{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:26:13Z","timestamp":1791462373357,"version":"4.3.4"},"reference-count":132,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001407","name":"All India Institute of Medical Sciences (AIIMS), New Delhi-India","doi-asserted-by":"publisher","award":["BT\/PR41958\/MED\/97\/524\/2021"],"award-info":[{"award-number":["BT\/PR41958\/MED\/97\/524\/2021"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"All India Institute of Medical Sciences (AIIMS), New Delhi-India","doi-asserted-by":"publisher","award":["AI-798"],"award-info":[{"award-number":["AI-798"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"All India Institute of Medical Sciences (AIIMS), New Delhi-India","doi-asserted-by":"publisher","award":["AC-21"],"award-info":[{"award-number":["AC-21"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Biotechnology, AIIMS, New Delhi-India for providing infrastructural facilities","award":["BT\/PR41958\/MED\/97\/524\/2021"],"award-info":[{"award-number":["BT\/PR41958\/MED\/97\/524\/2021"]}]},{"name":"Department of Biotechnology, AIIMS, New Delhi-India for providing infrastructural facilities","award":["AI-798"],"award-info":[{"award-number":["AI-798"]}]},{"name":"Department of Biotechnology, AIIMS, New Delhi-India for providing infrastructural facilities","award":["AC-21"],"award-info":[{"award-number":["AC-21"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Renewing interest in the study of intermediate metabolism and cellular bioenergetics is brought on by the global increase in the prevalence of metabolic illnesses. Understanding of the mechanisms that integrate energy metabolism in the entire organism has significantly improved with the application of contemporary biochemical tools for quantifying the fuel substrate metabolism with cutting-edge mouse genetic procedures. Several unexpected findings in genetically altered mice have prompted research into the direction of intermediate metabolism of skeletal cells. These findings point to the possibility of novel endocrine connections through which bone cells can convey their energy status to other metabolic control centers. Understanding the expanded function of skeleton system has in turn inspired new lines of research aimed at characterizing the energy needs and bioenergetic characteristics of these bone cells. Bone-forming osteoblast and bone-resorbing osteoclast cells require a constant and large supply of energy substrates such as glucose, fatty acids, glutamine, etc., for their differentiation and functional activity. According to latest research, important developmental signaling pathways in bone cells are connected to bioenergetic programs, which may accommodate variations in energy requirements during their life cycle. The present review article provides a unique perspective of the past and present research in the metabolic characteristics of bone cells along with mechanisms governing energy substrate utilization and bioenergetics. In addition, we discussed the therapeutic inventions which are currently being utilized for the treatment and management of bone-related diseases such as osteoporosis, rheumatoid arthritis (RA), osteogenesis imperfecta (OIM), etc., by modulating the energetics of bone cells. We further emphasized on the role of GUT-associated metabolites (GAMs) such as short-chain fatty acids (SCFAs), medium-chain fatty acids (MCFAs), indole derivates, bile acids, etc., in regulating the energetics of bone cells and their plausible role in maintaining bone health. Emphasis is importantly placed on highlighting knowledge gaps in this novel field of skeletal biology, i.e., \u201cOsteometabolism\u201d (proposed by our group) that need to be further explored to characterize the physiological importance of skeletal cell bioenergetics in the context of human health and bone related metabolic diseases.<\/jats:p>","DOI":"10.3390\/cells11233943","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T03:27:57Z","timestamp":1670383677000},"page":"3943","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Osteometabolism: Metabolic Alterations in Bone Pathologies"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3323-0713","authenticated-orcid":false,"given":"Rupesh K.","family":"Srivastava","sequence":"first","affiliation":[{"name":"Translational Immunology, Osteoimmunology & Immunoporosis Lab (TIOIL), Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi 110029, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Sapra","sequence":"additional","affiliation":[{"name":"Translational Immunology, Osteoimmunology & Immunoporosis Lab (TIOIL), Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi 110029, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0795-2819","authenticated-orcid":false,"given":"Pradyumna K.","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, ICMR-NIREH, Bhopal 462030, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev-physiol-021119-034332","article-title":"The Osteocyte: New Insights","volume":"82","author":"Robling","year":"2020","journal-title":"Annu. Rev. Physiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.2106\/JBJS.M.01096","article-title":"A Review of Osteocyte Function and the Emerging Importance of Sclerostin","volume":"96","author":"Compton","year":"2014","journal-title":"J. Bone Jt. