{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:19:16Z","timestamp":1791001156892,"version":"4.1.0"},"reference-count":58,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technology","award":["MOST 111-2314-B-040-016"],"award-info":[{"award-number":["MOST 111-2314-B-040-016"]}]},{"name":"Ministry of Science and Technology","award":["DMR-111-234"],"award-info":[{"award-number":["DMR-111-234"]}]},{"name":"Ministry of Science and Technology","award":["CSH-2019-C-39"],"award-info":[{"award-number":["CSH-2019-C-39"]}]},{"name":"China Medical University Hospital","award":["MOST 111-2314-B-040-016"],"award-info":[{"award-number":["MOST 111-2314-B-040-016"]}]},{"name":"China Medical University Hospital","award":["DMR-111-234"],"award-info":[{"award-number":["DMR-111-234"]}]},{"name":"China Medical University Hospital","award":["CSH-2019-C-39"],"award-info":[{"award-number":["CSH-2019-C-39"]}]},{"name":"Chung Shan Medical University Hospital","award":["MOST 111-2314-B-040-016"],"award-info":[{"award-number":["MOST 111-2314-B-040-016"]}]},{"name":"Chung Shan Medical University Hospital","award":["DMR-111-234"],"award-info":[{"award-number":["DMR-111-234"]}]},{"name":"Chung Shan Medical University Hospital","award":["CSH-2019-C-39"],"award-info":[{"award-number":["CSH-2019-C-39"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>In scaffold-regulated bone regeneration, most three-dimensional (3D)-printed scaffolds do not provide physical stimulation to stem cells. In this study, a magnetic scaffold was fabricated using fused deposition modeling with calcium silicate (CS), iron oxide nanoparticles (Fe3O4), and poly-\u03b5-caprolactone (PCL) as the matrix for internal magnetic sources. A static magnetic field was used as an external magnetic source. It was observed that 5% Fe3O4 provided a favorable combination of compressive strength (9.6 \u00b1 0.9 MPa) and degradation rate (21.6 \u00b1 1.9% for four weeks). Furthermore, the Fe3O4-containing scaffold increased in vitro bioactivity and Wharton\u2019s jelly mesenchymal stem cells\u2019 (WJMSCs) adhesion. Moreover, it was shown that the Fe3O4-containing scaffold enhanced WJMSCs\u2019 proliferation, alkaline phosphatase activity, and the osteogenic-related proteins of the scaffold. Under the synergistic effect of the static magnetic field, the CS scaffold containing Fe3O4 can not only enhance cell activity but also stimulate the simultaneous secretion of collagen I and osteocalcin. Overall, our results demonstrated that Fe3O4-containing CS\/PCL scaffolds could be fabricated three dimensionally and combined with a static magnetic field to affect cell behaviors, potentially increasing the likelihood of clinical applications for bone tissue engineering.<\/jats:p>","DOI":"10.3390\/cells11243967","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T03:35:53Z","timestamp":1670470553000},"page":"3967","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Synergistic Effect of Static Magnetic Fields and 3D-Printed Iron-Oxide-Nanoparticle-Containing Calcium Silicate\/Poly-\u03b5-Caprolactone Scaffolds for Bone Tissue Engineering"],"prefix":"10.3390","volume":"11","author":[{"given":"Chuan-Yi","family":"Kao","sequence":"first","affiliation":[{"name":"School of Medicine, Chung Shan Medical University, Taichung 406040, Taiwan"},{"name":"Department of Psychiatry, Chung Shan Medical University Hospital, Taichung 40201, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Li","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, College of Health Care, China Medical University, Taichung 406040, Taiwan"},{"name":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung 406040, Taiwan"},{"name":"Department of Orthopedics, China Medical University Hospital, Taichung 40447, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Hong","family":"Lin","sequence":"additional","affiliation":[{"name":"x-Dimension Center for Medical Research and Translation, China Medical University Hospital, Taichung 404332, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4295-2064","authenticated-orcid":false,"given":"Alvin Kai-Xing","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Education, China Medical University Hospital, Taichung 404332, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sing Yee","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Kuala Lumpur, Kuala Lumpur 50586, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsui-Hsien","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Dentistry, Chung Shan Medical University, Taichung 406040, Taiwan"},{"name":"Department of Stomatology, Chung Shan Medical University Hospital, Taichung 40201, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuan-Ti","family":"Hsu","sequence":"additional","affiliation":[{"name":"x-Dimension Center for Medical Research and Translation, China Medical University Hospital, Taichung 404332, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2109871","DOI":"10.1002\/adfm.202109871","article-title":"Bioprinted Constructs that Mimic the Ossification Center Microenvironment for Targeted Innervation in Bone Regeneration","volume":"32","author":"Li","year":"2021","journal-title":"Adv. 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