivity of Alzheimer and Parkinson Disease Proteins in Recipients of Cadaver-Derived Human Growth Hormone","volume":"70","author":"Irwin","year":"2013","journal-title":"JAMA Neurol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature15369","article-title":"Evidence for Human Transmission of Amyloid-\u03b2 Pathology and Cerebral Amyloid Angiopathy","volume":"525","author":"Jaunmuktane","year":"2015","journal-title":"Nature"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41586-018-0790-y","article-title":"Transmission of Amyloid-\u03b2 Protein Pathology from Cadaveric Pituitary Growth Hormone","volume":"564","author":"Purro","year":"2018","journal-title":"Nature"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00401-016-1588-3","article-title":"Significant Association of Cadaveric Dura Mater Grafting with Subpial A\u03b2 Deposition and Meningeal Amyloid Angiopathy","volume":"132","author":"Hamaguchi","year":"2016","journal-title":"Acta Neuropathol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Gomez-Gutierrez, R., and Morales, R. (2020). The Prion-like Phenomenon in Alzheimer\u2019s Disease: Evidence of Pathology Transmission in Humans. PLoS Pathog., 16.","DOI":"10.1371\/journal.ppat.1009004"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1128\/JVI.77.1.583-591.2003","article-title":"Rapid Prion Neuroinvasion Following Tongue Infection","volume":"77","author":"Bartz","year":"2003","journal-title":"J. Virol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1128\/JVI.02649-06","article-title":"The Nasal Cavity Is a Route for Prion Infection in Hamsters","volume":"81","author":"Kincaid","year":"2007","journal-title":"J. Virol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Duran-Aniotz, C., Morales, R., Moreno-Gonzalez, I., Hu, P.P., Fedynyshyn, J., and Soto, C. (2014). Aggregate-Depleted Brain Fails to Induce Abeta Deposition in a Mouse Model of Alzheimer\u2019s Disease. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0089014"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Koshy, S.M., Kincaid, A.E., and Bartz, J.C. (2022). Transport of Prions in the Peripheral Nervous System: Pathways, Cell Types, and Mechanisms. Viruses, 14.","DOI":"10.3390\/v14030630"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"10264","DOI":"10.1523\/JNEUROSCI.1608-14.2014","article-title":"Multiple Factors Contribute to the Peripheral Induction of Cerebral \u03b2-Amyloidosis","volume":"34","author":"Eisele","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrneurol.2015.119","article-title":"Clearance Systems in the Brain-Implications for Alzheimer Disease","volume":"11","author":"Carare","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"8850","DOI":"10.1073\/pnas.151261398","article-title":"Peripheral Anti-A Beta Antibody Alters CNS and Plasma A Beta Clearance and Decreases Brain A Beta Burden in a Mouse Model of Alzheimer\u2019s Disease","volume":"98","author":"DeMattos","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/ana.23857","article-title":"Anti-Amyloid \u03b2 Autoantibodies in Cerebral Amyloid Angiopathy-Related Inflammation: Implications for Amyloid-Modifying Therapies","volume":"73","author":"Piazza","year":"2013","journal-title":"Ann. Neurol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"997","DOI":"10.3233\/JAD-151139","article-title":"Patients That Have Undergone Hemodialysis Exhibit Lower Amyloid Deposition in the Brain: Evidence Supporting a Therapeutic Strategy for Alzheimer\u2019s Disease by Removal of Blood Amyloid","volume":"51","author":"Sakai","year":"2016","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"6074","DOI":"10.1038\/s41380-021-01073-6","article-title":"Physiological Clearance of Amyloid-Beta by the Kidney and Its Therapeutic Potential for Alzheimer\u2019s Disease","volume":"26","author":"Tian","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jalz.2008.10.004","article-title":"Amyloid Beta Peptides in Human Plasma and Tissues and Their Significance for Alzheimer\u2019s Disease","volume":"5","author":"Roher","year":"2009","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1038\/mp.2017.204","article-title":"Blood-Derived Amyloid-\u03b2 Protein Induces Alzheimer\u2019s Disease Pathologies","volume":"23","author":"Bu","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1006\/bbrc.1993.2582","article-title":"Blood-Brain Barrier Transport of Circulating Alzheimer\u2032s Amyloid \u03b2","volume":"197","author":"Zlokovic","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S1537-1891(02)00198-2","article-title":"Circulating Amyloid-\u03b2 Peptide Crosses the Blood\u2013Brain Barrier in Aged Monkeys and Contributes to Alzheimer\u2019s Disease Lesions","volume":"38","author":"Mackic","year":"2002","journal-title":"Vasc. Pharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1126\/science.1197623","article-title":"Decreased