{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:02:47Z","timestamp":1791471767329,"version":"4.3.4"},"reference-count":173,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"AHA-AIREA","doi-asserted-by":"publisher","award":["959725"],"award-info":[{"award-number":["959725"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"AHA-AIREA","doi-asserted-by":"publisher","award":["R15 HL14884401"],"award-info":[{"award-number":["R15 HL14884401"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"AHA-AIREA","doi-asserted-by":"publisher","award":["PLAKKOT-FY23"],"award-info":[{"award-number":["PLAKKOT-FY23"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"AHA-AIREA","doi-asserted-by":"publisher","award":["SUBRAMANIAN-FY23"],"award-info":[{"award-number":["SUBRAMANIAN-FY23"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH-NHLBI","award":["959725"],"award-info":[{"award-number":["959725"]}]},{"name":"NIH-NHLBI","award":["R15 HL14884401"],"award-info":[{"award-number":["R15 HL14884401"]}]},{"name":"NIH-NHLBI","award":["PLAKKOT-FY23"],"award-info":[{"award-number":["PLAKKOT-FY23"]}]},{"name":"NIH-NHLBI","award":["SUBRAMANIAN-FY23"],"award-info":[{"award-number":["SUBRAMANIAN-FY23"]}]},{"name":"OCASCR Research","award":["959725"],"award-info":[{"award-number":["959725"]}]},{"name":"OCASCR Research","award":["R15 HL14884401"],"award-info":[{"award-number":["R15 HL14884401"]}]},{"name":"OCASCR Research","award":["PLAKKOT-FY23"],"award-info":[{"award-number":["PLAKKOT-FY23"]}]},{"name":"OCASCR Research","award":["SUBRAMANIAN-FY23"],"award-info":[{"award-number":["SUBRAMANIAN-FY23"]}]},{"name":"College of Veterinary Medicine Oklahoma State University","award":["959725"],"award-info":[{"award-number":["959725"]}]},{"name":"College of Veterinary Medicine Oklahoma State University","award":["R15 HL14884401"],"award-info":[{"award-number":["R15 HL14884401"]}]},{"name":"College of Veterinary Medicine Oklahoma State University","award":["PLAKKOT-FY23"],"award-info":[{"award-number":["PLAKKOT-FY23"]}]},{"name":"College of Veterinary Medicine Oklahoma State University","award":["SUBRAMANIAN-FY23"],"award-info":[{"award-number":["SUBRAMANIAN-FY23"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The hypothalamus, one of the major regulatory centers in the brain, controls various homeostatic processes, and hypothalamic neural stem cells (htNSCs) have been observed to interfere with hypothalamic mechanisms regulating aging. NSCs play a pivotal role in the repair and regeneration of brain cells during neurodegenerative diseases and rejuvenate the brain tissue microenvironment. The hypothalamus was recently observed to be involved in neuroinflammation mediated by cellular senescence. Cellular senescence, or systemic aging, is characterized by a progressive irreversible state of cell cycle arrest that causes physiological dysregulation in the body and it is evident in many neuroinflammatory conditions, including obesity. Upregulation of neuroinflammation and oxidative stress due to senescence has the potential to alter the functioning of NSCs. Various studies have substantiated the chances of obesity inducing accelerated aging. Therefore, it is essential to explore the potential effects of htNSC dysregulation in obesity and underlying pathways to develop strategies to address obesity-induced comorbidities associated with brain aging. This review will summarize hypothalamic neurogenesis associated with obesity and prospective NSC-based regenerative therapy for the treatment of obesity-induced cardiovascular conditions.<\/jats:p>","DOI":"10.3390\/cells12050769","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T06:55:16Z","timestamp":1677567316000},"page":"769","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Implications of Hypothalamic Neural Stem Cells on Aging and Obesity-Associated Cardiovascular Diseases"],"prefix":"10.3390","volume":"12","author":[{"given":"Bhuvana","family":"Plakkot","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences, Oklahoma State University, Stillwater, OK 74078, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4812-8451","authenticated-orcid":false,"given":"Ashley","family":"Di Agostino","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Oklahoma State University, Stillwater, OK 74078, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8525-1295","authenticated-orcid":false,"given":"Madhan","family":"Subramanian","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Oklahoma State University, Stillwater, OK 74078, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.stem.2015.09.003","article-title":"Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later","volume":"17","author":"Bond","year":"2015","journal-title":"Cell Stem Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fnins.2015.00020","article-title":"Neurogenic niches in the brain: Help and hindrance of the barrier systems","volume":"9","author":"Stolp","year":"2015","journal-title":"Front. Neurosci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.conb.2013.09.004","article-title":"Adult