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Jann, J., Gascon, S., Roux, S., and Faucheux, N. (2020). Influence of the TGF-\u03b2 Superfamily on Osteoclasts\/Osteoblasts Balance in Physiological and Pathological Bone Conditions. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21207597"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.2147\/JIR.S351918","article-title":"The Rising Era of \u201cImmunoporosis\u201d: Role of Immune System in the Pathophysiology of Osteoporosis","volume":"15","author":"Srivastava","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1038\/s41598-018-38154-6","article-title":"Metabolomics Reveals Citric Acid Secretion in Mechanically Stimulated Osteocytes Is Inhibited by High Glucose","volume":"9","author":"Obeso","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Bellissimo, M.P., Roberts, J.L., Jones, D.P., Liu, K.H., Taibl, K.R., Uppal, K., Weitzmann, M.N., Pacifici, R., Drissi, H., and Ziegler, T.R. (2020). Metabolomic Associations with Serum Bone Turnover Markers. Nutrients, 12.","DOI":"10.3390\/nu12103161"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1007\/s00018-016-2425-5","article-title":"Wnt Signaling and Cellular Metabolism in Osteoblasts","volume":"74","author":"Karner","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1172\/JCI200419900","article-title":"PPAR \u03b3 Insufficiency Enhances Osteogenesis through Osteoblast Formation from Bone Marrow Progenitors","volume":"113","author":"Akune","year":"2004","journal-title":"J. Clin. Investig."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/nm1672","article-title":"PPAR-\u03b3 Regulates Osteoclastogenesis in Mice","volume":"13","author":"Wan","year":"2007","journal-title":"Nat. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.cmet.2010.04.015","article-title":"PGC1\u03b2 Mediates PPAR\u03b3 Activation of Osteoclastogenesis and Rosiglitazone-Induced Bone Loss","volume":"11","author":"Wei","year":"2010","journal-title":"Cell Metab."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1101\/gad.1661708","article-title":"Transcriptional Coactivators PGC-1\u03b1 and PGC-L\u03b2 Control Overlapping Programs Required for Perinatal Maturation of the Heart","volume":"22","author":"Lai","year":"2008","journal-title":"Genes Dev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bone.2017.08.008","article-title":"Glucose Metabolism in Bone","volume":"115","author":"Karner","year":"2018","journal-title":"Bone"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Donat, A., Knapstein, P.-R., Jiang, S., Baranowsky, A., Ballhause, T.-M., Frosch, K.-H., and Keller, J. (2021). Glucose Metabolism in Osteoblasts in Healthy and Pathophysiological Conditions. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22084120"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1016\/j.cell.2015.05.029","article-title":"Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation","volume":"161","author":"Wei","year":"2015","journal-title":"Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"108108","DOI":"10.1016\/j.celrep.2020.108108","article-title":"Malic Enzyme Couples Mitochondria with Aerobic Glycolysis in Osteoblasts","volume":"32","author":"Lee","year":"2020","journal-title":"Cell Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11914-022-00721-2","article-title":"Bioenergetic Metabolism in Osteoblast Differentiation","volume":"20","author":"Shen","year":"2022","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00281-019-00757-0","article-title":"Metabolic Reprogramming in Osteoclasts","volume":"41","year":"2019","journal-title":"Semin. Immunopathol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"21020","DOI":"10.1038\/s41598-020-77892-4","article-title":"Metabolic Reprogramming of Osteoclasts Represents a Therapeutic Target during the Treatment of Osteoporosis","volume":"10","author":"Taubmann","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.biocel.2016.08.034","article-title":"Energy Metabolism in Osteoclast Formation and Activity","volume":"79","author":"Lemma","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"11058","DOI":"10.1096\/fj.202000771R","article-title":"Both Aerobic Glycolysis and Mitochondrial Respiration Are Required for Osteoclast Differentiation","volume":"34","author":"Li","year":"2020","journal-title":"FASEB J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1159\/000110454","article-title":"Osteoclast Precursors Display Dynamic Metabolic Shifts toward Accelerated Glucose Metabolism at an Early Stage of RANKL-Stimulated Osteoclast Differentiation","volume":"20","author":"Kim","year":"2007","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Ahn, H., Lee, K., Kim, J.M., Kwon, S.H., Lee, S.H., Lee, S.Y., and Jeong, D. (2016). Accelerated Lactate Dehydrogenase Activity Potentiates Osteoclastogenesis via NFATc1 Signaling. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0153886"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1002\/jbmr.1976","article-title":"Metabolic Regulation of Osteoclast Differentiation and Function","volume":"28","author":"Indo","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s11914-021-00688-6","article-title":"Energy Metabolism of Osteocytes","volume":"19","author":"Karthik","year":"2021","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jmbbm.2013.06.013","article-title":"Osteocyte Differentiation Is Regulated by Extracellular Matrix Stiffness and Intercellular Separation","volume":"28","author":"Mullen","year":"2013","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.2106\/00004623-196446050-00006","article-title":"Parathormone-Induced Osteolysis in Dogs. A Microradiographic And Alpharadiographic Survey","volume":"46","author":"Belanger","year":"1964","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Kim, H., Oh, B., and Park-Min, K.-H. (2021). Regulation of Osteoclast Differentiation and Activity by Lipid Metabolism. Cells, 10.","DOI":"10.3390\/cells10010089"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev-physiol-021115-105045","article-title":"The Biochemistry and Physiology of Mitochondrial Fatty Acid \u03b2-Oxidation and Its Genetic Disorders","volume":"78","author":"Houten","year":"2016","journal-title":"Annu. Rev. Physiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.bbrc.2019.03.053","article-title":"Ctrp4, a New Adipokine, Promotes the Differentiation of Osteoblasts","volume":"512","author":"Li","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"578194","DOI":"10.3389\/fendo.2020.578194","article-title":"Dual Effects of Lipid Metabolism on Osteoblast Function","volume":"11","author":"Alekos","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e92704","DOI":"10.1172\/jci.insight.92704","article-title":"Fatty Acid Oxidation by the Osteoblast Is Required for Normal Bone Acquisition in a Sex- and Diet-Dependent Manner","volume":"2","author":"Kim","year":"2017","journal-title":"JCI Insight"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Kevorkova, O., Martineau, C., Martin-Falstrault, L., Sanchez-Dardon, J., Brissette, L., and Moreau, R. (2013). Low-Bone-Mass Phenotype of Deficient Mice for the Cluster of Differentiation 36 (CD36). PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0077701"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1042\/bj2480129","article-title":"Fatty Acid Oxidation in Bone Tissue and Bone Cells in Culture. Characterization and Hormonal Influences","volume":"248","author":"Adamek","year":"1987","journal-title":"Biochem. J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12929-017-0321-4","article-title":"Marrow Adipocytes Inhibit the Differentiation of Mesenchymal Stem Cells into Osteoblasts via Suppressing BMP-Signaling","volume":"24","author":"Abdallah","year":"2017","journal-title":"J. Biomed. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1080\/21623945.2017.1356505","article-title":"Intracellular Lipid Droplets Support Osteoblast Function","volume":"6","author":"Guntur","year":"2017","journal-title":"Adipocyte"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1359\/jbmr.2002.17.11.1997","article-title":"Role of the Cholesterol Biosynthetic Pathway in Osteoblastic Differentiation of Marrow Stromal Cells","volume":"17","author":"Parhami","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S8756-3282(98)00082-9","article-title":"Involvement of Cholesterol in Osteoclast-like Cell Formation via Cellular Fusion","volume":"23","author":"Sato","year":"1998","journal-title":"Bone"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"S108","DOI":"10.1038\/sj.cdd.4401399","article-title":"Osteoclast Formation, Survival and Morphology Are Highly Dependent on Exogenous Cholesterol\/Lipoproteins","volume":"11","author":"Luegmayr","year":"2004","journal-title":"Cell Death Differ."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s00774-009-0150-y","article-title":"Proteomic Analysis of Osteoclast Lipid Rafts: The Role of the Integrity of Lipid Rafts on V-ATPase Activity in Osteoclasts","volume":"28","author":"Ryu","year":"2010","journal-title":"J. Bone Miner. Metab."