{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:20:40Z","timestamp":1791490840246,"version":"4.3.4"},"reference-count":103,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T00:00:00Z","timestamp":1674950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Canadian Institutes of Health Research (CIHR)","award":["RGPIN-2022-04368"],"award-info":[{"award-number":["RGPIN-2022-04368"]}]},{"name":"Canadian Institutes of Health Research (CIHR)","award":["281993"],"award-info":[{"award-number":["281993"]}]},{"name":"Quantum Leap II program of the Consortium Qu\u00e9b\u00e9cois sur la D\u00e9couverte du M\u00e9dicament (CQDM)","award":["RGPIN-2022-04368"],"award-info":[{"award-number":["RGPIN-2022-04368"]}]},{"name":"Quantum Leap II program of the Consortium Qu\u00e9b\u00e9cois sur la D\u00e9couverte du M\u00e9dicament (CQDM)","award":["281993"],"award-info":[{"award-number":["281993"]}]},{"name":"Natural Sciences and Engineering Research Council of Canada (NSERC)","award":["RGPIN-2022-04368"],"award-info":[{"award-number":["RGPIN-2022-04368"]}]},{"name":"Natural Sciences and Engineering Research Council of Canada (NSERC)","award":["281993"],"award-info":[{"award-number":["281993"]}]},{"name":"Fonds de Recherche Qu\u00e9bec-Sant\u00e9 (FRQS)","award":["RGPIN-2022-04368"],"award-info":[{"award-number":["RGPIN-2022-04368"]}]},{"name":"Fonds de Recherche Qu\u00e9bec-Sant\u00e9 (FRQS)","award":["281993"],"award-info":[{"award-number":["281993"]}]},{"name":"Fondation Arbour and the Fondation Armand-Frappier","award":["RGPIN-2022-04368"],"award-info":[{"award-number":["RGPIN-2022-04368"]}]},{"name":"Fondation Arbour and the Fondation Armand-Frappier","award":["281993"],"award-info":[{"award-number":["281993"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The first studies suggesting that abnormal expression of galectins is associated with cancer were published more than 30 years ago. Today, the role of galectins in cancer is relatively well established. We know that galectins play an active role in many types of cancer by regulating cell growth, conferring cell death resistance, or inducing local and systemic immunosuppression, allowing tumor cells to escape the host immune response. However, most of these studies have focused on very few galectins, most notably galectin-1 and galectin-3, and more recently, galectin-7 and galectin-9. Whether other galectins play a role in cancer remains unclear. This is particularly true for placental galectins, a subgroup that includes galectin-13, -14, and -16. The role of these galectins in placental development has been well described, and excellent reviews on their role during pregnancy have been published. At first sight, it was considered unlikely that placental galectins were involved in cancer. Yet, placentation and cancer progression share several cellular and molecular features, including cell invasion, immune tolerance and vascular remodeling. The development of new research tools and the concomitant increase in database repositories for high throughput gene expression data of normal and cancer tissues provide a new opportunity to examine the potential involvement of placental galectins in cancer. In this review, we discuss the possible roles of placental galectins in cancer progression and why they should be considered in cancer studies. We also address challenges associated with developing novel research tools to investigate their protumorigenic functions and design highly specific therapeutic drugs.<\/jats:p>","DOI":"10.3390\/cells12030437","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T07:56:48Z","timestamp":1675065408000},"page":"437","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Placental Galectins in Cancer: Why We Should Pay More Attention"],"prefix":"10.3390","volume":"12","author":[{"given":"Camille","family":"Fuselier","sequence":"first","affiliation":[{"name":"INRS-Centre Armand-Frappier Sant\u00e9 Biotechnologie, Institut National de la Recherche Scientifique, 531 Boul. des Prairies, Laval, QC H7 V 1B7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Dumoulin","sequence":"additional","affiliation":[{"name":"INRS-Centre Armand-Frappier Sant\u00e9 Biotechnologie, Institut National de la Recherche Scientifique, 531 Boul. des Prairies, Laval, QC H7 V 1B7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Par\u00e9","sequence":"additional","affiliation":[{"name":"INRS-Centre Armand-Frappier Sant\u00e9 Biotechnologie, Institut National de la Recherche Scientifique, 531 Boul. des Prairies, Laval, QC H7 V 