{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:30:24Z","timestamp":1790213424974,"version":"4.1.0"},"reference-count":171,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["W81XWH2120457"],"award-info":[{"award-number":["W81XWH2120457"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Posttraumatic headache (PTH) attributed to traumatic brain injury (TBI) is a secondary headache developed within 7 days after head injury, and in a substantial number of patients PTH becomes chronic and lasts for more than 3 months. Current medications are almost entirely relied on the treatment of primary headache such as migraine, due to its migraine-like phenotype and the limited understanding on the PTH pathogenic mechanisms. To this end, increasing preclinical studies have been conducted in the last decade. We focus in this review on the trigeminovascular system from the animal studies since it provides the primary nociceptive sensory afferents innervating the head and face region, and the pathological changes in the trigeminal pathway are thought to play a key role in the development of PTH. In addition to the pathologies, PTH-like behaviors induced by TBI and further exacerbated by nitroglycerin, a general headache inducer through vasodilation are reviewed. We will overview the current pharmacotherapies including calcitonin gene-related peptide (CGRP) monoclonal antibody and sumatriptan in the PTH animal models. Given that modulation of the endocannabinoid (eCB) system has been well-documented in the treatment of migraine and TBI, the therapeutic potential of eCB in PTH will also be discussed.<\/jats:p>","DOI":"10.3390\/cells12010155","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T03:14:28Z","timestamp":1672370068000},"page":"155","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Preclinical Studies of Posttraumatic Headache and the Potential Therapeutics"],"prefix":"10.3390","volume":"12","author":[{"given":"Mikiei","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Anatomy, Physiology and Genetics, Uniformed Services University of Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology and Genetics, Uniformed Services University of Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.3171\/2017.10.JNS17352","article-title":"Estimating the global incidence of traumatic brain injury","volume":"130","author":"Dewan","year":"2018","journal-title":"J. Neurosurg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3233\/NRE-2007-22502","article-title":"The impact of traumatic brain injuries: A global perspective","volume":"22","author":"Hyder","year":"2007","journal-title":"NeuroRehabilitation"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Headache Classification Committee of the International Headache Society (IHS) (2018). The International Classification of Headache Disorders, 3rd edition. Cephalalgia, 38, 1\u2013211.","DOI":"10.1177\/0333102417738202"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41582-019-0243-8","article-title":"Post-traumatic headache: Epidemiology and pathophysiological insights","volume":"15","author":"Ashina","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1468-2982.2004.00818.x","article-title":"Chronic post-traumatic headache\u2014A clinical analysis in relation to the International Headache Classification, 2nd Edition","volume":"25","author":"Baandrup","year":"2005","journal-title":"Cephalalgia"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1177\/0333102411428954","article-title":"Characteristics of acute posttraumatic headache following mild head injury","volume":"31","author":"Platzer","year":"2011","journal-title":"Cephalalgia"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s10194-021-01287-7","article-title":"Psychiatric and cognitive comorbidities of persistent post-traumatic headache attributed to mild traumatic brain injury","volume":"22","author":"Ashina","year":"2021","journal-title":"J. Headache Pain"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1136\/emermed-2015-205429","article-title":"Risk factors and outcomes associated with post-traumatic headache after mild traumatic brain injury","volume":"34","author":"Yilmaz","year":"2017","journal-title":"Emerg. Med. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S1474-4422(21)00094-6","article-title":"Post-traumatic headache attributed to traumatic brain injury: Classification, clinical characteristics, and treatment","volume":"20","author":"Ashina","year":"2021","journal-title":"Lancet Neurol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/head.12254","article-title":"Medication usage patterns for headache treatment after mild traumatic brain injury","volume":"54","author":"DiTommaso","year":"2014","journal-title":"Headache"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/neu.1988.5.1","article-title":"Controlled cortical impact: A new experimental brain injury model","volume":"5","author":"Lighthall","year":"1988","journal-title":"J. Neurotrauma"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1089\/neu.2008.0898","article-title":"An introductory characterization of a combat-casualty-care relevant swine model of closed head injury resulting from exposure to explosive blast","volume":"26","author":"Bauman","year":"2009","journal-title":"J. Neurotrauma"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1089\/cns.1987.4.119","article-title":"Traumatic brain injury in the rat: Characterization of a midline fluid-percussion model","volume":"4","author":"McIntosh","year":"1987","journal-title":"Cent. Nerv. Syst. Trauma"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0306-4522(89)90247-9","article-title":"Traumatic brain injury in the rat: Characterization of a lateral fluid-percussion model","volume":"28","author":"McIntosh","year":"1989","journal-title":"Neuroscience"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0006-8993(81)90067-6","article-title":"Responses to cortical injury: