{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:20:14Z","timestamp":1790288414262,"version":"4.1.0"},"reference-count":181,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"China National Major Research and Development Plan","award":["0111900"],"award-info":[{"award-number":["0111900"]}]},{"name":"China National Major Research and Development Plan","award":["LQ20C020002"],"award-info":[{"award-number":["LQ20C020002"]}]},{"name":"China National Major Research and Development Plan","award":["IOS1758767"],"award-info":[{"award-number":["IOS1758767"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["0111900"],"award-info":[{"award-number":["0111900"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LQ20C020002"],"award-info":[{"award-number":["LQ20C020002"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["IOS1758767"],"award-info":[{"award-number":["IOS1758767"]}]},{"name":"U.S. National Science Foundation","award":["0111900"],"award-info":[{"award-number":["0111900"]}]},{"name":"U.S. National Science Foundation","award":["LQ20C020002"],"award-info":[{"award-number":["LQ20C020002"]}]},{"name":"U.S. National Science Foundation","award":["IOS1758767"],"award-info":[{"award-number":["IOS1758767"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Salicylic acid (SA) is a phenolic compound produced by all plants that has an important role in diverse processes of plant growth and stress responses. SA is also the principal metabolite of aspirin and is responsible for many of the anti-inflammatory, cardioprotective and antitumor activities of aspirin. As a result, the number of identified SA targets in both plants and humans is large and continues to increase. These SA targets include catalases\/peroxidases, metabolic enzymes, protein kinases and phosphatases, nucleosomal and ribosomal proteins and regulatory and signaling proteins, which mediate the diverse actions of SA in plants and humans. While some of these SA targets and actions are unique to plants or humans, many others are conserved or share striking similarities in the two types of organisms, which underlie a host of common biological processes that are regulated or impacted by SA. In this review, we compare shared and related SA targets and activities to highlight the common nature of actions by SA as a hormone in plants versus a therapeutic agent in humans. The cross examination of SA targets and activities can help identify new actions of SA and better explain their underlying mechanisms in plants and humans.<\/jats:p>","DOI":"10.3390\/cells12020219","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T01:33:30Z","timestamp":1672882410000},"page":"219","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Shared and Related Molecular Targets and Actions of Salicylic Acid in Plants and Humans"],"prefix":"10.3390","volume":"12","author":[{"given":"Yuanyuan","family":"Ding","sequence":"first","affiliation":[{"name":"College of Life Sciences, China Jiliang University, Hangzhou 310018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baofang","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Botany and Plant Pathology and Purdue Center for Plant Biology, Purdue University, West Lafayette, IN 47907-2054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Life Sciences, China Jiliang University, Hangzhou 310018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5472-4560","authenticated-orcid":false,"given":"Zhixiang","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Life Sciences, China Jiliang University, Hangzhou 310018, China"},{"name":"Department of Botany and Plant Pathology and Purdue Center for Plant Biology, Purdue University, West Lafayette, IN 47907-2054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.4161\/psb.4.6.8392","article-title":"Biosynthesis of salicylic acid in plants","volume":"4","author":"Chen","year":"2009","journal-title":"Plant Signal. 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