1B7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Nehm\u00e9","sequence":"additional","affiliation":[{"name":"INRS-Centre Armand-Frappier Sant\u00e9 Biotechnologie, Institut National de la Recherche Scientifique, 531 Boul. des Prairies, Laval, QC H7 V 1B7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samy","family":"Ajarrag","sequence":"additional","affiliation":[{"name":"INRS-Centre Armand-Frappier Sant\u00e9 Biotechnologie, Institut National de la Recherche Scientifique, 531 Boul. des Prairies, Laval, QC H7 V 1B7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippine","family":"Granger Joly de Boissel","sequence":"additional","affiliation":[{"name":"INRS-Centre Armand-Frappier Sant\u00e9 Biotechnologie, Institut National de la Recherche Scientifique, 531 Boul. des Prairies, Laval, QC H7 V 1B7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Chatenet","sequence":"additional","affiliation":[{"name":"INRS-Centre Armand-Frappier Sant\u00e9 Biotechnologie, Institut National de la Recherche Scientifique, 531 Boul. des Prairies, Laval, QC H7 V 1B7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1952-9380","authenticated-orcid":false,"given":"Nicolas","family":"Doucet","sequence":"additional","affiliation":[{"name":"INRS-Centre Armand-Frappier Sant\u00e9 Biotechnologie, Institut National de la Recherche Scientifique, 531 Boul. des Prairies, Laval, QC H7 V 1B7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1948-2041","authenticated-orcid":false,"given":"Yves","family":"St-Pierre","sequence":"additional","affiliation":[{"name":"INRS-Centre Armand-Frappier Sant\u00e9 Biotechnologie, Institut National de la Recherche Scientifique, 531 Boul. des Prairies, Laval, QC H7 V 1B7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0092-8674(94)90498-7","article-title":"Galectins: A Family of Animal Beta-Galactoside-Binding Lectins","volume":"76","author":"Barondes","year":"1994","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1126\/science.1102109","article-title":"Regulation of Cytokine Receptors by Golgi N-Glycan Processing and Endocytosis","volume":"306","author":"Partridge","year":"2004","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nrc3982","article-title":"Glycosylation in Cancer: Mechanisms and Clinical Implications","volume":"15","author":"Pinho","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1177\/1535370216650055","article-title":"Engineering Galectin\u2013Glycan Interactions for Immunotherapy and Immunomodulation","volume":"241","author":"Farhadi","year":"2016","journal-title":"Exp. Biol. Med."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Huang, Y., Wang, H.-C., Zhao, J., Wu, M.-H., and Shih, T.-C. (2021). Immunosuppressive Roles of Galectin-1 in the Tumor Microenvironment. Biomolecules, 11.","DOI":"10.3390\/biom11101398"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1182\/blood-2018-04-846014","article-title":"Extracellular Galectins as Controllers of Cytokines in Hematological Cancer","volume":"132","author":"Bruger","year":"2018","journal-title":"Blood"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/s41467-017-00925-6","article-title":"Galectin-3 Captures Interferon-Gamma in the Tumor Matrix Reducing Chemokine Gradient Production and T-Cell Tumor Infiltration","volume":"8","author":"Hirsch","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Chou, F.-C., Chen, H.-Y., Kuo, C.-C., and Sytwu, H.-K. (2018). Role of Galectins in Tumors and in Clinical Immunotherapy. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19020430"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e002371","DOI":"10.1136\/jitc-2021-002371","article-title":"Enhancing Clinical and Immunological Effects of Anti-PD-1 with Belapectin, a Galectin-3 Inhibitor","volume":"9","author":"Curti","year":"2021","journal-title":"J Immunother. Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5553","DOI":"10.1172\/JCI129025","article-title":"Galectin-1\u2013Driven T Cell Exclusion in the Tumor Endothelium Promotes Immunotherapy Resistance","volume":"129","author":"Nambiar","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/s41467-021-21099-2","article-title":"Galectin-9 Interacts with PD-1 and TIM-3 to Regulate T Cell Death and Is a Target for Cancer Immunotherapy","volume":"12","author":"Yang","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e20182041","DOI":"10.1084\/jem.20182041","article-title":"Sweetening the Hallmarks of Cancer: Galectins as Multifunctional Mediators of Tumor Progression","volume":"217","author":"Girotti","year":"2019","journal-title":"J. Exp. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.cell.2014.01.043","article-title":"Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors","volume":"156","author":"Croci","year":"2014","journal-title":"Cell"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.7150\/thno.25784","article-title":"HSP40 Co-Chaperone Protein Tid1 Suppresses Metastasis of Head and Neck Cancer by Inhibiting Galectin-7-TCF3-MMP9 Axis Signaling","volume":"8","author":"Chen","year":"2018","journal-title":"Theranostics"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.2353\/ajpath.2010.090876","article-title":"Overexpression of Galectin-7, A Myoepithelial Cell Marker, Enhances Spontaneous Metastasis of Breast Cancer Cells","volume":"176","author":"Demers","year":"2010","journal-title":"Am. J. Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.canlet.2021.04.011","article-title":"The TIM3\/Gal9 Signaling Pathway: An Emerging Target for Cancer Immunotherapy","volume":"510","author":"Kandel","year":"2021","journal-title":"Cancer Lett."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Li, C.-H., Chang, Y.-C., Chan, M.-H., Yang, Y.-F., Liang, S.-M., and Hsiao, M. (2021). Galectins in Cancer and the Microenvironment: Functional Roles, Therapeutic Developments, and Perspectives. Biomedicines, 9.","DOI":"10.3390\/biomedicines9091159"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.3892\/ijo.2014.2267","article-title":"Intracellular Galectins in Cancer Cells: Potential New Targets for Therapy (Review)","volume":"44","author":"Vladoiu","year":"2014","journal-title":"Int. J. Oncol."},{"key":"ref_19","unstructured":"Cummings, R.D., Liu, F.-T., Rabinovich, G.A., Stowell, S.R., and Vasta, G.R. (2022). Galectins, Cold Spring Harbor Laboratory Press."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0969-2126(01)00275-1","article-title":"Crystal Structure of Human Charcot-Leyden Crystal Protein, an Eosinophil Lysophospholipase, Identifies It as a New Member of the Carbohydrate-Binding Family of Galectins","volume":"3","author":"Leonidas","year":"1995","journal-title":"Structure"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"129755","DOI":"10.1016\/j.bbagen.2020.129755","article-title":"Human Galectin-16 Has a Pseudo Ligand Binding Site and Plays a Role in Regulating c-Rel-Mediated Lymphocyte Activity","volume":"1865","author":"Si","year":"2021","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jaci.2020.01.013","article-title":"Charcot-Leyden Crystal Protein\/Galectin-10 Interacts with Cationic Ribonucleases and Is Required for Eosinophil Granulogenesis","volume":"146","author":"Grozdanovic","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.2015.410","article-title":"C-Rel and Its Many Roles in Cancer: An Old Story with New Twists","volume":"114","author":"Hunter","year":"2016","journal-title":"Br. J. Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0092-8674(91)90211-G","article-title":"Identification of an Autocrine Negative Growth Factor: Mouse Beta-Galactoside-Binding Protein Is a Cytostatic Factor and Cell Growth Regulator","volume":"64","author":"Wells","year":"1991","journal-title":"Cell"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"44703","DOI":"10.1074\/jbc.M112.395152","article-title":"Structural Basis for Galectin-1-Dependent Pre-B Cell Receptor (Pre-BCR) Activation","volume":"287","author":"Elantak","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1091\/mbc.e10-06-0534","article-title":"Mitochondrial Proteomic Approach Reveals Galectin-7 as a Novel BCL-2 Binding Protein in Human Cells","volume":"22","author":"Villeneuve","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"17086","DOI":"10.1038\/s41598-017-17332-y","article-title":"E-Cadherin Dynamics Is Regulated by Galectin-7 at Epithelial Cell Surface","volume":"7","author":"Advedissian","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"9731","DOI":"10.1073\/pnas.0903568106","article-title":"A Primate Subfamily of Galectins Expressed at the Maternal-Fetal Interface That Promote Immune Cell Death","volume":"106","author":"Than","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/s41598-018-19465-0","article-title":"Galectin-13, a Different Prototype Galectin, Does Not Bind \u03b2-Galacto-Sides and Forms Dimers via Intermolecular Disulfide Bridges between Cys-136 and Cys-138","volume":"8","author":"Su","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/febs.15441","article-title":"Structure-Function Studies of Galectin-14, an Important Effector Molecule in Embryology","volume":"288","author":"Si","year":"2021","journal-title":"FEBS J."