{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:54:59Z","timestamp":1791996899615,"version":"4.4.0"},"reference-count":189,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Centre Hospitalier Universitaire de Lille"},{"name":"Centre de r\u00e9f\u00e9rence de la maladie de Huntington (C.S.)"},{"name":"Inserm"},{"name":"Universit\u00e9 de Lille"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The Hippo pathway consists of a cascade of kinases that controls the phosphorylation of the co-activators YAP\/TAZ. When unphosphorylated, YAP and TAZ translocate into the nucleus, where they mainly bind to the TEAD transcription factor family and activate genes related to cell proliferation and survival. In this way, the inhibition of the Hippo pathway promotes cell survival, proliferation, and stemness fate. Another pathway can modulate these processes, namely the Wnt\/\u03b2-catenin pathway that is indeed involved in cellular functions such as proliferation and cell survival, as well as apoptosis, growth, and cell renewal. Wnt signaling can act in a canonical or noncanonical way, depending on whether \u03b2-catenin is involved in the process. In this review, we will focus only on the canonical Wnt pathway. It has emerged that YAP\/TAZ are components of the \u03b2-catenin destruction complex and that there is a close relationship between the Hippo pathway and the canonical Wnt pathway. Furthermore, recent data have shown that both of these pathways may play a role in neurodegenerative diseases, such as Huntington\u2019s disease, Alzheimer\u2019s disease, or Amyotrophic Lateral Sclerosis. Thus, this review analyzes the Hippo pathway and the Wnt pathway, their crosstalk, and their involvement in Huntington\u2019s disease, as well as in other neurodegenerative disorders. Altogether, these data suggest possible therapeutic approaches targeting key players of these pathways.<\/jats:p>","DOI":"10.3390\/cells11223631","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T03:26:04Z","timestamp":1668655564000},"page":"3631","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Crosstalk between the Hippo Pathway and the Wnt Pathway in Huntington\u2019s Disease and Other Neurodegenerative Disorders"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9991-7430","authenticated-orcid":false,"given":"Pasquale","family":"Sileo","sequence":"first","affiliation":[{"name":"Univ. Lille, INSERM, CHU Lille, UMR-S 1172, Lille Neuroscience and Cognition Research Center, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mence","family":"Simonin","sequence":"additional","affiliation":[{"name":"Univ. Lille, INSERM, CHU Lille, UMR-S 1172, Lille Neuroscience and Cognition Research Center, F-59000 Lille, France"},{"name":"Centre de R\u00e9f\u00e9rence Maladie de Huntington, CHU Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9555-3446","authenticated-orcid":false,"given":"Patricia","family":"Melnyk","sequence":"additional","affiliation":[{"name":"Univ. Lille, INSERM, CHU Lille, UMR-S 1172, Lille Neuroscience and Cognition Research Center, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6416-6526","authenticated-orcid":false,"given":"Marie-Christine","family":"Chartier-Harlin","sequence":"additional","affiliation":[{"name":"Univ. Lille, INSERM, CHU Lille, UMR-S 1172, Lille Neuroscience and Cognition Research Center, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Cotelle","sequence":"additional","affiliation":[{"name":"Univ. Lille, INSERM, CHU Lille, UMR-S 1172, Lille Neuroscience and Cognition Research Center, F-59000 Lille, France"},{"name":"ENSCL-Centrale Lille, CS 90108, F-59652 Villeneuve d\u2019Ascq, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1152\/physrev.00005.2014","article-title":"The Biology of YAP\/TAZ: Hippo Signaling and Beyond","volume":"94","author":"Piccolo","year":"2014","journal-title":"Physiol. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nrc3458","article-title":"The Hippo Pathway and Human Cancer","volume":"13","author":"Harvey","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.trecan.2019.04.001","article-title":"Hippo Pathway in Cancer: Aberrant Regulation and Therapeutic Opportunities","volume":"5","author":"Calses","year":"2019","journal-title":"Trends Cancer"},{"key":"ref_4","first-page":"311","article-title":"Hippo Pathway\u2014Brief Overview of Its Relevance in Cancer","volume":"68","author":"Zygulska","year":"2017","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.cell.2006.10.018","article-title":"Wnt\/Beta-Catenin Signaling in Development and Disease","volume":"127","author":"Clevers","year":"2006","journal-title":"Cell"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1101\/gad.1957710","article-title":"Canonical and Noncanonical Wnts Use a Common Mechanism to Activate Completely Unrelated Coreceptors","volume":"24","author":"Grumolato","year":"2010","journal-title":"Genes Dev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.3892\/ijo.2017.4129","article-title":"Canonical and Non-Canonical WNT Signaling in Cancer Stem Cells and Their Niches: Cellular Heterogeneity, Omics Reprogramming, Targeted Therapy and Tumor Plasticity (Review)","volume":"51","author":"Katoh","year":"2017","journal-title":"Int. J. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nrg2042","article-title":"Frizzled\/PCP Signaling: A Conserved Mechanism Regulating Cell Polarity and Directed Motility","volume":"8","author":"Seifert","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1242\/dev.02772","article-title":"Tissue\/Planar Cell Polarity in Vertebrates: New Insights and New Questions","volume":"134","author":"Wang","year":"2007","journal-title":"Development"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nrd.2018.133","article-title":"Therapeutic Approaches to Huntington Disease: From the Bench to the Clinic","volume":"17","author":"Caron","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/d41586-021-01177-7","article-title":"Failure of Genetic Therapies for Huntington\u2019s Devastates Community","volume":"593","author":"Kwon","year":"2021","journal-title":"Nature"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1080\/17460441.2020.1746266","article-title":"Targeting the Wnt\/\u03b2-Catenin Pathway in Neurodegenerative Diseases: Recent Approaches and Current Challenges","volume":"15","author":"Serafino","year":"2020","journal-title":"Expert Opin Drug Discov."