{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:13:28Z","timestamp":1791288808739,"version":"4.3.0"},"reference-count":202,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,19]],"date-time":"2023-02-19T00:00:00Z","timestamp":1676764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"statutory funds of the Maj Institute of Pharmacology, Polish Academy of Sciences, Poland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The vitamin D receptor (VDR) belongs to the nuclear receptor superfamily of transcription factors. The VDR is expressed in diverse brain regions and has been implicated in the neuroprotective, antiaging, prosurvival, and anti-inflammatory action of vitamin D. Accordingly, a relationship between vitamin D insufficiency and susceptibility to neurodegenerative diseases has been suggested. However, due to the multitargeted mechanisms of vitamin D and its often overlapping genomic and nongenomic effects, the role of the VDR in brain pathologies remains obscure. In this narrative review, we present progress in deciphering the molecular mechanism of nuclear VDR-mediated vitamin D effects on prosurvival and anti-inflammatory signaling pathway activity within the central nervous system. In line with the concept of the neurovascular unit in pathomechanisms of neurodegenerative diseases, a discussion of the role of the VDR in regulating the immune and vascular brain systems is also included. Next, we discuss the results of preclinical and clinical studies evaluating the significance of vitamin D status and the efficacy of vitamin D supplementation in the treatment of Parkinson\u2019s and Alzheimer\u2019s diseases, emphasizing the possible role of the VDR in these phenomena. Finally, the associations of some VDR polymorphisms with higher risks and severity of these neurodegenerative disorders are briefly summarized.<\/jats:p>","DOI":"10.3390\/cells12040660","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T05:27:01Z","timestamp":1676870821000},"page":"660","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["The Vitamin D Receptor as a Potential Target for the Treatment of Age-Related Neurodegenerative Diseases Such as Alzheimer\u2019s and Parkinson\u2019s Diseases: A Narrative Review"],"prefix":"10.3390","volume":"12","author":[{"given":"W\u0142adys\u0142aw","family":"Laso\u0144","sequence":"first","affiliation":[{"name":"Maj Institute of Pharmacology Polish Academy of Sciences, Department of Experimental Neuroendocrinology, Sm\u0119tna 12 Str., 31-343 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6789-4489","authenticated-orcid":false,"given":"Danuta","family":"Jantas","sequence":"additional","affiliation":[{"name":"Maj Institute of Pharmacology Polish Academy of Sciences, Department of Experimental Neuroendocrinology, Sm\u0119tna 12 Str., 31-343 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7261-2821","authenticated-orcid":false,"given":"Monika","family":"Le\u015bkiewicz","sequence":"additional","affiliation":[{"name":"Maj Institute of Pharmacology Polish Academy of Sciences, Department of Experimental Neuroendocrinology, Sm\u0119tna 12 Str., 31-343 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Regulska","sequence":"additional","affiliation":[{"name":"Maj Institute of Pharmacology Polish Academy of Sciences, Department of Experimental Neuroendocrinology, Sm\u0119tna 12 Str., 31-343 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3109-0040","authenticated-orcid":false,"given":"Agnieszka","family":"Basta-Kaim","sequence":"additional","affiliation":[{"name":"Maj Institute of Pharmacology Polish Academy of Sciences, Department of Experimental Neuroendocrinology, Sm\u0119tna 12 Str., 31-343 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","article-title":"Ageing as a risk factor for neurodegenerative disease","volume":"15","author":"Hou","year":"2019","journal-title":"Nat. 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