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Szabolcsi, Z., Demeter, A., Kiraly, P., Balogh, A., Wilson, M.L., King, J.R., Hetey, S., Gelencser, Z., Matsuo, K., and Hargitai, B. (2021). Epigenetic Dysregulation of Trophoblastic Gene Expression in Gestational Trophoblastic Disease. Biomedicines, 9.","DOI":"10.3390\/biomedicines9121935"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.placenta.2014.07.015","article-title":"Evolutionary Origins of the Placental Expression of Chromosome 19 Cluster Galectins and Their Complex Dysregulation in Preeclampsia","volume":"35","author":"Than","year":"2014","journal-title":"Placenta"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"348","DOI":"10.3389\/fimmu.2014.00348","article-title":"Placental Protein 13 (PP13)\u2014A Placental Immunoregulatory Galectin Protecting Pregnancy","volume":"5","author":"Than","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.3389\/fimmu.2019.01240","article-title":"Placental Galectins Are Key Players in Regulating the Maternal Adaptive Immune Response","volume":"10","author":"Balogh","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"784473","DOI":"10.3389\/fimmu.2021.784473","article-title":"Medawar\u2019s PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation","volume":"12","author":"Menkhorst","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/humupd\/dml048","article-title":"Molecular Circuits Shared by Placental and Cancer Cells, and Their Implications in the Proliferative, Invasive and Migratory Capacities of Trophoblasts","volume":"13","author":"Ferretti","year":"2007","journal-title":"Hum. Reprod. Update"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0025-6196(11)60669-1","article-title":"Cancer and Pregnancy: Parallels in Growth, Invasion, and Immune Modulation and Implications for Cancer Therapeutic Agents","volume":"84","author":"Holtan","year":"2009","journal-title":"Mayo Clin. Proc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.placenta.2021.03.003","article-title":"A Crossroad between Placental and Tumor Biology: What Have We Learnt?","volume":"116","author":"Lala","year":"2021","journal-title":"Placenta"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nri.2017.64","article-title":"The Unique Immunological and Microbial Aspects of Pregnancy","volume":"17","author":"Mor","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of Cancer: The next Generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"St-Pierre, Y. (2021). Towards a Better Understanding of the Relationships between Galectin-7, P53 and MMP-9 during Cancer Progression. Biomolecules, 11.","DOI":"10.3390\/biom11060879"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Vokalova, L., Balogh, A., Toth, E., Van Breda, S.V., Sch\u00e4fer, G., Hoesli, I., Lapaire, O., Hahn, S., Than, N.G., and Rossi, S.W. (2020). Placental Protein 13 (Galectin-13) Polarizes Neutrophils Toward an Immune Regulatory Phenotype. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.00145"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"645658","DOI":"10.3389\/fcell.2021.645658","article-title":"Galectin-14 Promotes Trophoblast Migration and Invasion by Upregulating the Expression of MMP-9 and N-Cadherin","volume":"9","author":"Wang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jri.2013.05.005","article-title":"Galectin Signature in Normal Pregnancy and Preeclampsia","volume":"101\u2013102","author":"Blois","year":"2014","journal-title":"J. Reprod. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1056\/NEJM197111182852108","article-title":"Tumor Angiogenesis: Therapeutic Implications","volume":"285","author":"Folkman","year":"1971","journal-title":"N. Engl. J. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1093\/glycob\/cwu086","article-title":"Galectin-3 in Angiogenesis and Metastasis","volume":"24","author":"Funasaka","year":"2014","journal-title":"Glycobiology"},{"key":"ref_47","first-page":"90","article-title":"Galectins in Tumor Angiogenesis","volume":"2","author":"Griffioen","year":"2014","journal-title":"Ann. Transl. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nrc1527","article-title":"Galectins as Modulators of Tumour Progression","volume":"5","author":"Liu","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10456-008-9092-6","article-title":"Judah Folkman, a Pioneer in the Study of Angiogenesis","volume":"11","author":"Ribatti","year":"2008","journal-title":"Angiogenesis"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Thijssen, V.L. (2021). Galectins in Endothelial Cell Biology and Angiogenesis: The Basics. Biomolecules, 11.","DOI":"10.3390\/biom11091386"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.gde.2004.12.005","article-title":"Cellular Abnormalities of Blood Vessels as Targets in Cancer","volume":"15","author":"Baluk","year":"2005","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1177\/1947601911432334","article-title":"Molecular Mechanisms of Tumor Angiogenesis","volume":"2","author":"Ziyad","year":"2011","journal-title":"Genes Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"An, J., Nagaki, Y., Motoyama, S., Kuze, Y., Hoshizaki, M., Kemuriyama, K., Yamaguchi, T., Ebihara, T., Minamiya, Y., and Suzuki, Y. (2022). Identification of Galectin-7 as a Crucial Metastatic Enhancer of Squamous Cell Carcinoma Associated with Immunosuppression. Oncogene.","DOI":"10.1038\/s41388-022-02525-1"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1053\/plac.1999.0436","article-title":"Isolation and Sequence Analysis of a CDNA Encoding Human Placental Tissue Protein 13 (PP13), a New Lysophospholipase, Homologue of Human Eosinophil Charcot-Leyden Crystal Protein","volume":"20","author":"Than","year":"1999","journal-title":"Placenta"},{"key":"ref_55","unstructured":"de Araujo, L.O.F., and St-Pierre, Y. (2019). Galectin-14 Expression in Ovarian Cancer. bioRxiv, 717793."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Kaminker, J.D., and Timoshenko, A.V. (2021). Expression, Regulation, and Functions of the Galectin-16 Gene in Human Cells and Tissues. Biomolecules, 11.","DOI":"10.3390\/biom11121909"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"eabb6242","DOI":"10.1126\/sciadv.abb6242","article-title":"Tissue-Specific Genetic Features Inform Prediction of Drug Side Effects in Clinical Trials","volume":"6","author":"Duffy","year":"2020","journal-title":"Sci. Adv."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"7527","DOI":"10.1038\/sj.onc.1207997","article-title":"Dual Activities of Galectin-3 in Human Prostate Cancer: Tumor Suppression of Nuclear Galectin-3 vs Tumor Promotion of Cytoplasmic Galectin-3","volume":"23","author":"Califice","year":"2004","journal-title":"Oncogene"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"18183","DOI":"10.18632\/oncotarget.7784","article-title":"Galectin Signatuares Contribute to the Heterogeneity of Breast Cancer and Provide New Prognostic Information and Therapeutic Targets","volume":"7","author":"Grosset","year":"2016","journal-title":"Oncotarget"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/ijc.25750","article-title":"Galectin-4 Functions as a Tumor Suppressor of Human Colorectal Cancer","volume":"129","author":"Satelli","year":"2011","journal-title":"Int. J. Cancer"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"5672","DOI":"10.1158\/0008-5472.CAN-04-0985","article-title":"Suppression of Tumor Growth by Galectin-7 Gene Transfer","volume":"64","author":"Ueda","year":"2004","journal-title":"Cancer Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"6047","DOI":"10.1038\/s41598-021-84787-5","article-title":"Pancancer Survival Analysis of Cancer Hallmark Genes","volume":"11","author":"Nagy","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"18545","DOI":"10.1073\/pnas.1010978107","article-title":"Accumulation of Driver and Passenger Mutations during Tumor Progression","volume":"107","author":"Bozic","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1046\/j.1432-0436.1998.6330159.x","article-title":"Galectin-7, a Marker of All Types of Stratified Epithelia","volume":"63","author":"Magnaldo","year":"1998","journal-title":"Differentiation"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1006\/dbio.1995.1078","article-title":"Galectin-7, a Human 14-KDa S-Lectin, Specifically Expressed in Keratinocytes and Sensitive to Retinoic Acid","volume":"168","author":"Magnaldo","year":"1995","journal-title":"Dev. Biol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/sj.leu.2402870","article-title":"Upregulation of Galectin-7 in Murine Lymphoma Cells Is Associated with Progression toward an Aggressive Phenotype","volume":"17","author":"Moisan","year":"2003","journal-title":"Leukemia"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1158\/0008-5472.CAN-06-3891","article-title":"Galectin-7 in Lymphoma: Elevated Expression in Human Lymphoid Malignancies and Decreased Lymphoma Dissemination by Antisense Strategies in Experimental Model","volume":"67","author":"Demers","year":"2007","journal-title":"Cancer Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"5205","DOI":"10.1158\/0008-5472.CAN-05-0134","article-title":"A Novel Function for Galectin-7: Promoting Tumorigenesis by Up-Regulating MMP-9 Gene Expression","volume":"65","author":"Demers","year":"2005","journal-title":"Cancer Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.bbrc.2009.07.015","article-title":"Increased Galectin-7 Gene Expression in Lymphoma Cells Is under the Control of DNA Methylation","volume":"387","author":"Demers","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.18632\/oncotarget.1219","article-title":"Galectin-7 Is Epigenetically-Regulated Tumor Suppressor in Gastric Cancer","volume":"4","author":"Kim","year":"2013","journal-title":"Oncotarget"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Campion, C.G., Labrie, M., Grosset, A.