{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:48:07Z","timestamp":1792622887452,"version":"4.5.0"},"reference-count":471,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T00:00:00Z","timestamp":1667692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 EY012200"],"award-info":[{"award-number":["R01 EY012200"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 EY014237"],"award-info":[{"award-number":["R01 EY014237"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>In vitro differentiation of human pluripotent stem cells (hPSCs) into specialized tissues and organs represents a powerful approach to gain insight into those cellular and molecular mechanisms regulating human development. Although normal embryonic eye development is a complex process, generation of ocular organoids and specific ocular tissues from pluripotent stem cells has provided invaluable insights into the formation of lineage-committed progenitor cell populations, signal transduction pathways, and self-organization principles. This review provides a comprehensive summary of recent advances in generation of adenohypophyseal, olfactory, and lens placodes, lens progenitor cells and three-dimensional (3D) primitive lenses, \u201clentoid bodies\u201d, and \u201cmicro-lenses\u201d. These cells are produced alone or \u201ccommunity-grown\u201d with other ocular tissues. Lentoid bodies\/micro-lenses generated from human patients carrying mutations in crystallin genes demonstrate proof-of-principle that these cells are suitable for mechanistic studies of cataractogenesis. Taken together, current and emerging advanced in vitro differentiation methods pave the road to understand molecular mechanisms of cataract formation caused by the entire spectrum of mutations in DNA-binding regulatory genes, such as PAX6, SOX2, FOXE3, MAF, PITX3, and HSF4, individual crystallins, and other genes such as BFSP1, BFSP2, EPHA2, GJA3, GJA8, LIM2, MIP, and TDRD7 represented in human cataract patients.<\/jats:p>","DOI":"10.3390\/cells11213516","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T02:43:51Z","timestamp":1667789031000},"page":"3516","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Generation of Lens Progenitor Cells and Lentoid Bodies from Pluripotent Stem Cells: Novel Tools for Human Lens Development and Ocular Disease Etiology"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3957-789X","authenticated-orcid":false,"given":"Ale\u0161","family":"Cvekl","sequence":"first","affiliation":[{"name":"Departments Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA"},{"name":"Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3742-6000","authenticated-orcid":false,"given":"Michael John","family":"Camerino","sequence":"additional","affiliation":[{"name":"Departments Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA"},{"name":"Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/292154a0","article-title":"Establishment in culture of pluripotential cells from mouse embryos","volume":"292","author":"Evans","year":"1981","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","article-title":"Embryonic stem cell lines derived from human blastocysts","volume":"282","author":"Thomson","year":"1998","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.cell.2016.05.082","article-title":"Modeling Development and Disease with Organoids","volume":"165","author":"Clevers","year":"2016","journal-title":"Cell"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2019.09.029","article-title":"Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures","volume":"179","author":"Li","year":"2019","journal-title":"Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.stem.2022.04.003","article-title":"Engineering multiscale structural orders for high-fidelity embryoids and organoids","volume":"29","author":"Shao","year":"2022","journal-title":"Cell Stem Cell"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1038\/nprot.2014.158","article-title":"Generation of cerebral organoids from human pluripotent stem cells","volume":"9","author":"Lancaster","year":"2014","journal-title":"Nat. Protoc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1073\/pnas.46.9.1177","article-title":"Reconstitution of complete organs from single-cell suspensions of chick embryos in advanced stages of differentiation","volume":"46","author":"Weiss","year":"1960","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41586-022-05246-3","article-title":"Synthetic embryos complete gastrulation to neurulation and organogenesis","volume":"610","author":"Amadei","year":"2022","journal-title":"Nature"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1016\/j.cell.2022.07.028","article-title":"Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs","volume":"185","author":"Tarazi","year":"2022","journal-title":"Cell"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1258096","DOI":"10.1126\/science.1258096","article-title":"The new frontier of genome engineering with CRISPR-Cas9","volume":"346","author":"Doudna","year":"2014","journal-title":"Science"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1146\/annurev-biophys-062215-010822","article-title":"CRISPR-Cas9 structures and mechanisms","volume":"46","author":"Jiang","year":"2017","journal-title":"Annu. Rev. Biophys."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev-genet-120215-034854","article-title":"Single-Cell and Single-Molecule Analysis of Gene Expression Regulation","volume":"50","author":"Vera","year":"2016","journal-title":"Annu. Rev. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1172\/JCI40553","article-title":"Progress toward the clinical application of patient-specific pluripotent stem cells","volume":"120","author":"Kiskinis","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.preteyeres.2014.10.002","article-title":"Patient-specific induced pluripotent stem cells (iPSCs) for the study and treatment of retinal degenerative diseases","volume":"44","author":"Wiley","year":"2015","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nn.4273","article-title":"Modeling ALS with motor neurons derived from human induced pluripotent stem cells","volume":"19","author":"Sances","year":"2016","journal-title":"Nat. Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1167\/iovs.14-16049","article-title":"Advancing therapeutic strategies for inherited retinal degeneration: Recommendations from the Monaciano Symposium","volume":"56","author":"Thompson","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1167\/tvst.10.10.15","article-title":"Outer Retinal Cell Replacement: Putting the Pieces Together","volume":"10","author":"Ludwig","year":"2021","journal-title":"Transl. Vis. Sci. Technol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"109170","DOI":"10.1016\/j.exer.2022.109170","article-title":"Cell culture models to study retinal pigment epithelium-related pathogenesis in age-related macular degeneration","volume":"222","author":"Bharti","year":"2022","journal-title":"Exp. Eye Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"9688","DOI":"10.1073\/pnas.161144098","article-title":"Primary defects in the lens underlie complex anterior segment abnormalities of the Pax6 heterozygous eye","volume":"98","author":"Collinson","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7497","DOI":"10.1128\/MCB.00687-07","article-title":"Conditional deletion of activating protein 2\u03b1 (AP-2\u03b1) in the developing retina demonstrates non-cell-autonomous roles for AP-2\u03b1 in optic cup development","volume":"27","author":"Bassett","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1242\/dev.098822","article-title":"Stage-dependent requirement of neuroretinal Pax6 for lens and retina development","volume":"141","author":"Klimova","year":"2014","journal-title":"Development"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Rausch, R.L., Libby, R.T., and Kiernan, A.E. (2018). Ciliary margin-derived BMP4 does not have a major role in ocular development. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0197048"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ibad, R.T., Mazhar, B., Vincent, C., Bernard, C., D\u00e9gardin, J., Simonutti, M., Lamonerie, T., Di Nardo, A.A., Prochiantz, A., and Moya, K.L. (2020). OTX2 non-cell autonomous activity regulates inner retinal function. eNeuro, 7.","DOI":"10.1523\/ENEURO.0012-19.2020"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0168-9525(92)90280-H","article-title":"Embryonic lens induction: Shedding light on vertebrate tissue determination","volume":"8","author":"Grainger","year":"1992","journal-title":"Trends Genet."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1098\/rstb.2010.0175","article-title":"The lens: A classical model of embryonic induction providing new insights into cell determination in early development","volume":"366","author":"Gunhaga","year":"2011","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.tig.2017.08.001","article-title":"Signaling and Gene Regulatory Networks in Mammalian Lens Development","volume":"33","author":"Cvekl","year":"2017","journal-title":"Trends Genet."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.gde.2004.08.002","article-title":"Hierarchy of regulatory events in sensory placode development","volume":"14","author":"Bhattacharyya","year":"2004","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"101093","DOI":"10.1016\/j.preteyeres.2022.101093","article-title":"Cell fate decisions, transcription factors and signaling during early retinal development","volume":"91","author":"Diacou","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.1242\/dev.125.23.4835","article-title":"Formation of Rathke\u2019s pouch requires dual induction from the diencephalon","volume":"125","author":"Takuma","year":"1998","journal-title":"Development"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"R55","DOI":"10.1530\/JME-14-0237","article-title":"Genetic regulation of murine pituitary development","volume":"54","author":"Rizzoti","year":"2015","journal-title":"J. Mol. Endocrinol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ydbio.2006.03.009","article-title":"Induction and specification of cranial placodes","volume":"294","author":"Schlosser","year":"2006","journal-title":"Dev. Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1242\/dev.107953","article-title":"The cellular and molecular mechanisms of vertebrate lens development","volume":"141","author":"Cvekl","year":"2014","journal-title":"Development"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1101\/gad.12.23.3764","article-title":"BMP4 is essential for lens induction in the mouse embryo","volume":"12","author":"Furuta","year":"1998","journal-title":"Genes Dev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.devcel.2007.04.020","article-title":"Time of Exposure to BMP Signals Plays a Key Role in the Specification of the Olfactory and Lens Placodes Ex Vivo","volume":"13","author":"Edlund","year":"2007","journal-title":"Dev. Cell"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ydbio.2015.09.009","article-title":"Negative and positive auto-regulation of BMP expression in early eye development","volume":"407","author":"Huang","year":"2015","journal-title":"Dev. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nrc2780","article-title":"Fibroblast growth factor signalling: From development to cancer","volume":"10","author":"Turner","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/bies.20009","article-title":"Anterior eye development and ocular mesenchyme: New insights from mouse models and human diseases","volume":"26","author":"Cvekl","year":"2004","journal-title":"Bioessays"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1002\/dvdy.22033","article-title":"Signaling \u201ccross-talk\u201d is integrated by transcription factors in the development of the anterior segment in the eye","volume":"238","author":"Gage","year":"2009","journal-title":"Dev. Dyn."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1167\/iovs.12-9595","article-title":"Activation of the hedgehog signaling pathway in the developing lens stimulates ectopic FoxE3 expression and disruption in fiber cell differentiation","volume":"53","author":"Kerr","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"108231","DOI":"10.1016\/j.exer.2020.108231","article-title":"Corneal development: Role of the periocular mesenchyme and bi-directional signaling","volume":"201","author":"Walker","year":"2020","journal-title":"Exp. Eye Res."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Weigele, J., and Bohnsack, B.L. (2020). Genetics underlying the interactions between neural crest cells and eye development. J. Dev. Biol., 8.","DOI":"10.3390\/jdb8040026"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Duester, G. (2022). Towards a Better Vision of Retinoic Acid Signaling during Eye Development. Cells, 11.","DOI":"10.3390\/cells11030322"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/bs.pmbts.2015.04.003","article-title":"Corneal development: Different cells from a common progenitor","volume":"134","author":"Lwigale","year":"2015","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2005.01.020","article-title":"Growth factor regulation of lens development","volume":"280","author":"Lovicu","year":"2005","journal-title":"Dev. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1098\/rstb.2010.0339","article-title":"Understanding the role of growth factors in embryonic development: Insights from the lens","volume":"366","author":"Lovicu","year":"2011","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Shu, D.Y., and Lovicu, F.J. (2021). Insights into Bone Morphogenetic Protein\u2014(BMP-) Signaling in Ocular Lens Biology and Pathology. Cells, 10.","DOI":"10.3390\/cells10102604"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"210265","DOI":"10.1098\/rsob.210265","article-title":"Jack of all trades, master of each: The diversity of fibroblast growth factor signalling in eye development","volume":"12","author":"Makrides","year":"2022","journal-title":"Open Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ydbio.2008.09.003","article-title":"Essential role of BMPs in FGF-induced secondary lens fiber differentiation","volume":"324","author":"Boswell","year":"2008","journal-title":"Dev. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1091\/mbc.e12-01-0075","article-title":"A balance of FGF and BMP signals regulates cell cycle exit and Equarin expression in lens cells","volume":"23","author":"Jarrin","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1091\/mbc.E15-02-0117","article-title":"Synergistic interaction between the fibroblast growth factor and bone morphogenetic protein signaling pathways in lens cells","volume":"26","author":"Boswell","year":"2015","journal-title":"Mol. Biol. Cell"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Li, H., Mao, Y., Bouaziz, M., Yu, H., Qu, X., Wang, F., Feng, G.-S., Shawber, C., and Zhang, X. (2019). Lens differentiation is controlled by the balance between PDGF and FGF signaling. PLoS Biol., 17.","DOI":"10.1371\/journal.pbio.3000133"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1152\/physiologyonline.2001.16.3.118","article-title":"Molecular solutions to mammalian lens transparency","volume":"16","author":"Donaldson","year":"2001","journal-title":"Physiology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"108564","DOI":"10.1016\/j.exer.2021.108564","article-title":"Crystallin gene expression: Insights from studies of transcriptional bursting","volume":"207","author":"Cvekl","year":"2021","journal-title":"Exp. Eye Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.semcdb.2006.10.011","article-title":"The role of the lens actin cytoskeleton in fiber cell elongation and differentiation","volume":"17","author":"Rao","year":"2006","journal-title":"Semin. Cell. Dev. