{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:38:35Z","timestamp":1792201115202,"version":"4.4.0"},"reference-count":184,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>At the end of gestation, the cervical tissue changes profoundly. As a result of these changes, the uterine cervix becomes soft and vulnerable to dilation. The process occurring in the cervical tissue can be described as cervical ripening. The ripening is a process derivative of enzymatic breakdown and inflammatory response. Therefore, it is apparent that cervical remodeling is a derivative of the reactions mediated by multiple factors such as hormones, prostaglandins, nitric oxide, and inflammatory cytokines. However, despite the research carried out over the years, the cellular pathways responsible for regulating this process are still poorly understood. A comprehensive understanding of the entire process of cervical ripening seems crucial in the context of labor induction. Greater knowledge could provide us with the means to help women who suffer from dysfunctional labor. The overall objective of this review is to present the current understanding of cervical ripening in terms of molecular regulation and cell signaling.<\/jats:p>","DOI":"10.3390\/cells11223690","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T03:11:21Z","timestamp":1669000281000},"page":"3690","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Signaling Pathways Regulating Human Cervical Ripening in Preterm and Term Delivery"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3327-3334","authenticated-orcid":false,"given":"Maciej W.","family":"Socha","sequence":"first","affiliation":[{"name":"Department of Perinatology, Gynecology and Gynecologic Oncology, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, \u0141ukasiewicza 1, 85-821 Bydgoszcz, Poland"},{"name":"Department of Obstetrics and Gynecology, St. Adalbert\u2019s Hospital in Gda\u0144sk, Copernicus Healthcare Entity, Jana Paw\u0142a II 50, 80-462 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5847-3092","authenticated-orcid":false,"given":"Wojciech","family":"Flis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, St. Adalbert\u2019s Hospital in Gda\u0144sk, Copernicus Healthcare Entity, Jana Paw\u0142a II 50, 80-462 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9938-7249","authenticated-orcid":false,"given":"Mi\u0142osz","family":"Pietrus","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Oncology, Jagiellonian University Medical College, Kopernika 23, 31-501 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3195-4515","authenticated-orcid":false,"given":"Mateusz","family":"Wart\u0119ga","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie- Sk\u0142odowskiej 9, 85-094 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martyna","family":"Stankiewicz","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Gynecology and Gynecologic Oncology, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, \u0141ukasiewicza 1, 85-821 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/1471-0528.13301","article-title":"The Association between the Regular Use of Preventive Labour Induction and Improved Term Birth Outcomes: Findings of a Systematic Review and Meta-Analysis","volume":"122","author":"Nicholson","year":"2015","journal-title":"BJOG Int. J. Obstet. 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