neural stem cells and their niche: A dynamic duo during homeostasis, regeneration, and aging","volume":"23","author":"Crouch","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tins.2012.12.008","article-title":"Hypothalamic tanycytes: Potential roles in the control of feeding and energy balance","volume":"36","author":"Bolborea","year":"2013","journal-title":"Trends Neurosci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1002\/cne.24376","article-title":"A comparative study of the neural stem cell niche in the adult hypothalamus of human, mouse, rat and gray mouse lemur (Microcebus murinus)","volume":"526","author":"Pellegrino","year":"2018","journal-title":"J. Comp. Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.expneurol.2004.12.021","article-title":"Neurogenesis in the ependymal layer of the adult rat 3rd ventricle","volume":"192","author":"Xu","year":"2005","journal-title":"Exp. Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nn.3079","article-title":"Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche","volume":"15","author":"Lee","year":"2012","journal-title":"Nat. Neurosci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/ncb2562","article-title":"IKK\u03b2\/NF-\u03baB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes","volume":"14","author":"Li","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"ref_9","first-page":"183","article-title":"Cancer, aging and cellular senescence","volume":"14","author":"Campisi","year":"2000","journal-title":"In Vivo"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"13460","DOI":"10.18632\/aging.203111","article-title":"Aging is associated with glial senescence in the brainstem-implications for age-related sympathetic overactivity","volume":"13","author":"Balasubramanian","year":"2021","journal-title":"Aging"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.neurobiolaging.2008.03.002","article-title":"Early age-related changes in adult hippocampal neurogenesis in C57 mice","volume":"31","author":"Nada","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.exger.2014.09.018","article-title":"Cellular senescence and the aging brain","volume":"68","author":"Chinta","year":"2015","journal-title":"Exp. Gerontol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1523\/JNEUROSCI.16-06-02027.1996","article-title":"Neurogenesis in the dentate gyrus of the adult rat: Age-related decrease of neuronal progenitor proliferation","volume":"16","author":"Kuhn","year":"1996","journal-title":"J. Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1523\/JNEUROSCI.4608-03.2004","article-title":"Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice","volume":"24","author":"Maslov","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.stem.2015.08.001","article-title":"Aberrant lipid metabolism in the forebrain niche suppresses adult neural stem cell proliferation in an animal model of Alzheimer\u2019s disease","volume":"17","author":"Hamilton","year":"2015","journal-title":"Cell Stem Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.cmet.2018.12.008","article-title":"Obesity-induced cellular senescence drives anxiety and impairs neurogenesis","volume":"29","author":"Ogrodnik","year":"2019","journal-title":"Cell Metab."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1126\/science.288.5471.1660","article-title":"Generalized potential of adult neural stem cells","volume":"288","author":"Clarke","year":"2000","journal-title":"Science"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1002\/jnr.21585","article-title":"Inflammation: A new candidate in modulating adult neurogenesis","volume":"86","author":"Das","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neuron.2009.08.039","article-title":"Immune activation in brain aging and neurodegeneration: Too much or too little?","volume":"64","author":"Lucin","year":"2009","journal-title":"Neuron"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pneurobio.2005.06.004","article-title":"Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism","volume":"76","author":"Block","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1172\/JCI43134","article-title":"Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice","volume":"122","author":"McNay","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nn.3091","article-title":"Fat incites tanycytes to neurogenesis","volume":"15","author":"Dietrich","year":"2012","journal-title":"Nat. Neurosci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1046\/j.1460-9568.2003.02567.x","article-title":"Expression of the ecto-ATPase NTPDase2 in the germinal zones of the developing and adult rat brain","volume":"17","author":"Braun","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1113\/jphysiol.2010.202051","article-title":"ATP-mediated glucosensing by hypothalamic tanycytes","volume":"589","author":"Frayling","year":"2011","journal-title":"J. Physiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1002\/cne.23144","article-title":"Doublecortin