I. Methodology and local effects of contusions in the rat","volume":"211","author":"Feeney","year":"1981","journal-title":"Brain Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1227\/00006123-198805000-00007","article-title":"Experimental closed head injury in rats: Prostaglandin production in a noninjured zone","volume":"22","author":"Shohami","year":"1988","journal-title":"Neurosurgery"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3171\/jns.1994.80.2.0291","article-title":"A new model of diffuse brain injury in rats. Part I: Pathophysiology and biomechanics","volume":"80","author":"Marmarou","year":"1994","journal-title":"J. Neurosurg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1177\/0333102420937664","article-title":"Increased severity of closed head injury or repetitive subconcussive head impacts enhances post-traumatic headache-like behaviors in a rat model","volume":"40","author":"Bree","year":"2020","journal-title":"Cephalalgia"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1177\/0333102415617412","article-title":"Responses of dural mast cells in concussive and blast models of mild traumatic brain injury in mice: Potential implications for post-traumatic headache","volume":"36","author":"Levy","year":"2016","journal-title":"Cephalalgia"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1097\/j.pain.0000000000002103","article-title":"Different forms of traumatic brain injuries cause different tactile hypersensitivity profiles","volume":"162","author":"Wattiez","year":"2021","journal-title":"Pain"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/1531-8249(200005)47:5<614::AID-ANA9>3.0.CO;2-N","article-title":"An association between migraine and cutaneous allodynia","volume":"47","author":"Burstein","year":"2000","journal-title":"Ann. Neurol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1177\/0883073816650036","article-title":"Persistent Headache and Cephalic Allodynia Attributed to Head Trauma in Children and Adolescents","volume":"31","author":"Markus","year":"2016","journal-title":"J. Child Neurol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ynpai.2017.10.001","article-title":"The grimace scale reliably assesses chronic pain in a rodent model of trigeminal neuropathic pain","volume":"2","author":"Akintola","year":"2017","journal-title":"Neurobiol. Pain"},{"key":"ref_24","first-page":"55","article-title":"The Rat Grimace Scale: A partially automated method for quantifying pain in the laboratory rat via facial expressions","volume":"7","author":"Sotocinal","year":"2011","journal-title":"Mol. Pain"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J. Neurosci. Methods"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","article-title":"Efficient analysis of experimental observations","volume":"20","author":"Dixon","year":"1980","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1177\/03331024211010304","article-title":"Photophobia and allodynia in persistent post-traumatic headache are associated with higher disease burden","volume":"41","author":"Cortez","year":"2021","journal-title":"Cephalalgia"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1177\/0333102420907597","article-title":"Enhanced post-traumatic headache-like behaviors and diminished contribution of peripheral CGRP in female rats following a mild closed head injury","volume":"40","author":"Bree","year":"2020","journal-title":"Cephalalgia"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1177\/0333102416681571","article-title":"Development of CGRP-dependent pain and headache related behaviours in a rat model of concussion: Implications for mechanisms of post-traumatic headache","volume":"38","author":"Bree","year":"2018","journal-title":"Cephalalgia"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1177\/0333102419877662","article-title":"CGRP-dependent and independent mechanisms of acute and persistent post-traumatic headache following mild traumatic brain injury in mice","volume":"39","author":"Navratilova","year":"2019","journal-title":"Cephalalgia"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/head.13248","article-title":"Intranasal Oxytocin Attenuates Reactive and Ongoing, Chronic Pain in a Model of Mild Traumatic Brain Injury","volume":"58","author":"Meidahl","year":"2018","journal-title":"Headache"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.pain.2005.05.011","article-title":"Use of a novel thermal operant behavioral assay for characterization of orofacial pain sensitivity","volume":"116","author":"Neubert","year":"2005","journal-title":"Pain"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuropharm.2016.03.016","article-title":"Trigeminal neuroplasticity underlies allodynia in a preclinical model of mild closed head traumatic brain injury (cTBI)","volume":"107","author":"Mustafa","year":"2016","journal-title":"Neuropharmacology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"100030","DOI":"10.1016\/j.ynpai.2019.100030","article-title":"Chronic pain after blast-induced traumatic brain injury in awake rats","volume":"6","author":"Uddin","year":"2019","journal-title":"Neurobiol. Pain"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1080\/02699052.2018.1536282","article-title":"Blast-induced brain injury in rats leads to transient vestibulomotor deficits and persistent orofacial pain","volume":"32","author":"Studlack","year":"2018","journal-title":"Brain Inj."