{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T14:25:27Z","timestamp":1768141527955,"version":"3.49.0"},"reference-count":51,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,25]],"date-time":"2022-12-25T00:00:00Z","timestamp":1671926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfeicoamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance code 001"],"award-info":[{"award-number":["Finance code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfeicoamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["34935.406.36850.19112012"],"award-info":[{"award-number":["34935.406.36850.19112012"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004612","name":"Funda\u00e7\u00e3o Arauc\u00e1ria","doi-asserted-by":"publisher","award":["Finance code 001"],"award-info":[{"award-number":["Finance code 001"]}],"id":[{"id":"10.13039\/501100004612","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004612","name":"Funda\u00e7\u00e3o Arauc\u00e1ria","doi-asserted-by":"publisher","award":["34935.406.36850.19112012"],"award-info":[{"award-number":["34935.406.36850.19112012"]}],"id":[{"id":"10.13039\/501100004612","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>This study aimed to verify the role of TGFB1 variants (c.\u20131638G&gt;A, c.\u20131347C&gt;T, c.29C&gt;T, and c.74G&gt;C) in HPV infection susceptibility and cervical lesions development, and their impact on TGFB1 cervical and plasma levels. TGFB1 genotypes were assessed with PCR-RFLP and haplotypes were inferred for 190 HPV-uninfected and 161 HPV-infected women. TGFB1 levels were determined with immunofluorimetric assay. Case-control analyses were performed with logistic regression adjusted for possible confounders. Women carrying \u20131347TT or \u20131347CT+TT as well as those with 29CT, 29CC, or 29CT+CC were more likely to have HPV than \u20131347CC and 29TT carriers, respectively. Regarding haplotypes, the most frequent were *4 (GCTG) and *3 (GTCG). Women *4\/*4 were less likely to have HPV than those with no *4 copy. Comparing the inheritance of *3 and *4, carriers of *3\/*4 or *3\/*3 were more susceptible to HPV than *4\/*4. The TGFB1 plasma and cervical levels were higher in the infected patients. Plasma levels were also higher in infected women with low-grade lesions. HPV-infected patients carrying *3\/Other and *3\/Other+*3\/*3 presented lower TGFB1 plasma levels than those with no copy of *3. TGFB1 variants could contribute to the comprehension of the TGFB1 role in HPV-caused cervical disease.<\/jats:p>","DOI":"10.3390\/cells12010084","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T07:31:56Z","timestamp":1672126316000},"page":"84","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Haplotype Structures and Protein Levels of TGFB1 in HPV Infection and Cervical Lesion: A Case-Control Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Kleber Paiva","family":"Trugilo","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Genetics and Immunology, Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, Londrina 86057-970, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme Cesar Martelossi","family":"Cebinelli","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Genetics and Immunology, Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, Londrina 86057-970, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9rica Rom\u00e3o","family":"Pereira","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Genetics and Immunology, Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, Londrina 86057-970, PR, Brazil"},{"name":"Laboratory of Mutagenesis and Oncogenetics, Department of Biological Sciences, State University of Londrina, Londrina 86057-970, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00e1dia Calvo Martins","family":"Okuyama","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Genetics and Immunology, Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, Londrina 86057-970, PR, Brazil"},{"name":"Laboratory of Mutagenesis and Oncogenetics, Department of Biological Sciences, State University of Londrina, Londrina 86057-970, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Cezar-dos-Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Genetics and Immunology, Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, Londrina 86057-970, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2020-7482","authenticated-orcid":false,"given":"Eliza Pizarro","family":"Castilha","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Genetics and Immunology, Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, Londrina 86057-970, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamires","family":"Flauzino","sequence":"additional","affiliation":[{"name":"Laboratory of Research in Applied Immunology, State