{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T13:39:44Z","timestamp":1773063584032,"version":"3.50.1"},"reference-count":84,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Psoriasis is a persistent T-cell-supported inflammatory cutaneous disorder, which is defined by a significant expansion of basal cells in the epidermis. Cell cycle and STAT genes that control cell cycle progression and viral infection have been revealed to be comorbid with the development of certain cancers and other disorders, due to their abnormal or scanty expression. The purpose of this study is to evaluate the expression of certain cell cycle and STAT1\/3 genes in psoriasis patients and to determine the types of comorbidities associated with these genes. To do so, we opted to adopt the in silico methodology, since it is a quick and easy way to discover any potential comorbidity risks that may exist in psoriasis patients. With the genes collected from early research groups, protein networks were created in this work using the NetworkAnalyst program. The crucial hub genes were identified by setting the degree parameter, and they were then used in gene ontology and pathway assessments. The transcription factors that control the hub genes were detected by exploring TRRUST, and DGIdb was probed for remedies that target transcription factors and hubs. Using the degree filter, the first protein subnetwork produced seven hub genes, including STAT3, CCNB1, STAT1, CCND1, CDC20, HSPA4, and MAD2L1. The hub genes were shown to be implicated in cell cycle pathways by the gene ontology and Reactome annotations. The former four hubs were found in signaling pathways, including prolactin, FoxO, JAK\/STAT, and p53, according to the KEGG annotation. Furthermore, they enhanced several malignancies, including pancreatic cancer, Kaposi\u2019s sarcoma, non-small cell lung cancer, and acute myeloid leukemia. Viral infections, including measles, hepatitis C, Epstein\u2013Barr virus, and HTLV-1 and viral carcinogenesis were among the other susceptible diseases. Diabetes and inflammatory bowel disease were conjointly annotated. In total, 129 medicines were discovered in DGIdb to be effective against the transcription factors BRCA1, RELA, TP53, and MYC, as opposed to 10 medications against the hubs, STAT3 and CCND1, in tandem with 8 common medicines. The study suggests that the annotated medications should be tested in suitable psoriatic cell lines and animal models to optimize the drugs used based on the kind, severity, and related comorbidities of psoriasis. Furthermore, a personalized medicine protocol must be designed for each psoriasis patient that displays different comorbidities.<\/jats:p>","DOI":"10.3390\/cells11233867","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T02:24:46Z","timestamp":1669861486000},"page":"3867","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Differentially Expressed Cell Cycle Genes and STAT1\/3-Driven Multiple Cancer Entanglement in Psoriasis, Coupled with Other Comorbidities"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1084-0081","authenticated-orcid":false,"given":"Subhashini","family":"Dorai","sequence":"first","affiliation":[{"name":"The Centre for Molecular Data Science and Systems Biology, Department of Bioinformatics, School of Bio and Chemical Engineering, Sathyabama Institute of Science and Technology, Deemed to be University, Chennai 600119, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5842-5365","authenticated-orcid":false,"given":"Daniel","family":"Alex Anand","sequence":"additional","affiliation":[{"name":"The Centre for Molecular Data Science and Systems Biology, Department of Bioinformatics, School of Bio and Chemical Engineering, Sathyabama Institute of Science and Technology, Deemed to be University, Chennai 600119, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41419-022-04523-3","article-title":"Advances in the pathogenesis of psoriasis: From keratinocyte perspective","volume":"13","author":"Zhou","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/bjd.18178","article-title":"Psoriatic epidermis is associated with upregulation of CDK2 and inhibition of CDK4 activity","volume":"182","author":"Henri","year":"2020","journal-title":"Br. J. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1365-2133.1974.tb06446.x","article-title":"The cell cycle in psoriasis","volume":"90","author":"Goodwin","year":"1974","journal-title":"Br. J. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/jdv.12165","article-title":"Risk of cancer in psoriasis: A systematic review and meta-analysis of epidemiological studies","volume":"27","author":"Pouplard","year":"2013","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1038\/sj.jid.5700410","article-title":"The risk of lymphoma in patients with psoriasis","volume":"126","author":"Gelfand","year":"2006","journal-title":"J. Investig. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1038\/jid.2009.113","article-title":"Psoriasis and risk of incident cancer: An inception cohort study with a nested case-control analysis","volume":"129","author":"Brauchli","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1001\/jamadermatol.2015.4847","article-title":"The risk of cancer in patients with psoriasis: A population-based cohort study in the health improvement network","volume":"152","author":"Shin","year":"2016","journal-title":"JAMA Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Zhou, S., and Yao, Z. (2022). Roles of infection in psoriasis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23136955"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1001\/jamadermatol.2015.3605","article-title":"Psoriasis and the risk of depression in the US population: National Health and Nutrition Examination Survey 2009-2012","volume":"152","author":"Cohen","year":"2016","journal-title":"JAMA Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cyto.2017.05.018","article-title":"IL-17A causes depression-like symptoms via NF\u03baB and p38MAPK signaling pathways in mice: Implications for psoriasis associated depression","volume":"97","author":"Nadeem","year":"2017","journal-title":"Cytokine"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"W167","DOI":"10.1093\/nar\/gku443","article-title":"NetworkAnalyst--integrative approaches for protein-protein interaction network analysis and visual exploration","volume":"42","author":"Xia","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gku1003","article-title":"STRING v10: Protein-protein interaction networks, integrated over the tree of life","volume":"43","author":"Szklarczyk","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"11432","DOI":"10.1038\/srep11432","article-title":"TRRUST: A reference database of human transcriptional regulatory interactions","volume":"5","author":"Han","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"D380","DOI":"10.1093\/nar\/gkx1013","article-title":"TRRUST v2: An expanded reference database of human and mouse transcriptional regulatory interactions","volume":"46","author":"Han","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1152\/physiolgenomics.00157.2002","article-title":"Novel mechanisms of T-cell and dendritic cell activation revealed by profiling of psoriasis on the 63,100-element oligonucleotide array","volume":"13","author":"Zhou","year":"2003","journal-title":"Physiol. Genom."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Yao, Y., Richman, L., Morehouse, C., de los Reyes, M., Higgs, B.W., Boutrin, A., White, B., Coyle, A., Krueger, J., and Kiener, P.A. (2008). Type I interferon: Potential therapeutic target for psoriasis?. PLoS ONE, 3.","DOI":"10.1371\/annotation\/fbcbcab9-2e87-4ec7-af6e-c6e9e64ad4b3"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1038\/jid.2010.36","article-title":"Assessment of the psoriatic transcriptome in a large sample: Additional regulated genes and comparisons with in vitro models","volume":"130","author":"Gudjonsson","year":"2010","journal-title":"J. Investig. Dermatol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Su\u00e1rez-Fari\u00f1as, M., Lowes, M.A., Zaba, L.C., and Krueger, J.G. (2010). Evaluation of the psoriasis transcriptome across different studies by gene set enrichment analysis (GSEA). PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0010247"},{"key":"ref_19","unstructured":"Subhashini, D., and Anand, D.A. (2021, January 27\u201329). Network biology of KEGG enriched viral comorbidities in psoriasis subjects. Proceedings of the 3rd IEEE international conference on Innovations in power and advanced computing technologies, i-PACT 2021, Vellore, India."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.25303\/1710rjbt43049","article-title":"Computational protein subgraph analysis providing insights into effective therapeutic management of psoriasis and its comorbidities","volume":"17","author":"Subhashini","year":"2022","journal-title":"Res. J. Biotech."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"D1144","DOI":"10.1093\/nar\/gkaa1084","article-title":"Integration of the Drug-Gene Interaction database (DGIdb 4.0) with open crowdsource efforts","volume":"49","author":"Freshour","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Detroja, T.S., Gil-Henn, H., and Samson, A.O. (2022). Text-mining approach to identify hub genes of cancer metastasis and potential drug repurposing to target them. J. Clin. Med., 11.","DOI":"10.3390\/jcm11082130"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Yu, D., Lim, J., Wang, X., Liang, F., and Xiao, G. (2017). Enhanced construction of gene regulatory networks using hub gene information. BMC Bioinfo., 18.","DOI":"10.1186\/s12859-017-1576-1"},{"key":"ref_24","unstructured":"Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., and Walter, P. (2022, September 23). An Overview of the Cell Cycle, Molecular Biology of the Cell, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK26869\/."