Clearance of CNS \u03b2-Amyloid in Alzheimer\u2019s Disease","volume":"330","author":"Mawuenyega","year":"2010","journal-title":"Science"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1007\/s12035-016-9826-1","article-title":"Associations Between Hepatic Functions and Plasma Amyloid-Beta Levels-Implications for the Capacity of Liver in Peripheral Amyloid-Beta Clearance","volume":"54","author":"Wang","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnagi.2019.00174","article-title":"Liver Dysfunction as a Novel Player in Alzheimer\u2019s Progression: Looking Outside the Brain","volume":"11","author":"Estrada","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"ref_42","first-page":"510","article-title":"Plasma Amyloid Beta Levels Are Associated with Cerebral Amyloid and Tau Deposition","volume":"11","author":"Risacher","year":"2019","journal-title":"Alzheimer\u2019s Dement. Diagn. Assess. Dis. Monit."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Giampietri, L., Belli, E., Beatino, M.F., Giannoni, S., Palermo, G., Campese, N., Tognoni, G., Siciliano, G., Ceravolo, R., and De Luca, C. (2022). Fluid Biomarkers in Alzheimer\u2019s Disease and Other Neurodegenerative Disorders: Toward Integrative Diagnostic Frameworks and Tailored Treatments. Diagnostics, 12.","DOI":"10.3390\/diagnostics12040796"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1001\/jamaneurol.2021.3180","article-title":"Head-to-Head Comparison of 8 Plasma Amyloid-\u03b2 42\/40 Assays in Alzheimer Disease","volume":"78","author":"Janelidze","year":"2021","journal-title":"JAMA Neurol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0299-y","article-title":"Diagnosis of Alzheimer\u2019s Disease Utilizing Amyloid and Tau as Fluid Biomarkers","volume":"51","author":"Lee","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00401-017-1703-0","article-title":"Amyloid-\u03b2 Accumulation in the CNS in Human Growth Hormone Recipients in the UK","volume":"134","author":"Ritchie","year":"2017","journal-title":"Acta Neuropathol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/1531-8249(200010)48:4<567::AID-ANA3>3.0.CO;2-W","article-title":"Nasal Administration of Amyloid-\u03b2 Peptide Decreases Cerebral Amyloid Burden in a Mouse Model of Alzheimer\u2019s Disease","volume":"48","author":"Weiner","year":"2000","journal-title":"Ann. Neurol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3389\/fnana.2014.00063","article-title":"Anatomy, Histochemistry, and Immunohistochemistry of the Olfactory Subsystems in Mice","volume":"8","author":"Barrios","year":"2014","journal-title":"Front. Neuroanat."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.cell.2009.10.001","article-title":"Common Sense about Taste: From Mammals to Insects","volume":"139","author":"Yarmolinsky","year":"2009","journal-title":"Cell"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/373523a0","article-title":"Alzheimer-Type Neuropathology in Transgenic Mice Overexpressing V717F Beta-Amyloid Precursor Protein","volume":"373","author":"Games","year":"1995","journal-title":"Nature"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00401-020-02201-2","article-title":"The Existence of A\u03b2 Strains and Their Potential for Driving Phenotypic Heterogeneity in Alzheimer\u2019s Disease","volume":"142","author":"Lau","year":"2021","journal-title":"Acta Neuropathol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.febslet.2014.01.038","article-title":"Peripherally Administrated Prions Reach the Brain at Sub-Infectious Quantities in Experimental Hamsters","volume":"588","author":"Chen","year":"2014","journal-title":"FEBS Lett."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1096\/fj.11-180729","article-title":"Initial Fate of Prions upon Peripheral Infection: Half-life, Distribution, Clearance, and Tissue Uptake","volume":"25","author":"Urayama","year":"2011","journal-title":"FASEB J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40478-018-0511-7","article-title":"Intravenous Injection of Beta-Amyloid Seeds Promotes Cerebral Amyloid Angiopathy (CAA)","volume":"6","author":"Burwinkel","year":"2018","journal-title":"Acta Neuropathol. Commun."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/21\/3442\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:07:03Z","timestamp":1760144823000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/21\/3442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,31]]},"references-count":54,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["cells11213442"],"URL":"https:\/\/doi.org\/10.3390\/cells11213442","relation":{},"ISSN":["2073-4409"],"issn-type":[{"type":"electronic","value":"2073-4409"}],"subject":[],"published":{"date-parts":[[2022,10,31]]}}}