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.cell.2005.06.007","article-title":"The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAP","volume":"122","author":"Huang","year":"2005","journal-title":"Cell"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.cub.2007.10.039","article-title":"YAP1 Increases Organ Size and Expands Undifferentiated Progenitor Cells","volume":"17","author":"Camargo","year":"2007","journal-title":"Curr. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.cell.2007.07.019","article-title":"Elucidation of a Universal Size-Control Mechanism in Drosophila and Mammals","volume":"130","author":"Dong","year":"2007","journal-title":"Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/gad.274027.115","article-title":"Mechanisms of Hippo Pathway Regulation","volume":"30","author":"Meng","year":"2016","journal-title":"Genes Dev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1242\/dev.027151","article-title":"Mammalian Tead Proteins Regulate Cell Proliferation and Contact Inhibition as Transcriptional Mediators of Hippo Signaling","volume":"135","author":"Ota","year":"2008","journal-title":"Development"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"13355","DOI":"10.1074\/jbc.M900843200","article-title":"TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition","volume":"284","author":"Zhang","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1101\/gad.1664408","article-title":"TEAD Mediates YAP-Dependent Gene Induction and Growth Control","volume":"22","author":"Zhao","year":"2008","journal-title":"Genes Dev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"5117","DOI":"10.1038\/onc.2012.5","article-title":"YAP Induces Malignant Mesothelioma Cell Proliferation by Upregulating Transcription of Cell Cycle-Promoting Genes","volume":"31","author":"Mizuno","year":"2012","journal-title":"Oncogene"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1038\/onc.2010.504","article-title":"AXL Receptor Kinase Is a Mediator of YAP-Dependent Oncogenic Functions in Hepatocellular Carcinoma","volume":"30","author":"Xu","year":"2011","journal-title":"Oncogene"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/ncb1993","article-title":"YAP-Dependent Induction of Amphiregulin Identifies a Non-Cell-Autonomous Component of the Hippo Pathway","volume":"11","author":"Zhang","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1128\/MCB.01874-07","article-title":"TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway","volume":"28","author":"Lei","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"37159","DOI":"10.1074\/jbc.M110.152942","article-title":"The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCF\u03b2-TrCP E3 Ligase","volume":"285","author":"Liu","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1101\/gad.1843810","article-title":"A Coordinated Phosphorylation by Lats and CK1 Regulates YAP Stability through SCF\u03b2-TRCP","volume":"24","author":"Zhao","year":"2010","journal-title":"Genes Dev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1101\/gad.1602907","article-title":"Inactivation of YAP Oncoprotein by the Hippo Pathway Is Involved in Cell Contact Inhibition and Tissue Growth Control","volume":"21","author":"Zhao","year":"2007","journal-title":"Genes Dev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.devcel.2011.08.028","article-title":"Tao-1 Phosphorylates Hippo\/MST Kinases to Regulate the Hippo-Salvador-Warts Tumor Suppressor Pathway","volume":"21","author":"Boggiano","year":"2011","journal-title":"Dev. Cell"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.devcel.2011.09.012","article-title":"The Sterile 20-like Kinase Tao-1 Controls Tissue Growth by Regulating the Salvador-Warts-Hippo Pathway","volume":"21","author":"Poon","year":"2011","journal-title":"Dev. Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1042\/BJ20040025","article-title":"Regulation of the MST1 Kinase by Autophosphorylation, by the Growth Inhibitory Proteins, RASSF1 and NORE1, and by Ras","volume":"381","author":"Praskova","year":"2004","journal-title":"Biochem. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"42987","DOI":"10.1074\/jbc.M208538200","article-title":"Mapping of MST1 Kinase Sites of Phosphorylation: ACTIVATION AND AUTOPHOSPHORYLATION *","volume":"277","author":"Glantschnig","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1111\/j.1742-4658.2006.05427.x","article-title":"Association of Mammalian Sterile Twenty Kinases, Mst1 and Mst2, with HSalvador via C-Terminal Coiled-Coil Domains, Leads to Its Stabilization and Phosphorylation","volume":"273","author":"Callus","year":"2006","journal-title":"FEBS J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cub.2008.02.006","article-title":"MOBKL1A\/MOBKL1B Phosphorylation by MST1 and MST2 Inhibits Cell Proliferation","volume":"18","author":"Praskova","year":"2008","journal-title":"Curr. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.bbrc.2006.03.244","article-title":"The Human Tumour Suppressor LATS1 Is Activated by Human MOB1 at the Membrane","volume":"345","author":"Hergovich","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.cell.2013.08.025","article-title":"Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin\/NF2","volume":"154","author":"Yin","year":"2013","journal-title":"Cell"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1084\/jem.20140341","article-title":"Regulation of YAP by MTOR and Autophagy Reveals a Therapeutic Target of Tuberous Sclerosis Complex","volume":"211","author":"Liang","year":"2014","journal-title":"J. Exp. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.3389\/fonc.2020.01266","article-title":"Multiple Roles of Vestigial-Like Family Members in Tumor Development","volume":"10","author":"Yamaguchi","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.devcel.2013.04.021","article-title":"The Hippo Effector Yorkie Controls Normal Tissue Growth by Antagonizing Scalloped-Mediated Default Repression","volume":"25","author":"Koontz","year":"2013","journal-title":"Dev. Cell"},{"key":"ref_38","first-page":"1","article-title":"Transcriptional Repression of Estrogen Receptor Alpha by YAP Reveals the Hippo Pathway as Therapeutic Target for ER+ Breast Cancer","volume":"13","author":"Ma","year":"2022","journal-title":"Nat. Commun. 