{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T01:32:56Z","timestamp":1781314376724,"version":"3.54.1"},"reference-count":54,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation\u2014FAPESP","doi-asserted-by":"publisher","award":["2014\/06892-3"],"award-info":[{"award-number":["2014\/06892-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation\u2014FAPESP","doi-asserted-by":"publisher","award":["2018\/05006-0"],"award-info":[{"award-number":["2018\/05006-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation\u2014FAPESP","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil","doi-asserted-by":"publisher","award":["2014\/06892-3"],"award-info":[{"award-number":["2014\/06892-3"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil","doi-asserted-by":"publisher","award":["2018\/05006-0"],"award-info":[{"award-number":["2018\/05006-0"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The pleiotropic role of the major histocompatibility complex class I (MHC-I) reflects the close association between the nervous and immune systems. In turn, MHC-I upregulation postinjury is associated with a better regenerative outcome in isogenic mice following peripheral nerve damage. In the present work, we compared the time course of neuronal, glial, and sensorimotor recovery (1, 3, 5, 7, and 28 days after lesion\u2014dal) following unilateral sciatic nerve crush in A\/J and C57BL\/6J mice. The A\/J strain showed higher expression of MHC-I (7 dal, ** p &lt; 0.01), Iba-1 (microglial reaction, 7 dal, *** p &lt; 0.001), and GFAP (astrogliosis, 5 dal, * p &lt; 0.05) than the C57BL\/6J counterpart. Synaptic coverage (synaptophysin) was equivalent in both strains over time. In addition, mRNA expression of microdissected spinal motoneurons revealed an increase in cytoskeleton-associated molecules (cofilin, shp2, and crmp2, * p &lt; 0.05), but not trkB, in C57BL\/6J mice. Gait recovery, studied by the sciatic functional index, was faster in the A\/J strain, despite the equivalent results of C57BL\/6J at 28 days after injury. A similar recovery was also seen for the nociceptive threshold (von Frey test). Interestingly, when evaluating proprioceptive recovery, C57BL\/6J animals showed an enlarged base of support, indicating abnormal ambulation postinjury. Overall, the present results reinforce the role of MHC-I expression in the plasticity of the nervous system following axotomy, which in turn correlates with the variable recovery capacity among strains of mice.<\/jats:p>","DOI":"10.3390\/cells11233710","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T08:27:29Z","timestamp":1669105649000},"page":"3710","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Time Course of MHC-I Expression in C57BL\/6J and A\/J Mice Correlates with the Degree of Retrograde Gliosis in the Spinal Cord following Sciatic Nerve Crush"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1232-2694","authenticated-orcid":false,"given":"Bruno Henrique de Melo","family":"Lima","sequence":"first","affiliation":[{"name":"Laboratory of Nerve Regeneration, University of Campinas\u2014UNICAMP, Cidade Universit\u00e1ria \u201cZeferino Vaz\u201d, Rua Monteiro Lobato 255, Campinas 13083-862, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2303-8127","authenticated-orcid":false,"given":"Andr\u00e9 Luis","family":"Bombeiro","sequence":"additional","affiliation":[{"name":"Laboratory of Nerve Regeneration, University of Campinas\u2014UNICAMP, Cidade Universit\u00e1ria \u201cZeferino Vaz\u201d, Rua Monteiro Lobato 255, Campinas 13083-862, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1942-800X","authenticated-orcid":false,"given":"Luciana Politti","family":"Cartarozzi","sequence":"additional","affiliation":[{"name":"Laboratory of Nerve Regeneration, University of Campinas\u2014UNICAMP, Cidade Universit\u00e1ria \u201cZeferino Vaz\u201d, Rua Monteiro Lobato 255, Campinas 13083-862, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4224-4575","authenticated-orcid":false,"given":"Alexandre Leite Rodrigues de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Nerve Regeneration, University of Campinas\u2014UNICAMP, Cidade Universit\u00e1ria \u201cZeferino Vaz\u201d, Rua Monteiro Lobato 255, Campinas 13083-862, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1365-2990.2010.01095.x","article-title":"Interferon (IFN) Beta Treatment Induces Major Histocompatibility Complex (MHC) Class I Expression in the Spinal Cord and Enhances Axonal Growth and Motor Function Recovery following Sciatic Nerve Crush in Mice","volume":"36","author":"Zanon","year":"2010","journal-title":"Neuropathol. 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