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00232-007-9033-0","article-title":"Connexins in lens development and cataractogenesis","volume":"218","author":"Gong","year":"2007","journal-title":"J. Memb. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.exer.2008.11.007","article-title":"Lens intermediate filaments","volume":"88","author":"FitzGerald","year":"2009","journal-title":"Exp. Eye Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1172\/JCI38277","article-title":"Functions of the intermediate filament cytoskeleton in the eye lens","volume":"119","author":"Song","year":"2009","journal-title":"J. Clin. Investig."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fphys.2014.00020","article-title":"Connexin hemichannels in the lens","volume":"5","author":"Beyer","year":"2014","journal-title":"Front. Physiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.exer.2016.03.005","article-title":"The lens actin filament cytoskeleton: Diverse structures for complex functions","volume":"156","author":"Cheng","year":"2017","journal-title":"Exp. Eye Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.exer.2008.08.017","article-title":"On the mechanism of organelle degradation in the vertebrate lens","volume":"88","author":"Bassnett","year":"2009","journal-title":"Exp. Eye Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.exer.2016.02.011","article-title":"Disassembly of the lens fiber cell nucleus to create a clear lens: The p27 descent","volume":"156","author":"Rowan","year":"2017","journal-title":"Exp. Eye Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"108129","DOI":"10.1016\/j.exer.2020.108129","article-title":"Hypoxia regulates the degradation of non-nuclear organelles during lens differentiation through activation of HIF1a","volume":"198","author":"Brennan","year":"2020","journal-title":"Exp. Eye Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/aja.1001590406","article-title":"The surface morphology of embryonic and adult chick lens-fiber cells","volume":"159","author":"Kuszak","year":"1980","journal-title":"Am. J. Anat."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/BF02152295","article-title":"The three-dimensional organization of lens fibers in the rhesus monkey","volume":"219","author":"Willekens","year":"1982","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s002329900033","article-title":"Dye transfer between cells of the lens","volume":"150","author":"Rae","year":"1996","journal-title":"J. Memb. Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1242\/jcs.045203","article-title":"The stratified syncytium of the vertebrate lens","volume":"122","author":"Shi","year":"2009","journal-title":"J. Cell Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jtbi.2015.03.021","article-title":"A stochastic model of eye lens growth","volume":"376","author":"Shi","year":"2015","journal-title":"J. Theor. Biol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"160695","DOI":"10.1098\/rsos.160695","article-title":"A full lifespan model of vertebrate lens growth","volume":"4","author":"Shi","year":"2017","journal-title":"R. Soc. Open Sci."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Lovicu, F.J., and Robinson, M.L. (2004). Development of the Ocular Lens: Lens Fiber Differentiation. Cambridge University Press.","DOI":"10.1017\/CBO9780511529825"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.preteyeres.2013.01.005","article-title":"Adaptation of the central retina for high acuity vision: Cones, the fovea and the avascular zone","volume":"35","author":"Provis","year":"2013","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.preteyeres.2018.03.006","article-title":"The primate fovea: Structure, function and development","volume":"66","author":"Bringmann","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.exer.2018.05.012","article-title":"Anolis carolinensis as a model to understand the molecular and cellular basis of foveal development","volume":"173","author":"Sannan","year":"2018","journal-title":"Exp. Eye Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1167\/iovs.17-23120","article-title":"Assessment of outer retinal remodeling in the hibernating 13-lined ground squirrel","volume":"59","author":"Sajdak","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1002\/dvdy.348","article-title":"Ocular elongation and retraction in foveated reptiles","volume":"250","author":"Rasys","year":"2021","journal-title":"Dev. Dynam."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"7634","DOI":"10.1073\/pnas.78.12.7634","article-title":"Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells","volume":"78","author":"Martin","year":"1981","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature00900","article-title":"Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson\u2019s disease","volume":"418","author":"Kim","year":"2002","journal-title":"Nature"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0092-8674(02)00835-8","article-title":"Directed differentiation of embryonic stem cells into motor neurons","volume":"110","author":"Wichterle","year":"2002","journal-title":"Cell"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1089\/clo.2004.6.217","article-title":"Derivation and comparative assessment of retinal pigment epithelium from human embryonic stem cells using transcriptomics","volume":"6","author":"Klimanskaya","year":"2004","journal-title":"Clon. Stem Cells"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1073\/pnas.70.5.1495","article-title":"Differentiation of lens tissue from the progeny of chick retinal pigment cells cultured in vitro: A demonstration of a switch of cell types in clonal cell culture","volume":"70","author":"Eguchi","year":"1973","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/978-1-4899-5292-9_32","article-title":"Tissue culture of chick embryonic choroidal cells: Cell aggregation and pigment accumulation","volume":"158","author":"Chader","year":"1982","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0014-4835(88)90057-7","article-title":"Crystallins and their synthesis in human lens epithelial cells in tissue culture","volume":"47","author":"Reddy","year":"1988","journal-title":"Exp. Eye Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1046\/j.1432-0436.1994.56120067.x","article-title":"Differentiation and angiogenic growth factor message in two mammalian lens epithelial cell lines","volume":"56","author":"Kidd","year":"1994","journal-title":"Differentiation"},{"key":"ref_85","first-page":"2304","article-title":"Effects of growth factors on proliferation and differentiation in human lens epithelial cells in early subculture","volume":"36","author":"Ibaraki","year":"1995","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1006\/exer.1996.0162","article-title":"A Study of Growth Factor Receptors in Human Lens Epithelial Cells and their Relationship to Fiber Differentiation","volume":"63","author":"Ibaraki","year":"1996","journal-title":"Exp. Eye Res."},{"key":"ref_87","first-page":"57","article-title":"Protein kinase C\u03b1 and \u03b3 in N\/N 1003A rabbit lens epithelial cell differentiation","volume":"7","author":"Wagner","year":"2001","journal-title":"Mol. Vis."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0014-4835(05)80208-8","article-title":"Lens fiber cell differentiation and expression of crystallins in Co-cultures of human fetal lens epithelial cells and fibroblasts","volume":"54","author":"Nagineni","year":"1992","journal-title":"Exp. Eye Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1167\/iovs.06-0949","article-title":"In vitro generation of functional lens-like structures with relevance to age-related nuclear cataract","volume":"48","author":"McAvoy","year":"2007","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1091\/mbc.e06-09-0809","article-title":"The anaphase-promoting complex coordinates initiation of lens differentiation","volume":"18","author":"Wu","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.preteyeres.2009.12.001","article-title":"Development and use of the lens epithelial explant system to study lens differentiation and cataractogenesis","volume":"29","author":"Pino","year":"2010","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_92","first-page":"e319","article-title":"Making lineage decisions with biological noise: Lessons from the early mouse embryo","volume":"7","author":"Simon","year":"2018","journal-title":"Dev. Biol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0925-4773(00)00387-7","article-title":"Zebrafish mutations in Gli-mediated hedgehog signaling lead to lens transdifferentiation from the adenohypophysis anlage","volume":"96","author":"Kondoh","year":"2000","journal-title":"Mech. Dev."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1387\/ijdb.041868hk","article-title":"Interplay of Pax6 and SOX2 in lens development as a paradigm of genetic switch mechanisms for cell differentiation","volume":"48","author":"Kondoh","year":"2004","journal-title":"Int. J. Dev. Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ydbio.2005.07.019","article-title":"The duality of \u03b2-catenin function: A requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm","volume":"285","author":"Smith","year":"2005","journal-title":"Dev. Biol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/dvg.20277","article-title":"Abnormal lens morphogenesis and ectopic lens formation in the absence of \u03b2-catenin function","volume":"45","author":"Kreslova","year":"2007","journal-title":"Genesis"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1242\/dev.126.11.2397","article-title":"Expression of ptc and gli genes in talpid3 suggests bifurcation in Shh pathway","volume":"126","author":"Lewis","year":"1999","journal-title":"Development"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0925-4773(96)00632-6","article-title":"Ectopic lens induction in fish in response to the murine homeobox gene Six3","volume":"60","author":"Oliver","year":"1996","journal-title":"Mech. Dev."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1006\/dbio.1997.8573","article-title":"Lens Induction by Pax-6 in Xenopus laevis","volume":"185","author":"Altmann","year":"1997","journal-title":"Dev. Biol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ydbio.2008.07.009","article-title":"Eye formation in the absence of retina","volume":"322","author":"Swindell","year":"2008","journal-title":"Dev. Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1006\/dbio.1997.8800","article-title":"Role of Mitf in differentiation and transdifferentiation of chicken pigmented epithelial cell","volume":"193","author":"Mochii","year":"1998","journal-title":"Dev. Biol."},{"key":"ref_102","first-page":"251","article-title":"The effects of growth factors on multicellular spheroids formed by chick embryonic retinal cells","volume":"51","author":"Matsuo","year":"1997","journal-title":"Acta Med. Okayama"},{"key":"ref_103","first-page":"1","article-title":"Lens regeneration in axolotl: New evidence of developmental plasticity","volume":"10","author":"Maki","year":"2012","journal-title":"BMC Biol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1749-0774.2002.tb00112.x","article-title":"In vitro differentiation of mouse embryonic stem cells after activation by retinoic acid","volume":"15","author":"Kawamorita","year":"2002","journal-title":"Hum. Cell"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/dvdy.10425","article-title":"Generation of structures formed by lens and retinal cells differentiating from embryonic stem cells","volume":"228","author":"Hirano","year":"2003","journal-title":"Dev. Dyn."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"Ii41","DOI":"10.1007\/s00415-002-1208-0","article-title":"Generation of dopaminergic neurons from embryonic stem cells","volume":"249","author":"Sasai","year":"2002","journal-title":"J. Neurol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"4871","DOI":"10.1016\/j.biomaterials.2006.05.006","article-title":"Efficient generation of dopaminergic neurons from mouse embryonic stem cells enclosed in hollow fibers","volume":"27","author":"Yamazoe","year":"2006","journal-title":"Biomaterials"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1167\/iovs.02-1168","article-title":"Induction of the differentiation of lentoids from primate embryonic stem cells","volume":"44","author":"Ooto","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1073\/pnas.032662199","article-title":"Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity","volume":"99","author":"Kawasaki","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nature09941","article-title":"Self-organizing optic-cup morphogenesis in three-dimensional culture","volume":"472","author":"Eiraku","year":"2011","journal-title":"Nature"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.stem.2012.05.009","article-title":"Self-formation of optic cups and storable stratified neural retina from human ESCs","volume":"10","author":"Nakano","year":"2012","journal-title":"Cell Stem Cell"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/nbt1001-971","article-title":"Feeder-free growth of undifferentiated human embryonic stem cells","volume":"19","author":"Xu","year":"2001","journal-title":"Nat. Biotechnol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1084\/jem.145.1.204","article-title":"A murine tumor producing a matrix of basement membrane","volume":"145","author":"Orkin","year":"1977","journal-title":"J. Exp. Med."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Hughes, C., Ma, B., and Lajoie, G.A. (2010). De novo sequencing methods in proteomics. Proteome Bioinformatics, Springer.","DOI":"10.1007\/978-1-60761-444-9_8"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.semcancer.2005.05.004","article-title":"Matrigel: Basement membrane matrix with biological activity","volume":"15","author":"Kleinman","year":"2005","journal-title":"Proc. Semin. Canc. Biol."},{"key":"ref_116","first-page":"3898","article-title":"Growth and differentiation of human lens epithelial cells in vitro on matrix","volume":"41","author":"Blakely","year":"2000","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1242\/dev.107.2.221","article-title":"Fibroblast growth factor (FGF) induces different responses in lens epithelial cells depending on its concentration","volume":"107","author":"McAvoy","year":"1989","journal-title":"Development"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1006\/dbio.1998.9153","article-title":"BMP7 acts in murine lens placode development","volume":"207","author":"Wawersik","year":"1999","journal-title":"Dev. Biol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0012-1606(03)00179-9","article-title":"A role for Wnt\/beta-catenin signaling in lens epithelial differentiation","volume":"259","author":"Stump","year":"2003","journal-title":"Dev. Biol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ydbio.2008.09.002","article-title":"Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture","volume":"324","author":"Chen","year":"2008","journal-title":"Dev. Biol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0174-173X(85)80013-3","article-title":"Immunochemical characterization of type IV procollagen from anterior lens capsule","volume":"5","author":"Brinker","year":"1985","journal-title":"Coll. Relat. Res."