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/nrm2510","article-title":"Cyclin-dependent kinases and cell-cycle transitions: Does one fit all?","volume":"9","author":"Hochegger","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.bbrc.2007.05.037","article-title":"Cyclin D1 down-regulation is essential for DBC2\u2019s tumor suppressor function","volume":"358","author":"Yoshihara","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Cao, L., Chen, F., Yang, X., Xu, W., Xie, J., and Yu, L. (2014). Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages. BMC Evol. Biol., 14.","DOI":"10.1186\/1471-2148-14-10"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1007\/s00432-011-1039-4","article-title":"The CDK inhibitors in cancer research and therapy","volume":"137","author":"Cicenas","year":"2011","journal-title":"J. Cancer. Res. Clin. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Ding, L., Cao, J., Lin, W., Chen, H., Xiong, X., Ao, H., Yu, M., Lin, J., and Cui, Q. (2020). The roles of cyclin-dependent kinases in cell-cycle progression and therapeutic strategies in human breast cancer. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21061960"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1093\/nar\/gkl010","article-title":"BRCA1: Cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution","volume":"34","author":"Deng","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrc2602","article-title":"Cell cycle, CDKs and cancer: A changing paradigm","volume":"9","author":"Malumbres","year":"2009","journal-title":"Nat. Rev. Cancer."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1101\/gad.12.22.3499","article-title":"Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization","volume":"12","author":"Diehl","year":"1998","journal-title":"Genes. Dev."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"\u0141ukasik, P., Za\u0142uski, M., and Gutowska, I. (2021). Cyclin-dependent kinases (CDK) and their role in diseases development-review. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22062935"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/j.1349-7006.2007.00449.x","article-title":"Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression","volume":"98","author":"Tashiro","year":"2007","journal-title":"Cancer Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.febslet.2008.03.057","article-title":"Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest","volume":"582","author":"Sun","year":"2008","journal-title":"FEBS Lett."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"622212","DOI":"10.3389\/fphar.2020.622212","article-title":"Ursolic acid regulates cell cycle and proliferation in colon adenocarcinoma by suppressing cyclin B1","volume":"11","author":"Yang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Palombo, R., and Paronetto, M.P. (2022). pncCCND1_B engages an inhibitory protein network to downregulate CCND1 expression upon DNA damage. Cancers, 14.","DOI":"10.3390\/cancers14061537"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jocn.2017.05.005","article-title":"Upregulation of cyclin B1 plays potential roles in the invasiveness of pituitary adenomas","volume":"43","author":"Zhao","year":"2017","journal-title":"J. Clin. Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"7897346","DOI":"10.1155\/2018\/7897346","article-title":"Upregulation of BUB1B, CCNB1, CDC7, CDC20, and MCM3 in tumor tissues predicted worse overall survival and disease-free survival in hepatocellular carcinoma patients","volume":"2018","author":"Zhuang","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1177\/15353702211049149","article-title":"CCNB1 promotes the development of hepatocellular carcinoma by mediating DNA replication in the cell cycle","volume":"247","author":"Rong","year":"2022","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s13046-022-02363-9","article-title":"CDC20 in and out of mitosis: A prognostic factor and therapeutic target in hematological malignancies","volume":"41","author":"Bruno","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.molcel.2007.06.009","article-title":"Cdc20: A WD40 activator for a cell cycle degradation machine","volume":"27","author":"Yu","year":"2007","journal-title":"Mol. Cell"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1126\/science.1074757","article-title":"Segregating sister genomes: The molecular biology of chromosome separation","volume":"297","author":"Nasmyth","year":"2002","journal-title":"Science"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1038\/bjc.2014.252","article-title":"Cdc20 and securin overexpression predict short-term breast cancer survival","volume":"110","author":"Karra","year":"2014","journal-title":"Br. J. Cancer"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.1128\/MCB.00689-13","article-title":"The G2\/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20","volume":"33","author":"Lim","year":"2013","journal-title":"Mol. Cell Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1080\/15384101.2017.1387700","article-title":"Cell division cycle 20 promotes cell proliferation and invasion and inhibits apoptosis in osteosarcoma cells","volume":"17","author":"Shang","year":"2018","journal-title":"Cell Cycle"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.3892\/ijo.2014.2559","article-title":"Increased CDC20 expression is associated with development and progression of hepatocellular carcinoma","volume":"45","author":"Li","year":"2014","journal-title":"Int. J. Onco."