and doublecortin-like are expressed in overlapping and non-overlapping neuronal cell population: Implications for neurogenesis","volume":"520","author":"Saaltink","year":"2012","journal-title":"J. Comp. Neurol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1365-2826.2007.01576.x","article-title":"Morphological evidence for direct interaction between gonadotrophin-releasing hormone neurones and astroglial cells in the human hypothalamus","volume":"19","author":"Baroncini","year":"2007","journal-title":"J. Neuroendocrinol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1677\/joe.1.06929","article-title":"Photoperiodic regulation of cellular retinoic acid-binding protein 1, GPR50 and nestin in tanycytes of the third ventricle ependymal layer of the Siberian hamster","volume":"191","author":"Barrett","year":"2006","journal-title":"J. Endocrinol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0165-3806(02)00509-6","article-title":"Nestin-containing cells express glial fibrillary acidic protein in the proliferative regions of central nervous system of postnatal developing and adult mice","volume":"139","author":"Wei","year":"2002","journal-title":"Dev. Brain Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1210\/en.2011-1039","article-title":"Melatonin controls photoperiodic changes in tanycyte vimentin and neural cell adhesion molecule expression in the Djungarian hamster (Phodopus sungorus)","volume":"152","author":"Bolborea","year":"2011","journal-title":"Endocrinology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/exnr.1998.6784","article-title":"Tanycytes present in the adult rat mediobasal hypothalamus support the regeneration of monoaminergic axons","volume":"151","author":"Chauvet","year":"1998","journal-title":"Exp. Neurol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1600-079X.2010.00750.x","article-title":"Expression of the orphan GPR50 protein in rodent and human dorsomedial hypothalamus, tanycytes and median eminence","volume":"48","author":"Sidibe","year":"2010","journal-title":"J. Pineal Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"eabn8861","DOI":"10.1126\/science.abn8861","article-title":"Comment on \u201cImpact of neurodegenerative diseases on human adult hippocampal neurogenesis\u201d","volume":"376","author":"Sorrells","year":"2022","journal-title":"Science"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1126\/science.abl5163","article-title":"Impact of neurodegenerative diseases on human adult hippocampal neurogenesis","volume":"374","author":"Trinchero","year":"2021","journal-title":"Science"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1038\/s41467-019-10765-1","article-title":"Immature excitatory neurons develop during adolescence in the human amygdala","volume":"10","author":"Sorrells","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.cell.2011.08.031","article-title":"Synaptic plasticity of feeding circuits: Hormones and hysteresis","volume":"146","author":"Dietrich","year":"2011","journal-title":"Cell"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.tins.2012.12.005","article-title":"Hypothalamic control of energy balance: Insights into the role of synaptic plasticity","volume":"36","author":"Dietrich","year":"2013","journal-title":"Trends Neurosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1126\/science.1127971","article-title":"Regulating energy balance: The substrate strikes back","volume":"312","author":"Flier","year":"2006","journal-title":"Science"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.tem.2004.07.009","article-title":"Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis","volume":"15","author":"Niswender","year":"2004","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.cell.2007.04.001","article-title":"The hormonal control of food intake","volume":"129","author":"Coll","year":"2007","journal-title":"Cell"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nn1454","article-title":"Molecular and anatomical determinants of central leptin resistance","volume":"8","author":"Myers","year":"2005","journal-title":"Nat. Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"E697","DOI":"10.1073\/pnas.1218284110","article-title":"Modulation of AgRP-neuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance","volume":"110","author":"Olofsson","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1172\/JCI59660","article-title":"Obesity is associated with hypothalamic injury in rodents and humans","volume":"122","author":"Thaler","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/nm.2126","article-title":"Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits","volume":"16","author":"Padilla","year":"2010","journal-title":"Nat. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/cne.21492","article-title":"Evidence for constitutive neural cell proliferation in the adult murine hypothalamus","volume":"505","author":"Kokoeva","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1523\/JNEUROSCI.2479-09.2010","article-title":"De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance","volume":"30","author":"Pierce","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1089\/scd.2015.0319","article-title":"Neurogenic niche microglia undergo positional remodeling and progressive activation contributing to age-associated reductions in neurogenesis","volume":"25","author":"Fonseca","year":"2016","journal-title":"Stem Cells Dev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/nn.3163","article-title":"Cross-talk between neural stem cells and immune cells: The key to better brain repair?","volume":"15","author":"Kokaia","year":"2012","journal-title":"Nat. Neurosci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4172\/2155-9562.S4-001","article-title":"Impact of cytokines on neural stem\/progenitor cell fate","volume":"S4","author":"Breton","year":"2011","journal-title":"J. Neurol. Neurophysiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1111\/jcmm.12298","article-title":"TGF-beta signalling in the adult neurogenic niche promotes stem cell quiescence as well as generation of new neurons","volume":"18","author":"Kandasamy","year":"2014","journal-title":"J. Cell. Mol. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/01.jnen.0000218444.53405.f0","article-title":"Transforming growth factor-\u03b21 is a negative modulator of adult neurogenesis","volume":"65","author":"Wachs","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1126\/science.1251141","article-title":"Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors","volume":"344","author":"Katsimpardi","year":"2014","journal-title":"Science"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/jnc.12969","article-title":"Aging and brain rejuvenation as systemic events","volume":"132","author":"Bouchard","year":"2015","journal-title":"J. Neurochem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cell.2008.07.043","article-title":"Hypothalamic IKK\u03b2\/NF-\u03baB and ER stress link overnutrition to energy imbalance and obesity","volume":"135","author":"Zhang","year":"2008","journal-title":"Cell"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cmet.2006.06.010","article-title":"Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells","volume":"4","author":"Kievit","year":"2006","journal-title":"Cell Metab."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nm1071","article-title":"Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity","volume":"10","author":"Mori","year":"2004","journal-title":"Nat. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"894","DOI":"10.2337\/db09-1024","article-title":"Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis","volume":"59","author":"Reed","year":"2010","journal-title":"Diabetes"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"14230","DOI":"10.1074\/jbc.M800061200","article-title":"Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo","volume":"283","author":"Zabolotny","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1172\/JCI39620","article-title":"PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice","volume":"120","author":"Banno","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nm1435","article-title":"Neuronal PTP1B regulates body weight, adiposity and leptin action","volume":"12","author":"Bence","year":"2006","journal-title":"Nat. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.1210\/en.2007-1506","article-title":"Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats","volume":"149","author":"Picardi","year":"2008","journal-title":"Endocrinology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.brainres.2009.03.027","article-title":"Allopregnanolone treatment delays cholesterol accumulation and reduces autophagic\/lysosomal dysfunction and inflammation in Npc1\u2212\/\u2212 mouse brain","volume":"1270","author":"Liao","year":"2009","journal-title":"Brain Res."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Dugan, L.L., Ali, S.S., Shekhtman, G., Roberts, A.J., Lucero, J., Quick, K.L., and Behrens, M.M. (2009). IL-6 mediated degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice through activation of neuronal NADPH oxidase. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0005518"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"9873","DOI":"10.1074\/jbc.M111.312694","article-title":"Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis","volume":"287","author":"Niture","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.cmet.2012.09.007","article-title":"Mitochondrial SKN-1\/Nrf mediates a conserved starvation response","volume":"16","author":"Paek","year":"2012","journal-title":"Cell Metab."