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s13075-018-1690-0","article-title":"Enhanced IL-6\/Phosphorylated STAT3 Signaling Is Related to the Imbalance of Circulating T Follicular Helper\/T Follicular Regulatory Cells in Patients with Rheumatoid Arthritis","volume":"20","author":"Niu","year":"2018","journal-title":"Arthritis Res. Ther."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.bbalip.2018.12.009","article-title":"Free Fatty Acid Receptor 4-\u03b2-Arrestin 2 Pathway Mediates the Effects of Different Classes of Unsaturated Fatty Acids in Osteoclasts and Osteoblasts","volume":"1864","author":"Kasonga","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"101113","DOI":"10.1016\/j.plipres.2021.101113","article-title":"Potential Modulatory Mechanisms of Action by Long-Chain Polyunsaturated Fatty Acids on Bone Cell and Chondrocyte Metabolism","volume":"83","author":"Abshirini","year":"2021","journal-title":"Prog. Lipid Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1172\/JCI78470","article-title":"Increased Glutamine Catabolism Mediates Bone Anabolism in Response to WNT Signaling","volume":"125","author":"Karner","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e71595","DOI":"10.7554\/eLife.71595","article-title":"SLC1A5 Provides Glutamine and Asparagine Necessary for Bone Development in Mice","volume":"10","author":"Sharma","year":"2021","journal-title":"eLife"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"jcs251645","DOI":"10.1242\/jcs.251645","article-title":"Biphasic Regulation of Glutamine Consumption by WNT during Osteoblast Differentiation","volume":"134","author":"Shen","year":"2020","journal-title":"J. Cell Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.cmet.2019.01.016","article-title":"Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells","volume":"29","author":"Yu","year":"2019","journal-title":"Cell Metab."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/jbmr.4219","article-title":"Glutamine Metabolism in Osteoprogenitors Is Required for Bone Mass Accrual and PTH-Induced Bone Anabolism in Male Mice","volume":"36","author":"Stegen","year":"2021","journal-title":"J. Bone Miner. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41420-022-01077-3","article-title":"High Glutamine Suppresses Osteogenesis through MTORC1-Mediated Inhibition of the MTORC2\/AKT-473\/RUNX2 Axis","volume":"8","author":"Gayatri","year":"2022","journal-title":"Cell Death Discov."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"115836","DOI":"10.1016\/j.bone.2020.115836","article-title":"Glutamine Metabolite \u03b1-Ketoglutarate Acts as an Epigenetic Co-Factor to Interfere with Osteoclast Differentiation","volume":"145","author":"Lee","year":"2021","journal-title":"Bone"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1210\/endo-98-4-943","article-title":"Hormonal Control of Bone Collagen Synthesis in Vitro: Effects of Parathyroid Hormone and Calcitonin","volume":"98","author":"Dietrich","year":"1976","journal-title":"Endocrinology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/jbmr.5650030317","article-title":"Glucose Transport in Osteoblast-Enriched Bone Explants: Characterization and Insulin Regulation","volume":"3","author":"Hahn","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1210\/en.2016-1583","article-title":"Glucose Transporter-4 Facilitates Insulin-Stimulated Glucose Uptake in Osteoblasts","volume":"157","author":"Li","year":"2016","journal-title":"Endocrinology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/dmrr.537","article-title":"Influence of Diabetic Metabolic State on Fracture Healing in Spontaneously Diabetic Rats","volume":"21","author":"Follak","year":"2005","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.yexcr.2006.02.007","article-title":"Hypoxia Inhibits the Growth, Differentiation and Bone-Forming Capacity of Rat Osteoblasts","volume":"312","author":"Utting","year":"2006","journal-title":"Exp. Cell Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1002\/stem.1441","article-title":"Inhibitory Effects of Hypoxia on Metabolic Switch and Osteogenic Differentiation of Human Mesenchymal Stem Cells","volume":"31","author":"Hsu","year":"2013","journal-title":"Stem Cells"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"8673","DOI":"10.1073\/pnas.1324290111","article-title":"Up-Regulation of Glycolytic Metabolism Is Required for HIF1\u03b1-Driven Bone Formation","volume":"111","author":"Regan","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Tan, J.K., Mohamad Hazir, N.S., and Alias, E. (2021). Impacts of Hypoxia on Osteoclast Formation and Activity: Systematic Review. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221810146"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jcp.10321","article-title":"Hypoxia Is a Major Stimulator of Osteoclast Formation and Bone Resorption","volume":"196","author":"Arnett","year":"2003","journal-title":"J. Cell. Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature07019","article-title":"Osteoclast Size Is Controlled by Fra-2 through LIF\/LIF-Receptor Signalling and Hypoxia","volume":"454","author":"Bozec","year":"2008","journal-title":"Nature"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1002\/path.4159","article-title":"Differential Regulation of HIF-mediated Pathways Increases Mitochondrial Metabolism and ATP Production in Hypoxic Osteoclasts","volume":"229","author":"Morten","year":"2013","journal-title":"J. Pathol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1101\/gad.255000.114","article-title":"Oxygen-Sensing PHDs Regulate Bone Homeostasis through the Modulation of Osteoprotegerin","volume":"29","author":"Wu","year":"2015","journal-title":"Genes Dev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41413-019-0054-y","article-title":"Controlling Hypoxia-Inducible Factor-2\u03b1 Is Critical for Maintaining Bone Homeostasis in Mice","volume":"7","author":"Lee","year":"2019","journal-title":"Bone Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.immuni.2017.06.018","article-title":"Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis","volume":"47","author":"Murata","year":"2017","journal-title":"Immunity"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41413-021-00142-4","article-title":"Endocrine Role of Bone in the Regulation of Energy Metabolism","volume":"9","author":"Zhou","year":"2021","journal-title":"Bone Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1172\/JCI75554","article-title":"Insulin, Osteoblasts, and Energy Metabolism: Why Bone Counts Calories","volume":"124","author":"Riddle","year":"2014","journal-title":"J. Clin. Investig."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"19","DOI":"10.23736\/S0391-1977.17.02544-5","article-title":"Relationship between Insulin Resistance, Hs-CRP, and Body Fat and Serum Osteoprotegerin\/RANKL in Prediabetic Patients","volume":"43","author":"Bilgir","year":"2018","journal-title":"Minerva Endocrinol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s13105-013-0261-8","article-title":"The Association of Insulin Resistance with Serum Osteoprotegerin in Obese Adolescents","volume":"69","author":"Suliburska","year":"2013","journal-title":"J. Physiol. Biochem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"40253","DOI":"10.1038\/srep40253","article-title":"Osteopontin Regulates Macrophage Activation and Osteoclast Formation in Hypertensive Patients with Vascular Calcification","volume":"7","author":"Ge","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/stem.1567","article-title":"An Osteopontin-Integrin Interaction Plays a Critical Role in Directing Adipogenesis and Osteogenesis by Mesenchymal Stem Cells","volume":"32","author":"Chen","year":"2014","journal-title":"Stem Cells"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Chapman, J., Miles, P.D., Ofrecio, J.M., Neels, J.G., Yu, J.G., Resnik, J.L., Wilkes, J., Talukdar, S., Thapar, D., and Johnson, K. (2010). Osteopontin Is Required for the Early Onset of High Fat Diet-Induced Insulin Resistance in Mice. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0013959"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cmet.2019.02.008","article-title":"A New Transkingdom Dimension to NO Signaling","volume":"29","author":"Ma","year":"2019","journal-title":"Cell Metab."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/jcb.20154","article-title":"Inhibitory Helix-Loop-Helix Transcription Factors Id1\/Id3 Promote Bone Formation in Vivo","volume":"93","author":"Maeda","year":"2004","journal-title":"J. Cell. Biochem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.cmet.2013.09.014","article-title":"Osteocytes Regulate Primary Lymphoid Organs and Fat Metabolism","volume":"18","author":"Sato","year":"2013","journal-title":"Cell Metab."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3389\/fendo.2017.00359","article-title":"Effect of Osteocyte-Ablation on Inorganic Phosphate Metabolism: Analysis of Bone\u2013Kidney\u2013Gut Axis","volume":"8","author":"Fujii","year":"2017","journal-title":"Front. Endocrinol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.2147\/DMSO.S316964","article-title":"Osteoclasts May Affect Glucose Uptake-Related Insulin Resistance by Secreting Resistin","volume":"14","author":"Li","year":"2021","journal-title":"Diabetes Metab. Syndr. Obes. Targets Ther."