University of Londrina, Londrina 86057-970, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4000-2417","authenticated-orcid":false,"given":"Val\u00e9ria Bumiller-Bini","family":"Hoch","sequence":"additional","affiliation":[{"name":"Laboratory of Human Molecular Genetics, Department of Genetics, Federal University of Paran\u00e1, Curitiba 80060-000, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Angelica Ehara","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Laboratory of Studies and Applications of DNA Polymorphisms and Immunology, Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, Londrina 86057-970, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta Losi","family":"Guembarovski","sequence":"additional","affiliation":[{"name":"Laboratory of Mutagenesis and Oncogenetics, Department of Biological Sciences, State University of Londrina, Londrina 86057-970, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9666-6963","authenticated-orcid":false,"given":"Karen Braj\u00e3o","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Genetics and Immunology, Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, Londrina 86057-970, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.semcancer.2013.11.002","article-title":"The Human Papillomavirus Family and Its Role in Carcinogenesis","volume":"26","author":"Tommasino","year":"2014","journal-title":"Semin. Cancer Biol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Fernandes, Q., Allouch, S., Gupta, I., Elmakaty, I., Elzawawi, K.E., Amarah, A., Al-Thawadi, H., Al-Farsi, H., Vranic, S., and al Moustafa, A.-E. (2022). Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions. Pathogens, 11.","DOI":"10.3390\/pathogens11111380"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.virol.2010.02.002","article-title":"Classification of Papillomaviruses (PVs) Based on 189 PV Types and Proposal of Taxonomic Amendments","volume":"401","author":"Bernard","year":"2010","journal-title":"Virology"},{"key":"ref_4","unstructured":"(2022, December 15). HPV and Cancer\u2014NCI, Available online: https:\/\/www.cancer.gov\/about-cancer\/causes-prevention\/risk\/infectious-agents\/hpv-and-cancer."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3257939","DOI":"10.1155\/2019\/3257939","article-title":"Human Papillomavirus Infection and Cervical Cancer: Epidemiology, Screening, and Vaccination-Review of Current Perspectives","volume":"2019","author":"Chan","year":"2019","journal-title":"J. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.1002\/cam4.1501","article-title":"The Precision Prevention and Therapy of HPV-Related Cervical Cancer: New Concepts and Clinical Implications","volume":"7","author":"Hu","year":"2018","journal-title":"Cancer Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1155\/2007\/914823","article-title":"The epidemiology of human papillomavirus infection and cervical cancer","volume":"23","author":"Bosch","year":"2007","journal-title":"Dis. Markers"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ygyno.2015.07.110","article-title":"A population-based case-control study of genetic variation in cytokine genes associated with risk of cervical and vulvar cancers","volume":"139","author":"Hardikar","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bjps.2003.12.012","article-title":"What is transforming growth factor-beta (TGF-b)?","volume":"57","author":"Chin","year":"2004","journal-title":"Br. J Plast. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/1479-5876-10-183","article-title":"TGF-\u03b2\u2014An excellent servant but a bad master","volume":"10","author":"Kubiczkova","year":"2012","journal-title":"J. Transl. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/nrc3603","article-title":"The roles of TGF\u03b2 in the tumour microenvironment","volume":"13","author":"Pickup","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1093\/nar\/15.7.3188","article-title":"Intron-exon structure of the human transforming growth factor-beta precursor gene","volume":"15","author":"Derynck","year":"1987","journal-title":"Nucleic Acids Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1684\/ecn.2016.0382","article-title":"TGF-\u03b21 functional polymorphisms: A review","volume":"27","author":"Cebinelli","year":"2016","journal-title":"Eur. Cytokine Netw."