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.freeradbiomed.2015.06.030","article-title":"Roles of Nrf2 in cell proliferation and differentiation","volume":"88","author":"Murakami","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.devcel.2007.12.002","article-title":"Keap1\/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila","volume":"14","author":"Sykiotis","year":"2008","journal-title":"Dev. Cell"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"R435","DOI":"10.1152\/ajpregu.00206.2019","article-title":"Obesity-induced sympathoexcitation is associated with Nrf2 dysfunction in the rostral ventrolateral medulla","volume":"318","author":"Balasubramanian","year":"2020","journal-title":"Am. J. Physiol.-Regul. Integr. Comp. Physiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.stem.2010.11.028","article-title":"Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K\/Akt-dependant manner","volume":"8","author":"Orozco","year":"2011","journal-title":"Cell Stem Cell"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"690686","DOI":"10.3389\/fragi.2021.690686","article-title":"An NRF2 perspective on stem cells and ageing","volume":"2","author":"Dodson","year":"2021","journal-title":"Front. Aging"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.celrep.2016.03.084","article-title":"Optimal ROS signaling is critical for nuclear reprogramming","volume":"15","author":"Zhou","year":"2016","journal-title":"Cell Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1177\/0963689718774030","article-title":"A role for Nrf2 expression in defining the aging of hippocampal neural stem cells","volume":"27","author":"Ray","year":"2018","journal-title":"Cell Transplant."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Blasco","year":"2013","journal-title":"Cell"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1007\/s11357-022-00567-7","article-title":"Obesity as a premature aging phenotype\u2014Implications for sarcopenic obesity","volume":"44","author":"Nunan","year":"2022","journal-title":"GeroScience"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.yfrne.2012.12.001","article-title":"Role of the hypothalamus in mediating protective effects of dietary restriction during aging","volume":"34","author":"Dacks","year":"2013","journal-title":"Front. Neuroendocrinol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e12379","DOI":"10.14814\/phy2.12379","article-title":"Transient early food restriction leads to hypothalamic changes in the long-lived crowded litter female mice","volume":"3","author":"Sadagurski","year":"2015","journal-title":"Physiol. Rep."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.cmet.2013.07.013","article-title":"Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH","volume":"18","author":"Satoh","year":"2013","journal-title":"Cell Metab."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nature12143","article-title":"Hypothalamic programming of systemic ageing involving IKK-\u03b2, NF-\u03baB and GnRH","volume":"497","author":"Zhang","year":"2013","journal-title":"Nature"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tem.2012.11.003","article-title":"Neuroinflammation and neurodegeneration in overnutrition-induced diseases","volume":"24","author":"Cai","year":"2013","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"E1003","DOI":"10.1152\/ajpendo.90377.2008","article-title":"Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet","volume":"296","author":"Posey","year":"2009","journal-title":"Am. J. Physiol. -Endocrinol. Metab."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1093\/brain\/awr237","article-title":"Reduced ventricular proliferation in the foetal cortex following maternal inflammation in the mouse","volume":"134","author":"Stolp","year":"2011","journal-title":"Brain"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature23282","article-title":"Hypothalamic stem cells control ageing speed partly through exosomal miRNAs","volume":"548","author":"Zhang","year":"2017","journal-title":"Nature"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/nature02060","article-title":"Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation","volume":"425","author":"Molofsky","year":"2003","journal-title":"Nature"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"38592","DOI":"10.1074\/jbc.M111.252171","article-title":"Aging neural progenitor cells have decreased mitochondrial content and lower oxidative metabolism","volume":"286","author":"Stoll","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nature08197","article-title":"Recent progress in the biology and physiology of sirtuins","volume":"460","author":"Finkel","year":"2009","journal-title":"Nature"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3389\/fphys.2013.00147","article-title":"Mitochondria and FOXO3: Breath or die","volume":"4","author":"Hagenbuchner","year":"2013","journal-title":"Front. Physiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3298","DOI":"10.1093\/brain\/aws259","article-title":"Interleukin 6-preconditioned neural stem cells reduce ischaemic injury in stroke mice","volume":"135","author":"Sakata","year":"2012","journal-title":"Brain"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.stem.2009.09.013","article-title":"FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis","volume":"5","author":"Paik","year":"2009","journal-title":"Cell Stem Cell"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Gemma, C., Vila, J., Bachstetter, A., and Bickford, P.C. (2007). Oxidative stress and the aging brain: From theory to prevention. Brain Aging, 353\u2013374.","DOI":"10.1201\/9781420005523-15"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/j.bbabio.2015.04.010","article-title":"Mitochondria, autophagy and age-associated neurodegenerative diseases: New insights into a complex interplay","volume":"1847","author":"Lionaki","year":"2015","journal-title":"Biochim. Biophys. Acta (BBA)-Bioenerg."