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41467-019-14003-6","article-title":"Identification of Osteoclast-Osteoblast Coupling Factors in Humans Reveals Links between Bone and Energy Metabolism","volume":"11","author":"Weivoda","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"37808","DOI":"10.1074\/jbc.M112.385369","article-title":"Intracellular and Extracellular ATP Coordinately Regulate the Inverse Correlation between Osteoclast Survival and Bone Resorption","volume":"287","author":"Miyazaki","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/jbmr.3358","article-title":"Metabolomic Pathways to Osteoporosis in Middle-Aged Women: A Genome-Metabolome-Wide Mendelian Randomization Study","volume":"33","author":"Moayyeri","year":"2018","journal-title":"J. Bone Miner. Res."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Anagnostis, P., Florentin, M., Livadas, S., Lambrinoudaki, I., and Goulis, D.G. (2022). Bone Health in Patients with Dyslipidemias: An Underestimated Aspect. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031639"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"725341","DOI":"10.3389\/fphar.2021.725341","article-title":"An Integrated Metabolomic Study of Osteoporosis: Discovery and Quantification of Hyocholic Acids as Candidate Markers","volume":"12","author":"Deng","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"16456","DOI":"10.1038\/s41598-018-34574-6","article-title":"Integrative Bone Metabolomics\u2014Lipidomics Strategy for Pathological Mechanism of Postmenopausal Osteoporosis Mouse Model","volume":"8","author":"Zhao","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.it.2012.01.010","article-title":"Metabolic Pathways in T Cell Fate and Function","volume":"33","author":"Gerriets","year":"2012","journal-title":"Trends Immunol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.isci.2018.07.005","article-title":"Initial B Cell Activation Induces Metabolic Reprogramming and Mitochondrial Remodeling","volume":"5","author":"Waters","year":"2018","journal-title":"iScience"},{"key":"ref_84","first-page":"420","article-title":"Metabolic Reprograming in Macrophage Polarization","volume":"5","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"652771","DOI":"10.3389\/fimmu.2021.652771","article-title":"Metabolic Control of Autoimmunity and Tissue Inflammation in Rheumatoid Arthritis","volume":"12","author":"Qiu","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13075-021-02437-7","article-title":"Increase of Aerobic Glycolysis Mediated by Activated T Helper Cells Drives Synovial Fibroblasts towards an Inflammatory Phenotype: New Targets for Therapy?","volume":"23","author":"Kvacskay","year":"2021","journal-title":"Arthritis Res. Ther."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.2147\/JIR.S337620","article-title":"Increased EEF2K Promotes Glycolysis and Aggressive Behaviors of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis","volume":"15","author":"Chen","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"101249","DOI":"10.1016\/j.arr.2020.101249","article-title":"The Role of Metabolism in Chondrocyte Dysfunction and the Progression of Osteoarthritis","volume":"66","author":"Zheng","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nrrheum.2017.50","article-title":"The Role of Metabolism in the Pathogenesis of Osteoarthritis","volume":"13","author":"Mobasheri","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.maturitas.2014.12.003","article-title":"Chondrosenescence: Definition, Hallmarks and Potential Role in the Pathogenesis of Osteoarthritis","volume":"80","author":"Mobasheri","year":"2015","journal-title":"Maturitas"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"630791","DOI":"10.3389\/fimmu.2021.630791","article-title":"Serum Metabolomics Signatures Associated with Ankylosing Spondylitis and TNF Inhibitor Therapy","volume":"12","author":"Ou","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.clnesp.2022.06.011","article-title":"Metabolomic Profiling in Ankylosing Spondylitis Using Time-of-Flight Mass Spectrometry","volume":"50","year":"2022","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"15621","DOI":"10.1038\/ncomms15621","article-title":"Succinate and Its G-Protein-Coupled Receptor Stimulates Osteoclastogenesis","volume":"8","author":"Guo","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature13909","article-title":"Ischaemic Accumulation of Succinate Controls Reperfusion Injury through Mitochondrial ROS","volume":"515","author":"Chouchani","year":"2014","journal-title":"Nature"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"111389","DOI":"10.1016\/j.celrep.2022.111389","article-title":"Targeting the Succinate Receptor Effectively Inhibits Periodontitis","volume":"40","author":"Guo","year":"2022","journal-title":"Cell Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1530\/JOE-17-0335","article-title":"Metabolic Phenotype in the Mouse Model of Osteogenesis Imperfecta","volume":"234","author":"Tauer","year":"2017","journal-title":"J. Endocrinol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ymgme.2021.02.004","article-title":"Skeletal Muscle Specific Mitochondrial Dysfunction and Altered Energy Metabolism in a Murine Model (Oim\/Oim) of Severe Osteogenesis Imperfecta","volume":"132","author":"Gremminger","year":"2021","journal-title":"Mol. Genet. Metab."