},{"key":"ref_122","first-page":"506","article-title":"Immunofluorescent studies of fibronectin and laminin in the human eye","volume":"28","author":"Kohno","year":"1987","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1097\/01.LAB.0000042240.52093.0F","article-title":"Neurologic defects and selective disruption of basement membranes in mice lacking entactin-1\/nidogen-1","volume":"82","author":"Dong","year":"2002","journal-title":"Lab. Investig."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/dvdy.10050","article-title":"Role for \u03b16 integrin during lens development: Evidence for signaling through IGF-1R and ERK","volume":"223","author":"Walker","year":"2002","journal-title":"Dev. Dyn."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/emboj\/cdg019","article-title":"Heparan sulfate chains of perlecan are indispensable in the lens capsule but not in the kidney","volume":"22","author":"Rossi","year":"2003","journal-title":"EMBO J."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.1096\/fj.10-157255","article-title":"Efficient generation of lens progenitor cells and lentoid bodies from human embryonic stem cells in chemically defined conditions","volume":"24","author":"Yang","year":"2010","journal-title":"FASEB J."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Qiu, X., Yang, J., Liu, T., Jiang, Y., Le, Q., and Lu, Y. (2012). Efficient generation of lens progenitor cells from cataract patient\u2013specific induced pluripotent stem cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0032612"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1002\/jcp.25374","article-title":"Generation of Human Lens Epithelial-Like Cells from Patient-Specific Induced Pluripotent Stem Cells","volume":"231","author":"Li","year":"2016","journal-title":"J. Cell Physiol."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Anchan, R.M., Lachke, S.A., Gerami-Naini, B., Lindsey, J., Ng, N., Naber, C., Nickerson, M., Cavallesco, R., Rowan, S., and Eaton, J.L. (2014). Pax6- and Six3-mediated induction of lens cell fate in mouse and human ES cells. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0115106"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1038\/sj.emboj.7601114","article-title":"Regulation of \u03b1A-crystallin via Pax6, c-Maf, CREB and a broad domain of lens-specific chromatin","volume":"25","author":"Yang","year":"2006","journal-title":"EMBO J."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Anand, T., Talluri, T.R., Kumar, D., Garrels, W., Mukherjee, A., Debowski, K., Behr, R., and Kues, W.A. (2016). Differentiation of induced pluripotent stem cells to lentoid bodies expressing a lens cell-specific fluorescent reporter. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0157570"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1093\/nar\/gks1305","article-title":"Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells","volume":"41","author":"Grabundzija","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1242\/dev.079590","article-title":"In vitro organogenesis in three dimensions: Self-organising stem cells","volume":"139","author":"Sasai","year":"2012","journal-title":"Development"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature17000","article-title":"Co-ordinated ocular development from human iPS cells and recovery of corneal function","volume":"531","author":"Hayashi","year":"2016","journal-title":"Nature"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1186\/s13287-021-02651-9","article-title":"Multiocular organoids from human induced pluripotent stem cells displayed retinal, corneal, and retinal pigment epithelium lineages","volume":"12","author":"Veiga","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1167\/iovs.16-20504","article-title":"Generation of Functional Lentoid Bodies from Human Induced Pluripotent Stem Cells Derived From Urinary Cells","volume":"58","author":"Fu","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"dev155838","DOI":"10.1242\/dev.155838","article-title":"Light-focusing human micro-lenses generated from pluripotent stem cells model lens development and drug-induced cataract in vitro","volume":"145","author":"Murphy","year":"2018","journal-title":"Development"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41536-021-00171-x","article-title":"Modeling congenital cataract in vitro using patient-specific induced pluripotent stem cells","volume":"6","author":"Lyu","year":"2021","journal-title":"NPJ Regen. Med."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"108317","DOI":"10.1016\/j.exer.2020.108317","article-title":"A simplified method for producing human lens epithelial cells and light-focusing micro-lenses from pluripotent stem cells","volume":"202","author":"Dewi","year":"2021","journal-title":"Exp. Eye Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.celrep.2013.10.048","article-title":"Specification of functional cranial placode derivatives from human pluripotent stem cells","volume":"5","author":"Dincer","year":"2013","journal-title":"Cell Rep."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.stemcr.2016.05.005","article-title":"Derivation of diverse hormone-releasing pituitary cells from human pluripotent stem cells","volume":"6","author":"Zimmer","year":"2016","journal-title":"Stem Cell Reps."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.stem.2017.08.015","article-title":"A modular platform for differentiation of human PSCs into all major ectodermal lineages","volume":"21","author":"Tchieu","year":"2017","journal-title":"Cell Stem Cell"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"94","DOI":"10.5966\/sctm.2012-0100","article-title":"Derivation of multiple cranial tissues and isolation of lens epithelium-like cells from human embryonic stem cells","volume":"2","author":"Mengarelli","year":"2013","journal-title":"Stem Cells Transl. Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ydbio.2013.04.023","article-title":"Differential BMP signaling controls formation and differentiation of multipotent preplacodal ectoderm progenitors from human embryonic stem cells","volume":"379","author":"Leung","year":"2013","journal-title":"Dev. Biol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.stemcr.2016.03.011","article-title":"Intercellular Adhesion-Dependent Cell Survival and ROCK-Regulated Actomyosin-Driven Forces Mediate Self-Formation of a Retinal Organoid","volume":"6","author":"Lowe","year":"2016","journal-title":"Stem Cell Reps."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"10824","DOI":"10.1073\/pnas.1901572116","article-title":"Generation, transcriptome profiling, and functional validation of cone-rich human retinal organoids","volume":"116","author":"Kim","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1038\/ncomms5047","article-title":"Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs","volume":"5","author":"Zhong","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1089\/scd.2011.0073","article-title":"Differentiation of Human Embryonic Stem Cell\u2013Derived Retinal Progenitors into Retinal Cells by Sonic Hedgehog and\/or Retinal Pigmented Epithelium and Transplantation into the Subretinal Space of Sodium Iodate\u2013Injected Rabbits","volume":"21","author":"Amirpour","year":"2011","journal-title":"Stem Cells Dev."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1002\/sctm.17-0059","article-title":"Enhanced Stem Cell Differentiation and Immunopurification of Genome Engineered Human Retinal Ganglion Cells","volume":"6","author":"Sluch","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"ref_150","first-page":"131","article-title":"Cell transplantation of retinal ganglion cells derived from hESCs","volume":"38","author":"Zhang","year":"2020","journal-title":"Restor. Neurol. Neurosci."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1242\/dev.125385","article-title":"Differentiation of human embryonic stem cells into cone photoreceptors through simultaneous inhibition of BMP, TGF\u03b2 and Wnt signaling","volume":"142","author":"Zhou","year":"2015","journal-title":"Development"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"eaat5580","DOI":"10.1126\/scitranslmed.aat5580","article-title":"Clinical-grade stem cell\u2013derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs","volume":"11","author":"Sharma","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"10950","DOI":"10.1073\/pnas.1422818112","article-title":"Small-molecule\u2013directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells","volume":"112","author":"Maruotti","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.stemcr.2013.12.014","article-title":"Small-Molecule Induction Promotes Corneal Epithelial Cell Differentiation from Human Induced Pluripotent Stem Cells","volume":"2","author":"Mikhailova","year":"2014","journal-title":"Stem Cell Reps."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.jtos.2020.07.009","article-title":"Tissue engineered corneal epithelium derived from clinical-grade human embryonic stem cells","volume":"18","author":"He","year":"2020","journal-title":"Ocul. Surf."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/stem.2750","article-title":"Differences in the Activity of Endogenous Bone Morphogenetic Protein Signaling Impact on the Ability of Induced Pluripotent Stem Cells to Differentiate to Corneal Epithelial-Like Cells","volume":"36","author":"Kamarudin","year":"2018","journal-title":"Stem Cells"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Gr\u00f6nroos, P., Ilmarinen, T., and Skottman, H. (2021). Directed differentiation of human pluripotent stem cells towards corneal endothelial-like cells under defined conditions. Cells, 10.","DOI":"10.3390\/cells10020331"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.3390\/cimb43030147","article-title":"Bone Morphogenetic Protein 4 (BMP4) Enhances the Differentiation of Human Induced Pluripotent Stem Cells into Limbal Progenitor Cells","volume":"43","author":"Lee","year":"2021","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"7065","DOI":"10.1167\/iovs.14-14800","article-title":"Induction of trabecular meshwork cells from induced pluripotent stem cells","volume":"55","author":"Ding","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1167\/iovs.62.10.28","article-title":"iPSC-Derived Trabecular Meshwork Cells Stimulate Endogenous TM Cell Division Through Gap Junction in a Mouse Model of Glaucoma","volume":"62","author":"Sui","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.bbrc.2020.05.225","article-title":"Two-step induction of trabecular meshwork cells from induced pluripotent stem cells for glaucoma","volume":"529","author":"Kumar","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.diff.2017.11.003","article-title":"Directed differentiation of periocular mesenchyme from human embryonic stem cells","volume":"99","author":"Lovatt","year":"2018","journal-title":"Differentiation"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/dbio.2001.0156","article-title":"Vertebrate Cranial Placodes I. Embryonic Induction","volume":"232","author":"Baker","year":"2001","journal-title":"Dev. Biol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ydbio.2014.02.011","article-title":"Establishing the pre-placodal region and breaking it into placodes with distinct identities","volume":"389","author":"Moody","year":"2014","journal-title":"Dev. Biol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1387\/ijdb.170298as","article-title":"Specification of sensory placode progenitors: Signals and transcription factor networks","volume":"62","author":"Streit","year":"2018","journal-title":"Int. J. Dev. Biol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nbt.1529","article-title":"Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling","volume":"27","author":"Chambers","year":"2009","journal-title":"Nat. Biotechnol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nature12298","article-title":"Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture","volume":"500","author":"Koehler","year":"2013","journal-title":"Nature"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nprot.2010.35","article-title":"Derivation of neural crest cells from human pluripotent stem cells","volume":"5","author":"Lee","year":"2010","journal-title":"Nat. Protoc."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.celrep.2013.03.025","article-title":"Modeling neural crest induction, melanocyte specification, and disease-related pigmentation defects in hESCs and patient-specific iPSCs","volume":"3","author":"Mica","year":"2013","journal-title":"Cell Reps."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1002\/dvdy.24677","article-title":"Identification of novel Gata3 distal enhancers active in mouse embryonic lens","volume":"247","author":"Martynova","year":"2018","journal-title":"Dev. Dyn."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/dvdy.21445","article-title":"Cell autonomous roles for AP-2\u03b1 in lens vesicle separation and maintenance of the lens epithelial cell phenotype","volume":"237","author":"Pontoriero","year":"2008","journal-title":"Dev. Dyn."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/nature01245","article-title":"Structural basis of BMP signalling inhibition by the cystine knot protein Noggin","volume":"420","author":"Groppe","year":"2002","journal-title":"Nature"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0092-8674(00)80851-X","article-title":"Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity","volume":"101","author":"Plotnikov","year":"2000","journal-title":"Cell"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0166-2236(96)01046-6","article-title":"Bone morphogenetic proteins in the nervous system","volume":"20","author":"Mehler","year":"1997","journal-title":"Trends Neurosci."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S1097-2765(03)00094-7","article-title":"The BMP7\/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly","volume":"11","author":"Greenwald","year":"2003","journal-title":"Mol. Cell"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41594-019-0216-z","article-title":"Crystal structure of a mammalian Wnt\u2013frizzled complex","volume":"26","author":"Hirai","year":"2019","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.devcel.2011.09.003","article-title":"Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5\/6","volume":"21","author":"Ahn","year":"2011","journal-title":"Dev. Cell"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/s41467-018-03219-7","article-title":"How ligand binds to the type 1 insulin-like growth factor receptor","volume":"9","author":"Xu","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1002\/stem.2023","article-title":"IGF-1 Signaling Plays an Important Role in the Formation of Three-Dimensional Laminated Neural Retina and Other Ocular Structures from Human Embryonic Stem Cells","volume":"33","author":"Mellough","year":"2015","journal-title":"Stem Cells"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2008.323","article-title":"Roles of TGF-\u03b2 family signaling in stem cell renewal and differentiation","volume":"19","author":"Watabe","year":"2009","journal-title":"Cell Res."