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1126\/science.aac9868","article-title":"A mechanism for the segregation of age in mammalian neural stem cells","volume":"349","author":"Moore","year":"2015","journal-title":"Science"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/ncb2102","article-title":"O2 regulates stem cells through Wnt\/\u03b2-catenin signalling","volume":"12","author":"Mazumdar","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.ijdevneu.2011.06.003","article-title":"Impaired hypoxic response in senescent mouse brain","volume":"29","author":"Rabie","year":"2011","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1523\/JNEUROSCI.20-08-02896.2000","article-title":"Peripheral infusion of IGF-I selectively induces neurogenesis in the adult rat hippocampus","volume":"20","author":"Aberg","year":"2000","journal-title":"J. Neurosci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.arr.2005.02.001","article-title":"Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging","volume":"4","author":"Sonntag","year":"2005","journal-title":"Ageing Res. Rev."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/acel.12365","article-title":"Suppression of IGF-I signals in neural stem cells enhances neurogenesis and olfactory function during aging","volume":"14","author":"Chaker","year":"2015","journal-title":"Aging Cell"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1126\/science.1124147","article-title":"Hypothalamic mTOR signaling regulates food intake","volume":"312","author":"Cota","year":"2006","journal-title":"Science"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/1566524013666131118103706","article-title":"Hypothalamic mTOR: The rookie energy sensor","volume":"14","author":"Roa","year":"2014","journal-title":"Curr. Mol. Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.neuron.2012.03.043","article-title":"Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons","volume":"75","author":"Yang","year":"2012","journal-title":"Neuron"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.cmet.2009.03.005","article-title":"Critical role for hypothalamic mTOR activity in energy balance","volume":"9","author":"Mori","year":"2009","journal-title":"Cell Metab."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/417039a","article-title":"Astroglia induce neurogenesis from adult neural stem cells","volume":"417","author":"Song","year":"2002","journal-title":"Nature"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.1096\/fj.11-184697","article-title":"Reduction in paracrine Wnt3 factors during aging causes impaired adult neurogenesis","volume":"25","author":"Okamoto","year":"2011","journal-title":"FASEB J."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/j.1474-9726.2012.00816.x","article-title":"Aging brain microenvironment decreases hippocampal neurogenesis through Wnt-mediated survivin signaling","volume":"11","author":"Miranda","year":"2012","journal-title":"Aging Cell"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.stem.2012.11.010","article-title":"Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline","volume":"12","author":"Seib","year":"2013","journal-title":"Cell Stem Cell"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1016\/j.bbagen.2014.01.010","article-title":"Extracellular matrix: A dynamic microenvironment for stem cell niche","volume":"1840","author":"Gattazzo","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA)-Gen. Subj."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1002\/stem.746","article-title":"Rho GTPases mediate the mechanosensitive lineage commitment of neural stem cells","volume":"29","author":"Keung","year":"2011","journal-title":"Stem Cells"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1093\/hmg\/ddx128","article-title":"Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis","volume":"26","author":"Li","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nature20577","article-title":"m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination","volume":"540","author":"Haussmann","year":"2016","journal-title":"Nature"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1038\/nn.4378","article-title":"Evolving insights into RNA modifications and their functional diversity in the brain","volume":"19","author":"Nainar","year":"2016","journal-title":"Nat. Neurosci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1101\/gad.262766.115","article-title":"RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation","volume":"29","author":"Yue","year":"2015","journal-title":"Genes Dev."