{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:41:18Z","timestamp":1788795678661,"version":"build-2803163510"},"reference-count":170,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Natural Science Foundation of Shanghai","award":["16ZR1410100"],"award-info":[{"award-number":["16ZR1410100"]}]},{"name":"the Natural Science Foundation of Shanghai","award":["20ZR1416600"],"award-info":[{"award-number":["20ZR1416600"]}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["16ZR1410100"],"award-info":[{"award-number":["16ZR1410100"]}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["20ZR1416600"],"award-info":[{"award-number":["20ZR1416600"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Excitatory (glutamatergic) synaptic transmission underlies many aspects of brain activity and the genesis of normal human behavior. The postsynaptic scaffolding proteins SAP90\/PSD-95-associated proteins (SAPAPs), which are abundant components of the postsynaptic density (PSD) at excitatory synapses, play critical roles in synaptic structure, formation, development, plasticity, and signaling. The convergence of human genetic data with recent in vitro and in vivo animal model data indicates that mutations in the genes encoding SAPAP1\u20134 are associated with neurological and psychiatric disorders, and that dysfunction of SAPAP scaffolding proteins may contribute to the pathogenesis of various neuropsychiatric disorders, such as schizophrenia, autism spectrum disorders, obsessive compulsive disorders, Alzheimer\u2019s disease, and bipolar disorder. Here, we review recent major genetic, epigenetic, molecular, behavioral, electrophysiological, and circuitry studies that have advanced our knowledge by clarifying the roles of SAPAP proteins at the synapses, providing new insights into the mechanistic links to neurodevelopmental and neuropsychiatric disorders.<\/jats:p>","DOI":"10.3390\/cells11233815","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T01:42:02Z","timestamp":1669686122000},"page":"3815","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["SAPAP Scaffold Proteins: From Synaptic Function to Neuropsychiatric Disorders"],"prefix":"10.3390","volume":"11","author":[{"given":"Yunxia","family":"Bai","sequence":"first","affiliation":[{"name":"Key Laboratory of Brain Functional Genomics (STCSM & MOE), Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China"},{"name":"Shanghai Changning Mental Health Center, Shanghai 200335, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Brain Functional Genomics (STCSM & MOE), Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China"},{"name":"Shanghai Changning Mental Health Center, Shanghai 200335, China"},{"name":"NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai 200062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxia","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Brain Functional Genomics (STCSM & MOE), Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China"},{"name":"Shanghai Changning Mental Health Center, Shanghai 200335, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev-neuro-062111-150442","article-title":"Functional consequences of mutations in postsynaptic scaffolding proteins and relevance to psychiatric disorders","volume":"35","author":"Ting","year":"2012","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1503\/jpn.170066","article-title":"Genetic variability in scaffolding proteins and risk for schizophrenia and autism-spectrum disorders: A systematic review","volume":"43","author":"Soler","year":"2018","journal-title":"J. Psychiatry Neurosci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0187-x","article-title":"Excitatory and inhibitory synaptic dysfunction in mania: An emerging hypothesis from animal model studies","volume":"50","author":"Lee","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13041-017-0324-9","article-title":"The DLGAP family: Neuronal expression, function and role in brain disorders","volume":"10","author":"Rasmussen","year":"2017","journal-title":"Mol. Brain"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.biopsych.2015.04.020","article-title":"Learning from animal models of obsessive-compulsive disorder","volume":"79","author":"Monteiro","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nrn.2016.183","article-title":"SHANK proteins: Roles at the synapse and in autism spectrum disorder","volume":"18","author":"Monteiro","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"104596","DOI":"10.1016\/j.neubiorev.2022.104596","article-title":"The Homer1 family of proteins at the crossroad of dopamine-glutamate signaling: An emerging molecular \u201cLego\u201d in the pathophysiology of psychiatric disorders. A systematic review and translational insight","volume":"136","author":"Barone","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1146\/annurev.biochem.76.060805.160029","article-title":"The postsynaptic architecture of excitatory synapses: A more quantitative view","volume":"76","author":"Sheng","year":"2007","journal-title":"Annu. Rev. Biochem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"a005678","DOI":"10.1101\/cshperspect.a005678","article-title":"The postsynaptic organization of synapses","volume":"3","author":"Sheng","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.neuron.2016.12.037","article-title":"Optogenetic Control of Synaptic Composition and Function","volume":"93","author":"Sinnen","year":"2017","journal-title":"Neuron"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/35039075","article-title":"Postsynaptic organization and regulation of excitatory synapses","volume":"1","author":"Scannevin","year":"2000","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/jb\/mvy022","article-title":"Postsynaptic density proteins