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-60327-411-1_1","article-title":"SNPs: Impact on gene function and phenotype","volume":"578","author":"Shastry","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1001\/jama.1991.03460040048027","article-title":"Genital Human Papillomavirus Infection in Female University Students as Determined by a PCR-Based Method","volume":"265","author":"Bauer","year":"1991","journal-title":"JAMA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/s00404-012-2399-y","article-title":"Prevalence of HPV infection and genotypes in women with normal cervical cytology in the state of Paran\u00e1, Brazil","volume":"286","author":"Martins","year":"2012","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/ijc.20370","article-title":"Polymorphisms and haplotype structures in genes for transforming growth factor\u03b21 and its receptors in familial and unselected breast cancers","volume":"112","author":"Jin","year":"2004","journal-title":"Int. J. Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1086\/428594","article-title":"Accounting for Decay of Linkage Disequilibrium in Haplotype Inference and Missing-Data Imputation","volume":"76","author":"Stephens","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1086\/319501","article-title":"A New Statistical Method for Haplotype Reconstruction from Population Data","volume":"68","author":"Stephens","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: Analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1093\/molbev\/msw054","article-title":"MEGA7: Molecular Evolutionary Genetics Analysis version 7.0 for bigger datasets","volume":"33","author":"Kumar","year":"2016","journal-title":"Mol. Biol. Evol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bjid.2015.10.008","article-title":"Cervical human papillomavirus infection and persistence: A clinic-based study in the countryside from South Brazil","volume":"20","author":"Coser","year":"2016","journal-title":"Braz. J. Infect. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S1473-3099(07)70158-5","article-title":"Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: A meta-analysis","volume":"7","author":"Diaz","year":"2007","journal-title":"Lancet Infect. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1007\/s00432-019-02951-x","article-title":"FOXP3 immunoregulatory gene variants are independent predictors of human papillomavirus infection and cervical cancer precursor lesions","volume":"145","author":"Ferreira","year":"2019","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12929-018-0472-y","article-title":"Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: A case-control study","volume":"25","author":"Okuyama","year":"2018","journal-title":"J. Biomed. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.meegid.2017.05.020","article-title":"IL-10 gene polymorphism c.-592C > A increases HPV infection susceptibility and influences IL-10 levels in HPV infected women","volume":"53","author":"Berti","year":"2017","journal-title":"Infect. Genet. Evol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00430-018-0557-y","article-title":"Polymorphisms in the TGFB1 signal peptide influence human papillomavirus infection and development of cervical lesions","volume":"208","author":"Trugilo","year":"2019","journal-title":"Med. Microbiol. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00439-006-0194-1","article-title":"A molecular mechanism for the differential regulation of TGF-\u03b21 expression due to the common SNP-509C-T (c.-1347C > T)","volume":"120","author":"Shah","year":"2006","journal-title":"Hum. Genet."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/hmg\/8.1.93","article-title":"Genetic control of the circulating concentration of transforming growth factor type beta1","volume":"8","author":"Grainger","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0022-1759(99)00127-1","article-title":"Identification of human TGF-\u03b21 signal (leader) sequence polymorphisms by PCR-RFLP","volume":"234","author":"Wood","year":"2000","journal-title":"J. Immunol. Methods"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1097\/00007890-199810270-00009","article-title":"Genotypic variation in the transforming growth factor-beta1 gene: Association with transforming growth factor-beta1 production, fibrotic lung disease, and graft fibrosis after lung transplantation","volume":"66","author":"Awad","year":"1998","journal-title":"Transplantation"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"15376","DOI":"10.3390\/ijms140815376","article-title":"The L10P polymorphism and serum levels of transforming growth factor beta1 in human breast cancer","volume":"14","author":"Taubenschuss","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1161\/01.CIR.101.24.2783","article-title":"Association of a T29 \u2192 C Polymorphism of the Transforming Growth Factor-\u03b21 Gene With Genetic Susceptibility to Myocardial Infarction in Japanese","volume":"101","author":"Yokota","year":"2000","journal-title":"Circulation"},{"key":"ref_35","unstructured":"(2021, December 18). Genome Aggregation Database (gnomAD). Available online: https:\/\/gnomad.broadinstitute.org\/."