2022 131"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"E2441","DOI":"10.1073\/pnas.1212021109","article-title":"The Hippo Pathway Target, YAP, Promotes Metastasis through Its TEAD-Interaction Domain","volume":"109","author":"Lamar","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.devcel.2010.11.012","article-title":"The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-\u03b2-SMAD Pathway","volume":"19","author":"Varelas","year":"2010","journal-title":"Dev. Cell"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in Mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.devcel.2009.02.003","article-title":"The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass","volume":"16","author":"Nishioka","year":"2009","journal-title":"Dev. Cell"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.cell.2013.07.042","article-title":"A Mechanical Checkpoint Controls Multicellular Growth through YAP\/TAZ Regulation by Actin-Processing Factors","volume":"154","author":"Aragona","year":"2013","journal-title":"Cell"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"ra33","DOI":"10.1126\/scisignal.2001823","article-title":"\u03b1-Catenin Is a Tumor Suppressor That Controls Cell Accumulation by Regulating the Localization and Activity of the Transcriptional Coactivator Yap1","volume":"4","author":"Silvis","year":"2011","journal-title":"Sci. Signal."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.chembiol.2012.07.005","article-title":"Identification of Serum-Derived Sphingosine-1-Phosphate as a Small Molecule Regulator of YAP","volume":"19","author":"Miller","year":"2012","journal-title":"Chem. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1101\/gad.197582.112","article-title":"Regulation of the Hippo\u2013YAP Pathway by Protease-Activated Receptors (PARs)","volume":"26","author":"Mo","year":"2012","journal-title":"Genes Dev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1101\/gad.210773.112","article-title":"The Hippo Pathway: Regulators and Regulations","volume":"27","author":"Yu","year":"2013","journal-title":"Genes Dev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/cr.2015.88","article-title":"Opposing Roles of Conventional and Novel PKC Isoforms in Hippo-YAP Pathway Regulation","volume":"25","author":"Gong","year":"2015","journal-title":"Cell Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1172\/JCI79573","article-title":"Estrogen Regulates Hippo Signaling via GPER in Breast Cancer","volume":"125","author":"Zhou","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cell.2012.06.037","article-title":"Regulation of the Hippo-YAP Pathway by G-Protein Coupled Receptor Signaling","volume":"150","author":"Yu","year":"2012","journal-title":"Cell"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.ccr.2014.04.016","article-title":"Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry","volume":"25","author":"Feng","year":"2014","journal-title":"Cancer Cell"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.ccr.2014.04.017","article-title":"Mutant Gq\/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP","volume":"25","author":"Yu","year":"2014","journal-title":"Cancer Cell"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ncb2936","article-title":"Metabolic Control of YAP and TAZ by the Mevalonate Pathway","volume":"16","author":"Sorrentino","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"ref_54","first-page":"E89","article-title":"Interplay of Mevalonate and Hippo Pathways Regulates RHAMM Transcription via YAP to Modulate Breast Cancer Cell Motility","volume":"111","author":"Wang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.cell.2006.03.046","article-title":"A Conserved MST-FOXO Signaling Pathway Mediates Oxidative-Stress Responses and Extends Life Span","volume":"125","author":"Lehtinen","year":"2006","journal-title":"Cell"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/ni.3268","article-title":"The Kinases Mst1 and Mst2 Positively Regulate Phagocyte ROS Induction and Bactericidal Activity","volume":"16","author":"Geng","year":"2015","journal-title":"Nat. Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1038\/ncomms4315","article-title":"A Functional Interaction between Hippo-YAP Signaling and FoxO1 Mediates the Oxidative Stress Response","volume":"5","author":"Shao","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"51044","DOI":"10.18632\/oncotarget.10480","article-title":"The eIF2\u03b1 serine 51 phosphorylation-ATF4 arm promotes HIPPO signaling and cell death under oxidative stress","volume":"7","author":"Rajesh","year":"2016","journal-title":"Oncotarget"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.celrep.2014.09.036","article-title":"Energy Stress Regulates Hippo\u2013YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin Like-1 Protein","volume":"9","author":"deRan","year":"2014","journal-title":"Cell Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/ncb3111","article-title":"Cellular Energy Stress Induces AMPK-Mediated Regulation of YAP and the Hippo Pathway","volume":"17","author":"Mo","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/ncb3113","article-title":"AMPK Modulates Hippo Pathway Activity to Regulate Energy Homeostasis","volume":"17","author":"Wang","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"22429","DOI":"10.1074\/jbc.R600015200","article-title":"Wnt Signaling: Multiple Pathways, Multiple Receptors, and Multiple Transcription Factors","volume":"281","author":"Gordon","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.gde.2006.12.007","article-title":"The Many Ways of Wnt in Cancer","volume":"17","author":"Polakis","year":"2007","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/nrm2717","article-title":"Proximal Events in Wnt Signal Transduction","volume":"10","author":"Angers","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.molcel.2014.04.014","article-title":"Mitotic Wnt Signaling Promotes Protein Stabilization and Regulates Cell Size","volume":"54","author":"Acebron","year":"2014","journal-title":"Mol. Cell"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Atlasi, Y., Noori, R., Gaspar, C., Franken, P., Sacchetti, A., Rafati, H., Mahmoudi, T., Decraene, C., Calin, G.A., and Merrill, B.J. (2013). Wnt Signaling Regulates the Lineage