and their involvement in neurodevelopmental disorders","volume":"163","author":"Kaizuka","year":"2018","journal-title":"J. Biochem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature06104","article-title":"Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice","volume":"448","author":"Welch","year":"2007","journal-title":"Nature"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/2040-2392-5-32","article-title":"Autism-associated gene Dlgap2 mutant mice demonstrate exacerbated aggressive behaviors and orbitofrontal cortex deficits","volume":"5","author":"Liao","year":"2014","journal-title":"Mol. Autism"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/s41598-018-20610-y","article-title":"Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability","volume":"8","author":"Coba","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41398-018-0327-z","article-title":"Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice","volume":"9","author":"Schob","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Wang, T., Bai, Y., Zheng, X., Liu, X., Xing, S., Wang, L., Wang, H., Feng, G., and Li, C. (2022). Sapap4 deficiency leads to postsynaptic defects and abnormal behaviors relevant to hyperkinetic neuropsychiatric disorder in mice. Cereb Cortex.","DOI":"10.1093\/cercor\/bhac123"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/cne.20060","article-title":"Differential mRNA expression and protein localization of the SAP90\/PSD-95-associated proteins (SAPAPs) in the nervous system of the mouse","volume":"472","author":"Welch","year":"2004","journal-title":"J. Comp. Neurol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.molbrainres.2004.03.014","article-title":"Distinct spatiotemporal expression of SAPAP transcripts in the developing rat brain: A novel dendritically localized mRNA","volume":"126","author":"Kindler","year":"2004","journal-title":"Brain Res. Mol. Brain Res."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Li, J.M., Lu, C.L., Cheng, M.C., Luu, S.U., Hsu, S.H., Hu, T.M., Tsai, H.Y., and Chen, C.H. (2014). Role of the DLGAP2 gene encoding the SAP90\/PSD-95-associated protein 2 in schizophrenia. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0085373"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1038\/s41380-019-0588-9","article-title":"Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence","volume":"26","author":"Meng","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"108091","DOI":"10.1016\/j.celrep.2020.108091","article-title":"Cross-species analyses identify dlgap2 as a regulator of age-related cognitive decline and alzheimer\u2019s dementia","volume":"32","author":"Ouellette","year":"2020","journal-title":"Cell Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"6163","DOI":"10.1093\/hmg\/ddu337","article-title":"Epigenetic remodelling and dysregulation of DLGAP4 is linked with early-onset cerebellar ataxia","volume":"23","author":"Minocherhomji","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/mp.2011.154","article-title":"De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia","volume":"17","author":"Kirov","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/mp.2012.85","article-title":"Genome-wide association study of obsessive-compulsive disorder","volume":"18","author":"Stewart","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s11689-016-9170-9","article-title":"Uncovering obsessive-compulsive disorder risk genes in a pediatric cohort by high-resolution analysis of copy number variation","volume":"8","author":"Gazzellone","year":"2016","journal-title":"J. Neurodev. Disord."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e00914","DOI":"10.1002\/brb3.914","article-title":"DLGAP1 and NMDA receptor-associated postsynaptic density protein genes influence executive function in attention deficit hyperactivity disorder","volume":"8","author":"Fan","year":"2018","journal-title":"Brain Behav."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.neurobiolaging.2018.10.017","article-title":"Translating Alzheimer\u2019s disease-associated polymorphisms into functional candidates: A survey of IGAP genes and SNPs","volume":"74","author":"Katsumata","year":"2019","journal-title":"Neurobiol. Aging"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nature09146","article-title":"Functional impact of global rare copy number variation in autism spectrum disorders","volume":"466","author":"Pinto","year":"2010","journal-title":"Nature"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nature13908","article-title":"The contribution of de novo coding mutations to autism spectrum disorder","volume":"515","author":"Iossifov","year":"2014","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1002\/ajmg.b.30897","article-title":"Sapap3 and pathological grooming in humans: Results from the OCD collaborative genetics study","volume":"150B","author":"Bienvenu","year":"2009","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.comppsych.2010.05.007","article-title":"Investigating SAPAP3 variants in the etiology of obsessive-compulsive disorder and trichotillomania in the South African white population","volume":"52","author":"Boardman","year":"2011","journal-title":"Compr. Psychiatry"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/ajmg.b.31134","article-title":"Family-based genetic association study of DLGAP3 in Tourette Syndrome","volume":"156B","author":"Crane","year":"2011","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1038\/s41467-022-30443-z","article-title":"Novel role of the synaptic scaffold protein Dlgap4 in ventricular surface integrity and neuronal migration during cortical development","volume":"13","author":"Romero","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.bbrc.2018.10.016","article-title":"SAPAP4 