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1210\/en.2004-0231","article-title":"Minireview: Leptin and development of hypothalamic feeding circuits","volume":"145","author":"Bouret","year":"2004","journal-title":"Endocrinology"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.brainres.2008.12.026","article-title":"Impaired neurogenesis in adult type-2 diabetic rats","volume":"1258","author":"Lang","year":"2009","journal-title":"Brain Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.expneurol.2007.11.009","article-title":"Prominently decreased hippocampal neurogenesis in a spontaneous model of type 1 diabetes, the nonobese diabetic mouse","volume":"210","author":"Beauquis","year":"2008","journal-title":"Exp. Neurol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1096\/fj.06-5989fje","article-title":"Leptin signaling in neurotensin neurons involves STAT, MAP kinases ERK1\/2, and p38 through c-Fos and ATF1","volume":"20","author":"Cui","year":"2006","journal-title":"FASEB J."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1210\/en.2010-1217","article-title":"Fetal hypothalamic neuroprogenitor cell culture: Preferential differentiation paths induced by leptin and insulin","volume":"152","author":"Desai","year":"2011","journal-title":"Endocrinology"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0361-9230(99)00197-5","article-title":"Leptin-induced increase in sympathetic nervous and cardiovascular tone is mediated by proopiomelanocortin (POMC) products","volume":"50","author":"Dunbar","year":"1999","journal-title":"Brain Res. Bull."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1161\/01.HYP.33.1.542","article-title":"Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic","volume":"33","author":"Haynes","year":"1999","journal-title":"Hypertension"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nn1455","article-title":"Anatomy and regulation of the central melanocortin system","volume":"8","author":"Cone","year":"2005","journal-title":"Nat. Neurosci."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"King, C., and Sarvetnick, N. (2011). The incidence of type-1 diabetes in NOD mice is modulated by restricted flora not germ-free conditions. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0017049"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.cmet.2008.12.001","article-title":"The geometry of leptin action in the brain: More complicated than a simple ARC","volume":"9","author":"Myers","year":"2009","journal-title":"Cell Metab."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/cne.22571","article-title":"Forebrain origins of glutamatergic innervation to the rat paraventricular nucleus of the hypothalamus: Differential inputs to the anterior versus posterior subregions","volume":"519","author":"Jones","year":"2011","journal-title":"J. Comp. Neurol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fnins.2013.00019","article-title":"Unraveling the central proopiomelanocortin neural circuits","volume":"7","author":"Mercer","year":"2013","journal-title":"Front. Neurosci."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Kawabe, T., Kawabe, K., and Sapru, H.N. (2012). Cardiovascular responses to chemical stimulation of the hypothalamic arcuate nucleus in the rat: Role of the hypothalamic paraventricular nucleus. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0045180"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Kawabe, T., Kawabe, K., and Sapru, H.N. (2012). Effect of barodenervation on cardiovascular responses elicited from the hypothalamic arcuate nucleus of the rat. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0053111"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1113\/jphysiol.2013.268763","article-title":"Neuropeptide Y acts in the paraventricular nucleus to suppress sympathetic nerve activity and its baroreflex regulation","volume":"592","author":"Cassaglia","year":"2014","journal-title":"J. Physiol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.tem.2004.10.007","article-title":"The electrophysiology of feeding circuits","volume":"15","author":"Jobst","year":"2004","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/embor.2012.174","article-title":"Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis","volume":"13","author":"Varela","year":"2012","journal-title":"EMBO Rep."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"17271","DOI":"10.1074\/jbc.R110.113175","article-title":"Obesity-induced hypertension: Role of sympathetic nervous system, leptin, and melanocortins","volume":"285","author":"Hall","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cmet.2007.09.006","article-title":"High-fat diet disrupts behavioral and molecular circadian rhythms in mice","volume":"6","author":"Kohsaka","year":"2007","journal-title":"Cell Metab."