Differentiation Potential of Mouse Embryonic Stem Cells through Tcf3 Down-Regulation. PLoS Genet., 9.","DOI":"10.1371\/journal.pgen.1003424"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1248012","DOI":"10.1126\/science.1248012","article-title":"Stem Cell Signaling. An Integral Program for Tissue Renewal and Regeneration: Wnt Signaling and Stem Cell Control","volume":"346","author":"Clevers","year":"2014","journal-title":"Science"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2008.06.026","article-title":"Opposing Wnt Pathways Orient Cell Polarity during Organogenesis","volume":"134","author":"Green","year":"2008","journal-title":"Cell"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/onc.2016.304","article-title":"Wnt Signaling in Cancer","volume":"36","author":"Zhan","year":"2017","journal-title":"Oncogene"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0168-9525(01)02349-6","article-title":"An Ancient Cluster of Wnt Paralogues","volume":"17","author":"Nusse","year":"2001","journal-title":"Trends Genet."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/nchembio.2005","article-title":"Fatty Acylation of Wnt Proteins","volume":"12","author":"Nile","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.ydbio.2011.11.003","article-title":"Porcupine-Mediated Lipidation Is Required for Wnt Recognition by Wls","volume":"361","author":"Herr","year":"2012","journal-title":"Dev. Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1126\/science.1222879","article-title":"Structural Basis of Wnt Recognition by Frizzled","volume":"337","author":"Janda","year":"2012","journal-title":"Science"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"34167","DOI":"10.1074\/jbc.M112.381970","article-title":"Precise Regulation of Porcupine Activity Is Required for Physiological Wnt Signaling","volume":"287","author":"Proffitt","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature01611","article-title":"Wnt Proteins Are Lipid-Modified and Can Act as Stem Cell Growth Factors","volume":"423","author":"Willert","year":"2003","journal-title":"Nature"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Castro, L.F.C., Wilson, J.M., Gon\u00e7alves, O., Galante-Oliveira, S., Rocha, E., and Cunha, I. (2011). The Evolutionary History of the Stearoyl-CoA Desaturase Gene Family in Vertebrates. BMC Evol. Biol., 11.","DOI":"10.1186\/1471-2148-11-132"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature14259","article-title":"Notum Deacylates Wnt Proteins to Suppress Signaling Activity","volume":"519","author":"Kakugawa","year":"2015","journal-title":"Nature"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"7482","DOI":"10.1038\/sj.onc.1210055","article-title":"\u03b2-Catenin Destruction Complex: Insights and Questions from a Structural Perspective","volume":"25","author":"Kimelman","year":"2006","journal-title":"Oncogene"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"a007898","DOI":"10.1101\/cshperspect.a007898","article-title":"The \u03b2-Catenin Destruction Complex","volume":"5","author":"Stamos","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1126\/science.280.5363.596","article-title":"Functional Interaction of an Axin Homolog, Conductin, with Beta-Catenin, APC, and GSK3beta","volume":"280","author":"Behrens","year":"1998","journal-title":"Science"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0960-9822(98)70226-X","article-title":"Downregulation of Beta-Catenin by Human Axin and Its Association with the APC Tumor Suppressor, Beta-Catenin and GSK3 Beta","volume":"8","author":"Hart","year":"1998","journal-title":"Curr. Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1073\/pnas.92.7.3046","article-title":"Regulation of Intracellular Beta-Catenin Levels by the Adenomatous Polyposis Coli (APC) Tumor-Suppressor Protein","volume":"92","author":"Munemitsu","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1126\/science.8259518","article-title":"Association of the APC Gene Product with Beta-Catenin","volume":"262","author":"Rubinfeld","year":"1993","journal-title":"Science"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1101\/gad.230302","article-title":"Axin-Mediated CKI Phosphorylation of Beta-Catenin at Ser 45: A Molecular Switch for the Wnt Pathway","volume":"16","author":"Amit","year":"2002","journal-title":"Genes Dev."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0092-8674(02)00685-2","article-title":"Control of Beta-Catenin Phosphorylation\/Degradation by a Dual-Kinase Mechanism","volume":"108","author":"Liu","year":"2002","journal-title":"Cell"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1126\/science.272.5264.1023","article-title":"Binding of GSK3beta to the APC-Beta-Catenin Complex and Regulation of Complex Assembly","volume":"272","author":"Rubinfeld","year":"1996","journal-title":"Science"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1101\/gad.13.3.270","article-title":"The SCFbeta-TRCP-Ubiquitin Ligase Complex Associates Specifically with Phosphorylated Destruction Motifs in IkappaBalpha and Beta-Catenin and Stimulates IkappaBalpha Ubiquitination in Vitro","volume":"13","author":"Winston","year":"1999","journal-title":"Genes Dev."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0960-9822(99)80091-8","article-title":"The F-Box Protein Beta-TrCP Associates with Phosphorylated Beta-Catenin and Regulates Its Activity in the Cell","volume":"9","author":"Hart","year":"1999","journal-title":"Curr. Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1093\/emboj\/16.13.3797","article-title":"Beta-Catenin Is a Target for the Ubiquitin-Proteasome Pathway","volume":"16","author":"Aberle","year":"1997","journal-title":"EMBO J."