{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:47:32Z","timestamp":1790189252067,"version":"4.1.0"},"reference-count":93,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"French Ministry of Health","award":["PHRCI-20-036"],"award-info":[{"award-number":["PHRCI-20-036"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Medication-related osteonecrosis of the jaw (MRONJ) is a complication caused by anti-resorptive agents and anti-angiogenesis drugs. Since we wanted to write a protocol for a randomized clinical trial (RCT), we reviewed the literature for the essential information needed to estimate the size of the active patient population and measure the effects of therapeutics. At the same time, we designed a questionnaire intended for clinicians to collect detailed information about their practices. Twelve essential criteria and seven additional items were identified and compiled from 43 selected articles. Some of these criteria were incorporated in the questionnaire coupled with data on clinical practices. Our review found extensive missing data and a lack of consensus. For example, the success rate often combined MRONJ stages, diseases, and drug treatments. The occurrence date and evaluation methods were not harmonized or quantitative enough. The primary and secondary endpoints, failure definition, and date coupled to bone measurements were not well established. This information is critical for writing a RCT protocol. With this review article, we aim to encourage authors to contribute all their findings in the field to bridge the current knowledge gap and provide a stronger database for the coming years.<\/jats:p>","DOI":"10.3390\/cells11244097","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T07:27:30Z","timestamp":1671434850000},"page":"4097","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Reporting Criteria for Clinical Trials on Medication-Related Osteonecrosis of the Jaw (MRONJ): A Review and Recommendations"],"prefix":"10.3390","volume":"11","author":[{"given":"Camille","family":"Gaudet","sequence":"first","affiliation":[{"name":"Service de Chirurgie Maxillo-Faciale, Stomatologie et Odontologie Hospitali\u00e8re, CHU Besan\u00e7on, F-25000 Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Odet","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Maxillo-Faciale, Stomatologie et Odontologie Hospitali\u00e8re, CHU Besan\u00e7on, F-25000 Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Meyer","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Maxillo-Faciale, Stomatologie et Odontologie Hospitali\u00e8re, CHU Besan\u00e7on, F-25000 Besan\u00e7on, France"},{"name":"Laboratoire de Nanom\u00e9decine, Imagerie, Th\u00e9rapeutique EA 4662, Universit\u00e9 Bourgogne Franche-Comt\u00e9, F-25000 Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brice","family":"Chatelain","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Maxillo-Faciale, Stomatologie et Odontologie Hospitali\u00e8re, CHU Besan\u00e7on, F-25000 Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Weber","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Maxillo-Faciale, Stomatologie et Odontologie Hospitali\u00e8re, CHU Besan\u00e7on, F-25000 Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Laure","family":"Parmentier","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de M\u00e9thodologie, INSERM Centre d\u2019Investigation Clinique 1431, CHU Besan\u00e7on, F-25000 Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Derruau","sequence":"additional","affiliation":[{"name":"P\u00f4le M\u00e9decine Bucco-Dentaire, H\u00f4pital Maison Blanche, CHU Reims, F-51092 Reims, France"},{"name":"Laboratoire BioSpecT EA-7506, UFR de Pharmacie, Universit\u00e9 de Reims Champagne-Ardenne, F-51100 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9531-8756","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Laurence","sequence":"additional","affiliation":[{"name":"P\u00f4le M\u00e9decine Bucco-Dentaire, H\u00f4pital Maison Blanche, CHU Reims, F-51092 Reims, France"},{"name":"Biomat\u00e9riaux et Inflammation en Site Osseux, P\u00f4le Sant\u00e9, URCA, HERVI EA3801 UFR de M\u00e9decine, Universit\u00e9 de Reims Champagne Ardenne, F-51100 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0499-0254","authenticated-orcid":false,"given":"C\u00e9dric","family":"Mauprivez","sequence":"additional","affiliation":[{"name":"P\u00f4le