{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:02:25Z","timestamp":1792803745841,"version":"4.5.0"},"reference-count":176,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Danish Parkinson Foundation"},{"name":"Faculty of Health Sciences at the University of Southern Denmark","id":[{"id":"https:\/\/ror.org\/03yrrjy16","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Parkinson\u2019s disease (PD) is a neurodegenerative disorder that has been associated with mitochondrial dysfunction, oxidative stress, and defects in mitophagy as well as \u03b1-synuclein-positive inclusions, termed Lewy bodies (LBs), which are a common pathological hallmark in PD. Mitophagy is a process that maintains cellular health by eliminating dysfunctional mitochondria, and it is triggered by ubiquitination of mitochondrial-associated proteins\u2014e.g., through the PINK1\/Parkin pathway\u2014which results in engulfment by the autophagosome and degradation in lysosomes. Deubiquitinating enzymes (DUBs) can regulate this process at several levels by deubiquitinating mitochondrial substrates and other targets in the mitophagic pathway, such as Parkin. Moreover, DUBs can affect \u03b1-synuclein aggregation through regulation of degradative pathways, deubiquitination of \u03b1-synuclein itself, and\/or via co-localization with \u03b1-synuclein in inclusions. DUBs with a known association to PD are described in this paper, along with their function. Of interest, DUBs could be useful as novel therapeutic targets against PD through regulation of PD-associated defects.<\/jats:p>","DOI":"10.3390\/cells12040651","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T05:27:01Z","timestamp":1676870821000},"page":"651","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Role of Deubiquitinases in Parkinson\u2019s Disease\u2014Therapeutic Perspectives"],"prefix":"10.3390","volume":"12","author":[{"given":"Pernille Y. \u00d8.","family":"Nielsen","sequence":"first","affiliation":[{"name":"Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, 5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Okarmus","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, 5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9571-1336","authenticated-orcid":false,"given":"Morten","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, 5000 Odense, Denmark"},{"name":"Department of Neurology, Odense University Hospital, 5000 Odense, Denmark"},{"name":"BRIDGE\u2014Brain Research Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, 5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/NHH.0000000000000398","article-title":"Parkinson Disease","volume":"34","author":"Capriotti","year":"2016","journal-title":"Home Healthc Now"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ncl.2013.04.013","article-title":"Nonmotor symptoms in Parkinson\u2019s disease: Expanding the view of Parkinson\u2019s disease beyond a pure motor, pure dopaminergic problem","volume":"31 (3 Suppl.)","author":"Sung","year":"2013","journal-title":"Neurol. 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