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Pesquisa do Estado de S\u00e3o Paulo)","award":["#2013\/15447-0"],"award-info":[{"award-number":["#2013\/15447-0"]}]},{"name":"FAPESP\/Brazil (Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo)","award":["Uc Me 169-17"],"award-info":[{"award-number":["Uc Me 169-17"]}]},{"name":"the Brazil\u2013France research cooperation program USP\/COFECUB","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"the Brazil\u2013France research cooperation program USP\/COFECUB","award":["#448242\/2014-1"],"award-info":[{"award-number":["#448242\/2014-1"]}]},{"name":"the Brazil\u2013France research cooperation program USP\/COFECUB","award":["312802\/2018-8"],"award-info":[{"award-number":["312802\/2018-8"]}]},{"name":"the Brazil\u2013France research cooperation program USP\/COFECUB","award":["302060\/2019-7"],"award-info":[{"award-number":["302060\/2019-7"]}]},{"name":"the Brazil\u2013France research cooperation program USP\/COFECUB","award":["304755\/2019-2"],"award-info":[{"award-number":["304755\/2019-2"]}]},{"name":"the Brazil\u2013France research cooperation program USP\/COFECUB","award":["#2013\/15447-0"],"award-info":[{"award-number":["#2013\/15447-0"]}]},{"name":"the Brazil\u2013France research cooperation program USP\/COFECUB","award":["Uc Me 169-17"],"award-info":[{"award-number":["Uc Me 169-17"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Vitiligo is the most frequent cause of depigmentation worldwide. Genetic association studies have discovered about 50 loci associated with disease, many with immunological functions. Among them is HLA-G, which modulates immunity by interacting with specific inhibitory receptors, mainly LILRB1 and LILRB2. Here we investigated the LILRB1 and LILRB2 association with vitiligo risk and evaluated the possible role of interactions between HLA-G and its receptors in this pathogenesis. We tested the association of the polymorphisms of HLA-G, LILRB1, and LILRB2 with vitiligo using logistic regression along with adjustment by ancestry. Further, methods based on the multifactor dimensionality reduction (MDR) approach (MDR v.3.0.2, GMDR v.0.9, and MB-MDR) were used to detect potential epistatic interactions between polymorphisms from the three genes. An interaction involving rs9380142 and rs2114511 polymorphisms was identified by all methods used. The polymorphism rs9380142 is an HLA-G 3\u2032UTR variant (+3187) with a well-established role in mRNA stability. The polymorphism rs2114511 is located in the exonic region of LILRB1. Although no association involving this SNP has been reported, ChIP-Seq experiments have identified this position as an EBF1 binding site. These results highlight the role of an epistatic interaction between HLA-G and LILRB1 in vitiligo pathogenesis.<\/jats:p>","DOI":"10.3390\/cells12040630","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T02:28:27Z","timestamp":1676514507000},"page":"630","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evidence for Epistatic Interaction between HLA-G and LILRB1 in the Pathogenesis of Nonsegmental Vitiligo"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8155-0244","authenticated-orcid":false,"given":"Maria Luiza de","family":"Oliveira-Caramez","sequence":"first","affiliation":[{"name":"Departamento de Gen\u00e9tica, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto 14049-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Veiga-Castelli","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto 14049-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6853-1559","authenticated-orcid":false,"given":"Andreia S.","family":"Souza","sequence":"additional","affiliation":[{"name":"Molecular Genetics and Bioinformatics Laboratory, School of Medicine, S\u00e3o Paulo State University (UNESP), Botucatu 18618-687, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Nahas","family":"Cardili","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednica M\u00e9dica, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto 14049-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Courtin","sequence":"additional","affiliation":[{"name":"Institut de Recherche pour le D\u00e9veloppement, UMR 261 MERIT, Universit\u00e9 de Paris, F-75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0656-1736","authenticated-orcid":false,"given":"Milena","family":"Fl\u00f3ria-Santos","sequence":"additional","affiliation":[{"name":"Departamento de Enfermagem Materno-Infantil e Sa\u00fade P\u00fablica\u2014(EERP\/ERM), Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto 14049-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Donadi","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednica M\u00e9dica, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto 14049-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7520-6420","authenticated-orcid":false,"given":"Silvana","family":"Giuliatti","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto 14049-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Sabbagh","sequence":"additional","affiliation":[{"name":"Institut de Recherche pour le D\u00e9veloppement, UMR 261 MERIT, Universit\u00e9 de Paris, F-75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick C.","family":"Castelli","sequence":"additional","affiliation":[{"name":"Molecular Genetics and Bioinformatics Laboratory, School of Medicine, S\u00e3o Paulo State University (UNESP), Botucatu 18618-687, SP, Brazil"},{"name":"Pathology Department, School of Medicine, S\u00e3o Paulo State University (UNESP), Botucatu 18618-687, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7337-1203","authenticated-orcid":false,"given":"Celso Teixeira","family":"Mendes-Junior","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisas Forenses e Gen\u00f4micas, Departamento de Qu\u00edmica, Faculdade de Filosofia, Ci\u00eancias e Letras de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-901, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0140-6736(14)60763-7","article-title":"Vitiligo","volume":"386","author":"Ezzedine","year":"2015","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1111\/j.1755-148X.2012.00997.x","article-title":"Revised 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