M\u00e9decine Bucco-Dentaire, H\u00f4pital Maison Blanche, CHU Reims, F-51092 Reims, France"},{"name":"Biomat\u00e9riaux et Inflammation en Site Osseux, P\u00f4le Sant\u00e9, URCA, BIOS EA 4691, Universit\u00e9 de Reims Champagne Ardenne, F-51100 Reims, France"},{"name":"UFR d\u2019Odontologie, Universit\u00e9 de Reims Champagne Ardenne, F-51100 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Brenet","sequence":"additional","affiliation":[{"name":"Service d\u2019ORL et Chirurgie Cervico-Faciale, CHU Reims, F-51092 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8072-9728","authenticated-orcid":false,"given":"Halima","family":"Kerdjoudj","sequence":"additional","affiliation":[{"name":"Biomat\u00e9riaux et Inflammation en Site Osseux, P\u00f4le Sant\u00e9, URCA, BIOS EA 4691, Universit\u00e9 de Reims Champagne Ardenne, F-51100 Reims, France"},{"name":"UFR d\u2019Odontologie, Universit\u00e9 de Reims Champagne Ardenne, F-51100 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6015-8983","authenticated-orcid":false,"given":"Mathilde","family":"Fenelon","sequence":"additional","affiliation":[{"name":"CHU Bordeaux, Dentistry and Oral Health Department, F-33404 Bordeaux, France"},{"name":"INSERM U1026, University of Bordeaux, Tissue Bioengineering (BioTis), F-33076 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Fricain","sequence":"additional","affiliation":[{"name":"CHU Bordeaux, Dentistry and Oral Health Department, F-33404 Bordeaux, France"},{"name":"INSERM U1026, University of Bordeaux, Tissue Bioengineering (BioTis), F-33076 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narcisse","family":"Zwetyenga","sequence":"additional","affiliation":[{"name":"Chirurgie Maxillo-Faciale-Stomatologie-Chirurgie Plastique R\u00e9paratrice et Esth\u00e9tique-Chirurgie de La main, CHU Dijon, F-21079 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1323-3626","authenticated-orcid":false,"given":"David","family":"Hoarau","sequence":"additional","affiliation":[{"name":"Chirurgie Maxillo-Faciale-Stomatologie-Chirurgie Plastique R\u00e9paratrice et Esth\u00e9tique-Chirurgie de La main, CHU Dijon, F-21079 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Curien","sequence":"additional","affiliation":[{"name":"Service d\u2019Odontologie, CHR Metz-Thionville, F-57530 Thionville, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Gerard","sequence":"additional","affiliation":[{"name":"Service d\u2019Odontologie, CHR Metz-Thionville, F-57530 Thionville, 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EA 4662, Universit\u00e9 Bourgogne Franche-Comt\u00e9, F-25000 Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"key":"ref_1","first-page":"2","article-title":"American Association of Oral and Maxillofacial Surgeons Position Paper on Bisphosphonate-Related Osteonecrosis of the Jaws\u20142009 Update","volume":"67","author":"Ruggiero","year":"2009","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American Association of Oral and Maxillofacial Surgeons Position Paper on Medication-Related Osteonecrosis of the Jaw\u20142014 Update","volume":"72","author":"Ruggiero","year":"2014","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1200\/jop.2006.2.1.7","article-title":"Practical guidelines for the prevention, diagnosis, and treatment of osteonecrosis of the jaw in patients with cancer","volume":"2","author":"Ruggiero","year":"2006","journal-title":"J. Oncol. Pract."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1051\/mbcb\/2012049","article-title":"Ost\u00e9on\u00e9croses des maxillaires dues aux bisphosphonates administr\u00e9s par voie intraveineuse: Incidence et facteurs de risque","volume":"19","author":"Gunepin","year":"2013","journal-title":"M\u00e9d. Buccale Chir. Buccale"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/jbmr.3017","article-title":"Uncertainty of current algorithm for bisphosphonate-related osteonecrosis of the jaw in population-based studies: A systematic review","volume":"32","author":"Kim","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Lorenzo-Pouso, A.I., Bag\u00e1n, J., Bag\u00e1n, L., G\u00e1ndara-Vila, P., Chamorro-Petronacci, C.M., Castelo-Baz, P., Blanco-Carri\u00f3n, A., Blanco-Fern\u00e1ndez, M.\u00c1., \u00c1lvarez-Calder\u00f3n, \u00d3., and Carballo, J. (2021). 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