{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:54:38Z","timestamp":1790553278781,"version":"4.1.0"},"reference-count":176,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T00:00:00Z","timestamp":1671840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JSPS Grants-in-Aid for Scientific Research","award":["C 23592588"],"award-info":[{"award-number":["C 23592588"]}]},{"name":"JSPS Grants-in-Aid for Scientific Research","award":["EY024589"],"award-info":[{"award-number":["EY024589"]}]},{"name":"National Eye Institute","award":["C 23592588"],"award-info":[{"award-number":["C 23592588"]}]},{"name":"National Eye Institute","award":["EY024589"],"award-info":[{"award-number":["EY024589"]}]},{"name":"National Institute of Health","award":["C 23592588"],"award-info":[{"award-number":["C 23592588"]}]},{"name":"National Institute of Health","award":["EY024589"],"award-info":[{"award-number":["EY024589"]}]},{"name":"Bridge Grant, UNMC","award":["C 23592588"],"award-info":[{"award-number":["C 23592588"]}]},{"name":"Bridge Grant, UNMC","award":["EY024589"],"award-info":[{"award-number":["EY024589"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Decorin is an archetypal member of the small leucine-rich proteoglycan gene family and is involved in various biological functions and many signaling networks, interacting with extra-cellular matrix (ECM) components, growth factors, and receptor tyrosine kinases. Decorin also modulates the growth factors, cell proliferation, migration, and angiogenesis. It has been reported to be involved in many ischemic and fibrotic eye diseases, such as congenital stromal dystrophy of the cornea, anterior subcapsular fibrosis of the lens, proliferative vitreoretinopathy, et al. Furthermore, recent evidence supports its role in secondary posterior capsule opacification (PCO) after cataract surgery. The expression of decorin mRNA in lens epithelial cells in vitro was found to decrease upon transforming growth factor (TGF)-\u03b2-2 addition and increase upon fibroblast growth factor (FGF)-2 addition. Wound healing of the injured lens in mice transgenic for lens-specific human decorin was promoted by inhibiting myofibroblastic changes. Decorin may be associated with epithelial\u2013mesenchymal transition and PCO development in the lens. Gene therapy and decorin administration have the potential to serve as excellent therapeutic approaches for modifying impaired wound healing, PCO, and other eye diseases related to fibrosis and angiogenesis. In this review, we present findings regarding the roles of decorin in the lens and ocular diseases.<\/jats:p>","DOI":"10.3390\/cells12010074","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T07:30:06Z","timestamp":1672126206000},"page":"74","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Role of Decorin in the Lens and Ocular Diseases"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6789-9311","authenticated-orcid":false,"given":"Eri","family":"Kubo","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Kanazawa Medical University, Kanazawa 920-0293, Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kanazawa Medical University, Kanazawa 920-0293, Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teppei","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kanazawa Medical University, Kanazawa 920-0293, Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6458-5330","authenticated-orcid":false,"given":"Hiroshi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kanazawa Medical University, Kanazawa 920-0293, Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhirendra P.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Nebraska Medical Center, Omaha, NE 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.2174\/156652411794859241","article-title":"Decorin biology, expression, function and therapy in the cornea","volume":"11","author":"Mohan","year":"2011","journal-title":"Curr. 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