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"24735","DOI":"10.1074\/jbc.272.40.24735","article-title":"Serine Phosphorylation-Regulated Ubiquitination and Degradation of Beta-Catenin","volume":"272","author":"Orford","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/382225a0","article-title":"A New Member of the Frizzled Family from Drosophila Functions as a Wingless Receptor","volume":"382","author":"Bhanot","year":"1996","journal-title":"Nature"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"a007880","DOI":"10.1101\/cshperspect.a007880","article-title":"Frizzled and LRP5\/6 Receptors for Wnt\/\u03b2-Catenin Signaling","volume":"4","author":"MacDonald","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/S0960-9822(02)70716-1","article-title":"A Frizzled Homolog Functions in a Vertebrate Wnt Signaling Pathway","volume":"6","author":"Miller","year":"1996","journal-title":"Curr. Biol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/35035124","article-title":"An LDL-Receptor-Related Protein Mediates Wnt Signaling in Mice","volume":"407","author":"Pinson","year":"2000","journal-title":"Nature"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/35035117","article-title":"LDL-Receptor-Related Proteins in Wnt Signal Transduction","volume":"407","author":"Tamai","year":"2000","journal-title":"Nature"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/35035110","article-title":"Arrow Encodes an LDL-Receptor-Related Protein Essential for Wingless Signaling","volume":"407","author":"Wehrli","year":"2000","journal-title":"Nature"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1101\/gad.8.1.118","article-title":"The Drosophila Segment Polarity Gene Dishevelled Encodes a Novel Protein Required for Response to the Wingless Signal","volume":"8","author":"Klingensmith","year":"1994","journal-title":"Genes Dev."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.1242\/dev.121.12.4095","article-title":"Dishevelled Is a Component of the Frizzled Signaling Pathway in Drosophila","volume":"121","author":"Krasnow","year":"1995","journal-title":"Development"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"5103","DOI":"10.1242\/dev.01318","article-title":"Wnt Signals across the Plasma Membrane to Activate the Beta-Catenin Pathway by Forming Oligomers Containing Its Receptors, Frizzled and LRP","volume":"131","author":"Cong","year":"2004","journal-title":"Development"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"E812","DOI":"10.1073\/pnas.1114802109","article-title":"Wnt\/\u03b2-Catenin Signaling Requires Interaction of the Dishevelled DEP Domain and C Terminus with a Discontinuous Motif in Frizzled","volume":"109","author":"Tauriello","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1097-2765(03)00484-2","article-title":"A Mechanism for Wnt Coreceptor Activation","volume":"13","author":"Tamai","year":"2004","journal-title":"Mol. Cell"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.devcel.2009.11.006","article-title":"Cell Cycle Control of Wnt Receptor Activation","volume":"17","author":"Davidson","year":"2009","journal-title":"Dev. Cell"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/nature04170","article-title":"Casein Kinase 1 Gamma Couples Wnt Receptor Activation to Cytoplasmic Signal Transduction","volume":"438","author":"Davidson","year":"2005","journal-title":"Nature"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nature04185","article-title":"A Dual-Kinase Mechanism for Wnt Co-Receptor Phosphorylation and Activation","volume":"438","author":"Zeng","year":"2005","journal-title":"Nature"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S1097-2765(01)00224-6","article-title":"Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway","volume":"7","author":"Mao","year":"2001","journal-title":"Mol. Cell"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"8032","DOI":"10.1073\/pnas.0803025105","article-title":"LRP6 Transduces a Canonical Wnt Signal Independently of Axin Degradation by Inhibiting GSK3\u2019s Phosphorylation of Beta-Catenin","volume":"105","author":"Cselenyi","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Piao, S., Lee, S.H., Kim, H., Yum, S., Stamos, J.L., Xu, Y., Lee, S.J., Lee, J., Oh, S., and Han, J.K. (2008). Direct Inhibition of GSK3\u03b2 by the Phosphorylated Cytoplasmic Domain of LRP6 in Wnt\/\u03b2-Catenin Signaling. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0004046"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"e01998","DOI":"10.7554\/eLife.01998","article-title":"Structural Basis of GSK-3 Inhibition by N-Terminal Phosphorylation and by the Wnt Receptor LRP6","volume":"3","author":"Stamos","year":"2014","journal-title":"elife"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/26982","article-title":"Drosophila Tcf and Groucho Interact to Repress Wingless Signaling Activity","volume":"395","author":"Cavallo","year":"1998","journal-title":"Nature"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/26989","article-title":"The Xenopus Wnt Effector XTcf-3 Interacts with Groucho-Related Transcriptional Repressors","volume":"395","author":"Roose","year":"1998","journal-title":"Nature"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/382638a0","article-title":"Functional Interaction of Beta-Catenin with the Transcription Factor LEF-1","volume":"382","author":"Behrens","year":"1996","journal-title":"Nature"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0092-8674(00)80112-9","article-title":"XTcf-3 Transcription Factor Mediates Beta-Catenin-Induced Axis Formation in Xenopus Embryos","volume":"86","author":"Molenaar","year":"1996","journal-title":"Cell"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0092-8674(00)81925-X","article-title":"Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene DTCF","volume":"88","author":"Cavallo","year":"1997","journal-title":"Cell"},{"key":"ref_114","first-page":"1914","article-title":"Tissue- and Stage-Specific Wnt Target Gene Expression Is Controlled Subsequent to \u03b2-Catenin Recruitment to Cis-Regulatory Modules","volume":"143","author":"Nakamura","year":"2016","journal-title":"Development"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cell.2014.06.013","article-title":"YAP\/TAZ Incorporation in the \u03b2-Catenin Destruction Complex Orchestrates the Wnt Response","volume":"158","author":"Azzolin","year":"2014","journal-title":"Cell"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/emboj.2011.487","article-title":"A Molecular Mechanism That Links Hippo Signaling to the Inhibition of Wnt\/\u03b2-Catenin Signaling","volume":"31","author":"Imajo","year":"2012","journal-title":"EMBO J."