deletion causes synaptic dysfunction in the nucleus accumbens","volume":"505","author":"Wu","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1083\/jcb.136.3.669","article-title":"GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95\/SAP90 family of channel clustering molecules","volume":"136","author":"Kim","year":"1997","journal-title":"J. Cell Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"11943","DOI":"10.1074\/jbc.272.18.11943","article-title":"SAPAPs. A family of PSD-95\/SAP90-associated proteins localized at postsynaptic density","volume":"272","author":"Takeuchi","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1523\/JNEUROSCI.20-12-04524.2000","article-title":"Interaction of the postsynaptic density-95\/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein","volume":"20","author":"Naisbitt","year":"2000","journal-title":"J. Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1126\/science.277.5331.1511","article-title":"Binding of neuroligins to PSD-95","volume":"277","author":"Irie","year":"1997","journal-title":"Science"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"13500","DOI":"10.1523\/JNEUROSCI.6439-10.2011","article-title":"Neurexin-neuroligin adhesions capture surface-diffusing AMPA receptors through PSD-95 scaffolds","volume":"31","author":"Mondin","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/35050030","article-title":"Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms","volume":"408","author":"Chen","year":"2000","journal-title":"Nature"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.neuron.2007.01.030","article-title":"The interaction between Stargazin and PSD-95 regulates AMPA receptor surface trafficking","volume":"53","author":"Bats","year":"2007","journal-title":"Neuron"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0028-3908(03)00267-3","article-title":"Interaction of transmembrane AMPA receptor regulatory proteins with multiple membrane associated guanylate kinases","volume":"45","author":"Dakoji","year":"2003","journal-title":"Neuropharmacology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.neuron.2012.03.034","article-title":"High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes","volume":"74","author":"Schwenk","year":"2012","journal-title":"Neuron"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"20953","DOI":"10.1073\/pnas.0811025106","article-title":"Differential trafficking of AMPA and NMDA receptors by SAP102 and PSD-95 underlies synapse development","volume":"105","author":"Elias","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1007\/s00018-019-03068-7","article-title":"AMPA receptors and their minions: Auxiliary proteins in AMPA receptor trafficking","volume":"76","author":"Bissen","year":"2019","journal-title":"Cell Mol. Life Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0896-6273(00)81008-9","article-title":"SynGAP: A synaptic RasGAP that associates with the PSD-95\/SAP90 protein family","volume":"20","author":"Kim","year":"1998","journal-title":"Neuron"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0092-8674(00)81053-3","article-title":"Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains","volume":"84","author":"Brenman","year":"1996","journal-title":"Cell"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0896-6273(00)80590-5","article-title":"SAP90 binds and clusters kainate receptors causing incomplete desensitization","volume":"21","author":"Garcia","year":"1998","journal-title":"Neuron"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Hu, T.M., Wu, C.L., Hsu, S.H., Tsai, H.Y., Cheng, F.Y., and Cheng, M.C. (2022). Ultrarare loss-of-function mutations in the genes encoding the ionotropic glutamate receptors of kainate subtypes associated with schizophrenia disrupt the interaction with PSD95. J. Pers. Med., 12.","DOI":"10.3390\/jpm12050783"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"21105","DOI":"10.1074\/jbc.273.33.21105","article-title":"A novel multiple PDZ domain-containing molecule interacting with N-methyl-D-aspartate receptors and neuronal cell adhesion proteins","volume":"273","author":"Hirao","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1471-4159.2006.04170.x","article-title":"Synaptic scaffolding molecule (S-SCAM) membrane-associated guanylate kinase with inverted organization (MAGI)-2 is associated with cell adhesion molecules at inhibitory synapses in rat hippocampal neurons","volume":"100","author":"Sumita","year":"2007","journal-title":"J. Neurochem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"14762","DOI":"10.1074\/jbc.M300184200","article-title":"Tamalin is a scaffold protein that interacts with multiple neuronal proteins in distinct modes of protein-protein association","volume":"278","author":"Kitano","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1046\/j.1365-2443.2000.00318.x","article-title":"Association of synapse-associated protein 90\/ postsynaptic density-95-associated protein (SAPAP) with neurofilaments","volume":"5","author":"Hirao","year":"2000","journal-title":"Genes Cells"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0896-6273(00)80809-0","article-title":"Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor\/PSD-95\/GKAP complex and cortactin","volume":"23","author":"Naisbitt","year":"1999","journal-title":"Neuron"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"27463","DOI":"10.1074\/jbc.274.39.27463","article-title":"Synamon, a novel neuronal protein interacting with synapse-associated protein 90\/postsynaptic density-95-associated protein","volume":"274","author":"Yao","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"106340","DOI":"10.1016\/j.phrs.2022.106340","article-title":"Shank postsynaptic scaffolding proteins in autism spectrum disorder: Mouse models and their dysfunctions in behaviors, synapses, and molecules","volume":"182","author":"Jung","year":"2022","journal-title":"Pharm. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"5838","DOI":"10.1128\/MCB.18.10.5838","article-title":"Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons","volume":"18","author":"Du","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrn1517","article-title":"PDZ domain proteins of synapses","volume":"5","author":"Kim","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"E3081","DOI":"10.1073\/pnas.1523265113","article-title":"A binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function","volume":"113","author":"Zeng","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/nn.4594","article-title":"Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders","volume":"20","author":"Li","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"30914","DOI":"10.1074\/jbc.274.43.30914","article-title":"nArgBP2, a novel neural member of ponsin\/ArgBP2\/vinexin family that interacts with synapse-associated protein 90\/postsynaptic density-95-associated protein (SAPAP)","volume":"274","author":"Kawabe","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"6749","DOI":"10.1073\/pnas.1600944113","article-title":"nArgBP2 regulates excitatory synapse formation by controlling dendritic spine morphology","volume":"113","author":"Lee","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1523\/JNEUROSCI.2528-15.2016","article-title":"Impaired dendritic development and memory in sorbs2 knock-out mice","volume":"36","author":"Zhang","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1073\/pnas.0409376102","article-title":"The Abl\/Arg substrate ArgBP2\/nArgBP2 coordinates the function of multiple regulatory mechanisms converging on the actin cytoskeleton","volume":"102","author":"Cestra","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0014-5793(01)02718-1","article-title":"Identification of novel cellular proteins that bind to the LC8 dynein light chain using a pepscan technique","volume":"503","author":"Yelamos","year":"2001","journal-title":"FEBS Lett."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1046\/j.1365-2443.2000.00374.x","article-title":"The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthase","volume":"5","author":"Haraguchi","year":"2000","journal-title":"Genes Cells"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.bbrc.2014.08.073","article-title":"Structure of the GH1 domain of guanylate kinase-associated protein from Rattus norvegicus","volume":"452","author":"Tong","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.mcn.2018.06.001","article-title":"The association of spinophilin with disks large-associated protein 3 (SAPAP3) is regulated by metabotropic glutamate receptor (mGluR) 5","volume":"90","author":"Morris","year":"2018","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Roselli, F., Livrea, P., and Almeida, O.F. (2011). CDK5 is essential for soluble amyloid beta-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0023097"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/srep00484","article-title":"Synthesis of two SAPAP3 isoforms from a single mRNA is mediated via alternative translational initiation","volume":"2","author":"Chua","year":"2012","journal-title":"Sci. Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.neuron.2019.06.011","article-title":"A single-cell transcriptomic atlas of human neocortical development during mid-gestation","volume":"103","author":"Polioudakis","year":"2019","journal-title":"Neuron"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nrn3546","article-title":"Proteostasis in complex dendrites","volume":"14","author":"Hanus","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.neuron.2012.02.036","article-title":"The local transcriptome in the synaptic neuropil revealed by deep sequencing and high-resolution imaging","volume":"74","author":"Cajigas","year":"2012","journal-title":"Neuron"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1126\/science.273.5280.1402","article-title":"A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity","volume":"273","author":"Kang","year":"1996","journal-title":"Science"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0896-6273(01)00295-1","article-title":"Dynamic visualization of local protein synthesis in hippocampal neurons","volume":"30","author":"Aakalu","year":"2001","journal-title":"Neuron"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"7436","DOI":"10.1073\/pnas.90.16.7436","article-title":"Regulatory subunits of cAMP-dependent protein kinases are degraded after conjugation to ubiquitin: A molecular mechanism underlying long-term synaptic plasticity","volume":"90","author":"Hegde","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0896-6273(03)00635-4","article-title":"Compartmentalized synthesis and degradation of proteins in neurons","volume":"40","author":"Steward","year":"2003","journal-title":"Neuron"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1038\/emboj.2010.173","article-title":"Protein homeostasis and synaptic plasticity","volume":"29","author":"Cajigas","year":"2010","journal-title":"EMBO J."