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.jpain.2018.06.004","article-title":"Nociceptive and Cognitive Changes in a Murine Model of Polytrauma","volume":"19","author":"Sahbaie","year":"2018","journal-title":"J. Pain"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/head.14318","article-title":"Cutaneous heat and light-induced pain thresholds in post-traumatic headache attributed to mild traumatic brain injury","volume":"62","author":"Starling","year":"2022","journal-title":"Headache"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1089\/neu.2015.4087","article-title":"Trigeminal Pain Molecules, Allodynia, and Photosensitivity Are Pharmacologically and Genetically Modulated in a Model of Traumatic Brain Injury","volume":"33","author":"Daiutolo","year":"2016","journal-title":"J. Neurotrauma"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"13841","DOI":"10.1038\/s41598-019-50312-y","article-title":"Sensory sensitivity as a link between concussive traumatic brain injury and PTSD","volume":"9","author":"Hoffman","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"682935","DOI":"10.3389\/fnbeh.2021.682935","article-title":"Measuring Anxiety-Like Behaviors in Rodent Models of Traumatic Brain Injury","volume":"15","author":"Tucker","year":"2021","journal-title":"Front. Behav. Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1097\/j.pain.0000000000001818","article-title":"Low-dose interleukin-2 reverses behavioral sensitization in multiple mouse models of headache disorders","volume":"161","author":"Zhang","year":"2020","journal-title":"Pain"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1093\/brain\/123.9.1830","article-title":"Nitric oxide-induced headache in patients with chronic tension-type headache","volume":"123","author":"Ashina","year":"2000","journal-title":"Brain"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.pharmthera.2008.08.003","article-title":"The role of nitric oxide (NO) in migraine, tension-type headache and cluster headache","volume":"120","author":"Olesen","year":"2008","journal-title":"Pharmacol. Ther."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/0333102418777507","article-title":"The development of a mouse model of mTBI-induced post-traumatic migraine, and identification of the delta opioid receptor as a novel therapeutic target","volume":"39","author":"Moye","year":"2019","journal-title":"Cephalalgia"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/ana.410280213","article-title":"Vasoactive peptide release in the extracerebral circulation of humans during migraine headache","volume":"28","author":"Goadsby","year":"1990","journal-title":"Ann. Neurol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1177\/0333102420981666","article-title":"Hypersensitivity to calcitonin gene-related peptide in chronic migraine","volume":"41","author":"Iljazi","year":"2021","journal-title":"Cephalalgia"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1002\/ana.25915","article-title":"Hypersensitivity to Calcitonin Gene-Related Peptide in Post-Traumatic Headache","volume":"88","author":"Ashina","year":"2020","journal-title":"Ann. Neurol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s10194-022-01499-5","article-title":"CGRP-induced migraine-like headache in persistent post-traumatic headache attributed to mild traumatic brain injury","volume":"23","author":"Ashina","year":"2022","journal-title":"J. Headache Pain"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/S0140-6736(19)32504-8","article-title":"Targeting calcitonin gene-related peptide: A new era in migraine therapy","volume":"394","author":"Charles","year":"2019","journal-title":"Lancet"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41582-018-0003-1","article-title":"CGRP as the target of new migraine therapies-successful translation from bench to clinic","volume":"14","author":"Edvinsson","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1146\/annurev-pharmtox-010814-124701","article-title":"Calcitonin gene-related peptide (CGRP): A new target for migraine","volume":"55","author":"Russo","year":"2015","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/384560a0","article-title":"Sensitization of meningeal sensory neurons and the origin of headaches","volume":"384","author":"Strassman","year":"1996","journal-title":"Nature"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1177\/0333102418786261","article-title":"Current understanding of trigeminal ganglion structure and function in headache","volume":"39","author":"Messlinger","year":"2019","journal-title":"Cephalalgia"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.jpain.2013.03.010","article-title":"Differentiation of nerve fibers storing CGRP and CGRP receptors in the peripheral trigeminovascular system","volume":"14","author":"Eftekhari","year":"2013","journal-title":"J. Pain"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1002\/cne.21607","article-title":"Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: Differences between peripheral and central CGRP receptor distribution","volume":"507","author":"Lennerz","year":"2008","journal-title":"J. Comp. Neurol"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/jnr.24341","article-title":"The role of satellite glial cells in orofacial pain","volume":"97","author":"Fan","year":"2019","journal-title":"J. Neurosci. Res."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Ye, Y., Salvo, E., Romero-Reyes, M., Akerman, S., Shimizu, E., Kobayashi, Y., Michot, B., and Gibbs, J. (2021). Glia and Orofacial Pain: Progress and Future Directions. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22105345"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/glia.23554","article-title":"Gap junction mediated signaling between satellite glia and neurons in trigeminal ganglia","volume":"67","author":"Spray","year":"2019","journal-title":"Glia"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1152\/jn.90722.2008","article-title":"Evidence for a role of connexin 43 in trigeminal pain using RNA interference in vivo","volume":"100","author":"Ohara","year":"2008","journal-title":"J. Neurophysiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.neuroscience.2010.01.005","article-title":"Inwardly rectifying potassium channel Kir4.1 is responsible for the native inward potassium conductance of satellite glial cells in sensory ganglia","volume":"166","author":"Tang","year":"2010","journal-title":"Neuroscience"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1523\/JNEUROSCI.5053-07.2008","article-title":"Silencing