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1126\/science.276.5314.955","article-title":"Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors","volume":"276","author":"Mohammadi","year":"1997","journal-title":"Science"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bone.2017.09.004","article-title":"Structural basis for the potent and selective binding of LDN-212854 to the BMP receptor kinase ALK2","volume":"109","author":"Williams","year":"2018","journal-title":"Bone"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/nature00989","article-title":"Patched acts catalytically to suppress the activity of Smoothened","volume":"418","author":"Taipale","year":"2002","journal-title":"Nature"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/ncb435","article-title":"Patching the gaps in Hedgehog signalling","volume":"9","author":"Rohatgi","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1242\/dev.118.1.117","article-title":"Acidic and basic FGF in ocular media and lens: Implications for lens polarity and growth patterns","volume":"118","author":"Schulz","year":"1993","journal-title":"Development"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/gene.20094","article-title":"Modulation of zebrafish pitx3 expression in the primordia of the pituitary, lens, olfactory epithelium and cranial ganglia by hedgehog and nodal signaling","volume":"41","author":"Zilinski","year":"2005","journal-title":"Genesis"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.diff.2009.09.004","article-title":"CD44 expression is developmentally regulated in the mouse lens and increases in the lens epithelium after injury","volume":"79","author":"Desai","year":"2010","journal-title":"Differentiation"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"dev200831","DOI":"10.1242\/dev.200831","article-title":"Human stem cell models to study placode development, function and pathology","volume":"149","author":"Conti","year":"2022","journal-title":"Development"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1089\/scd.2021.0257","article-title":"A molecular analysis of neural olfactory placode differentiation in human pluripotent stem cells","volume":"31","author":"Bricker","year":"2022","journal-title":"Stem Cells Dev."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.devcel.2006.08.009","article-title":"Lens specification is the ground state of all sensory placodes, from which FGF promotes olfactory identity","volume":"11","author":"Bailey","year":"2006","journal-title":"Dev. Cell"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"101813","DOI":"10.1016\/j.scr.2020.101813","article-title":"Generation and proteome profiling of PBMC-originated, iPSC-derived lentoid bodies","volume":"46","author":"Ali","year":"2020","journal-title":"Stem Cell Res."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1007\/s00439-020-02195-7","article-title":"The cataract-linked RNA-binding protein Celf1 post-transcriptionally controls the spatiotemporal expression of the key homeodomain transcription factors Pax6 and Prox1 in lens development","volume":"139","author":"Aryal","year":"2020","journal-title":"Hum. Genet."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.exer.2018.10.011","article-title":"Proteome-transcriptome analysis and proteome remodeling in mouse lens epithelium and fibers","volume":"179","author":"Zhao","year":"2019","journal-title":"Exp. Eye Res."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.exer.2004.04.007","article-title":"Identification and functional clustering of global gene expression differences between age-related cataract and clear human lenses and aged human lenses","volume":"79","author":"Hawse","year":"2004","journal-title":"Exp. Eye Res."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"106657","DOI":"10.1016\/j.dib.2020.106657","article-title":"Single cell RNA-sequencing data generated from human pluripotent stem cell-derived lens epithelial cells","volume":"34","author":"Shparberg","year":"2021","journal-title":"Data Brief"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/stem.1037","article-title":"Efficient stage-specific differentiation of human pluripotent stem cells toward retinal photoreceptor cells","volume":"30","author":"Mellough","year":"2012","journal-title":"Stem Cells"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1016\/j.celrep.2018.10.032","article-title":"Selective laminin-directed differentiation of human induced pluripotent stem cells into distinct ocular lineages","volume":"25","author":"Shibata","year":"2018","journal-title":"Cell Reps."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41586-019-1825-8","article-title":"Multi-omics profiling of mouse gastrulation at single-cell resolution","volume":"576","author":"Argelaguet","year":"2019","journal-title":"Nature"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/s41551-021-00770-5","article-title":"Computational reconstruction of the signalling networks surrounding implanted biomaterials from single-cell transcriptomics","volume":"5","author":"Cherry","year":"2021","journal-title":"Nat. Biomed. Eng."},{"key":"ref_200","first-page":"3303","article-title":"IGF-1 enhancement of FGF-induced lens fiber differentiation in rats of different ages","volume":"34","author":"Richardson","year":"1993","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"17954","DOI":"10.1074\/jbc.273.28.17954","article-title":"Involvement of retinoic acid\/retinoid receptors in the regulation of murine \u03b1B-crystallin\/small heat shock protein gene expression in the lens","volume":"273","author":"Cvekl","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1006\/dbio.2000.9652","article-title":"Altered retinoid signaling in the heads of small eye mouse embryos","volume":"221","author":"Enwright","year":"2000","journal-title":"Dev. Biol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0378-1119(02)00425-0","article-title":"Complex regulatory element within the \u03b3E-and \u03b3F-crystallin enhancers mediates Pax6 regulation and is required for induction by retinoic acid","volume":"286","author":"Czerny","year":"2002","journal-title":"Gene"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/nature04175","article-title":"BMP inhibition-driven regulation of six-3 underlies induction of newt lens regeneration","volume":"438","author":"Grogg","year":"2005","journal-title":"Nature"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ydbio.2013.12.036","article-title":"Retinoic acid regulation by CYP26 in vertebrate lens regeneration","volume":"386","author":"Thomas","year":"2014","journal-title":"Dev. Biol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"dev167171","DOI":"10.1242\/dev.167171","article-title":"Lens-regulated retinoic acid signalling controls expansion of the developing eye","volume":"145","author":"Smith","year":"2018","journal-title":"Development"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1126\/science.3187521","article-title":"Growth and Transparency in the Lens, an Epithelial Tissue, Stimulated by Pulses of PDGF","volume":"242","author":"Brewitt","year":"1988","journal-title":"Science"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"4490","DOI":"10.1167\/iovs.06-0401","article-title":"Phosphatidylinositol 3-Kinase Is Necessary for Lens Fiber Cell Differentiation and Survival","volume":"47","author":"Weber","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"113043","DOI":"10.1016\/j.yexcr.2022.113043","article-title":"Suppression of PI3K signaling is linked to autophagy activation and the spatiotemporal induction of the lens organelle free zone","volume":"412","author":"Gheyas","year":"2022","journal-title":"Exp. Cell Res."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1387\/ijdb.041895ms","article-title":"Development and pathology of the hyaloid, choroidal and retinal vasculature","volume":"48","year":"2004","journal-title":"Int. J. Dev. Biol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.bbagen.2015.05.017","article-title":"\u03b2A3\/A1-crystallin and persistent fetal vasculature (PFV) disease of the eye","volume":"1860","author":"Zigler","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.preteyeres.2017.10.001","article-title":"Development of the hyaloid, choroidal and retinal vasculatures in the fetal human eye","volume":"62","author":"Lutty","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1167\/iovs.02-1226","article-title":"Vascular Endothelial Growth Factor Expression and Signaling in the Lens","volume":"44","author":"Shui","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.exer.2008.07.017","article-title":"The function of VEGF-A in lens development: Formation of the hyaloid capillary network and protection against transient nuclear cataracts","volume":"88","author":"Garcia","year":"2009","journal-title":"Exp. Eye Res."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1242\/dev.021097","article-title":"Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis","volume":"135","author":"Chen","year":"2008","journal-title":"Development"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1073\/pnas.052484199","article-title":"The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development","volume":"99","author":"McKeller","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ydbio.2013.05.003","article-title":"A distant, cis-acting enhancer drives induction of Arf by Tgf\u03b2 in the developing eye","volume":"380","author":"Zheng","year":"2013","journal-title":"Dev. Biol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.semcdb.2007.08.014","article-title":"Maintaining transparency: A review of the developmental physiology and pathophysiology of two avascular tissues","volume":"19","author":"Beebe","year":"2008","journal-title":"Proc. Semin. Cell Dev. Biol."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1242\/jcs.113.11.1913","article-title":"Expression of autofluorescent proteins reveals a novel protein permeable pathway between cells in the lens core","volume":"113","author":"Shestopalov","year":"2000","journal-title":"J. Cell Sci."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.1242\/jeb.00670","article-title":"The effect of elevated intraocular oxygen on organelle degradation in the embryonic chicken lens","volume":"206","author":"Bassnett","year":"2003","journal-title":"J. Exp. Biol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1113\/jphysiol.2004.068619","article-title":"Regulation of tissue oxygen levels in the mammalian lens","volume":"559","author":"McNulty","year":"2004","journal-title":"J. Physiol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s10384-014-0318-4","article-title":"Preserve the (intraocular) environment: The importance of maintaining normal oxygen gradients in the eye","volume":"58","author":"Beebe","year":"2014","journal-title":"Jpn. J. Ophthalmol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1167\/iovs.07-1164","article-title":"Age-dependent control of lens growth by hypoxia","volume":"49","author":"Shui","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1146\/annurev.biochem.74.082803.133142","article-title":"Proline hydroxylation and gene expression","volume":"74","author":"Kaelin","year":"2005","journal-title":"Annu. Rev. Biochem."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cell.2012.01.021","article-title":"Hypoxia-inducible factors in physiology and medicine","volume":"148","author":"Semenza","year":"2012","journal-title":"Cell"},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Disatham, J., Brennan, L., Chauss, D., Kantorow, J., Afzali, B., and Kantorow, M. (2021). A functional map of genomic HIF1\u03b1-DNA complexes in the eye lens revealed through multiomics analysis. BMC Genom., 22.","DOI":"10.1186\/s12864-021-07795-9"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13072-022-00440-z","article-title":"Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation","volume":"15","author":"Disatham","year":"2022","journal-title":"Epigenetics Chromatin"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.exer.2018.06.003","article-title":"BNIP3L\/NIX is required for elimination of mitochondria, endoplasmic reticulum and Golgi apparatus during eye lens organelle-free zone formation","volume":"174","author":"Brennan","year":"2018","journal-title":"Exp. Eye Res."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"108682","DOI":"10.1016\/j.exer.2021.108682","article-title":"Mechanisms of organelle elimination for lens development and differentiation","volume":"209","author":"Brennan","year":"2021","journal-title":"Exp. Eye Res."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000264555","article-title":"Studies on the citric acid cycle and its portion of glucose breakdown by calf and bovine lenses in vitro","volume":"2","author":"Hockwin","year":"1971","journal-title":"Ophthal. Res."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0014-4835(75)90122-0","article-title":"The metabolism of the bovine lens in air and nitrogen","volume":"20","author":"Linklater","year":"1975","journal-title":"Exp. Eye Res."},{"key":"ref_232","first-page":"1933","article-title":"Comparative study of vitreous oxygen tension in human and rabbit eyes","volume":"30","author":"Sakaue","year":"1989","journal-title":"Investig. Ophthal. Vis. Sci."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.semcdb.2006.10.004","article-title":"Cell cycle regulation in the developing lens","volume":"17","author":"Griep","year":"2006","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1242\/dev.129.15.3727","article-title":"Bmp signaling is required for development of primary lens fiber cells","volume":"129","author":"Faber","year":"2002","journal-title":"Development"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/dvdy.20356","article-title":"Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation","volume":"233","author":"Garcia","year":"2005","journal-title":"Dev. Dyn."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ydbio.2008.03.028","article-title":"Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation","volume":"318","author":"Zhao","year":"2008","journal-title":"Dev. Biol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1242\/dev.123653","article-title":"Neural retina identity is specified by lens-derived BMP signals","volume":"142","author":"Pandit","year":"2015","journal-title":"Development"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1152\/physrev.1997.77.1.21","article-title":"Physiological properties of the normal lens","volume":"77","author":"Mathias","year":"1997","journal-title":"Physiol. Rev."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1152\/physrev.00034.2009","article-title":"Lens gap junctions in growth, differentiation, and homeostasis","volume":"90","author":"Mathias","year":"2010","journal-title":"Physiol. Rev."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.bbagen.2015.08.016","article-title":"The etiology of human age-related cataract. Proteins don\u2019t last forever","volume":"1860","author":"Truscott","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.exer.2016.05.027","article-title":"Novel roles for the lens in preserving overall ocular health","volume":"156","author":"Lim","year":"2017","journal-title":"Exp. Eye Res."},{"key":"ref_242","doi-asserted-by":"crossref","unstructured":"Schey, K.L., Petrova, R.S., Gletten, R.B., and Donaldson, P.J. (2017). The Role of Aquaporins in Ocular Lens Homeostasis. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18122693"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.1226340","article-title":"Printing and prototyping of tissues and scaffolds","volume":"338","author":"Derby","year":"2012","journal-title":"Science"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"2041731416671926","DOI":"10.1177\/2041731416671926","article-title":"Multi-compartmental biomaterial scaffolds for patterning neural tissue organoids in models of neurodevelopment and tissue regeneration","volume":"7","author":"McMurtrey","year":"2016","journal-title":"J. Tissue Eng."