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.devcel.2010.03.007","article-title":"The Hippo Pathway Regulates Wnt\/Beta-Catenin Signaling","volume":"18","author":"Varelas","year":"2010","journal-title":"Dev. Cell"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/j.cell.2012.11.027","article-title":"Role of TAZ as Mediator of Wnt Signaling","volume":"151","author":"Azzolin","year":"2012","journal-title":"Cell"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1126\/science.1199010","article-title":"Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size","volume":"332","author":"Heallen","year":"2011","journal-title":"Science"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.1038\/onc.2017.75","article-title":"Stearoyl-CoA-Desaturase 1 Regulates Lung Cancer Stemness via Stabilization and Nuclear Localization of YAP\/TAZ","volume":"36","author":"Noto","year":"2017","journal-title":"Oncogene"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"11355","DOI":"10.1038\/s41598-018-29319-4","article-title":"Hippo Signaling Pathway Dysregulation in Human Huntington\u2019s Disease Brain and Neuronal Stem Cells","volume":"8","author":"Mueller","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40478-017-0420-1","article-title":"A Novel Form of Necrosis, TRIAD, Occurs in Human Huntington\u2019s Disease","volume":"5","author":"Yamanishi","year":"2017","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_123","first-page":"4749","article-title":"Targeting TEAD\/YAP-Transcription-Dependent Necrosis, TRIAD, Ameliorates Huntington\u2019s Disease Pathology","volume":"25","author":"Mao","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"33791","DOI":"10.1074\/jbc.M204861200","article-title":"Glycogen Synthase Kinase-3beta Inhibitors Prevent Cellular Polyglutamine Toxicity Caused by the Huntington\u2019s Disease Mutation","volume":"277","author":"Carmichael","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1038\/emboj.2010.117","article-title":"Mutant Huntingtin-Impaired Degradation of \u03b2-Catenin Causes Neurotoxicity in Huntington\u2019s Disease","volume":"29","author":"Godin","year":"2010","journal-title":"EMBO J."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"50514","DOI":"10.1074\/jbc.M309348200","article-title":"Enhanced Akt Signaling Is an Early Pro-Survival Response That Reflects N-Methyl-D-Aspartate Receptor Activation in Huntington\u2019s Disease Knock-in Striatal Cells","volume":"278","author":"Gines","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.bbrc.2015.02.137","article-title":"Micro RNA-214 Contributes to Proteasome Independent Downregulation of Beta Catenin in Huntington\u2019s Disease Knock-in Striatal Cell Model STHdhQ111\/Q111","volume":"459","author":"Ghatak","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.celrep.2017.04.021","article-title":"Huntington\u2019s Disease IPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits","volume":"19","author":"Lim","year":"2017","journal-title":"Cell Rep."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.stemcr.2020.01.015","article-title":"Aberrant Development Corrected in Adult-Onset Huntington\u2019s Disease IPSC-Derived Neuronal Cultures via WNT Signaling Modulation","volume":"14","author":"Hernandez","year":"2020","journal-title":"Stem Cell Rep."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.bbrc.2012.10.039","article-title":"MiR-214 Inhibits Cell Growth in Hepatocellular Carcinoma through Suppression of \u03b2-Catenin","volume":"428","author":"Wang","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Xia, H., Ooi, L.L.P.J., and Hui, K.M. (2012). MiR-214 Targets \u03b2-Catenin Pathway to Suppress Invasion, Stem-Like Traits and Recurrence of Human Hepatocellular Carcinoma. PLoS ONE, 7.","DOI":"10.1371\/annotation\/1be2a62e-45a1-4c13-9a8d-f265005a21e0"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/jnr.24551","article-title":"The Emerging Role of Hippo Signaling in Neurodegeneration","volume":"98","author":"Sahu","year":"2020","journal-title":"J. Neurosci. Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3389\/fnins.2020.00595","article-title":"The Effects of YAP and Its Related Mechanisms in Central Nervous System Diseases","volume":"14","author":"Jin","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41467-020-14353-6","article-title":"YAP-Dependent Necrosis Occurs in Early Stages of Alzheimer\u2019s Disease and Regulates Mouse Model Pathology","volume":"11","author":"Tanaka","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/jnr.21902","article-title":"Progressive Decrease in the Level of YAPdeltaCs, Prosurvival Isoforms of YAP, in the Spinal Cord of Transgenic Mouse Carrying a Mutant SOD1 Gene","volume":"87","author":"Morimoto","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Sadri-Vakili, G., Mueller, K., Granucci, E., Dios, A., Berry, J., and Vakili, K. Alterations in Hippo Pathway Signaling as a Mechanism of Neuronal Death in Amyotrophic Lateral Sclerosis (P4.436). Neurology 2018, 90 (15 supplement). Available online: https:\/\/n.neurology.org\/content\/90\/15_Supplement\/P4.436.","DOI":"10.1212\/WNL.90.15_supplement.P4.436"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.yexcr.2018.08.001","article-title":"Hippo, Drosophila MST, Is a Novel Modifier of Motor Neuron Degeneration Induced by Knockdown of Caz, Drosophila FUS","volume":"371","author":"Azuma","year":"2018","journal-title":"Exp. Cell Res."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"12066","DOI":"10.1073\/pnas.1300894110","article-title":"MST1 Functions as a Key Modulator of Neurodegeneration in a Mouse Model of ALS","volume":"110","author":"Lee","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"e1269","DOI":"10.1038\/cddis.2014.218","article-title":"Mammalian STE20-like Kinase 2, Not Kinase 1, Mediates Photoreceptor Cell Death during Retinal Detachment","volume":"5","author":"Matsumoto","year":"2014","journal-title":"Cell Death Dis."