the Kir4.1 potassium channel subunit in satellite glial cells of the rat trigeminal ganglion results in pain-like behavior in the absence of nerve injury","volume":"28","author":"Vit","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.brainres.2007.12.028","article-title":"Calcitonin gene-related peptide stimulation of nitric oxide synthesis and release from trigeminal ganglion glial cells","volume":"1196","author":"Li","year":"2008","journal-title":"Brain Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature12808","article-title":"Transcranial amelioration of inflammation and cell death after brain injury","volume":"505","author":"Roth","year":"2014","journal-title":"Nature"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.neuroscience.2016.04.046","article-title":"Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies","volume":"328","author":"Miller","year":"2016","journal-title":"Neuroscience"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1177\/0333102416677051","article-title":"Anatomy and immunochemical characterization of the non-arterial peptidergic diffuse dural innervation of the rat and Rhesus monkey: Implications for functional regulation and treatment in migraine","volume":"37","author":"Rice","year":"2017","journal-title":"Cephalalgia"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(99)01855-7","article-title":"Morphological and functional demonstration of rat dura mater mast cell-neuron interactions in vitro and in vivo","volume":"849","author":"Rozniecki","year":"1999","journal-title":"Brain Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.semcdb.2017.02.002","article-title":"Mast cell secretome: Soluble and vesicular components","volume":"67","author":"Vukman","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3389\/fncel.2019.00110","article-title":"Mast Cell Neural Interactions in Health and Disease","volume":"13","author":"Mittal","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/ejp.583","article-title":"Mild closed head injury promotes a selective trigeminal hypernociception: Implications for the acute emergence of post-traumatic headache","volume":"19","author":"Benromano","year":"2015","journal-title":"Eur. J. Pain"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1097\/j.pain.0000000000001481","article-title":"Intact mast cell content during mild head injury is required for development of latent pain sensitization: Implications for mechanisms underlying post-traumatic headache","volume":"160","author":"Bree","year":"2019","journal-title":"Pain"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nrneurol.2013.192","article-title":"Cortical spreading depression and migraine","volume":"9","author":"Charles","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.wneu.2019.10.048","article-title":"Cortical Spreading Depression in the Setting of Traumatic Brain Injury","volume":"134","author":"Soldozy","year":"2020","journal-title":"World Neurosurg."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.npep.2015.03.008","article-title":"Up-regulation of calcitonin gene-related peptide in trigeminal ganglion following chronic exposure to paracetamol in a CSD migraine animal model","volume":"51","author":"Yisarakun","year":"2015","journal-title":"Neuropeptides"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1126\/science.1231897","article-title":"Spreading depression triggers headache by activating neuronal Panx1 channels","volume":"339","author":"Karatas","year":"2013","journal-title":"Science"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"ENEURO.0287-16.2016","DOI":"10.1523\/ENEURO.0287-16.2016","article-title":"Cortical Spreading Depression Promotes Persistent Mechanical Sensitization of Intracranial Meningeal Afferents: Implications for the Intracranial Mechanosensitivity of Migraine","volume":"3","author":"Zhao","year":"2016","journal-title":"eNeuro"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/ana.22329","article-title":"Activation of central trigeminovascular neurons by cortical spreading depression","volume":"69","author":"Zhang","year":"2011","journal-title":"Ann. Neurol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1177\/0333102411422383","article-title":"Effect of cortical spreading depression on basal and evoked traffic in the trigeminovascular sensory system","volume":"31","author":"Lambert","year":"2011","journal-title":"Cephalalgia"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/ana.25926","article-title":"Optogenetic Spreading Depression Elicits Trigeminal Pain and Anxiety Behavior","volume":"89","author":"Harriott","year":"2021","journal-title":"Ann. Neurol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1089\/neu.2018.5844","article-title":"Cortical Spreading Depression Denotes Concussion Injury","volume":"36","author":"Bouley","year":"2019","journal-title":"J. Neurotrauma"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1152\/physrev.00034.2015","article-title":"Pathophysiology of Migraine: A Disorder of Sensory Processing","volume":"97","author":"Goadsby","year":"2017","journal-title":"Physiol. Rev."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.neuron.2004.12.042","article-title":"Positive feedback in a brainstem tactile sensorimotor loop","volume":"45","author":"Nguyen","year":"2005","journal-title":"Neuron"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3109\/08990220.2014.897602","article-title":"Neuropathology in sensory, but not motor, brainstem nuclei of the rat whisker circuit after diffuse brain injury","volume":"31","author":"Miremami","year":"2014","journal-title":"Somatosens. Mot. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s10194-017-0726-1","article-title":"Frequent mild head injury promotes trigeminal sensitivity concomitant with microglial proliferation, astrocytosis, and increased neuropeptide levels in the trigeminal pain system","volume":"18","author":"Tyburski","year":"2017","journal-title":"J. Headache Pain"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1111\/j.1526-4610.2012.02160.x","article-title":"Nociceptive neuropeptide increases and periorbital allodynia in a model of traumatic brain injury","volume":"52","author":"Elliott","year":"2012","journal-title":"Headache"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"981","DOI":"10.4103\/1673-5374.208594","article-title":"Mild closed head traumatic brain injury-induced changes in monoamine neurotransmitters in the trigeminal subnuclei of a rat model: Mechanisms underlying orofacial allodynias and headache","volume":"12","author":"Mustafa","year":"2017","journal-title":"Neural Regen. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.bbr.2016.12.038","article-title":"Does time heal all wounds? Experimental diffuse traumatic brain injury results in persisting histopathology in the thalamus","volume":"340","author":"Thomas","year":"2018","journal-title":"Behav. Brain Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neuroscience.2012.08.058","article-title":"Morphological and genetic activation of microglia after diffuse traumatic brain injury in the rat","volume":"225","author":"Cao","year":"2012","journal-title":"Neuroscience"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1089\/neu.2011.2091","article-title":"Hypersensitive glutamate signaling correlates with the development of late-onset behavioral morbidity in diffuse brain-injured circuitry","volume":"29","author":"Thomas","year":"2012","journal-title":"J. Neurotrauma"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1007\/BF02423504","article-title":"Stimulation of cranial vessels excites nociceptive neurones in several thalamic nuclei of the cat","volume":"81","author":"Zagami","year":"1990","journal-title":"Exp. Brain Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"14204","DOI":"10.1523\/JNEUROSCI.3285-11.2011","article-title":"Cortical projections of functionally identified thalamic trigeminovascular neurons: Implications for migraine headache and its associated symptoms","volume":"31","author":"Noseda","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1097\/j.pain.0000000000002147","article-title":"Increase in trigeminal ganglion neurons that respond to both calcitonin gene-related peptide and pituitary adenylate cyclase-activating polypeptide in mouse models of chronic migraine and posttraumatic headache","volume":"162","author":"Guo","year":"2021","journal-title":"Pain"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1177\/03331024221099841","article-title":"Preclinical assessment of onabotulinumtoxinA for the treatment of mild traumatic brain injury-related acute and persistent post-traumatic headache","volume":"42","author":"Navratilova","year":"2022","journal-title":"Cephalalgia"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s10194-019-0968-1","article-title":"Migraine-provoking substances evoke periorbital allodynia in mice","volume":"20","author":"Landini","year":"2019","journal-title":"J. Headache Pain"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1177\/0333102420981688","article-title":"CGRP monoclonal antibody prevents the loss of diffuse noxious inhibitory controls (DNIC) in a mouse model of post-traumatic headache","volume":"41","author":"Kopruszinski","year":"2021","journal-title":"Cephalalgia"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s10194-017-0807-1","article-title":"Blocking CGRP in migraine patients\u2014A review of pros and cons","volume":"18","author":"Deen","year":"2017","journal-title":"J. Headache Pain"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.me.44.020193.001045","article-title":"SUMATRIPTAN: A receptor-targeted treatment for migraine","volume":"44","author":"Moskowitz","year":"1993","journal-title":"Annu. Rev. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/ana.410330109","article-title":"The trigeminovascular system and migraine: Studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats","volume":"33","author":"Goadsby","year":"1993","journal-title":"Ann. Neurol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1523\/JNEUROSCI.19-09-03423.1999","article-title":"Regulation of calcitonin gene-related peptide secretion by a serotonergic antimigraine drug","volume":"19","author":"Durham","year":"1999","journal-title":"J. Neurosci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"107528","DOI":"10.1016\/j.pharmthera.2020.107528","article-title":"Pharmacological treatment of migraine: CGRP and 5-HT beyond the triptans","volume":"211","author":"Villalon","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1093\/brain\/awq159","article-title":"Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers","volume":"133","author":"Ossipov","year":"2010","journal-title":"Brain"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/ana.21897","article-title":"Triptan-induced latent sensitization: A possible basis for medication overuse headache","volume":"67","author":"Ossipov","year":"2010","journal-title":"Ann. Neurol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.biopsych.2015.07.028","article-title":"An Introduction to the Endogenous Cannabinoid System","volume":"79","author":"Lu","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.phrs.2009.02.010","article-title":"The endocannabinoid system: Its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation","volume":"60","year":"2009","journal-title":"Pharmacol. Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"20941","DOI":"10.1073\/pnas.1011663107","article-title":"Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening","volume":"107","author":"Bachovchin","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1038\/jcbfm.2011.53","article-title":"N-arachidonoyl-L-serine is neuroprotective after traumatic brain injury by reducing apoptosis","volume":"31","author":"Trembovler","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3389\/fnmol.2018.00487","article-title":"Cannabinoid Ligands Targeting TRP Channels","volume":"11","author":"Muller","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fphar.2017.00069","article-title":"Endocannabinoids: A Promising Impact for Traumatic Brain Injury","volume":"8","author":"Schurman","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Lo Castro, F., Baraldi, C., Pellesi, L., and Guerzoni, S. (2022). Clinical Evidence of Cannabinoids in Migraine: A Narrative Review. J. Clin. Med., 11.","DOI":"10.3390\/jcm11061479"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1089\/neu.2020.7148","article-title":"Use of Medical Cannabis to Treat Traumatic Brain Injury","volume":"38","author":"Hergert","year":"2021","journal-title":"J. Neurotrauma"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1113\/jphysiol.2002.035063","article-title":"The actions of anandamide on rat superficial medullary dorsal horn neurons in vitro","volume":"548","author":"Jennings","year":"2003","journal-title":"J. Physiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/sj.bjp.0705711","article-title":"Modulation of trigeminal sensory neuron activity by the dual cannabinoid-vanilloid agonists anandamide, N-arachidonoyl-dopamine and arachidonyl-2-chloroethylamide","volume":"141","author":"Price","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuropharm.2017.12.013","article-title":"Differential neuromodulatory role of endocannabinoids in the rodent trigeminal sensory ganglion and cerebral cortex relevant to pain processing","volume":"131","author":"Eroli","year":"2018","journal-title":"Neuropharmacology"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/sj.bjp.0702636","article-title":"Cannabinoid receptor activation inhibits GABAergic neurotransmission in rostral ventromedial medulla neurons in vitro","volume":"127","author":"Vaughan","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"878","DOI":"10.4103\/1673-5374.131607","article-title":"Regulatory effects of anandamide on intracellular Ca2+ concentration increase in trigeminal ganglion neurons","volume":"9","author":"Zhang","year":"2014","journal-title":"Neural Regen. Res."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Della Pietra, A., Giniatullin, R., and Savinainen, J.R. (2021). Distinct Activity of Endocannabinoid-Hydrolyzing Enzymes MAGL and FAAH in Key Regions of Peripheral and Central Nervous System Implicated in Migraine. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031204"},{"key":"ref_116","first-page":"31","article-title":"Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?","volume":"25","author":"Russo","year":"2004","journal-title":"Neuro Endocrinol. Lett."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1468-2982.2005.01031.x","article-title":"Biochemical changes in endocannabinoid system are expressed in platelets of female but not male migraineurs","volume":"26","author":"Cupini","year":"2006","journal-title":"Cephalalgia"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.nbd.2008.01.003","article-title":"Degradation of endocannabinoids in chronic migraine and medication overuse headache","volume":"30","author":"Cupini","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1177\/0333102420949201","article-title":"Peripheral changes of endocannabinoid system components in episodic and chronic migraine patients: A pilot study","volume":"41","author":"Greco","year":"2021","journal-title":"Cephalalgia"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00228-007-0391-4","article-title":"Endocannabinoids in platelets of chronic migraine patients and medication-overuse headache patients: Relation with serotonin levels","volume":"64","author":"Rossi","year":"2008","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1038\/sj.npp.1301246","article-title":"Endocannabinoids in chronic migraine: CSF findings suggest a system failure","volume":"32","author":"Sarchielli","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1468-2982.2009.01924.x","article-title":"Alterations of the endocannabinoid system in an animal model of migraine: Evaluation in cerebral areas of rat","volume":"30","author":"Greco","year":"2010","journal-title":"Cephalalgia"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"615028","DOI":"10.3389\/fphar.2020.615028","article-title":"DAGLalpha Inhibition as a Non-invasive and Translational Model of Episodic Headache","volume":"11","author":"Levine","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10194-010-0274-4","article-title":"Effects of anandamide in migraine: Data from an animal model","volume":"12","author":"Greco","year":"2011","journal-title":"J. Headache Pain"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.euroneuro.2015.04.001","article-title":"Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice","volume":"25","author":"Nozaki","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"105157","DOI":"10.1016\/j.nbd.2020.105157","article-title":"Characterization of the peripheral FAAH inhibitor, URB937, in animal models of acute and chronic migraine","volume":"147","author":"Greco","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1177\/0333102414566862","article-title":"Effects of peripheral FAAH blockade on NTG-induced hyperalgesia\u2014Evaluation of URB937 in an animal model of migraine","volume":"35","author":"Greco","year":"2015","journal-title":"Cephalalgia"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1124\/jpet.103.059808","article-title":"Anandamide is able to inhibit trigeminal neurons using an in vivo model of trigeminovascular-mediated nociception","volume":"309","author":"Akerman","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1111\/ejn.14897","article-title":"Receptor mechanisms mediating the anti-neuroinflammatory effects of endocannabinoid system modulation in a rat model of