-A., and St-Pierre, Y. (2014). The CCAAT\/Enhancer-Binding Protein Beta-2 Isoform (CEBP\u03b2-2) Upregulates Galectin-7 Expression in Human Breast Cancer Cells. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0095087"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Campion, C.G., Labrie, M., Lavoie, G., and St-Pierre, Y. (2013). Expression of Galectin-7 Is Induced in Breast Cancer Cells by Mutant P53. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0072468"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Dall\u2019Olio, F., and Trinchera, M. (2017). Epigenetic Bases of Aberrant Glycosylation in Cancer. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18050998"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/iub.1690","article-title":"Analyzing Epigenetic Control of Galectin Expression Indicates Silencing of Galectin-12 by Promoter Methylation in Colorectal Cancer","volume":"69","author":"Katzenmaier","year":"2017","journal-title":"IUBMB Life"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1128\/MCB.16.6.2736","article-title":"Cell-Specific Transcriptional Regulation and Reactivation of Galectin-1 Gene Expression Are Controlled by DNA Methylation of the Promoter Region","volume":"16","author":"Benvenuto","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0014-5793(97)01553-6","article-title":"High Resolution Methylation Analysis of the Galectin-1 Gene Promoter Region in Expressing and Nonexpressing Tissues","volume":"421","author":"Salvatore","year":"1998","journal-title":"FEBS Lett."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nrc3486","article-title":"Cancer as a Dysregulated Epigenome Allowing Cellular Growth Advantage at the Expense of the Host","volume":"13","author":"Timp","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.placenta.2021.01.006","article-title":"Syncytins Expressed in Human Placental Trophoblast","volume":"113","author":"Roberts","year":"2021","journal-title":"Placenta"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.cellsig.2013.11.002","article-title":"Epigenetic and Non-Epigenetic Regulation of Syncytin-1 Expression in Human Placenta and Cancer Tissues","volume":"26","author":"Huang","year":"2014","journal-title":"Cell. Signal."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2147\/OTT.S191041","article-title":"Upregulation of Syncytin-1 Promotes Invasion and Metastasis by Activating Epithelial-Mesenchymal Transition-Related Pathway in Endometrial Carcinoma","volume":"12","author":"Liu","year":"2018","journal-title":"Onco. Targets Ther."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12977-017-0342-9","article-title":"DNA Hypomethylation and Aberrant Expression of the Human Endogenous Retrovirus ERVWE1\/Syncytin-1 in Seminomas","volume":"14","author":"Hron","year":"2017","journal-title":"Retrovirology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13046-015-0199-5","article-title":"Therapeutic Potential of Antiviral Drugs Targeting Chemorefractory Colorectal Adenocarcinoma Cells Overexpressing Endogenous Retroviral Elements","volume":"34","author":"Acikelli","year":"2015","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Rasoulzadeh, Z., Ghods, R., Kazemi, T., Mirzadegan, E., Ghaffari-Tabrizi-Wizsy, N., Rezania, S., Kazemnejad, S., Arefi, S., Ghasemi, J., and Vafaei, S. (2016). Placental Kisspeptins Differentially Modulate Vital Parameters of Estrogen Receptor-Positive and -Negative Breast Cancer Cells. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0153684"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3389\/fendo.2018.00222","article-title":"Biological Significance of Kisspeptin\u2013Kiss 1 Receptor Signaling in the Habenula of Teleost Species","volume":"9","author":"Ogawa","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1093\/jnci\/88.23.1731","article-title":"KiSS-1, a Novel Human Malignant Melanoma Metastasis-Suppressor Gene","volume":"88","author":"Lee","year":"1996","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"213","DOI":"10.21873\/anticanres.13942","article-title":"Kisspeptin Promotes Glioblastoma Cell Invasiveness Via the Gq-PLC-PKC Pathway","volume":"40","author":"Kim","year":"2020","journal-title":"Anticancer. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"4617","DOI":"10.1038\/sj.onc.1206542","article-title":"Cleavage of Metastasis Suppressor Gene Product KiSS-1 Protein\/Metastin by Matrix Metalloproteinases","volume":"22","author":"Takino","year":"2003","journal-title":"Oncogene"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/j.1349-7006.2008.00814.x","article-title":"Human Homolog of NOTUM, Overexpressed in Hepatocellular Carcinoma, Is Regulated Transcriptionally by \u03b2-Catenin\/TCF","volume":"99","author":"Torisu","year":"2008","journal-title":"Cancer Sci."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Zhang, T., Yin, Q., and Luo, H. (2021). Development and Validation of Genomic and Epigenomic Signatures Associated with Tumor Immune Microenvironment in Hepatoblastoma. BMC Cancer, 21.","DOI":"10.1186\/s12885-021-08893-3"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"5241","DOI":"10.1080\/21655979.2021.1961657","article-title":"Notum Palmitoleoyl-Protein Carboxylesterase Regulates Fas Cell Surface Death Receptor-Mediated Apoptosis via the Wnt Signaling Pathway in Colon Adenocarcinoma","volume":"12","author":"Gong","year":"2021","journal-title":"Bioengineered"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"485","DOI":"10.21873\/cgp.20107","article-title":"NOTUM Is Involved in the Progression of Colorectal Cancer","volume":"15","author":"Yoon","year":"2018","journal-title":"Cancer Genom. Proteom."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.tcb.2012.06.001","article-title":"How Does Lin28 Let-7 Control Development and Disease?","volume":"22","author":"Thornton","year":"2012","journal-title":"Trends Cell Biol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1038\/s41467-020-17150-3","article-title":"Pancreatic Circulating Tumor Cell Profiling Identifies LIN28B as a Metastasis Driver and Drug Target","volume":"11","author":"Franses","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1016\/j.celrep.2018.02.002","article-title":"A LIN28B Tumor-Specific Transcript in Cancer","volume":"22","author":"Guo","year":"2018","journal-title":"Cell Rep."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"5338","DOI":"10.1172\/JCI135373","article-title":"LIN28B Promotes the Development of Neuroendocrine Prostate Cancer","volume":"130","author":"Lovnicki","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s12943-015-0402-5","article-title":"Aberrant Regulation of the LIN28A\/LIN28B and Let-7 Loop in Human Malignant Tumors and Its Effects on the Hallmarks of Cancer","volume":"14","author":"Wang","year":"2015","journal-title":"Mol. Cancer"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/ng1636","article-title":"Homozygous HOXA1 Mutations Disrupt Human Brainstem, Inner Ear, Cardiovascular and Cognitive Development","volume":"37","author":"Tischfield","year":"2005","journal-title":"Nat. Genet."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/glycob\/cwz081","article-title":"Galectin-13\/Placental Protein 13: Redox-Active Disulfides as Switches for Regulating Structure, Function and Cellular Distribution","volume":"30","author":"Yang","year":"2020","journal-title":"Glycobiology"},{"key":"ref_99","first-page":"1896","article-title":"HOXA1 Upregulation Is Associated with Poor Prognosis and Tumor Progression in Breast Cancer","volume":"17","author":"Liu","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1007\/s13277-012-0472-6","article-title":"Overexpression of HOXA1 Correlates with Poor Prognosis in Patients with Hepatocellular Carcinoma","volume":"33","author":"Zha","year":"2012","journal-title":"Tumor Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"W214","DOI":"10.1093\/nar\/gkq537","article-title":"The GeneMANIA Prediction Server: Biological Network Integration for Gene Prioritization and Predicting Gene Function","volume":"38","author":"Donaldson","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/sj.onc.1205186","article-title":"Endonuclein Is a Cell Cycle Regulated WD-Repeat Protein That Is up-Regulated in Adenocarcinoma of the Pancreas","volume":"21","author":"Baandrup","year":"2002","journal-title":"Oncogene"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"10025","DOI":"10.2147\/OTT.S263815","article-title":"PWP1 Promotes the Malignant Phenotypes of Lung Cancer Cells by Interacting with DVL2 and Merlin","volume":"13","author":"Wei","year":"2020","journal-title":"Onco. 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