{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T06:47:55Z","timestamp":1772002075029,"version":"3.50.1"},"reference-count":81,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001381","name":"National Research Foundation (NRF)","doi-asserted-by":"publisher","award":["NRF-2018R1A2B6002251"],"award-info":[{"award-number":["NRF-2018R1A2B6002251"]}],"id":[{"id":"10.13039\/501100001381","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korea government and Hallym University Medical Center","award":["NRF-2018R1A2B6002251"],"award-info":[{"award-number":["NRF-2018R1A2B6002251"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Damage to human corneal endothelial cells (hCECs) leads to bullous keratopathy because these cells cannot be regenerated in vivo. In this study, we investigated the protective role of microRNA (miR)-302a against interferon-\u03b3 (IFN-\u03b3)-induced senescence and cell death of hCECs. Cultured hCECs were transfected with miR-302a and treated with IFN-\u03b3 (20 ng\/mL) to evaluate the protective effect of miR-302a on IFN-\u03b3-induced cell death. Senescence was evaluated by the senescence-associated \u03b2-galactosidase (SA-\u03b2-gal) assay, and the secretion of senescence-associated secretory phenotype (SASP) factors was analyzed. Mitochondrial function and endoplasmic reticulum (ER) stress were assessed. We revealed that miR-302a enhanced the cell viability and proliferation of hCECs and that IFN-\u03b3 increased the cell size, the number of SA-\u03b2-gal-positive cells, and SASP factors, and arrested the cell cycle, which was eliminated by miR-302a. miR-302a ameliorated mitochondrial oxidative stress and ER stress levels which were induced by IFN-\u03b3. IFN-\u03b3 decreased the mitochondrial membrane potential and promoted autophagy, which was eliminated by miR-302a. The in vivo study showed that regeneration of rat CECs was promoted in the miR-302a group by inhibiting IFN-\u03b3 and enhancing mitochondrial function. In conclusion, miR-302a eliminated IFN-\u03b3-induced senescence and cellular damage by regulating the oxidative and ER stress, and promoting the proliferation of CECs. Therefore, miR-302a may be a therapeutic option to protect hCECs against IFN-\u03b3-induced stress.<\/jats:p>","DOI":"10.3390\/cells12010036","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T03:24:30Z","timestamp":1671679470000},"page":"36","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["MiR-302a Regenerates Human Corneal Endothelial Cells against IFN-\u03b3-Induced Cell Death"],"prefix":"10.3390","volume":"12","author":[{"given":"Se-Hie","family":"Park","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Hallym University Medical Center, College of Medicine, Hallym University, Seoul 07441, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Sun","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hallym University Medical Center, College of Medicine, Hallym University, Seoul 07441, Republic of Korea"},{"name":"Hallym BioEyeTech Research Center, Hallym University College of Medicine, Seoul 07442, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun-Hee","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hallym University Medical Center, College of Medicine, Hallym University, Seoul 07441, Republic of Korea"},{"name":"Hallym BioEyeTech Research Center, Hallym University College of Medicine, Seoul 07442, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4307-7000","authenticated-orcid":false,"given":"Young-Joo","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hallym University Medical Center, College of Medicine, Hallym University, Seoul 07441, Republic of Korea"},{"name":"Hallym BioEyeTech Research Center, Hallym University College of Medicine, Seoul 07442, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jtos.2020.10.006","article-title":"Corneal stromal wound healing: Major regulators and therapeutic targets","volume":"19","author":"Kamil","year":"2021","journal-title":"Ocul. 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