migraine","volume":"55","author":"Kilinc","year":"2022","journal-title":"Eur. J. Neurosci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"809352","DOI":"10.3389\/fpain.2022.809352","article-title":"Inhibition of Nociception in a Preclinical Episodic Migraine Model by Dietary Supplementation of Grape Seed Extract Involves Activation of Endocannabinoid Receptors","volume":"3","author":"Woodman","year":"2022","journal-title":"Front. Pain Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.neuropharm.2014.06.006","article-title":"The fatty acid amide hydrolase inhibitor PF-3845 promotes neuronal survival, attenuates inflammation and improves functional recovery in mice with traumatic brain injury","volume":"85","author":"Tchantchou","year":"2014","journal-title":"Neuropharmacology"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1046\/j.1471-4159.2001.00542.x","article-title":"Anandamide, but not 2-arachidonoylglycerol, accumulates during in vivo neurodegeneration","volume":"78","author":"Hansen","year":"2001","journal-title":"J. Neurochem."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/35097089","article-title":"An endogenous cannabinoid (2-AG) is neuroprotective after brain injury","volume":"413","author":"Panikashvili","year":"2001","journal-title":"Nature"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Selvaraj, P., Tanaka, M., Wen, J., and Zhang, Y. (2021). The Novel Monoacylglycerol Lipase Inhibitor MJN110 Suppresses Neuroinflammation, Normalizes Synaptic Composition and Improves Behavioral Performance in the Repetitive Traumatic Brain Injury Mouse Model. Cells, 10.","DOI":"10.3390\/cells10123454"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/978-3-030-21735-8_16","article-title":"Bioactive Lipids in Cancer, Inflammation and Related Diseases: Acute and Chronic Mild Traumatic Brain Injury Differentially Changes Levels of Bioactive Lipids in the CNS Associated with Headache","volume":"1161","author":"Leishman","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"E6937","DOI":"10.1073\/pnas.1803389115","article-title":"Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception","volume":"115","author":"Long","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3389\/fphar.2017.00095","article-title":"Palmitoylethanolamide Reduces Neuropsychiatric Behaviors by Restoring Cortical Electrophysiological Activity in a Mouse Model of Mild Traumatic Brain Injury","volume":"8","author":"Guida","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.bbi.2012.07.021","article-title":"Administration of palmitoylethanolamide (PEA) protects the neurovascular unit and reduces secondary injury after traumatic brain injury in mice","volume":"26","author":"Ahmad","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1089\/neu.2018.6226","article-title":"Therapeutic Effect of a Novel Fatty Acid Amide Hydrolase Inhibitor PF04457845 in the Repetitive Closed Head Injury Mouse Model","volume":"36","author":"Selvaraj","year":"2019","journal-title":"J. Neurotrauma"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1089\/neu.2014.3508","article-title":"Endocannabinoid degradation inhibition improves neurobehavioral function, blood-brain barrier integrity, and neuroinflammation following mild traumatic brain injury","volume":"32","author":"Katz","year":"2015","journal-title":"J. Neurotrauma"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1089\/neu.2016.4452","article-title":"Inhibition of Endocannabinoid Degradation Improves Outcomes from Mild Traumatic Brain Injury: A Mechanistic Role for Synaptic Hyperexcitability","volume":"34","author":"Mayeux","year":"2017","journal-title":"J. Neurotrauma"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1152\/jn.00570.2019","article-title":"Endocannabinoid degradation inhibitors ameliorate neuronal and synaptic alterations following traumatic brain injury","volume":"123","author":"Fucich","year":"2020","journal-title":"J. Neurophysiol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/jcbfm.2014.216","article-title":"Inhibition of monoacylglycerol lipase prevents chronic traumatic encephalopathy-like neuropathology in a mouse model of repetitive mild closed head injury","volume":"35","author":"Zhang","year":"2015","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1089\/neu.2012.2647","article-title":"Selective inhibition of alpha\/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury","volume":"30","author":"Tchantchou","year":"2013","journal-title":"J. Neurotrauma"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3389\/fneur.2020.00087","article-title":"Endocannabinoid Modulation of Microglial Phenotypes in Neuropathology","volume":"11","author":"Tanaka","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3389\/fnmol.2017.00200","article-title":"Direct Anandamide Activation of TRPV1 Produces Divergent Calcium and Current Responses","volume":"10","author":"Fenwick","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1038\/sj.bjp.0705896","article-title":"Anandamide acts as a vasodilator of dural blood vessels in vivo by activating TRPV1 receptors","volume":"142","author":"Akerman","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/sj.bjp.0707141","article-title":"Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol","volume":"150","author":"Ho","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Zubrzycki, M., Zubrzycka, M., Wysiadecki, G., Szemraj, J., Jerczynska, H., and Stasiolek, M. (2022). Effect of Fatty Acid Amide Hydrolase Inhibitor URB597 on Orofacial Pain Perception in Rats. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23094665"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0006-8993(98)01368-7","article-title":"Anatomical basis for cannabinoid-induced antinociception as revealed by intracerebral microinjections","volume":"822","author":"Martin","year":"1999","journal-title":"Brain Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1016\/0024-3205(95)00195-C","article-title":"An examination of the central sites of action of cannabinoid-induced antinociception in the rat","volume":"56","author":"Martin","year":"1995","journal-title":"Life Sci."