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"e00032","DOI":"10.1016\/j.bprint.2018.e00032","article-title":"Spatiotemporal control of growth factors in three-dimensional printed scaffolds","volume":"12","author":"Bittner","year":"2018","journal-title":"Bioprinting"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1080\/07388551.2021.1932716","article-title":"Synthetic scaffolds for 3D cell cultures and organoids: Applications in regenerative medicine","volume":"42","author":"Marchini","year":"2022","journal-title":"Crit. Rev. Biotechnol."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.exer.2013.12.004","article-title":"A gradient of matrix-bound FGF-2 and perlecan is available to lens epithelial cells","volume":"120","author":"Wu","year":"2014","journal-title":"Exp. Eye Res."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"8097","DOI":"10.1016\/j.biomaterials.2011.07.025","article-title":"Bioprinting of growth factors onto aligned sub-micron fibrous scaffolds for simultaneous control of cell differentiation and alignment","volume":"32","author":"Ker","year":"2011","journal-title":"Biomaterials"},{"key":"ref_249","doi-asserted-by":"crossref","unstructured":"Vojtov\u00e1, L., Pavli\u0148\u00e1kov\u00e1, V., Muchov\u00e1, J., Kacvinsk\u00e1, K., Brtn\u00edkov\u00e1, J., Knoz, M., Lipov\u00fd, B., Faldyna, M., G\u00f6pfert, E., and Holoubek, J. (2021). Healing and angiogenic properties of collagen\/chitosan scaffolds enriched with hyperstable FGF2-STAB\u00ae protein: In vitro, ex ovo and in vivo comprehensive evaluation. Biomedicines, 9.","DOI":"10.3390\/biomedicines9060590"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.exer.2008.08.002","article-title":"The lens capsule","volume":"88","author":"Danysh","year":"2009","journal-title":"Exp. Eye Res."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.matbio.2020.12.005","article-title":"Dynamics of the lens basement membrane capsule and its interaction with connective tissue-like extracapsular matrix proteins","volume":"96","author":"DeDreu","year":"2021","journal-title":"Matrix Biol."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/08977199709021506","article-title":"Binding of FGF-1 and FGF-2 to heparan sulphate proteoglycans of the mammalian lens capsule","volume":"14","author":"Schulz","year":"1997","journal-title":"Growth Factors"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"108709","DOI":"10.1016\/j.exer.2021.108709","article-title":"Hallmarks of lens aging and cataractogenesis","volume":"210","author":"Wishart","year":"2021","journal-title":"Exp. Eye Res."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0040-8166(86)90009-1","article-title":"Macromolecular organization of bovine lens capsule","volume":"18","author":"Cammarata","year":"1986","journal-title":"Tissue Cell"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1387\/ijdb.041880jk","article-title":"Development of lens sutures","volume":"48","author":"Kuszak","year":"2004","journal-title":"Int. J. Dev. Biol."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.ydbio.2004.04.010","article-title":"Segregation of lens and olfactory precursors from a common territory: Cell sorting and reciprocity of Dlx5 and Pax6 expression","volume":"271","author":"Bhattacharyya","year":"2004","journal-title":"Dev. Biol."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1242\/dev.01964","article-title":"A balance of FGF, BMP and WNT signalling positions the future placode territory in the head","volume":"132","author":"Litsiou","year":"2005","journal-title":"Development"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1387\/ijdb.130155mb","article-title":"Clonal analyses in the anterior pre-placodal region: Implications for the early lineage bias of placodal progenitors","volume":"57","author":"Bhattacharyya","year":"2013","journal-title":"Int. J. Dev. Biol."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ydbio.2011.09.024","article-title":"Origin and segregation of cranial placodes in Xenopus laevis","volume":"360","author":"Pieper","year":"2011","journal-title":"Dev. Biol."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1242\/dev.127.17.3645","article-title":"The olfactory placodes of the zebrafish form by convergence of cellular fields at the edge of the neural plate","volume":"127","author":"Whitlock","year":"2000","journal-title":"Development"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1242\/dev.01723","article-title":"Pitx3 defines an equivalence domain for lens and anterior pituitary placode","volume":"132","author":"Dutta","year":"2005","journal-title":"Development"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1073\/pnas.1719674115","article-title":"Neural induction by the node and placode induction by head mesoderm share an initial state resembling neural plate border and ES cells","volume":"115","author":"Trevers","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.devcel.2016.02.020","article-title":"Spatial transcriptome for the molecular annotation of lineage fates and cell identity in mid-gastrula mouse embryo","volume":"36","author":"Peng","year":"2016","journal-title":"Dev. Cell"},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/s41586-019-1469-8","article-title":"Molecular architecture of lineage allocation and tissue organization in early mouse embryo","volume":"572","author":"Peng","year":"2019","journal-title":"Nature"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41556-020-0489-9","article-title":"Single-cell chromatin accessibility maps reveal regulatory programs driving early mouse organogenesis","volume":"22","author":"Wilson","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/371072a0","article-title":"p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens","volume":"371","author":"Morgenbesser","year":"1994","journal-title":"Nature"},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/387151a0","article-title":"Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith\u2013Wiedemann syndrome","volume":"387","author":"Zhang","year":"1997","journal-title":"Nature"},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1101\/gad.12.20.3162","article-title":"Cooperation between the Cdk inhibitors p27KIP1 and p57KIP2 in the control of tissue growth and development","volume":"12","author":"Zhang","year":"1998","journal-title":"Genes Dev."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"7236","DOI":"10.1128\/MCB.00780-07","article-title":"The Notch signaling pathway controls the size of the ocular lens by directly suppressing p57Kip2 expression","volume":"27","author":"Jia","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ydbio.2015.12.027","article-title":"FGFR and PTEN signaling interact during lens development to regulate cell survival","volume":"410","author":"Chaffee","year":"2016","journal-title":"Dev. Biol."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1101\/gad.8.11.1285","article-title":"Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: Implications for tumor suppressor gene function in development","volume":"8","author":"Pan","year":"1994","journal-title":"Genes Dev."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/j.1460-2075.1995.tb07053.x","article-title":"Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo","volume":"14","author":"Morgenbesser","year":"1995","journal-title":"EMBO J."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1242\/dev.125.17.3365","article-title":"Overlapping effects of different members of the FGF family on lens fiber differentiation in transgenic mice","volume":"125","author":"Lovicu","year":"1998","journal-title":"Development"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"8970","DOI":"10.1128\/MCB.23.24.8970-8981.2003","article-title":"Requirement of PDZ-containing proteins for cell cycle regulation and differentiation in the mouse lens epithelium","volume":"23","author":"Nguyen","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1159\/000082285","article-title":"Distinct capacities of individual E2Fs to induce cell cycle re-entry in postmitotic lens fiber cells of transgenic mice","volume":"26","author":"Chen","year":"2004","journal-title":"Dev. Neurosci."},{"key":"ref_276","first-page":"215","article-title":"Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb","volume":"13","author":"Saavedra","year":"2002","journal-title":"Cell Growth Differ."},{"key":"ref_277","first-page":"1343","article-title":"Pax-6 interactions with TATA-box-binding protein and retinoblastoma protein","volume":"40","author":"Cvekl","year":"1999","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1387\/ijdb.041866ac","article-title":"Regulation of gene expression by Pax6 in ocular cells: A case of tissue-preferred expression of crystallins in lens","volume":"48","author":"Cvekl","year":"2004","journal-title":"Int. J. Dev. Biol."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"17144","DOI":"10.1073\/pnas.0407577101","article-title":"Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina","volume":"101","author":"Gotoh","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"4933","DOI":"10.1242\/dev.02679","article-title":"Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development","volume":"133","author":"Pan","year":"2006","journal-title":"Development"},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1002\/dvdy.22036","article-title":"Cell-autonomous requirements for Dlg-1 for lens epithelial cell structure and fiber cell morphogenesis","volume":"238","author":"Rivera","year":"2009","journal-title":"Dev. Dyn."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.diff.2010.05.005","article-title":"Sef is a negative regulator of fiber cell differentiation in the ocular lens","volume":"80","author":"Newitt","year":"2010","journal-title":"Differentiation"},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ydbio.2011.04.007","article-title":"Genetic epistasis between heparan sulfate and FGF\u2013Ras signaling controls lens development","volume":"355","author":"Qu","year":"2011","journal-title":"Dev. Biol."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1167\/iovs.12-11357","article-title":"Wnt-frizzled signaling is part of an FGF-induced cascade that promotes lens fiber differentiation","volume":"54","author":"Dawes","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1167\/iovs.15-17727","article-title":"Dlg-1 interacts with and regulates the activities of fibroblast growth factor receptors and EphA2 in the mouse lens","volume":"57","author":"Lee","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"e32586","DOI":"10.7554\/eLife.32586","article-title":"Crk proteins transduce FGF signaling to promote lens fiber cell elongation","volume":"7","author":"Collins","year":"2018","journal-title":"eLIFE"},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.exer.2018.02.025","article-title":"Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred","volume":"170","author":"Zhao","year":"2018","journal-title":"Exp. Eye Res."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1167\/iovs.62.14.5","article-title":"An Atlas of Heparan Sulfate Proteoglycans in the Postnatal Rat Lens","volume":"62","author":"Wishart","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"190220","DOI":"10.1098\/rsob.190220","article-title":"Transcriptomic analysis and novel insights into lens fibre cell differentiation regulated by Gata3","volume":"9","author":"Martynova","year":"2019","journal-title":"Open Biol."},{"key":"ref_290","first-page":"318","article-title":"Prox1 and fibroblast growth factor receptors form a novel regulatory loop controlling lens fiber differentiation and gene expression","volume":"143","author":"Audette","year":"2016","journal-title":"Development"},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ydbio.2008.06.002","article-title":"Notch signaling regulates growth and differentiation in the mammalian lens","volume":"321","author":"Rowan","year":"2008","journal-title":"Dev. Biol."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/dvdy.23739","article-title":"Requirements for Jag1-Rbpj mediated Notch signaling during early mouse lens development","volume":"241","author":"Le","year":"2012","journal-title":"Dev. Dyn."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ydbio.2011.11.011","article-title":"Conditional ablation of the Notch2 receptor in the ocular lens","volume":"362","author":"Saravanamuthu","year":"2012","journal-title":"Dev. Biol."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"10199","DOI":"10.1093\/nar\/gkt824","article-title":"Histone posttranslational modifications and cell fate determination: Lens induction requires the lysine acetyltransferases CBP and p300","volume":"41","author":"Wolf","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"3947","DOI":"10.1074\/jbc.M115.705103","article-title":"Regulation of c-Maf and \u03b1A-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling","volume":"291","author":"Xie","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.exer.2018.01.014","article-title":"A role for Hippo\/YAP-signaling in FGF-induced lens epithelial cell proliferation and fibre differentiation","volume":"169","author":"Dawes","year":"2018","journal-title":"Exp. Eye Res."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1167\/tvst.9.3.21","article-title":"Generation of a retina reporter hiPSC line to label progenitor, ganglion, and photoreceptor cell types","volume":"9","author":"Lam","year":"2020","journal-title":"Transl. Vis. Sci. Technol."},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0960-9822(95)00128-X","article-title":"Chimeric green fluorescent protein as a tool for visualizing subcellular organelles in living cells","volume":"5","author":"Rizzuto","year":"1995","journal-title":"Curr. Biol."},{"key":"ref_299","first-page":"21.25.21","article-title":"The Fluorescent Protein Color Palette","volume":"36","author":"Olenych","year":"2007","journal-title":"Curr. Prot. Cell Biol."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"13176","DOI":"10.1074\/jbc.RA118.001927","article-title":"Transcriptional burst fraction and size dynamics during lens fiber cell differentiation and detailed insights into the denucleation process","volume":"293","author":"Limi","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.devcel.2016.02.001","article-title":"Nuclear condensation during mouse erythropoiesis requires caspase-3-mediated nuclear opening","volume":"36","author":"Zhao","year":"2016","journal-title":"Dev. Cell"},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.exphem.2019.05.006","article-title":"PSC-RED and MNC-RED: Albumin-free and low-transferrin robust erythroid differentiation protocols to produce human enucleated red blood cells","volume":"75","author":"Olivier","year":"2019","journal-title":"Exp. Hematol."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.exer.2016.11.021","article-title":"Transcriptome analysis of adult and fetal trabecular meshwork, cornea, and ciliary body tissues by RNA sequencing","volume":"167","author":"Carnes","year":"2018","journal-title":"Exp. Eye Res."