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.neuroscience.2004.11.043","article-title":"Localization of Immunoreactivity for Deleted in Colorectal Cancer (DCC), the Receptor for the Guidance Factor Netrin-1, in Ventral Tier Dopamine Projection Pathways in Adult Rodents","volume":"131","author":"Osborne","year":"2005","journal-title":"Neuroscience"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1634\/stemcells.2006-0119","article-title":"Axonal Growth Regulation of Fetal and Embryonic Stem Cell-Derived Dopaminergic Neurons by Netrin-1 and Slits","volume":"24","author":"Lin","year":"2006","journal-title":"Stem Cells"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.mcn.2014.05.003","article-title":"Evidence for Topographic Guidance of Dopaminergic Axons by Differential Netrin-1 Expression in the Striatum","volume":"61","author":"Li","year":"2014","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"24503","DOI":"10.1073\/pnas.2004087117","article-title":"Netrin1 Deficiency Activates MST1 via UNC5B Receptor, Promoting Dopaminergic Apoptosis in Parkinson\u2019s Disease","volume":"117","author":"Ahn","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1093\/jmcb\/mjt051","article-title":"Wnt Signaling in the Nervous System and in Alzheimer\u2019s Disease","volume":"6","author":"Inestrosa","year":"2014","journal-title":"J. Mol. Cell Biol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-0173(00)00021-7","article-title":"Wnt Signaling Function in Alzheimer\u2019s Disease","volume":"33","author":"Inestrosa","year":"2000","journal-title":"Brain Res. Brain Res. Rev."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1358\/dnp.2009.22.10.1443391","article-title":"The Role of Wnt Signaling in Neuroprotection","volume":"22","author":"Cerpa","year":"2009","journal-title":"Drug News Perspect."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"7545","DOI":"10.1038\/sj.onc.1210064","article-title":"The Ups and Downs of Wnt Signaling in Prevalent Neurological Disorders","volume":"25","author":"Moon","year":"2006","journal-title":"Oncogene"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s11481-012-9412-x","article-title":"Wnt\/\u03b2-Catenin and Its Diverse Physiological Cell Signaling Pathways in Neurodegenerative and Neuropsychiatric Disorders","volume":"7","year":"2012","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1007\/s11481-012-9417-5","article-title":"Wnt Signaling: Role in Alzheimer Disease and Schizophrenia","volume":"7","author":"Inestrosa","year":"2012","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.arr.2008.11.003","article-title":"Wnt Signaling in Alzheimer\u2019s Disease: Up or down, That Is the Question","volume":"8","author":"Boonen","year":"2009","journal-title":"Ageing Res. Rev."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.pneurobio.2008.08.001","article-title":"Wnt Signaling in Neuroprotection and Stem Cell Differentiation","volume":"86","author":"Toledo","year":"2008","journal-title":"Prog. Neurobiol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/sj.mp.4001208","article-title":"Activation of Wnt Signaling Rescues Neurodegeneration and Behavioral Impairments Induced by Beta-Amyloid Fibrils","volume":"8","author":"Garrido","year":"2003","journal-title":"Mol. Psychiatry"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"745","DOI":"10.2174\/1871527312666131223113900","article-title":"Wnt\/\u03b2-Catenin Signaling in Alzheimer\u2019s Disease","volume":"13","author":"Avila","year":"2014","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.yexcr.2004.02.028","article-title":"Wnt-3a Overcomes Beta-Amyloid Toxicity in Rat Hippocampal Neurons","volume":"297","author":"Alvarez","year":"2004","journal-title":"Exp. Cell Res."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"S141","DOI":"10.3233\/JAD-2012-129025","article-title":"GSK3 and Tau: Two Convergence Points in Alzheimer\u2019s Disease","volume":"33","author":"Hernandez","year":"2013","journal-title":"J. Alzheimers. Dis."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"6021","DOI":"10.1523\/JNEUROSCI.1381-04.2004","article-title":"Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Associated with Neuronal Degeneration in Alzheimer\u2019s Brain","volume":"24","author":"Caricasole","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1523\/JNEUROSCI.4562-11.2012","article-title":"The Secreted Wnt Antagonist Dickkopf-1 Is Required for Amyloid \u03b2-Mediated Synaptic Loss","volume":"32","author":"Purro","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.nbd.2006.06.016","article-title":"Inhibition of Wnt Signaling, Modulation of Tau Phosphorylation and Induction of Neuronal Cell Death by DKK1","volume":"24","author":"Scali","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3389\/fncel.2013.00162","article-title":"Wnts in Action: From Synapse Formation to Synaptic Maintenance","volume":"7","author":"Dickins","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.ejps.2011.02.009","article-title":"Curcumin Activates Wnt\/\u03b2-Catenin Signaling Pathway through Inhibiting the Activity of GSK-3\u03b2 in APPswe Transfected SY5Y Cells","volume":"42","author":"Zhang","year":"2011","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"13138","DOI":"10.1523\/JNEUROSCI.1737-10.2010","article-title":"LRRK2 G2019S Mutation Induces Dendrite Degeneration through Mislocalization and Phosphorylation of Tau by Recruiting Autoactivated GSK3\u03b2","volume":"30","author":"Lin","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1093\/hmg\/ddp337","article-title":"Mutations in the LRRK2 Roc-COR Tandem Domain Link Parkinson\u2019s Disease to Wnt Signaling Pathways","volume":"18","author":"Sancho","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"4966","DOI":"10.1093\/hmg\/dds342","article-title":"LRRK2 Functions as a Wnt Signaling Scaffold, Bridging Cytosolic Proteins and Membrane-Localized LRP6","volume":"21","author":"Berwick","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neuropharm.2012.10.031","article-title":"Induction of Dickkopf-1 Contributes to the Neurotoxicity of MPP+ in PC12 Cells via Inhibition of the Canonical Wnt Signaling Pathway","volume":"67","author":"Dun","year":"2013","journal-title":"Neuropharmacology"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.neuropharm.2015.10.024","article-title":"Neuroprotective Effects of Ginsenoside Rg1 through the Wnt\/\u03b2-Catenin Signaling Pathway in Both in Vivo and in Vitro Models of Parkinson\u2019s Disease","volume":"101","author":"Zhou","year":"2016","journal-title":"Neuropharmacology"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neulet.2012.07.030","article-title":"Inhibition of the Canonical Wnt Pathway by Dickkopf-1 Contributes to the Neurodegeneration in 6-OHDA-Lesioned Rats","volume":"525","author":"Dun","year":"2012","journal-title":"Neurosci. Lett."