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1523\/JNEUROSCI.4047-15.2016","article-title":"Rescue of Impaired mGluR5-Driven Endocannabinoid Signaling Restores Prefrontal Cortical Output to Inhibit Pain in Arthritic Rats","volume":"36","author":"Kiritoshi","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1038\/s41593-019-0481-5","article-title":"A neuronal circuit for activating descending modulation of neuropathic pain","volume":"22","author":"Huang","year":"2019","journal-title":"Nat. Neurosci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.celrep.2015.07.001","article-title":"Role of Prelimbic GABAergic Circuits in Sensory and Emotional Aspects of Neuropathic Pain","volume":"12","author":"Zhang","year":"2015","journal-title":"Cell Rep."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neuropharm.2012.03.024","article-title":"Modulation of pyramidal cell output in the medial prefrontal cortex by mGluR5 interacting with CB1","volume":"66","author":"Kiritoshi","year":"2013","journal-title":"Neuropharmacology"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1744806918814345","DOI":"10.1177\/1744806918814345","article-title":"Analgesic effects of FAAH inhibitor in the insular cortex of nerve-injured rats","volume":"14","author":"Kim","year":"2018","journal-title":"Mol. Pain"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1523\/JNEUROSCI.1310-16.2016","article-title":"Compensatory Activation of Cannabinoid CB2 Receptor Inhibition of GABA Release in the Rostral Ventromedial Medulla in Inflammatory Pain","volume":"37","author":"Li","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.neuroscience.2003.10.001","article-title":"Antinociception and modulation of rostral ventromedial medulla neuronal activity by local microinfusion of a cannabinoid receptor agonist","volume":"124","author":"Meng","year":"2004","journal-title":"Neuroscience"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/26481","article-title":"An analgesia circuit activated by cannabinoids","volume":"395","author":"Meng","year":"1998","journal-title":"Nature"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"12198","DOI":"10.1073\/pnas.96.21.12198","article-title":"Pain modulation by release of the endogenous cannabinoid anandamide","volume":"96","author":"Walker","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/S0028-3908(03)00235-1","article-title":"Effects of direct periaqueductal grey administration of a cannabinoid receptor agonist on nociceptive and aversive responses in rats","volume":"45","author":"Finn","year":"2003","journal-title":"Neuropharmacology"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/j.1476-5381.2010.01063.x","article-title":"Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action","volume":"162","author":"Maione","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1124\/jpet.105.093286","article-title":"Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 receptors","volume":"316","author":"Maione","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"14869","DOI":"10.1523\/JNEUROSCI.0943-13.2013","article-title":"Endocannabinoids in the brainstem modulate dural trigeminovascular nociceptive traffic via CB1 and \u201ctriptan\u201d receptors: Implications in migraine","volume":"33","author":"Akerman","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1080\/02699052.2020.1807052","article-title":"Use of CGRP receptor blocker erenumab in the management of post-traumatic headache: A case series of 5 women","volume":"34","author":"VanderEnde","year":"2020","journal-title":"Brain Inj."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s10194-020-01136-z","article-title":"Efficacy, tolerability, and safety of erenumab for the preventive treatment of persistent post-traumatic headache attributed to mild traumatic brain injury: An open-label study","volume":"21","author":"Ashina","year":"2020","journal-title":"J. Headache Pain"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s10194-017-0796-0","article-title":"Persistent post-traumatic headache vs. migraine: An MRI study demonstrating differences in brain structure","volume":"18","author":"Schwedt","year":"2017","journal-title":"J. Headache Pain"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1177\/0333102418815650","article-title":"Differences in fibertract profiles between patients with migraine and those with persistent post-traumatic headache","volume":"39","author":"Chong","year":"2019","journal-title":"Cephalalgia"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1177\/0333102420941115","article-title":"Low plasma levels of calcitonin gene-related peptide in persistent post-traumatic headache attributed to mild traumatic brain injury","volume":"40","author":"Ashina","year":"2020","journal-title":"Cephalalgia"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/WCO.0000000000000440","article-title":"Calcitonin gene-related peptide in peripheral blood as a biomarker for migraine","volume":"30","author":"Ramon","year":"2017","journal-title":"Curr. Opin. Neurol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1177\/0333102420941114","article-title":"The analysis of calcitonin gene-related peptide\u2014A narrow path between useful and misleading findings","volume":"40","author":"Hoffmann","year":"2020","journal-title":"Cephalalgia"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/1\/155\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:56:13Z","timestamp":1760147773000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/1\/155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,30]]},"references-count":171,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["cells12010155"],"URL":"https:\/\/doi.org\/10.3390\/cells12010155","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,30]]}}}