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"e2200914119","DOI":"10.1073\/pnas.2200914119","article-title":"Cell atlas of the human ocular anterior segment: Tissue-specific and shared cell types","volume":"119","author":"Yan","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"110286","DOI":"10.1016\/j.ygeno.2022.110286","article-title":"The Human Eye Transcriptome Atlas: A searchable comparative transcriptome database for healthy and diseased human eye tissue","volume":"114","author":"Wolf","year":"2022","journal-title":"Genomics"},{"key":"ref_306","doi-asserted-by":"crossref","unstructured":"Wolf, J., Lapp, T., Reinhard, T., Agostini, H., Schlunck, G., and Lange, C. (2022). Web-based gene expression analysis-paving the way to decode healthy and diseased ocular tissue. Ophthalmologie, 1\u20137.","DOI":"10.1007\/s00347-022-01721-4"},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"1700394","DOI":"10.1002\/pmic.201700394","article-title":"The human eye proteome project: Updates on an emerging proteome","volume":"18","author":"Ahmad","year":"2018","journal-title":"Proteomics"},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"4542","DOI":"10.1167\/iovs.18-24539","article-title":"Effect of Resveratrol on Sirtuins, OPA1, and Fis1 Expression in Adult Zebrafish Retina","volume":"59","author":"Sheng","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1006\/exer.1998.0481","article-title":"Age-related changes in human lens crystallins identified by two-dimensional electrophoresis and mass spectrometry","volume":"67","author":"Lampi","year":"1998","journal-title":"Exp. Eye Res."},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1021\/pr050473a","article-title":"Age-related changes in human crystallins determined from comparative analysis of post-translational modifications in young and aged lens: Does deamidation contribute to crystallin insolubility?","volume":"5","author":"Wilmarth","year":"2006","journal-title":"J. Proteome Res."},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1167\/iovs.12-11168","article-title":"Proteomics and Phosphoproteomics Analysis of Human Lens Fiber Cell Membranes","volume":"54","author":"Wang","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1167\/iovs.16-19791","article-title":"Spatially directed proteomics of the human lens outer cortex reveals an intermediate filament switch associated with the remodeling zone","volume":"57","author":"Wenke","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1042\/BCJ20200798","article-title":"Spontaneous protein\u2013protein crosslinking at glutamine and glutamic acid residues in long-lived proteins","volume":"478","author":"Friedrich","year":"2021","journal-title":"Biochem. J."},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41586-019-1629-x","article-title":"The human body at cellular resolution: The NIH Human Biomolecular Atlas Program","volume":"574","author":"Snyder","year":"2019","journal-title":"Nature"},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.stem.2015.05.015","article-title":"Quantification of retinogenesis in 3D cultures reveals epigenetic memory and higher efficiency in iPSCs derived from rod photoreceptors","volume":"17","author":"Hiler","year":"2015","journal-title":"Cell Stem Cell"},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3389\/fncel.2020.00265","article-title":"The use of induced pluripotent stem cells as a model for developmental eye disorders","volume":"14","author":"Eintracht","year":"2020","journal-title":"Front. Cell Neurosci."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.drudis.2012.10.003","article-title":"Three-dimensional cell culture: The missing link in drug discovery","volume":"18","author":"Breslin","year":"2013","journal-title":"Drug Discov. Today"},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"12497","DOI":"10.18632\/aging.102584","article-title":"Age-related changes in eye lens biomechanics, morphology, refractive index and transparency","volume":"11","author":"Cheng","year":"2019","journal-title":"Aging"},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1242\/dev.103.Supplement.115","article-title":"Small eye (Sey): A mouse model for the genetic analysis of craniofacial abnormalities","volume":"103","author":"Hogan","year":"1988","journal-title":"Development"},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1101\/gad.10.4.435","article-title":"Multiple functions for Pax6 in mouse eye and nasal development","volume":"10","author":"Quinn","year":"1996","journal-title":"Genes Dev."},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1101\/gad.184000","article-title":"Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye","volume":"14","author":"Marquardt","year":"2000","journal-title":"Genes Dev."},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1093\/nar\/gkh334","article-title":"Functional interactions between alternatively spliced forms of Pax6 in crystallin gene regulation and in haploinsufficiency","volume":"32","author":"Chauhan","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"ref_323","first-page":"270","article-title":"Gene regulation by PAX6: Structural-functional correlations of missense mutants and transcriptional control of Trpm3\/miR-204","volume":"20","author":"Xie","year":"2014","journal-title":"Mol. Vis."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/ng0894-463","article-title":"PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects","volume":"7","author":"Glaser","year":"1994","journal-title":"Nat. Genet."},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.1365-2443.1997.1170315.x","article-title":"Autoregulation of Pax6 transcriptional activation by two distinct DNA-binding subdomains of the paired domain","volume":"2","author":"Yamaguchi","year":"1997","journal-title":"Genes Cells"},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/(SICI)1098-1004(1998)12:5<304::AID-HUMU3>3.0.CO;2-D","article-title":"Ten novel mutations found in aniridia","volume":"12","author":"Wolf","year":"1998","journal-title":"Hum. Mut."},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/ng0294-168","article-title":"Mutations at the PAX6 locus are found in heterogeneous anterior segment malformations including Peters\u2019 anomaly","volume":"6","author":"Hanson","year":"1994","journal-title":"Nat. Genet."},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/hmg\/8.2.165","article-title":"Missense Mutations in the Most Ancient Residues of the PAX6 Paired Domain Underlie a Spectrum of Human Congenital Eye Malformations","volume":"8","author":"Hanson","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1177\/112067210001000213","article-title":"Two nonsense mutations of PAX6 in two Japanese aniridia families: Case report and review of the literature","volume":"10","author":"Matsumoto","year":"2000","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/sj.ejhg.5201579","article-title":"Molecular analysis of a human PAX6 homeobox mutant","volume":"14","author":"Puppin","year":"2006","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/ejhg.2012.100","article-title":"Aniridia","volume":"20","author":"Hingorani","year":"2012","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_332","doi-asserted-by":"crossref","unstructured":"Cunha, D.L., Arno, G., Corton, M., and Moosajee, M. (2019). The Spectrum of PAX6 Mutations and Genotype-Phenotype Correlations in the Eye. Genes, 10.","DOI":"10.3390\/genes10121050"},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1006\/dbio.1998.9132","article-title":"AP-2\u03b1Transcription Factor Is Required for Early Morphogenesis of the Lens Vesicle","volume":"206","author":"Zhang","year":"1999","journal-title":"Dev. Biol."},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1002\/dvdy.24141","article-title":"AP-2\u03b1 is required after lens vesicle formation to maintain lens integrity","volume":"243","author":"Kerr","year":"2014","journal-title":"Dev. Dyn."},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3109\/13816810.2011.634878","article-title":"A family with branchio-oculo-facial syndrome with primarily ocular involvement associated with mutation of the TFAP2A gene","volume":"33","author":"Dumitrescu","year":"2012","journal-title":"Ophthal. Genet."},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1101\/gad.14.2.245","article-title":"A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle","volume":"14","author":"Blixt","year":"2000","journal-title":"Genes Dev."},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"8854","DOI":"10.1128\/MCB.25.20.8854-8863.2005","article-title":"Severe defects in proliferation and differentiation of lens cells in Foxe3 null mice","volume":"25","author":"Brownell","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1093\/hmg\/ddab142","article-title":"Comprehensive phenotypic and functional analysis of dominant and recessive FOXE3 alleles in ocular developmental disorders","volume":"30","author":"Reis","year":"2021","journal-title":"Hum. Mol. Genet."},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1093\/hmg\/9.11.1575","article-title":"Deletion in the promoter region and altered expression of Pitx3 homeobox gene in aphakia mice","volume":"9","author":"Semina","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"ref_340","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1002\/dvdy.21924","article-title":"Pitx3 controls multiple aspects of lens development","volume":"238","author":"Shah","year":"2009","journal-title":"Dev. Dyn."},{"key":"ref_341","doi-asserted-by":"crossref","unstructured":"Wada, K., Matsushima, Y., Tada, T., Hasegawa, S., Obara, Y., Yoshizawa, Y., Takahashi, G., Hiai, H., Shimanuki, M., and Suzuki, S. (2014). Expression of truncated PITX3 in the developing lens leads to microphthalmia and aphakia in mice. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0111432"},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1086\/505654","article-title":"Homozygous nonsense mutation in the FOXE3 gene as a cause of congenital primary aphakia in humans","volume":"79","author":"Valleix","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"ref_343","doi-asserted-by":"crossref","unstructured":"Sakazume, S., Sorokina, E., Iwamoto, Y., and Semina, E.V. (2007). Functional analysis of human mutations in homeodomain transcription factor PITX3. BMC Mol. Biol., 8.","DOI":"10.1186\/1471-2199-8-84"},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1750-1172-9-26","article-title":"Novel and recurrent PITX3 mutations in Belgian families with autosomal dominant congenital cataract and anterior segment dysgenesis have similar phenotypic and functional characteristics","volume":"9","author":"Verdin","year":"2014","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_345","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1073\/pnas.96.7.3781","article-title":"Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development","volume":"96","author":"Kim","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"19254","DOI":"10.1074\/jbc.274.27.19254","article-title":"Regulation of lens fiber cell differentiation by transcription factor c-Maf","volume":"274","author":"Kawauchi","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1242\/dev.127.2.307","article-title":"Regulation of mouse lens fiber cell development and differentiation by the Maf gene","volume":"127","author":"Ring","year":"2000","journal-title":"Development"},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"5694","DOI":"10.1128\/MCB.24.13.5694-5709.2004","article-title":"Synergistic transcription activation by Maf and Sox and their subnuclear localization are disrupted by a mutation in Maf that causes cataract","volume":"24","author":"Rajaram","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"ref_349","doi-asserted-by":"crossref","first-page":"43259","DOI":"10.1074\/jbc.M111.264580","article-title":"The orchestration of mammalian tissue morphogenesis through a series of coherent feed-forward loops","volume":"286","author":"Xie","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/humu.22948","article-title":"Sporadic and Familial Congenital Cataracts: Mutational Spectrum and New Diagnoses Using Next-Generation Sequencing","volume":"37","author":"Ma","year":"2016","journal-title":"Hum. Mut."},{"key":"ref_351","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1136\/bjo.87.4.411","article-title":"Pulverulent cataract with variably associated microcornea and iris coloboma in a MAF mutation family","volume":"87","author":"Jamieson","year":"2003","journal-title":"Br. J. Ophthalmol."},{"key":"ref_352","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s11033-017-4121-4","article-title":"Segregation of a novel p.(Ser270Tyr) MAF mutation and p.(Tyr56\u2217) CRYGD variant in a family with dominantly inherited congenital cataracts","volume":"44","author":"Dudakova","year":"2017","journal-title":"Mol. Biol. Reps."},{"key":"ref_353","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.1038\/sj.emboj.7600435","article-title":"HSF4 is required for normal cell growth and differentiation during mouse lens development","volume":"23","author":"Fujimoto","year":"2004","journal-title":"EMBO J."},{"key":"ref_354","doi-asserted-by":"crossref","first-page":"44497","DOI":"10.1074\/jbc.M405813200","article-title":"Developmentally dictated expression of heat shock factors: Exclusive expression of HSF4 in the postnatal lens and its specific interaction with \u03b1B-crystallin heat shock promoter","volume":"279","author":"Somasundaram","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_355","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.bbadis.2013.03.007","article-title":"HSF4 regulates DLAD expression and promotes lens de-nucleation","volume":"1832","author":"Cui","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_356","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1242\/dev.135285","article-title":"Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation","volume":"143","author":"He","year":"2016","journal-title":"Development"},{"key":"ref_357","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1756-8935-3-21","article-title":"Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation","volume":"3","author":"He","year":"2010","journal-title":"Epigenetics Chromatin"},{"key":"ref_358","first-page":"806","article-title":"A novel missense mutation in HSF4 causes autosomal-dominant congenital lamellar cataract in a British family","volume":"32","author":"Berry","year":"2018","journal-title":"Nature"},{"key":"ref_359","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1002\/humu.22610","article-title":"HSF 4 Mutation p. Arg116 H is Found in Age-Related Cataracts and in Normal Populations Produces Childhood Lamellar Cataract in Transgenic Mice","volume":"35","author":"Jing","year":"2014","journal-title":"Hum. Mut."},{"key":"ref_360","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1167\/iovs.03-1370","article-title":"A Homozygous Splice Mutation in the HSF4 Gene Is Associated with an Autosomal Recessive Congenital Cataract","volume":"45","author":"Smaoui","year":"2004","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_361","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ejmg.2014.05.002","article-title":"The genetic architecture of microphthalmia, anophthalmia and coloboma","volume":"57","author":"Williamson","year":"2014","journal-title":"Eur. J. Med. Genet."},{"key":"ref_362","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/bdrc.21097","article-title":"Conserved genetic pathways associated with microphthalmia, anophthalmia, and coloboma","volume":"105","author":"Reis","year":"2015","journal-title":"Birth Defects Res. C Embryo Today"},{"key":"ref_363","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/ejhg.2015.155","article-title":"Novel mutations in PAX6, OTX2 and NDP in anophthalmia, microphthalmia and coloboma","volume":"24","author":"Deml","year":"2016","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_364","doi-asserted-by":"crossref","unstructured":"Harding, P., and Moosajee, M. (2019). The molecular basis of human anophthalmia and microphthalmia. J. Dev. Biol., 7.","DOI":"10.3390\/jdb7030016"},{"key":"ref_365","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1086\/430721","article-title":"Heterozygous mutations of OTX2 cause severe ocular malformations","volume":"76","author":"Ragge","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"ref_366","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/s42003-020-01421-2","article-title":"Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract","volume":"3","author":"Zhao","year":"2020","journal-title":"Commun. Biol."