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/jcp.22291","article-title":"Adipocytes Decrease Runx2 Expression in Osteoblastic Cells: Roles of PPAR\u03b3 and Adiponectin","volume":"225","author":"Liu","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"ref_99","first-page":"4","article-title":"Relationship between Bone Metabolism and Adipogenesis","volume":"33","author":"Carnevale","year":"2010","journal-title":"J. Endocrinol. Investig."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00223-015-9954-z","article-title":"High-Fat Diet Causes Bone Loss in Young Mice by Promoting Osteoclastogenesis Through Alteration of the Bone Marrow Environment","volume":"96","author":"Shu","year":"2015","journal-title":"Calcif. Tissue Int."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41467-017-02490-4","article-title":"Short-Chain Fatty Acids Regulate Systemic Bone Mass and Protect from Pathological Bone Loss","volume":"9","author":"Lucas","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.bone.2019.05.016","article-title":"Short-Chain Fatty Acids and FFAR2 as Suppressors of Bone Resorption","volume":"125","author":"Duffles","year":"2019","journal-title":"Bone"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"105406","DOI":"10.1016\/j.phrs.2020.105406","article-title":"Fatty Acid Sensing GPCR (GPR84) Signaling Safeguards Cartilage Homeostasis and Protects against Osteoarthritis","volume":"164","author":"Wang","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Park, E.-J., Kim, S.A., Choi, Y.-M., Kwon, H.-K., Shim, W., Lee, G., and Choi, S. (2011). Capric Acid Inhibits NO Production and STAT3 Activation during LPS-Induced Osteoclastogenesis. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0027739"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.archoralbio.2014.05.009","article-title":"IL-17 Inhibits Osteoblast Differentiation and Bone Regeneration in Rat","volume":"59","author":"Kim","year":"2014","journal-title":"Arch. Oral Biol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1002\/jbmr.1961","article-title":"Positive Regulation of Osteogenesis by Bile Acid through FXR","volume":"28","author":"Cho","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e1486","DOI":"10.6061\/clinics\/2020\/e1486","article-title":"Association between Bile Acid Metabolism and Bone Mineral Density in Postmenopausal Women","volume":"75","author":"Zhao","year":"2020","journal-title":"Clinics"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1080\/09637486.2022.2078285","article-title":"Short-Chain Fatty Acids, Acetate and Propionate, Directly Upregulate Osteoblastic Differentiation","volume":"73","author":"Kondo","year":"2022","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1136\/annrheumdis-2021-221386","article-title":"Higher Serum Levels of Short-Chain Fatty Acids Are Associated with Non-Progression to Arthritis in Individuals at Increased Risk of RA","volume":"81","author":"Martinsson","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"101545","DOI":"10.1016\/j.jksus.2021.101545","article-title":"Propionate Restores Disturbed Gut Microbiota Induced by Methotrexate in Rheumatoid Arthritis: From Clinic to Experiments","volume":"33","author":"Fan","year":"2021","journal-title":"J. King Saud Univ. Sci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.cmet.2020.03.003","article-title":"Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells","volume":"31","author":"Rosser","year":"2020","journal-title":"Cell Metab."},{"key":"ref_112","unstructured":"Lin, X., Xiao, H.-M., Liu, H.-M., Lv, W.-Q., Greenbaum, J., Yuan, S.-J., Gong, R., Zhang, Q., Chen, Y.-C., and Peng, C. (2020). Gut Microbiota Impacts Bone via B.Vulgatus-Valeric Acid-Related Pathways. medRxiv."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Machate, D.J., Figueiredo, P.S., Marcelino, G., de Guimar\u00e3es, R.C.A., Hiane, P.A., Bogo, D., Pinheiro, V.A.Z., de Oliveira, L.C.S., and Pott, A. (2020). Fatty Acid Diets: Regulation of Gut Microbiota Composition and Obesity and Its Related Metabolic Dysbiosis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21114093"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1136\/gutjnl-2020-321173","article-title":"Bacteria-Derived Long Chain Fatty Acid Exhibits Anti-Inflammatory Properties in Colitis","volume":"70","author":"Pujo","year":"2021","journal-title":"Gut"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ejphar.2015.10.053","article-title":"Myristoleic Acid Inhibits Osteoclast Formation and Bone Resorption by Suppressing the RANKL Activation of Src and Pyk2","volume":"768","author":"Kwon","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.3389\/fimmu.2019.02757","article-title":"Free Fatty Acids in Bone Pathophysiology of Rheumatic Diseases","volume":"10","author":"Frommer","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1080\/19490976.2019.1674124","article-title":"Diversification of Host Bile Acids by Members of the Gut Microbiota","volume":"11","author":"Winston","year":"2020","journal-title":"Gut Microbes"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Ahn, T.