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-020-2308-7","article-title":"The mutational constraint spectrum quantified from variation in 141,456 humans","volume":"581","author":"Karczewski","year":"2020","journal-title":"Nature"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/ajhb.20976","article-title":"Genetic composition of Brazilian population samples based on a set of twenty-eight ancestry informative SNPs","volume":"22","author":"Lins","year":"2010","journal-title":"Am. J. Hum. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1073\/pnas.0126614100","article-title":"Color and genomic ancestry in Brazilians","volume":"100","author":"Parra","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1158\/1078-0432.CCR-09-2877","article-title":"Association of TGF-beta1 genetic variants with HPV16-positive oropharyngeal cancer","volume":"16","author":"Guan","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ejogrb.2008.04.007","article-title":"A pilot case-control association study of cytokine polymorphisms in Brazilian women presenting with HPV-related cervical lesions","volume":"140","author":"Fernandes","year":"2008","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1590\/0074-02760160051","article-title":"Influence of IL-6, IL-8, and TGF-\u03b21 gene polymorphisms on the risk of human papillomavirus-infection in women from Pernambuco, Brazil","volume":"111","author":"Tavares","year":"2016","journal-title":"Mem. Inst. Oswaldo Cruz."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Marangon, A.V., Guelsin, G.A.S., Visentainer, J.E.L., Borelli, S.D., Watanabe, M.A.E., Consolaro, M.E.L., Caleffi-Ferracioli, K.R., Rudnick, C.C.C., and Sell, A.M. (2013). The Association of the Immune Response Genes to Human Papillomavirus-Related Cervical Disease in a Brazilian Population. Biomed. Res. Int., 2013.","DOI":"10.1155\/2013\/146079"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3727\/096504009789745656","article-title":"Role of TGF-\u03b21 (\u2212509C > T) Promoter Polymorphism in Susceptibility to Cervical Cancer","volume":"18","author":"Singh","year":"2009","journal-title":"Oncol. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s00432-018-2585-9","article-title":"Transforming growth factor-beta 1 (TGF\u03b21) polymorphisms and haplotype structures have dual roles in breast cancer pathogenesis","volume":"144","author":"Vitiello","year":"2018","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1089\/vim.2006.19.468","article-title":"E6 and E7 Oncoproteins from Human Papillomavirus Type 16 Induce Activation of Human Transforming Growth Factor \u03b2 1 Promoter throughout Sp1 Recognition Sequence","volume":"19","year":"2006","journal-title":"Viral. Immunol. Summer"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"753","DOI":"10.5306\/wjco.v5.i4.753","article-title":"Role of IL-10 and TGF-\u03b21 in local immunosuppression in HPV-associated cervical neoplasia","volume":"5","year":"2014","journal-title":"World J. Clin. Oncol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.virol.2013.08.034","article-title":"TGF-\u03b2 regulation of gene expression at early and late stages of HPV16-mediated transformation of human keratinocytes","volume":"447","author":"Kowli","year":"2013","journal-title":"Virology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1128\/jvi.64.10.4767-4775.1990","article-title":"Transforming growth factors beta 1 and 2 transcriptionally regulate human papillomavirus (HPV) type 16 early gene expression in HPV-immortalized human genital epithelial cells","volume":"64","author":"Woodworth","year":"1990","journal-title":"J. Virol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/jmv.25312","article-title":"Detection of regulatory T cell phenotypic markers and cytokines in patients with human papillomavirus infection","volume":"91","author":"Bonin","year":"2019","journal-title":"J. Med. Virol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1172\/JCI89281","article-title":"Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-\u03b2 signaling","volume":"127","author":"Zhang","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"587193","DOI":"10.1155\/2015\/587193","article-title":"TGF\u03b2 Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis","volume":"2015","author":"Papageorgis","year":"2015","journal-title":"J. Oncol."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/1\/84\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:50:41Z","timestamp":1760147441000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/1\/84"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,25]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["cells12010084"],"URL":"https:\/\/doi.org\/10.3390\/cells12010084","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,25]]}}}