},{"key":"ref_367","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/humu.24218","article-title":"Identification of missense MAB21L1 variants in microphthalmia and aniridia","volume":"42","author":"Seese","year":"2021","journal-title":"Hum. Mut."},{"key":"ref_368","doi-asserted-by":"crossref","first-page":"6128","DOI":"10.18632\/aging.204203","article-title":"MAB21L1 promotes survival of lens epithelial cells through control of \u03b1B-crystallin and ATR\/CHK1\/p53 pathway","volume":"14","author":"Xiao","year":"2022","journal-title":"Aging"},{"key":"ref_369","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev-vision-091517-034346","article-title":"Biology of Inherited Cataracts and Opportunities for Treatment","volume":"5","author":"Shiels","year":"2019","journal-title":"Ann. Rev. Vis. Sci."},{"key":"ref_370","doi-asserted-by":"crossref","first-page":"108662","DOI":"10.1016\/j.exer.2021.108662","article-title":"Inherited cataracts: Genetic mechanisms and pathways new and old","volume":"209","author":"Shiels","year":"2021","journal-title":"Exp. Eye Res."},{"key":"ref_371","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1006\/exer.1996.0029","article-title":"Distribution and type of morphological damage in human nuclear age-related cataracts","volume":"62","author":"Lane","year":"1996","journal-title":"Exp. Eye Res."},{"key":"ref_372","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1006\/exer.2000.0937","article-title":"Structural evidence of human nuclear fiber compaction as a function of ageing and cataractogenesis","volume":"72","author":"Nordgren","year":"2001","journal-title":"Exp. Eye Res."},{"key":"ref_373","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.exer.2015.11.009","article-title":"Protein profiles in cortical and nuclear regions of aged human donor lenses: A confocal Raman microspectroscopic and imaging study","volume":"145","author":"Vrensen","year":"2016","journal-title":"Exp. Eye Res."},{"key":"ref_374","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1006\/exer.1998.0549","article-title":"An impediment to glutathione diffusion in older normal human lenses: A possible precondition for nuclear cataract","volume":"67","author":"Sweeney","year":"1998","journal-title":"Exp. Eye Res."},{"key":"ref_375","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1002\/prot.24872","article-title":"Age-related cleavages of crystallins in human lens cortical fiber cells generate a plethora of endogenous peptides and high molecular weight complexes","volume":"83","author":"Su","year":"2015","journal-title":"Proteins"},{"key":"ref_376","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/prca.201400061","article-title":"Quantitative proteomics analysis by iTRAQ in human nuclear cataracts of different ages and normal lens nuclei","volume":"9","author":"Zhou","year":"2015","journal-title":"Proteom. Clin. Appl."},{"key":"ref_377","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.bbapap.2019.06.009","article-title":"Cleavage C-terminal to Asp leads to covalent crosslinking of long-lived human proteins","volume":"1867","author":"Wang","year":"2019","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_378","first-page":"94","article-title":"Cholesterol, phospholipid, and protein changes in focal opacities in the human eye lens","volume":"39","author":"Duindam","year":"1998","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_379","doi-asserted-by":"crossref","first-page":"480","DOI":"10.4161\/auto.27292","article-title":"Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1\/\u03b2A3\/A1-crystallin via V-ATPase-MTORC1 signaling","volume":"10","author":"Valapala","year":"2014","journal-title":"Autophagy"},{"key":"ref_380","doi-asserted-by":"crossref","first-page":"AMD104","DOI":"10.1167\/iovs.18-24132","article-title":"A role for \u03b2A3\/A1-crystallin in type 2 EMT of RPE cells occurring in dry age-related macular degeneration","volume":"59","author":"Ghosh","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_381","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.stem.2013.11.006","article-title":"Human iPSC-based modeling of late-onset disease via progerin-induced aging","volume":"13","author":"Miller","year":"2013","journal-title":"Cell Stem Cell"},{"key":"ref_382","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/j.celrep.2020.01.007","article-title":"Single-cell transcriptomic comparison of human fetal retina, hPSC-derived retinal organoids, and long-term retinal cultures","volume":"30","author":"Sridhar","year":"2020","journal-title":"Cell Reps."},{"key":"ref_383","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41586-020-2975-4","article-title":"Reprogramming to recover youthful epigenetic information and restore vision","volume":"588","author":"Lu","year":"2020","journal-title":"Nature"},{"key":"ref_384","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0014-4835(02)00278-6","article-title":"Alpha-crystallin","volume":"76","author":"Horwitz","year":"2003","journal-title":"Exp. Eye Res."},{"key":"ref_385","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1146\/annurev-physchem-090419-121428","article-title":"\u03b1-Crystallins in the vertebrate eye lens: Complex oligomers and molecular chaperones","volume":"72","author":"Rocha","year":"2021","journal-title":"Ann. Rev. Phys. Chem."},{"key":"ref_386","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/sj.ejhg.5201046","article-title":"Cell death triggered by a novel mutation in the \u03b1A-crystallin gene underlies autosomal dominant cataract linked to chromosome 21q","volume":"11","author":"Mackay","year":"2003","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_387","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/hmg\/7.3.471","article-title":"Autosomal Dominant Congenital Cataract Associated with a Missense Mutation in the Human Alpha Crystallin Gene CRYAA","volume":"7","author":"Litt","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"ref_388","doi-asserted-by":"crossref","first-page":"426","DOI":"10.4238\/2015.January.23.16","article-title":"A novel 3-base pair deletion of the CRYAA gene identified in a large Chinese pedigree featuring autosomal dominant congenital perinuclear cataract","volume":"14","author":"Kong","year":"2015","journal-title":"Genet. Mol. Res."},{"key":"ref_389","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s13023-020-01484-8","article-title":"Expanding the phenotype of CRYAA nucleotide variants to a complex presentation of anterior segment dysgenesis","volume":"15","author":"Marakhonov","year":"2020","journal-title":"Orphanet. J. Rare Di.S"},{"key":"ref_390","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.biochi.2017.09.008","article-title":"Some properties of three \u03b1B-crystallin mutants carrying point substitutions in the C-terminal domain and associated with congenital diseases","volume":"142","author":"Gerasimovich","year":"2017","journal-title":"Biochimie"},{"key":"ref_391","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/pro.2229","article-title":"Evolution of crystallins for a role in the vertebrate eye lens","volume":"22","author":"Slingsby","year":"2013","journal-title":"Protein Sci."},{"key":"ref_392","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.pbiomolbio.2014.05.002","article-title":"The \u03b2\u03b3-crystallins: Native state stability and pathways to aggregation","volume":"115","author":"Serebryany","year":"2014","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_393","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pbiomolbio.2014.02.004","article-title":"Lens \u03b2-crystallins: The role of deamidation and related modifications in aging and cataract","volume":"115","author":"Lampi","year":"2014","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_394","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.bbadis.2016.02.003","article-title":"Human \u03b2A3\/A1-crystallin splicing mutation causes cataracts by activating the unfolded protein response and inducing apoptosis in differentiating lens fiber cells","volume":"1862","author":"Ma","year":"2016","journal-title":"Biochim. Et Biophys. Acta Mol. Basis Dis."},{"key":"ref_395","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/hmg\/ddh110","article-title":"Characterization of the G91del CRYBA1\/3-crystallin protein: A cause of human inherited cataract","volume":"13","author":"Reddy","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"ref_396","doi-asserted-by":"crossref","first-page":"E2050","DOI":"10.1002\/humu.21436","article-title":"A novel mutation in CRYBB1 associated with congenital cataract-microcornea syndrome: The p.Ser129Arg mutation destabilizes the \u03b2B1\/\u03b2A3-crystallin heteromer but not the \u03b2B1-crystallin homomer","volume":"32","author":"Wang","year":"2011","journal-title":"Hum. Mut."},{"key":"ref_397","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/hmg\/6.5.665","article-title":"Autosomal Dominant Cerulean Cataract Is Associated with a Chain Termination Mutation in the Human \u03b2-Crystallin Gene CRYBB2","volume":"6","author":"Litt","year":"1997","journal-title":"Hum. Mol. Genet."},{"key":"ref_398","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/humu.21648","article-title":"A novel mutation impairing the tertiary structure and stability of \u03b3C-crystallin (CRYGC) leads to cataract formation in humans and zebrafish lens","volume":"33","author":"Li","year":"2012","journal-title":"Hum. Mut."},{"key":"ref_399","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1093\/hmg\/9.12.1779","article-title":"Link between a novel human \u03b3D-crystallin allele and a unique cataract phenotype explained by protein crystallography","volume":"9","author":"Kmoch","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"ref_400","doi-asserted-by":"crossref","first-page":"E1939","DOI":"10.1002\/humu.21386","article-title":"A novel CRYGD mutation (p.Trp43Arg) causing autosomal dominant congenital cataract in a Chinese family","volume":"32","author":"Wang","year":"2011","journal-title":"Hum. Mut."},{"key":"ref_401","doi-asserted-by":"crossref","first-page":"9010","DOI":"10.1074\/jbc.270.15.9010","article-title":"Water channel properties of major intrinsic protein of lens","volume":"270","author":"Mulders","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_402","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/ng0296-212","article-title":"Mutations in the founder of the MIP gene family underlie cataract development in the mouse","volume":"12","author":"Shiels","year":"1996","journal-title":"Nat. Genet."},{"key":"ref_403","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1093\/oxfordjournals.hmg.a018925","article-title":"Functional impairment of lens aquaporin in two families with dominantly inherited cataracts","volume":"9","author":"Francis","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"ref_404","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/75538","article-title":"Missense mutations in MIP underlie autosomal dominant \u2018polymorphic\u2019and lamellar cataracts linked to 12q","volume":"25","author":"Berry","year":"2000","journal-title":"Nat. Genet."},{"key":"ref_405","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1167\/iovs.06-0947","article-title":"Refractive defects and cataracts in mice lacking lens intrinsic membrane protein-2","volume":"48","author":"Shiels","year":"2007","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_406","doi-asserted-by":"crossref","first-page":"7332","DOI":"10.1167\/iovs.11-7724","article-title":"Further analysis of the lens phenotype in Lim2-deficient mice","volume":"52","author":"Shi","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_407","doi-asserted-by":"crossref","unstructured":"Irum, B., Khan, S.Y., Ali, M., Kaul, H., Kabir, F., Rauf, B., Fatima, F., Nadeem, R., Khan, A.O., and Al Obaisi, S. (2016). Mutation in LIM2 is responsible for autosomal recessive congenital cataracts. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0162620"},{"key":"ref_408","doi-asserted-by":"crossref","unstructured":"Berry, V., Fujinami, K., Mochizuki, K., Iwata, T., Pontikos, N., Quinlan, R.A., and Michaelides, M. (2022). A recurrent variant in LIM2 causes an isolated congenital sutural\/lamellar cataract in a Japanese family. Ophthalmic Genet., 1\u20135.","DOI":"10.1080\/13816810.2022.2090010"},{"key":"ref_409","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/13816810.2020.1737950","article-title":"A novel missense mutation in LIM2 causing isolated autosomal dominant congenital cataract","volume":"41","author":"Berry","year":"2020","journal-title":"Ophthalmic Genet."},{"key":"ref_410","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1167\/iovs.16-19521","article-title":"Connexin 50 regulates surface ball-and-socket structures and fiber cell organization","volume":"57","author":"Wang","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_411","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1038\/s41467-020-18120-5","article-title":"Connexin-46\/50 in a dynamic lipid environment resolved by CryoEM at 1.9 \u00c5","volume":"11","author":"Flores","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_412","doi-asserted-by":"crossref","first-page":"101673","DOI":"10.1016\/j.jbc.2022.101673","article-title":"Cataract-linked serine mutations in the gap junction protein connexin50 expose a sorting signal that promotes its lysosomal degradation","volume":"298","author":"Minogue","year":"2022","journal-title":"J. Biol. Chem."},{"key":"ref_413","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1078\/0171-9335-00316","article-title":"Loss of function and impaired degradation of a cataract-associated mutant connexin50","volume":"82","author":"Berthoud","year":"2003","journal-title":"Eur. J. Cell Biol."},{"key":"ref_414","first-page":"323","article-title":"A novel mutation in GJA8 associated with jellyfish-like cataract in a family of Indian origin","volume":"14","author":"Vanita","year":"2008","journal-title":"Mol. Vis."},{"key":"ref_415","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41586-018-0786-7","article-title":"Structure of native lens connexin 46\/50 intercellular channels by cryo-EM","volume":"564","author":"Myers","year":"2018","journal-title":"Nature"},{"key":"ref_416","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1078\/0171-9335-00132","article-title":"Heteromeric connexons formed by the lens connexins, connexin43 and connexin56","volume":"80","author":"Berthoud","year":"2001","journal-title":"Eur. J. Cell Biol."},{"key":"ref_417","first-page":"579","article-title":"A novel mutation in GJA3 (connexin46) for autosomal dominant congenital nuclear pulverulent cataract","volume":"9","author":"Jiang","year":"2003","journal-title":"Mol. Vis."},{"key":"ref_418","first-page":"1837","article-title":"Molecular analysis of cataract families in India: New mutations in the CRYBB2 and GJA3 genes and rare polymorphisms","volume":"16","author":"Santhiya","year":"2010","journal-title":"Mol. Vis."