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev-cellbio-100109-104129","article-title":"Ubiquitination in postsynaptic function and plasticity","volume":"26","author":"Mabb","year":"2010","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nn1013","article-title":"Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system","volume":"6","author":"Ehlers","year":"2003","journal-title":"Nat. Neurosci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.biopsych.2013.01.008","article-title":"Circuit-selective striatal synaptic dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder","volume":"75","author":"Wan","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/378085a0","article-title":"Clustering of shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases","volume":"378","author":"Kim","year":"1995","journal-title":"Nature"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nrn.2016.18","article-title":"Mechanistic basis of MAGUK-organized complexes in synaptic development and signalling","volume":"17","author":"Zhu","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"5972","DOI":"10.1074\/jbc.M411220200","article-title":"Proteomic analysis of in vivo phosphorylated synaptic proteins","volume":"280","author":"Collins","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1038\/nn.3259","article-title":"GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling","volume":"15","author":"Shin","year":"2012","journal-title":"Nat. Neurosci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"rs8","DOI":"10.1126\/scisignal.aaf6716","article-title":"Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome","volume":"9","author":"Li","year":"2016","journal-title":"Sci. Signal"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1016\/j.celrep.2017.11.107","article-title":"Synaptic targeting and function of SAPAPs mediated by phosphorylation-dependent binding to PSD-95 MAGUKs","volume":"21","author":"Zhu","year":"2017","journal-title":"Cell Rep."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Hung, A.Y., Sung, C.C., Brito, I.L., and Sheng, M. (2010). Degradation of postsynaptic scaffold GKAP and regulation of dendritic spine morphology by the TRIM3 ubiquitin ligase in rat hippocampal neurons. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0009842"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1523\/JNEUROSCI.18-04-01217.1998","article-title":"Heterogeneity in the molecular composition of excitatory postsynaptic sites during development of hippocampal neurons in culture","volume":"18","author":"Rao","year":"1998","journal-title":"J. Neurosci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1046\/j.1365-2443.2003.00622.x","article-title":"Synaptic localization of SAPAP1, a synaptic membrane-associated protein","volume":"8","author":"Yao","year":"2003","journal-title":"Genes Cells"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"9391","DOI":"10.1523\/JNEUROSCI.3314-04.2004","article-title":"A functional role of postsynaptic density-95-guanylate kinase-associated protein complex in regulating Shank assembly and stability to synapses","volume":"24","author":"Romorini","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_93","first-page":"2030","article-title":"GKAP-DLC2 interaction organizes the postsynaptic scaffold complex to enhance synaptic NMDA receptor activity","volume":"125","author":"Moutin","year":"2012","journal-title":"J. Cell Sci."},{"key":"ref_94","first-page":"3451","article-title":"The stoichiometry of scaffold complexes in living neurons-DLC2 functions as a dimerization engine for GKAP","volume":"127","author":"Moutin","year":"2014","journal-title":"J. Cell Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"16685","DOI":"10.1523\/JNEUROSCI.2533-11.2011","article-title":"Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses","volume":"31","author":"Wan","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Lousada, E., Boudreau, M., Cohen-Adad, J., Nait Oumesmar, B., Burguiere, E., and Schreiweis, C. (2021). Reduced axon calibre in the associative striatum of the sapap3 knockout mouse. Brain Sci., 11.","DOI":"10.1101\/2021.01.12.426339"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/s41467-020-20343-5","article-title":"A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain","volume":"12","author":"Joglekar","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"a005736","DOI":"10.1101\/cshperspect.a005736","article-title":"Homeostatic synaptic plasticity: Local and global mechanisms for stabilizing neuronal function","volume":"4","author":"Turrigiano","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"9563","DOI":"10.1523\/JNEUROSCI.1701-11.2011","article-title":"Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity","volume":"31","author":"Chen","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1523\/JNEUROSCI.3032-07.2008","article-title":"Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1","volume":"28","author":"Hung","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.biopsych.2016.04.023","article-title":"Increased metabotropic glutamate receptor 5 signaling underlies obsessive-compulsive disorder-like behavioral and striatal circuit abnormalities in mice","volume":"80","author":"Ade","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1126\/science.1232380","article-title":"Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors","volume":"340","author":"Burguiere","year":"2013","journal-title":"Science"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1523\/JNEUROSCI.1728-18.2018","article-title":"Strengthened inputs from secondary motor cortex to striatum in a mouse model of compulsive behavior","volume":"39","author":"Corbit","year":"2019","journal-title":"J. Neurosci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1038\/s41386-020-0747-3","article-title":"Projection-specific deficits in synaptic transmission in adult Sapap3-knockout mice","volume":"45","author":"Hadjas","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41386-021-01161-9","article-title":"Optogenetic inhibition of indirect pathway neurons in the dorsomedial striatum reduces excessive grooming in Sapap3-knockout mice","volume":"47","author":"Tecuapetla","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cub.2020.10.045","article-title":"Dysfunction of orbitofrontal GABAergic interneurons leads