-K., Kim, K.-T., Joshi, H.P., Park, K.H., Kyung, J.W., Choi, U.-Y., Sohn, S., Sheen, S.-H., Shin, D.-E., and Lee, S.-H. (2020). Therapeutic Potential of Tauroursodeoxycholic Acid for the Treatment of Osteoporosis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21124274"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"116483","DOI":"10.1016\/j.bone.2022.116483","article-title":"Bilirubin Increases Viability and Decreases Osteoclast Apoptosis Contributing to Osteoporosis in Advanced Liver Diseases","volume":"162","author":"Jurado","year":"2022","journal-title":"Bone"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/s41564-021-00970-4","article-title":"Bifidobacterium Species Associated with Breastfeeding Produce Aromatic Lactic Acids in the Infant Gut","volume":"6","author":"Laursen","year":"2021","journal-title":"Nat. Microbiol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00223-021-00811-w","article-title":"Effects of Bisphosphonate Treatment on Circulating Lipid and Glucose Levels in Patients with Metabolic Bone Disorders","volume":"108","author":"Iannuzzo","year":"2021","journal-title":"Calcif. Tissue Int."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1210\/en.2019-00239","article-title":"Teriparatide Improves Bone and Lipid Metabolism in a Male Rat Model of Type 2 Diabetes Mellitus","volume":"160","author":"Nomura","year":"2019","journal-title":"Endocrinology"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1055\/s-2007-967090","article-title":"Acute and Chronic Effect of Teriparatide on Glucose Metabolism in Women with Established Osteoporosis","volume":"115","author":"Anastasilakis","year":"2007","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1002\/jbmr.2714","article-title":"PTH Promotes Bone Anabolism by Stimulating Aerobic Glycolysis via IGF Signaling","volume":"30","author":"Esen","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"733611","DOI":"10.3389\/fendo.2021.733611","article-title":"Endogenous Glucocorticoid Metabolism in Bone: Friend or Foe","volume":"12","author":"Martin","year":"2021","journal-title":"Front. Endocrinol."},{"key":"ref_126","unstructured":"Ilias, I., Milionis, C., and Zoumakis, E. (2000). An Overview of Glucocorticoid-Induced Osteoporosis, MDText.com, Inc."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4248\/BR201302001","article-title":"Endogenous Glucocorticoids and Bone","volume":"1","author":"Zhou","year":"2013","journal-title":"Bone Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-1-4939-2895-8_5","article-title":"Regulation of Glucose Homeostasis by Glucocorticoids","volume":"Volume 872","author":"Kuo","year":"2015","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"ref_129","first-page":"137","article-title":"Vitamin D and Gene Networks in Human Osteoblasts","volume":"5","year":"2014","journal-title":"Front. Physiol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/j.bone.2007.02.024","article-title":"Metabolism of Vitamin D3 in Human Osteoblasts: Evidence for Autocrine and Paracrine Activities of 1\u03b1,25-Dihydroxyvitamin D3","volume":"40","author":"Atkins","year":"2007","journal-title":"Bone"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"16030","DOI":"10.1038\/boneres.2016.30","article-title":"Vitamin D Receptor Expression in Human Bone Tissue and Dose-Dependent Activation in Resorbing Osteoclasts","volume":"4","author":"Zarei","year":"2016","journal-title":"Bone Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3389\/fimmu.2018.00657","article-title":"Immunoporosis: Immunology of Osteoporosis\u2014Role of T Cells","volume":"9","author":"Srivastava","year":"2018","journal-title":"Front. Immunol."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/23\/3943\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:35:19Z","timestamp":1760146519000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/23\/3943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,6]]},"references-count":132,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["cells11233943"],"URL":"https:\/\/doi.org\/10.3390\/cells11233943","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,6]]}}}