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3892\/mmr.2021.12122","article-title":"CDC20 promotes the progression of hepatocellular carcinoma by regulating epithelial-mesenchymal transition","volume":"24","author":"Yang","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Wei, R., Wang, Z., Zhang, Y., Wang, B., Shen, N., Li, E., Li, X., Shang, L., Shang, Y., and Yan, W. (2020). Bioinformatic analysis revealing mitotic spindle assembly regulated NDC80 and MAD2L1 as prognostic biomarkers in non-small cell lung cancer development. BMC Med. Genom., 13.","DOI":"10.1186\/s12920-020-00762-5"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"85235","DOI":"10.18632\/oncotarget.13252","article-title":"Prognostic and predictive values of CDK1 and MAD2L1 in lung adenocarcinoma","volume":"7","author":"Shi","year":"2016","journal-title":"Oncotarget"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"37216","DOI":"10.18632\/oncotarget.26469","article-title":"Y-box binding protein YBX1 and its correlated genes as biomarkers for poor outcomes in patients with breast cancer","volume":"9","author":"Shibata","year":"2018","journal-title":"Oncotarget"},{"key":"ref_52","unstructured":"Pensa, S., Regis, G., Boselli, D., Novelli, F., and Poli, V. (2022, September 23). STAT1 and STAT3 in tumorigenesis: Two sides of the same coin?, Madame Curie Bioscience Database, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK6568\/."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3389\/fcvm.2019.00150","article-title":"An update on the multifaceted roles of STAT3 in the heart","volume":"6","author":"Harhous","year":"2019","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_54","unstructured":"Borcherding, D. (2010). Human adipocytes: Dopamine receptors and the regulation of prolactin. [Ph.D. Thesis, University of Cincinnati]."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"S195","DOI":"10.4103\/2230-8210.104038","article-title":"Prolactin and cancer: Has the orphan finally found a home?","volume":"16","author":"Sethi","year":"2012","journal-title":"Indian J. Endocrinol. Metab."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Lee, J., Yun, J.S., and Ko, S.H. (2022). Advanced glycation end products and their effect on vascular complications in type 2 Diabetes mellitus. Nutrients, 14.","DOI":"10.3390\/nu14153086"},{"key":"ref_57","first-page":"2685648","article-title":"RAGE regulating vascular remodeling in diabetes by regulating mitochondrial dynamics with JAK2\/STAT3 pathway","volume":"2022","author":"Sun","year":"2022","journal-title":"Comput. Intell. Neurosci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"17810","DOI":"10.1038\/s41598-017-18132-0","article-title":"IFN\u03b3 induces PD-L1 overexpression by JAK2\/STAT1\/IRF-1 signaling in EBV-positive gastric carcinoma","volume":"7","author":"Moon","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1128\/JVI.77.7.4439-4443.2003","article-title":"Epstein-Barr virus regulates STAT1 through latent membrane protein 1","volume":"77","author":"Richardson","year":"2003","journal-title":"J. Virol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"5020","DOI":"10.1158\/0008-5472.CAN-11-0908","article-title":"STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis","volume":"71","author":"Corcoran","year":"2011","journal-title":"Cancer Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s13046-020-01687-8","article-title":"LncRNA PSMB8-AS1 contributes to pancreatic cancer progression via modulating miR-382-3p\/STAT1\/PD-L1 axis","volume":"39","author":"Zhang","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1136\/gut.51.3.379","article-title":"Activation of signal transducer and activator of transcription (STAT) 1 in human chronic inflammatory bowel disease","volume":"51","author":"Schreiber","year":"2002","journal-title":"Gut"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1097\/MIB.0000000000000180","article-title":"Stat3: Friend or foe in colitis and colitis-associated cancer?","volume":"20","author":"Han","year":"2014","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"110019","DOI":"10.1016\/j.biopha.2020.110019","article-title":"STAT3-induced upregulation of circCCDC66 facilitates the progression of non-small cell lung cancer by targeting miR-33a-5p\/KPNA4 axis","volume":"126","author":"Wang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Parakh, S., Ernst, M., and Poh, A.R. (2021). Multicellular effects of STAT3 in non-small cell lung cancer: Mechanistic insights and therapeutic opportunities. Cancers, 13.","DOI":"10.3390\/cancers13246228"},{"key":"ref_66","first-page":"153","article-title":"Chapter-9, Rac1b: An emerging therapeutic target for chemoresistance in colorectal cancer","volume":"Volume 8","author":"Goka","year":"2020","journal-title":"Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Sig. Transduct. Target Ther."