{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:37:05Z","timestamp":1787027825619,"version":"build-2736575974"},"reference-count":72,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cariplo Telethon GJC2021","award":["2022-0578"],"award-info":[{"award-number":["2022-0578"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>AL amyloidosis is caused by the misfolding of immunoglobulin light chains leading to an impaired function of tissues and organs in which they accumulate. Due to the paucity of -omics profiles from undissected samples, few studies have addressed amyloid-related damage system wide. To fill this gap, we evaluated proteome changes in the abdominal subcutaneous adipose tissue of patients affected by the AL isotypes \u03ba and \u03bb. Through our retrospective analysis based on graph theory, we have herein deduced new insights representing a step forward from the pioneering proteomic investigations previously published by our group. ECM\/cytoskeleton, oxidative stress and proteostasis were confirmed as leading processes. In this scenario, some proteins, including glutathione peroxidase 1 (GPX1), tubulins and the TRiC complex, were classified as biologically and topologically relevant. These and other results overlap with those already reported for other amyloidoses, supporting the hypothesis that amyloidogenic proteins could induce similar mechanisms independently of the main fibril precursor and of the target tissues\/organs. Of course, further studies based on larger patient cohorts and different tissues\/organs will be essential, which would be a key point that would allow for a more robust selection of the main molecular players and a more accurate correlation with clinical aspects.<\/jats:p>","DOI":"10.3390\/cells12050699","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T03:25:56Z","timestamp":1677122756000},"page":"699","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Protein Network in Subcutaneous Fat Biopsies from Patients with AL Amyloidosis: More Than Diagnosis?"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7143-6229","authenticated-orcid":false,"given":"Dario","family":"Di Silvestre","sequence":"first","affiliation":[{"name":"Institute for Biomedical Technologies (ITB), Biomedical Sciences, National Research Council (CNR), 20054 Segrate, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Brambilla","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Technologies (ITB), Biomedical Sciences, National Research Council (CNR), 20054 Segrate, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Lavatelli","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, University of Pavia, Via Forlanini 6, 27100 Pavia, Italy"},{"name":"Fondazione IRCCS Policlinico San Matteo, Viale Golgi 19, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maila","family":"Chiriv\u00ec","sequence":"additional","affiliation":[{"name":"UOC Neurology, Fondazione Ca\u2019Granda, Ospedale Maggiore Policlinico, Via F. Sforza, 28, 20122 Milan, Italy"},{"name":"Department of Molecular Medicine, Sapienza University, Viale Regina Elena, 324, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5292-8124","authenticated-orcid":false,"given":"Diana","family":"Canetti","sequence":"additional","affiliation":[{"name":"Centre for Amyloidosis, Division of Medicine, University College London, London NW3 2PF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Bearzi","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Technologies (ITB), Biomedical Sciences, National Research Council (CNR), 20054 Segrate, Italy"},{"name":"Fondazione Istituto Nazionale di Genetica Molecolare, Via F. Sforza 35, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Rizzi","sequence":"additional","affiliation":[{"name":"Fondazione Istituto Nazionale di Genetica Molecolare, Via F. Sforza 35, 20122 Milan, Italy"},{"name":"Department of Medical Surgical Science and Biotecnologies, Sapienza University, 04100 Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Bijzet","sequence":"additional","affiliation":[{"name":"Amyloidosis Center of Expertise, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"},{"name":"Department of Rheumatology & Clinical Immunology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1827-0482","authenticated-orcid":false,"given":"Bouke P. C.","family":"Hazenberg","sequence":"additional","affiliation":[{"name":"Amyloidosis Center of Expertise, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"},{"name":"Department of Rheumatology & Clinical Immunology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8678-662X","authenticated-orcid":false,"given":"Vittorio","family":"Bellotti","sequence":"additional","affiliation":[{"name":"Centre for Amyloidosis, Division of Medicine, University College London, London NW3 2PF, UK"},{"name":"Scientific Direction, Fondazione IRCSS Policlinico San Matteo, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian D.","family":"Gillmore","sequence":"additional","affiliation":[{"name":"Centre for Amyloidosis, Division of Medicine, University College London, London NW3 2PF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4364-0393","authenticated-orcid":false,"given":"Pierluigi","family":"Mauri","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Technologies (ITB), Biomedical Sciences, National Research Council (CNR), 20054 Segrate, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"key":"ref_1","first-page":"213","article-title":"Amyloid nomenclature 2022: Update, novel proteins, and recommendations by the International Society of Amyloidosis (ISA) Nomenclature Committee","volume":"29","author":"Buxbaum","year":"2022","journal-title":"Amyloid Int. 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