to impaired reversal learning in a mouse model of obsessive-compulsive disorder","volume":"31","author":"Yang","year":"2021","journal-title":"Curr. Biol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"6040","DOI":"10.1038\/s41467-021-26247-2","article-title":"Ketamine increases activity of a fronto-striatal projection that regulates compulsive behavior in SAPAP3 knockout mice","volume":"12","author":"Davis","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"20170023","DOI":"10.1098\/rstb.2017.0023","article-title":"Monoamine abnormalities in the SAPAP3 knockout model of obsessive-compulsive disorder-related behaviour","volume":"373","author":"Wood","year":"2018","journal-title":"Philos. Trans. R Soc. Lond. B Biol. Sci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"9442","DOI":"10.1038\/s41598-021-88769-5","article-title":"Disruption of prepulse inhibition is associated with compulsive behavior severity and nucleus accumbens dopamine receptor changes in Sapap3 knockout mice","volume":"11","author":"Manning","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Tomasetti, C., Iasevoli, F., Buonaguro, E.F., De Berardis, D., Fornaro, M., Fiengo, A.L., Martinotti, G., Orsolini, L., Valchera, A., and Di Giannantonio, M. (2017). Treating the synapse in major psychiatric disorders: The role of postsynaptic density network in dopamine-glutamate interplay and psychopharmacologic drugs molecular actions. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18010135"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/YPG.0000000000000230","article-title":"New insights and perspectives on the genetics of obsessive-compulsive disorder","volume":"29","author":"Zai","year":"2019","journal-title":"Psychiatr. Genet."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1017\/S146114570999071X","article-title":"DNA methylation in vulnerability to post-traumatic stress in rats: Evidence for the role of the post-synaptic density protein Dlgap2","volume":"13","author":"Cohen","year":"2010","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"17466","DOI":"10.1038\/s41598-018-35718-4","article-title":"Quantitative DNA methylation analysis of DLGAP2 gene using pyrosequencing in schizophrenia with tardive dyskinesia: A linear mixed model approach","volume":"8","author":"Li","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/15592294.2019.1656158","article-title":"Cannabis use is associated with potentially heritable widespread changes in autism candidate gene DLGAP2 DNA methylation in sperm","volume":"15","author":"Schrott","year":"2020","journal-title":"Epigenetics"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1038\/sj.npp.1300212","article-title":"Synapse-associated protein 90\/postsynaptic density-95-associated protein (SAPAP) is expressed differentially in phencyclidine-treated rats and is increased in the nucleus accumbens of patients with schizophrenia","volume":"28","author":"Kajimoto","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41419-022-04876-9","article-title":"SAPAP3 regulates epileptic seizures involving GluN2A in post-synaptic densities","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"25479","DOI":"10.1074\/jbc.M109.042663","article-title":"Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities","volume":"284","author":"Schutt","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1073\/pnas.1013855108","article-title":"Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome","volume":"108","author":"Krueger","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.biopsych.2015.07.021","article-title":"Metabotropic glutamate receptor and fragile X signaling in a female model of escalated aggression","volume":"79","author":"Been","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0092-8674(01)00568-2","article-title":"Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome","volume":"107","author":"Brown","year":"2001","journal-title":"Cell"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1038\/nn.3379","article-title":"The translation of translational control by FMRP: Therapeutic targets for FXS","volume":"16","author":"Darnell","year":"2013","journal-title":"Nat. Neurosci."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neuron.2008.10.004","article-title":"Fragile X syndrome: Loss of local mRNA regulation alters synaptic development and function","volume":"60","author":"Bassell","year":"2008","journal-title":"Neuron"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.devcel.2008.04.003","article-title":"A direct role for FMRP in activity-dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome","volume":"14","author":"Dictenberg","year":"2008","journal-title":"Dev. Cell"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"15537","DOI":"10.1073\/pnas.0707484104","article-title":"Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors","volume":"104","author":"Nakamoto","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"11459","DOI":"10.1038\/ncomms11459","article-title":"Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism","volume":"7","author":"Wang","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1196\/annals.1300.068","article-title":"Cocaine-induced expression differences in PSD-95\/SAP-90-associated protein 4 and in Ca2+\/calmodulin-dependent protein kinase subunits in amygdalae of taste aversion-prone and taste aversion-resistant rats","volume":"1003","author":"Elkins","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"296","DOI":"10.5607\/en.2016.25.6.296","article-title":"Bipolar disorder associated microRNA, miR-1908-5p, regulates the expression of genes functioning in neuronal glutamatergic synapses","volume":"25","author":"Kim","year":"2016","journal-title":"Exp. Neurobiol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1038\/nn.4395","article-title":"MeCP2 and histone deacetylases 1 and 2 in dorsal striatum collectively suppress repetitive behaviors","volume":"19","author":"Mahgoub","year":"2016","journal-title":"Nat. Neurosci."