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.immuni.2004.06.016","article-title":"Regulation of NF-kappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a","volume":"21","author":"Lin","year":"2004","journal-title":"Immunity"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"19349","DOI":"10.1074\/jbc.M109.002725","article-title":"14-3-3 protein masks the DNA binding interface of forkhead transcription factor FOXO4","volume":"284","author":"Silhan","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"30436","DOI":"10.1074\/jbc.M112.359661","article-title":"STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear\/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells","volume":"287","author":"Oh","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nri2097","article-title":"T(H)1 cells control themselves by producing interleukin-10","volume":"7","author":"Vieira","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-4608(98)00141-1","article-title":"High rate of chromosomal abnormalities in HTLV-I-infected T-cell colonies derived from prodromal phase of adult T-cell leukemia: A study of IL-2-stimulated colony formation in methylcellulose","volume":"109","author":"Fujimoto","year":"1999","journal-title":"Cancer Genet. Cytogenet."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"31991","DOI":"10.1074\/jbc.R400009200","article-title":"Life, death, and tax: Role of HTLV-I oncoprotein in genetic instability and cellular transformation","volume":"279","author":"Jeang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1073\/pnas.0406424101","article-title":"HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule","volume":"102","author":"Liu","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cell.2012.03.003","article-title":"MYC on the path to cancer","volume":"149","author":"Dang","year":"2012","journal-title":"Cell"},{"key":"ref_76","first-page":"1032","article-title":"Biology of head and neck cancers","volume":"Volume 73","author":"Xu","year":"2021","journal-title":"Cummings Otolaryngology: Head and Neck Surgery"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1038\/sj.onc.1208615","article-title":"The p53 pathway: Positive and negative feedback loops","volume":"24","author":"Harris","year":"2005","journal-title":"Oncogene"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/jcp.26816","article-title":"Effect of CCNB1 silencing on cell cycle, senescence, and apoptosis through the p53 signaling pathway in pancreatic cancer","volume":"234","author":"Zhang","year":"2018","journal-title":"J. Cell Physiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"738841","DOI":"10.3389\/fonc.2021.738841","article-title":"Expression levels of three key genes CCNB1, CDC20, and CENPF in HCC are associated with antitumor immunity","volume":"11","author":"Si","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1128\/JVI.01769-06","article-title":"Persistent activation of STAT3 by latent Kaposi\u2019s sarcoma-associated herpesvirus infection of endothelial cells","volume":"81","author":"Punjabi","year":"2007","journal-title":"J. Virol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"6438","DOI":"10.1074\/jbc.M108289200","article-title":"Kaposi\u2019s sarcoma-associated herpesvirus open reading frame 50 stimulates the transcriptional activity of STAT3","volume":"277","author":"Gwack","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_82","unstructured":"Vakiti, A., and Mewawalla, P. (2022, September 23). Acute Myeloid Leukemia, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK507875\/."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1586\/17474086.2015.971005","article-title":"STAT3 as a possible therapeutic target in human malignancies: Lessons from acute myeloid leukemia","volume":"8","author":"Bruserud","year":"2014","journal-title":"Expert Rev. Hematol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"625130","DOI":"10.3389\/fmed.2021.625130","article-title":"Acitretin promotes the differentiation of myeloid-derived suppressor cells in the treatment of psoriasis","volume":"8","author":"Liu","year":"2021","journal-title":"Front. Med."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/23\/3867\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:30:46Z","timestamp":1760146246000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/23\/3867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,30]]},"references-count":84,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["cells11233867"],"URL":"https:\/\/doi.org\/10.3390\/cells11233867","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,30]]}}}