{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:19:02Z","timestamp":1762604342497,"version":"build-2065373602"},"reference-count":22,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Acute coronary syndrome (ACS) encompasses a spectrum of presentations including unstable angina, non-ST elevation myocardial infarction (NSTEMI) and ST-elevation myocardial infarction (STEMI) [...]<\/jats:p>","DOI":"10.3390\/cells11244136","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T02:05:02Z","timestamp":1671501902000},"page":"4136","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Acute Coronary Syndrome: Unravelling the Biology to Identify New Therapies"],"prefix":"10.3390","volume":"11","author":[{"given":"Bradley","family":"Tucker","sequence":"first","affiliation":[{"name":"Royal Prince Alfred Hospital, Camperdown, Sydney 2050, Australia"},{"name":"Sydney Medical School, University of Sydney, Camperdown, Sydney 2050, Australia"},{"name":"Faculty of Medicine, University of New South Wales, Kensington, Sydney 2033, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Patel","sequence":"additional","affiliation":[{"name":"Royal Prince Alfred Hospital, Camperdown, Sydney 2050, Australia"},{"name":"Sydney Medical School, University of Sydney, Camperdown, Sydney 2050, Australia"},{"name":"Heart Research Institute, Newtown, Sydney 2042, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1056\/NEJMra1216063","article-title":"Mechanisms of Acute Coronary Syndromes and Their Implications for Therapy","volume":"368","author":"Libby","year":"2013","journal-title":"New Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Khandkar, C., Madhavan, M.V., Weaver, J.C., Celermajer, D.S., and Karimi Galougahi, K. (2021). Atherothrombosis in Acute Coronary Syndromes\u2014From Mechanistic Insights to Targeted Therapies. Cells, 10.","DOI":"10.3390\/cells10040865"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Vaidya, K., Tucker, B., Patel, S., and Ng, M.K.C. (2021). Acute Coronary Syndromes (ACS)\u2014Unravelling Biology to Identify New Therapies\u2014The Microcirculation as a Frontier for New Therapies in ACS. Cells, 10.","DOI":"10.3390\/cells10092188"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.1161\/CIR.0000000000001052","article-title":"Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association","volume":"145","author":"Tsao","year":"2022","journal-title":"Circulation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e022198","DOI":"10.1161\/JAHA.121.022198","article-title":"Event Rates and Risk Factors for Recurrent Cardiovascular Events and Mortality in a Contemporary Post Acute Coronary Syndrome Population Representing 239 234 Patients During 2005 to 2018 in the United States","volume":"11","author":"Steen","year":"2022","journal-title":"J. Am. Heart Assoc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1056\/NEJMoa1615664","article-title":"Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease","volume":"376","author":"Sabatine","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.ijcard.2022.09.062","article-title":"Higher mortality in acute coronary syndrome patients without standard modifiable risk factors: Results from a global meta-analysis of 1,285,722 patients","volume":"371","author":"Kong","year":"2023","journal-title":"Int. J. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1177\/2047487317720287","article-title":"Increasing proportion of ST elevation myocardial infarction patients with coronary atherosclerosis poorly explained by standard modifiable risk factors","volume":"24","author":"Vernon","year":"2017","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e013296","DOI":"10.1161\/JAHA.119.013296","article-title":"ST-Segment-Elevation Myocardial Infarction (STEMI) Patients Without Standard Modifiable Cardiovascular Risk Factors-How Common Are They, and What Are Their Outcomes?","volume":"8","author":"Vernon","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1056\/NEJMoa1912388","article-title":"Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction","volume":"381","author":"Tardif","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1056\/NEJMoa2021372","article-title":"Colchicine in Patients with Chronic Coronary Disease","volume":"383","author":"Nidorf","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Barraclough, J.Y., Patel, S., Yu, J., Neal, B., and Arnott, C. (2021). The Role of Sodium Glucose Cotransporter-2 Inhibitors in Atherosclerotic Cardiovascular Disease: A Narrative Review of Potential Mechanisms. Cells, 10.","DOI":"10.3390\/cells10102699"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2174\/1573403X13666170426104611","article-title":"The Anti-Inflammatory Effects of Statins on Coronary Artery Disease: An Updated Review of the Literature","volume":"13","author":"Diamantis","year":"2017","journal-title":"Curr. Cardiol. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1093\/eurheartj\/ehab115","article-title":"Efficacy and safety of low-dose colchicine in patients with coronary disease: A systematic review and meta-analysis of randomized trials","volume":"42","author":"Fiolet","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1161\/CIRCRESAHA.116.310527","article-title":"How Common Is Residual Inflammatory Risk?","volume":"120","author":"Ridker","year":"2017","journal-title":"Circ. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.1093\/eurheartj\/ehy633","article-title":"Residual inflammatory risk and the impact on clinical outcomes in patients after percutaneous coronary interventions","volume":"39","author":"Kalkman","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Bartlett, B., Ludewick, H.P., Lee, S., Verma, S., Francis, R.J., and Dwivedi, G. (2021). Imaging Inflammation in Patients and Animals: Focus on PET Imaging the Vulnerable Plaque. Cells, 10.","DOI":"10.3390\/cells10102573"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Yuvaraj, J., Cheng, K., Lin, A., Psaltis, P.J., Nicholls, S.J., and Wong, D.T.L. (2021). The Emerging Role of CT-Based Imaging in Adipose Tissue and Coronary Inflammation. Cells, 10.","DOI":"10.3390\/cells10051196"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Yuvaraj, J., Lin, A., Nerlekar, N., Munnur, R.K., Cameron, J.D., Dey, D., Nicholls, S.J., and Wong, D.T.L. (2021). Pericoronary Adipose Tissue Attenuation Is Associated with High-Risk Plaque and Subsequent Acute Coronary Syndrome in Patients with Stable Coronary Artery Disease. Cells, 10.","DOI":"10.3390\/cells10051143"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Vernon, S.T., Tang, O., Kim, T., Chan, A.S., Kott, K.A., Park, J., Hansen, T., Koay, Y.C., Grieve, S.M., and O\u2019Sullivan, J.F. (2021). Metabolic Signatures in Coronary Artery Disease: Results from the BioHEART-CT Study. Cells, 10.","DOI":"10.3390\/cells10050980"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Vargas-Alarc\u00f3n, G., P\u00e9rez-M\u00e9ndez, O., Gonz\u00e1lez-Pacheco, H., Ram\u00edrez-Bello, J., Posadas-S\u00e1nchez, R., Escobedo, G., and Fragoso, J.M. (2021). The rs508487, rs236911, and rs236918 Genetic Variants of the Proprotein Convertase Subtilisin\u2013Kexin Type 7 (PCSK7) Gene Are Associated with Acute Coronary Syndrome and with Plasma Concentrations of HDL-Cholesterol and Triglycerides. Cells, 10.","DOI":"10.3390\/cells10061444"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/24\/4136\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:44:23Z","timestamp":1760147063000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/24\/4136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,19]]},"references-count":22,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["cells11244136"],"URL":"https:\/\/doi.org\/10.3390\/cells11244136","relation":{},"ISSN":["2073-4409"],"issn-type":[{"type":"electronic","value":"2073-4409"}],"subject":[],"published":{"date-parts":[[2022,12,19]]}}}