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"100247","DOI":"10.1016\/j.bbih.2021.100247","article-title":"DNA methylation and exposure to violence among African American young adult males","volume":"14","author":"Saadatmand","year":"2021","journal-title":"Brain Behav. Immun. Health"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"6660","DOI":"10.1093\/nar\/gks302","article-title":"Sequence and expression analysis of gaps in human chromosome 20","volume":"40","author":"Minocherhomji","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1046\/j.1440-1819.2003.01162.x","article-title":"Mutation and association analysis of the DAP-1 gene with schizophrenia","volume":"57","author":"Aoyama","year":"2003","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.psychres.2012.08.014","article-title":"Genetic analysis of the DLGAP1 gene as a candidate gene for schizophrenia","volume":"205","author":"Li","year":"2013","journal-title":"Psychiatry Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"774","DOI":"10.15252\/msb.20145487","article-title":"Integrated systems analysis reveals a molecular network underlying autism spectrum disorders","volume":"10","author":"Li","year":"2014","journal-title":"Mol. Syst. Biol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/hbm.23025","article-title":"Recurrent major depression and right hippocampal volume: A bivariate linkage and association study","volume":"37","author":"Mathias","year":"2016","journal-title":"Hum. Brain Mapp."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/ajmg.b.30363","article-title":"Evidence of linkage and association on 18p11.2 for psychosis","volume":"141B","author":"Mukherjee","year":"2006","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1086\/302046","article-title":"Support for a chromosome 18p locus conferring susceptibility to functional psychoses in families with schizophrenia, by association and linkage analysis","volume":"63","author":"Schwab","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/2040-2392-4-26","article-title":"Deep exon resequencing of DLGAP2 as a candidate gene of autism spectrum disorders","volume":"4","author":"Chien","year":"2013","journal-title":"Mol. Autism"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ajhg.2014.03.018","article-title":"Convergence of genes and cellular pathways dysregulated in autism spectrum disorders","volume":"94","author":"Pinto","year":"2014","journal-title":"Am. J. Hum. Genet."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/ng1985","article-title":"Mapping autism risk loci using genetic linkage and chromosomal rearrangements","volume":"39","author":"Szatmari","year":"2007","journal-title":"Nat. Genet."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ajhg.2007.12.009","article-title":"Structural variation of chromosomes in autism spectrum disorder","volume":"82","author":"Marshall","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/ajmg.b.32785","article-title":"Segregating patterns of copy number variations in extended autism spectrum disorder (ASD) pedigrees","volume":"183","author":"Zarrei","year":"2020","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Catusi, I., Garzo, M., Capra, A.P., Briuglia, S., Baldo, C., Canevini, M.P., Cantone, R., Elia, F., Forzano, F., and Galesi, O. (2021). 8p23.2-pter microdeletions: Seven new cases narrowing the candidate region and review of the literature. Genes, 12.","DOI":"10.3390\/genes12050652"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"6837","DOI":"10.3892\/mmr.2017.7438","article-title":"Isolated chromosome 8p23.2pter deletion: Novel evidence for developmental delay, intellectual disability, microcephaly and neurobehavioral disorders","volume":"16","author":"Shi","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.pscychresns.2012.07.003","article-title":"Glutamate system genes and brain volume alterations in pediatric obsessive-compulsive disorder: A preliminary study","volume":"211","author":"Wu","year":"2013","journal-title":"Psychiatry Res."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Wu, Y., Ji, T., Wang, J., Xiao, J., Wang, H., Li, J., Gao, Z., Yang, Y., Cai, B., and Wang, L. (2010). Submicroscopic subtelomeric aberrations in Chinese patients with unexplained developmental delay\/mental retardation. BMC Med. Genet., 11.","DOI":"10.1186\/1471-2350-11-72"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1001\/archgenpsychiatry.2009.80","article-title":"Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation","volume":"66","author":"Guilmatre","year":"2009","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nature12975","article-title":"A polygenic burden of rare disruptive mutations in schizophrenia","volume":"506","author":"Purcell","year":"2014","journal-title":"Nature"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"4485","DOI":"10.1093\/hmg\/ddt297","article-title":"Pathogenic rare copy number variants in community-based schizophrenia suggest a potential role for clinical microarrays","volume":"22","author":"Costain","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"White, C.C., Yang, H.S., Yu, L., Chibnik, L.B., Dawe, R.J., Yang, J., Klein, H.U., Felsky, D., Ramos-Miguel, A., and Arfanakis, K. (2017). Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data. PLoS Med., 14.","DOI":"10.1371\/journal.pmed.1002287"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"989","DOI":"10.3233\/JAD-142106","article-title":"Genetic variation in imprinted genes is associated with risk of late-onset Alzheimer\u2019s disease","volume":"44","author":"Chaudhry","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1399-0004.2010.01395.x","article-title":"Identification and molecular characterization of two novel chromosomal deletions associated with autism","volume":"78","author":"Chien","year":"2010","journal-title":"Clin. Genet."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/mp.2008.83","article-title":"Multiple rare SAPAP3 missense variants in trichotillomania and OCD","volume":"14","author":"Zuchner","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/mp.2008.14","article-title":"A high-density SNP genome-wide linkage scan in a large autism extended pedigree","volume":"14","author":"Miller","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nrn3746","article-title":"Obsessive-compulsive disorder: An integrative genetic and neurobiological perspective","volume":"15","author":"Pauls","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/nature12630","article-title":"SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties","volume":"503","author":"Han","year":"2013","journal-title":"Nature"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"e12723","DOI":"10.1111\/gbb.12723","article-title":"Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2","volume":"20","author":"Horner","year":"2021","journal-title":"Genes Brain Behav."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"e12557","DOI":"10.1111\/gbb.12557","article-title":"Behavioral flexibility in a mouse model for obsessive-compulsive disorder: Impaired Pavlovian reversal learning in SAPAP3 mutants","volume":"18","author":"Mooij","year":"2019","journal-title":"Genes Brain Behav."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1038\/s41386-018-0307-2","article-title":"Impaired instrumental reversal learning is associated with increased medial prefrontal cortex activity in Sapap3 knockout mouse model of compulsive behavior","volume":"44","author":"Manning","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"12061","DOI":"10.1038\/s41598-019-48637-9","article-title":"Aberrant habit formation in the Sapap3-knockout mouse model of obsessive-compulsive disorder","volume":"9","author":"Hadjas","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Ehmer, I., Crown, L., van Leeuwen, W., Feenstra, M., Willuhn, I., and Denys, D. (2020). Evidence for distinct forms of compulsivity in the SAPAP3 mutant-mouse model for obsessive-compulsive disorder. eNeuro, 7.","DOI":"10.1523\/ENEURO.0245-19.2020"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"107162","DOI":"10.1016\/j.nlm.2020.107162","article-title":"Instrumental learning in a mouse model for obsessive-compulsive disorder: Impaired habit formation in Sapap3 mutants","volume":"168","author":"Ehmer","year":"2020","journal-title":"Neurobiol. Learn. Mem."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s42003-020-01611-y","article-title":"A cross-species assessment of behavioral flexibility in compulsive disorders","volume":"4","author":"Benzina","year":"2021","journal-title":"Commun. Biol."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Manning, E.E., Geramita, M.A., Piantadosi, S.C., Pierson, J.L., and Ahmari, S.E. (2021). Distinct patterns of abnormal lateral orbitofrontal cortex activity during compulsive grooming and reversal learning normalize after fluoxetine. Biol. Psychiatry.","DOI":"10.1101\/2021.03.02.433664"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.jpsychires.2022.05.024","article-title":"Valence processing alterations in SAPAP3 knockout mice and human OCD","volume":"151","author":"Kajs","year":"2022","journal-title":"J. Psychiatr. Res."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.biopsych.2018.05.011","article-title":"Differential effects of deep brain stimulation of the internal capsule and the striatum on excessive grooming in Sapap3 mutant mice","volume":"84","author":"Pinhal","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"108160","DOI":"10.1016\/j.neuropharm.2020.108160","article-title":"Progression of obsessive compulsive disorder-like grooming in Sapap3 knockout mice: A longitudinal [(11)C]ABP688 PET study","volume":"177","author":"Glorie","year":"2020","journal-title":"Neuropharmacology"},{"key":"ref_167","first-page":"39","article-title":"Striatal magnetic resonance spectroscopy abnormalities in young adult SAPAP3 knockout mice","volume":"1","author":"Mintzopoulos","year":"2016","journal-title":"Biol. Psychiatry Cogn. Neurosci. Neuroimaging"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s13550-020-00721-2","article-title":"Sapap3 deletion causes dynamic synaptic density abnormalities: A longitudinal [(11)C]UCB-J PET study in a model of obsessive-compulsive disorder-like behaviour","volume":"10","author":"Glorie","year":"2020","journal-title":"EJNMMI Res."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"10759","DOI":"10.1073\/pnas.1308195110","article-title":"Double deletion of melanocortin 4 receptors and SAPAP3 corrects compulsive behavior and obesity in mice","volume":"110","author":"Xu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1503\/jpn.180032","article-title":"Lateral orbitofrontal dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder","volume":"44","author":"Lei","year":"2019","journal-title":"J. Psychiatry Neurosci."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/23\/3815\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:28:41Z","timestamp":1760146121000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/23\/3815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,28]]},"references-count":170,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["cells11233815"],"URL":"https:\/\/doi.org\/10.3390\/cells11233815","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,28]]}}}