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1750-1326-6-49","article-title":"A Wnt1 Regulated Frizzled-1\/\u03b2-Catenin Signaling Pathway as a Candidate Regulatory Circuit Controlling Mesencephalic Dopaminergic Neuron-Astrocyte Crosstalk: Therapeutical Relevance for Neuron Survival and Neuroprotection","volume":"6","author":"Serapide","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.nbd.2010.10.023","article-title":"Reactive Astrocytes and Wnt\/\u03b2-Catenin Signaling Link Nigrostriatal Injury to Repair in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Model of Parkinson\u2019s Disease","volume":"41","author":"Tirolo","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1007\/s11064-013-1096-y","article-title":"Wnt Signaling Is Altered by Spinal Cord Neuronal Dysfunction in Amyotrophic Lateral Sclerosis Transgenic Mice","volume":"38","author":"Yu","year":"2013","journal-title":"Neurochem. Res."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1007\/s10529-013-1199-1","article-title":"Role of Wnt1 and Fzd1 in the Spinal Cord Pathogenesis of Amyotrophic Lateral Sclerosis-Transgenic Mice","volume":"35","author":"Wang","year":"2013","journal-title":"Biotechnol. Lett."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1179\/1743132812Y.0000000027","article-title":"Wnt Signaling Pathway Is Involved in the Pathogenesis of Amyotrophic Lateral Sclerosis in Adult Transgenic Mice","volume":"34","author":"Chen","year":"2012","journal-title":"Neurol. Res."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.bbrc.2012.03.006","article-title":"Activation of the Wnt\/\u03b2-Catenin Signaling Pathway Is Associated with Glial Proliferation in the Adult Spinal Cord of ALS Transgenic Mice","volume":"420","author":"Chen","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"6777","DOI":"10.1007\/s12035-019-1547-9","article-title":"Wnt Signaling Alterations in the Human Spinal Cord of Amyotrophic Lateral Sclerosis Cases: Spotlight on Fz2 and Wnt5a","volume":"56","author":"Gonzalez","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.lfs.2016.06.024","article-title":"The Role of the Wnt Canonical Signaling in Neurodegenerative Diseases","volume":"158","author":"Libro","year":"2016","journal-title":"Life Sci."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.jacbts.2018.07.005","article-title":"Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury","volume":"3","author":"Hara","year":"2018","journal-title":"JACC Basic Transl. Sci."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"352ra108","DOI":"10.1126\/scitranslmed.aaf2304","article-title":"Pharmacological Targeting of Kinases MST1 and MST2 Augments Tissue Repair and Regeneration","volume":"8","author":"Fan","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"e13465","DOI":"10.1111\/acel.13465","article-title":"YAP Prevents Premature Senescence of Astrocytes and Cognitive Decline of Alzheimer\u2019s Disease through Regulating CDK6 Signaling","volume":"20","author":"Xu","year":"2021","journal-title":"Aging Cell"},{"key":"ref_178","first-page":"1","article-title":"Astrocytic YAP Prevents the Demyelination through Promoting Expression of Cholesterol Synthesis Genes in Experimental Autoimmune Encephalomyelitis","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1523\/JNEUROSCI.2229-19.2020","article-title":"Astrocytic YAP Promotes the Formation of Glia Scars and Neural Regeneration after Spinal Cord Injury","volume":"40","author":"Xie","year":"2020","journal-title":"J. Neurosci."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-021-23395-3","article-title":"Small-Molecule Inhibition of Lats Kinases May Promote Yap-Dependent Proliferation in Postmitotic Mammalian Tissues","volume":"12","author":"Kastan","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"101779","DOI":"10.1016\/j.jbc.2022.101779","article-title":"Small Molecule LATS Kinase Inhibitors Block the Hippo Signaling Pathway and Promote Cell Growth under 3D Culture Conditions","volume":"298","author":"Aihara","year":"2022","journal-title":"J. Biol. Chem."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/s41589-021-00755-0","article-title":"YAP-Dependent Proliferation by a Small Molecule Targeting Annexin A2","volume":"17","author":"Shalhout","year":"2021","journal-title":"Nat. Chem. Biol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1021\/acschembio.9b00786","article-title":"Identification of Quinolinols as Activators of TEAD-Dependent Transcription","volume":"14","author":"Pobbati","year":"2019","journal-title":"ACS Chem. Biol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-19224-8","article-title":"A Protein Tertiary Structure Mimetic Modulator of the Hippo Signaling Pathway","volume":"11","author":"Adihou","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"73075","DOI":"10.7554\/eLife.73075","article-title":"Role of YAP in Early Ectodermal Specification and a Huntington\u2019s Disease Model of Human Neurulation","volume":"11","author":"Piccolo","year":"2022","journal-title":"elife"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.nbd.2004.07.011","article-title":"Anti-Inflammatory Treatment with Acetylsalicylate or Rofecoxib Is Not Neuroprotective in Huntington\u2019s Disease Transgenic Mice","volume":"17","author":"Norflus","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.expneurol.2004.01.003","article-title":"Environmental, Pharmacological, and Genetic Modulation of the HD Phenotype in Transgenic Mice","volume":"187","author":"Schilling","year":"2004","journal-title":"Exp. Neurol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.1021\/acs.jmedchem.0c01974","article-title":"Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling","volume":"64","author":"Bayle","year":"2021","journal-title":"J. Med. Chem."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.4155\/fmc-2021-0036","article-title":"Small-Molecule Inhibitors of Carboxylesterase Notum","volume":"13","author":"Zhao","year":"2021","journal-title":"Future Med. Chem."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/22\/3631\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:19:16Z","timestamp":1760145556000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/22\/3631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,16]]},"references-count":189,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["cells11223631"],"URL":"https:\/\/doi.org\/10.3390\/cells11223631","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,16]]}}}