},{"key":"ref_419","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Bennett, T.M., Ruzycki, P.A., and Shiels, A. (2021). Mutation of the EPHA2 tyrosine-kinase domain dysregulates cell pattern formation and cytoskeletal gene expression in the lens. Cells, 10.","DOI":"10.3390\/cells10102606"},{"key":"ref_420","doi-asserted-by":"crossref","first-page":"4717","DOI":"10.1167\/iovs.19-27370","article-title":"A novel human congenital cataract mutation in EPHA2 kinase domain (p. G668D) alters receptor stability and function","volume":"60","author":"Zhai","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_421","doi-asserted-by":"crossref","unstructured":"Bennett, T.M., M\u2019Hamdi, O., Hejtmancik, J.F., and Shiels, A. (2017). Germ-line and somatic EPHA2 coding variants in lens aging and cataract. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0189881"},{"key":"ref_422","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1080\/13816810.2017.1381977","article-title":"A recurrent splice-site mutation in EPHA2 causing congenital posterior nuclear cataract","volume":"39","author":"Berry","year":"2018","journal-title":"Ophthalmic Genet."},{"key":"ref_423","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/s41598-017-01182-9","article-title":"Targeted exome sequencing of congenital cataracts related genes: Broadening the mutation spectrum and genotype\u2013phenotype correlations in 27 Chinese Han families","volume":"7","author":"Zhai","year":"2017","journal-title":"Sci. Reps."},{"key":"ref_424","doi-asserted-by":"crossref","first-page":"102644","DOI":"10.1016\/j.scr.2021.102644","article-title":"Generation of an induced pluripotent stem cell line (SYSUSCi001-A) from a congenital cataract patient carrying heterozygous mutations in BFSP1 and RHO","volume":"59","author":"Chen","year":"2022","journal-title":"Stem Cell Res."},{"key":"ref_425","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1086\/302872","article-title":"Autosomal-dominant congenital cataract associated with a deletion mutation in the human beaded filament protein gene BFSP2","volume":"66","author":"Jakobs","year":"2000","journal-title":"Am. J. Hum. Genet."},{"key":"ref_426","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1126\/science.1195970","article-title":"Mutations in the RNA granule component TDRD7 cause cataract and glaucoma","volume":"331","author":"Lachke","year":"2011","journal-title":"Science"},{"key":"ref_427","doi-asserted-by":"crossref","unstructured":"Dewi, C.U., and O\u2019Connor, M.D. (2019). Use of human pluripotent stem cells to define initiating molecular mechanisms of cataract for anti-cataract drug discovery. Cells, 8.","DOI":"10.3390\/cells8101269"},{"key":"ref_428","doi-asserted-by":"crossref","first-page":"23750","DOI":"10.1002\/jcp.28943","article-title":"Opacification of lentoid bodies derived from human induced pluripotent stem cells is accelerated by hydrogen peroxide and involves protein aggregation","volume":"234","author":"Qin","year":"2019","journal-title":"J. Cell Physiol."},{"key":"ref_429","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1126\/science.aac9145","article-title":"Pharmacological chaperone for \u03b1-crystallin partially restores transparency in cataract models","volume":"350","author":"Makley","year":"2015","journal-title":"Science"},{"key":"ref_430","doi-asserted-by":"crossref","first-page":"8459","DOI":"10.1038\/s41598-019-44676-4","article-title":"Failure of oxysterols such as lanosterol to restore lens clarity from cataracts","volume":"9","author":"Daszynski","year":"2019","journal-title":"Sci. Reps."},{"key":"ref_431","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1167\/iovs.18-25647","article-title":"Mechanism of action of VP1-001 in cryAB (R120G)-associated and age-related cataracts","volume":"60","author":"Molnar","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_432","doi-asserted-by":"crossref","first-page":"959978","DOI":"10.3389\/fphar.2022.959978","article-title":"Postponement of the opacification of lentoid bodies derived from human induced pluripotent stem cells after lanosterol treatment-the first use of the lens aging model in vitro in cataract drug screening","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_433","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/s41431-018-0288-y","article-title":"Functional reassessment of PAX6 single nucleotide variants by in vitro splicing assay","volume":"27","author":"Filatova","year":"2019","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_434","doi-asserted-by":"crossref","first-page":"123","DOI":"10.14712\/fb2020066040123","article-title":"Phenotype Variability in Czech Patients Carrying PAX6 Disease-Causing Variants","volume":"66","author":"Moravikova","year":"2020","journal-title":"Folia Biol."},{"key":"ref_435","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1136\/jmedgenet-2020-106932","article-title":"Activation of cryptic donor splice sites by non-coding and coding PAX6 variants contributes to congenital aniridia","volume":"59","author":"Tarilonte","year":"2022","journal-title":"J. Med. Genet."},{"key":"ref_436","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cca.2006.06.017","article-title":"CRYAB promoter polymorphisms: Influence on multiple sclerosis susceptibility and clinical presentation","volume":"375","author":"Stoevring","year":"2007","journal-title":"Clin. Chim. Acta"},{"key":"ref_437","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nature09342","article-title":"Epigenetic memory in induced pluripotent stem cells","volume":"467","author":"Kim","year":"2010","journal-title":"Nature"},{"key":"ref_438","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.stem.2011.06.007","article-title":"Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells","volume":"9","author":"Russ","year":"2011","journal-title":"Cell Stem Cell"},{"key":"ref_439","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1756-8935-6-6","article-title":"Mitotic bookmarking by transcription factors","volume":"6","author":"Kadauke","year":"2013","journal-title":"Epigenetics Chromatin"},{"key":"ref_440","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.coisb.2018.08.003","article-title":"Remembering the past: Mitotic bookmarking in a developing embryo","volume":"11","author":"Bellec","year":"2018","journal-title":"Curr. Opin. Syst. Biol."},{"key":"ref_441","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41580-018-0077-z","article-title":"A changing paradigm of transcriptional memory propagation through mitosis","volume":"20","author":"Palozola","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_442","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ydbio.2019.04.020","article-title":"Lens differentiation is characterized by stage-specific changes in chromatin accessibility correlating with differentiation state-specific gene expression","volume":"453","author":"Disatham","year":"2019","journal-title":"Dev. Biol."},{"key":"ref_443","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13072-019-0272-y","article-title":"Profiling of chromatin accessibility and identification of general cis-regulatory mechanisms that control two ocular lens differentiation pathways","volume":"12","author":"Zhao","year":"2019","journal-title":"Epigenetics Chromatin"},{"key":"ref_444","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1080\/15592294.2016.1253651","article-title":"Lens development requires DNMT1 but takes place normally in the absence of both DNMT3A and DNMT3B activity","volume":"12","author":"Hoang","year":"2017","journal-title":"Epigenetics"},{"key":"ref_445","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1091\/mbc.e09-12-1031","article-title":"Lens fiber cell differentiation and denucleation are disrupted through expression of the N-terminal nuclear receptor box of NCOA6 and result in p53-dependent and p53-independent apoptosis","volume":"21","author":"Wang","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"ref_446","first-page":"18","article-title":"Znhit1 Regulates p21Cip1 to Control Mouse Lens Differentiation","volume":"63","author":"Lu","year":"2022","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_447","doi-asserted-by":"crossref","unstructured":"Atzmon, G., Rincon, M., Schechter, C.B., Shuldiner, A.R., Lipton, R.B., Bergman, A., and Barzilai, N. (2006). Lipoprotein Genotype and Conserved Pathway for Exceptional Longevity in Humans. PLoS Biol., 4.","DOI":"10.1371\/journal.pbio.0040113"},{"key":"ref_448","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/s43587-021-00108-5","article-title":"Rare genetic coding variants associated with human longevity and protection against age-related diseases","volume":"1","author":"Lin","year":"2021","journal-title":"Nat. Aging"},{"key":"ref_449","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1093\/gerona\/63.11.1201","article-title":"Life at the Extreme Limit: Phenotypic Characteristics of Supercentenarians in Okinawa","volume":"63","author":"Willcox","year":"2008","journal-title":"J. Gerontol."},{"key":"ref_450","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.exer.2016.11.008","article-title":"Spatial distributions of glutathione and its endogenous conjugates in normal bovine lens and a model of lens aging","volume":"154","author":"Spraggins","year":"2017","journal-title":"Exp. Eye Res."},{"key":"ref_451","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11306-019-1495-4","article-title":"Quantitative metabolomic analysis of changes in the lens and aqueous humor under development of age-related nuclear cataract","volume":"15","author":"Yanshole","year":"2019","journal-title":"Metabolomics"},{"key":"ref_452","doi-asserted-by":"crossref","unstructured":"Frankfater, C., Bozeman, S.L., Hsu, F.-F., and Andley, U.P. (2020). Alpha-crystallin mutations alter lens metabolites in mouse models of human cataracts. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0238081"},{"key":"ref_453","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1080\/15548627.2022.2025570","article-title":"The role of FYCO1-dependent autophagy in lens fiber cell differentiation","volume":"18","author":"Khan","year":"2022","journal-title":"Autophagy"},{"key":"ref_454","doi-asserted-by":"crossref","first-page":"e76923","DOI":"10.7554\/eLife.76923","article-title":"A native chemical chaperone in the human eye lens","volume":"11","author":"Serebryany","year":"2022","journal-title":"eLife"},{"key":"ref_455","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1089\/ten.2006.12.3307","article-title":"Engineering complex tissues","volume":"12","author":"Mikos","year":"2006","journal-title":"Tissue Eng."},{"key":"ref_456","doi-asserted-by":"crossref","unstructured":"Quinlan, R.A., and Clark, J.I. (2022). Insights into the Biochemical and Biophysical Mechanisms Mediating the Longevity of the Transparent Optics of the Eye Lens. J. Biol. Chem., 102537.","DOI":"10.1016\/j.jbc.2022.102537"},{"key":"ref_457","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.preteyeres.2012.03.001","article-title":"The gradient index lens of the eye: An opto-biological synchrony","volume":"31","author":"Pierscionek","year":"2012","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_458","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1098\/rstb.2010.0302","article-title":"Biological glass: Structural determinants of eye lens transparency","volume":"366","author":"Bassnett","year":"2011","journal-title":"Philos. Trans. R. Soc. Lond. B. Biol. Sci."},{"key":"ref_459","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1364\/BOE.386459","article-title":"Single function crystalline lens capable of mimicking ciliary body accommodation","volume":"11","author":"Coello","year":"2020","journal-title":"Biomed. Opt. Express"},{"key":"ref_460","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1002\/bit.24977","article-title":"Recreating a human trabecular meshwork outflow system on microfabricated porous structures","volume":"110","author":"Torrejon","year":"2013","journal-title":"Biotechnol. Bioeng."},{"key":"ref_461","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.actbio.2020.01.033","article-title":"A bioengineering approach to Schlemm\u2019s canal-like stem cell differentiation for in vitro glaucoma drug screening","volume":"105","author":"Tian","year":"2020","journal-title":"Acta. Biomater."},{"key":"ref_462","doi-asserted-by":"crossref","unstructured":"Kim, J., Park, J.Y., Kong, J.S., Lee, H., Won, J.Y., and Cho, D.W. (2021). Development of 3D Printed Bruch\u2019s Membrane-Mimetic Substance for the Maturation of Retinal Pigment Epithelial Cells. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031095"},{"key":"ref_463","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3727\/000000004783983882","article-title":"Collagen vitrigel: A novel scaffold that can facilitate a three-dimensional culture for reconstructing organoids","volume":"13","author":"Takezawa","year":"2004","journal-title":"Cell Transplant."},{"key":"ref_464","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/term.2598","article-title":"Collagen vitrigels with low-fibril density enhance human embryonic stem cell-derived retinal pigment epithelial cell maturation","volume":"12","author":"Wang","year":"2018","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_465","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.stem.2021.02.024","article-title":"Exploring the human lacrimal gland using organoids and single-cell sequencing","volume":"28","author":"Post","year":"2021","journal-title":"Cell Stem Cell"},{"key":"ref_466","doi-asserted-by":"crossref","first-page":"dev189746","DOI":"10.1242\/dev.189746","article-title":"Retinal organoids: A window into human retinal development","volume":"147","year":"2020","journal-title":"Development"},{"key":"ref_467","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.stem.2019.05.005","article-title":"Engineering stem cell self-organization to build better organoids","volume":"24","author":"Brassard","year":"2019","journal-title":"Cell Stem Cell"},{"key":"ref_468","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41563-020-00804-4","article-title":"Rethinking organoid technology through bioengineering","volume":"20","author":"Garreta","year":"2021","journal-title":"Nat. Mater."},{"key":"ref_469","doi-asserted-by":"crossref","first-page":"e46188","DOI":"10.7554\/eLife.46188","article-title":"Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform","volume":"8","author":"Achberger","year":"2019","journal-title":"eLife"},{"key":"ref_470","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1039\/D1LC00011J","article-title":"Retinal organoids on-a-chip: A micro-millifluidic bioreactor for long-term organoid maintenance","volume":"21","author":"Xue","year":"2021","journal-title":"Lab Chip"},{"key":"ref_471","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1039\/b908332d","article-title":"Integration and application of vitrified collagen in multilayered microfluidic devices for corneal microtissue culture","volume":"9","author":"Puleo","year":"2009","journal-title":"Lab Chip"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/21\/3516\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:11:34Z","timestamp":1760145094000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/21\/3516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,6]]},"references-count":471,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["cells11213516"],"URL":"https:\/\/doi.org\/10.3390\/cells11213516","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,6]]}}}