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/ijo.2009.257","article-title":"A free-choice high-fat high-sugar diet induces changes in arcuate neuropeptide expression that support hyperphagia","volume":"34","author":"Luijendijk","year":"2010","journal-title":"Int. J. Obes."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0006-8993(00)02580-4","article-title":"Leptin receptor, NPY, POMC mRNA expression in the diet-induced obese mouse brain","volume":"875","author":"Lin","year":"2000","journal-title":"Brain Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.cmet.2007.12.001","article-title":"Hypothalamic neural projections are permanently disrupted in diet-induced obese rats","volume":"7","author":"Bouret","year":"2008","journal-title":"Cell Metab."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1161\/HYPERTENSIONAHA.115.06017","article-title":"Role of the paraventricular nucleus of the hypothalamus in the sympathoexcitatory effects of leptin","volume":"66","author":"Shi","year":"2015","journal-title":"Hypertension"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Plakkot, B., and Subramanian, M. (2022). Evaluation of Hypothalamic Neural Stem Cell Niche\u2013Implications on Obesity-Induced Sympathoexcitation. FASEB J., 36.","DOI":"10.1096\/fasebj.2022.36.S1.R6154"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.cmet.2018.05.011","article-title":"Hallmarks of brain aging: Adaptive and pathological modification by metabolic states","volume":"27","author":"Mattson","year":"2018","journal-title":"Cell Metab."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40778-017-0072-x","article-title":"Dietary regulation of adult stem cells","volume":"3","author":"Mana","year":"2017","journal-title":"Curr. Stem Cell Rep."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/ana.21798","article-title":"Age and energy intake interact to modify cell stress pathways and stroke outcome","volume":"67","author":"Arumugam","year":"2010","journal-title":"Ann. Neurol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.nbd.2006.12.019","article-title":"Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer\u2019s disease","volume":"26","author":"Halagappa","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/jcbfm.2014.36","article-title":"Intermittent fasting attenuates increases in neurogenesis after ischemia and reperfusion and improves recovery","volume":"34","author":"Manzanero","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_139","first-page":"8","article-title":"Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults","volume":"45","author":"Umberger","year":"1999","journal-title":"Ann. Neurol. Off. J. Am. Neurol. Assoc. Child Neurol. Soc."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1093\/hmg\/ddy057","article-title":"Transcriptome analysis reveals intermittent fasting-induced genetic changes in ischemic stroke","volume":"27","author":"Kim","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"e01444","DOI":"10.1002\/brb3.1444","article-title":"Intermittent fasting increases adult hippocampal neurogenesis","volume":"10","author":"Baik","year":"2020","journal-title":"Brain Behav."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1101\/gad.975202","article-title":"Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells","volume":"16","author":"Hitoshi","year":"2002","journal-title":"Genes Dev."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3389\/fncel.2015.00447","article-title":"Notch1 regulates hippocampal plasticity through interaction with the reelin pathway, glutamatergic transmission and CREB signaling","volume":"9","author":"Brai","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1080\/01616412.2019.1610226","article-title":"Rosuvastatin improves neurite extension in cortical neurons through the Notch 1\/BDNF pathway","volume":"41","author":"He","year":"2019","journal-title":"Neurol. Res."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00109-007-0196-z","article-title":"Transcriptional regulation of neurogenesis: Potential mechanisms in cerebral ischemia","volume":"85","author":"Schwaninger","year":"2007","journal-title":"J. Mol. Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1038\/ncomms4557","article-title":"Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys","volume":"5","author":"Colman","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1126\/science.1172539","article-title":"Extending healthy life span\u2014From yeast to humans","volume":"328","author":"Fontana","year":"2010","journal-title":"Science"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.tips.2009.11.004","article-title":"Calorie restriction and cancer prevention: Metabolic and molecular mechanisms","volume":"31","author":"Longo","year":"2010","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.arr.2011.11.005","article-title":"Of mice and men: The benefits of caloric restriction, exercise, and mimetics","volume":"11","author":"Mercken","year":"2012","journal-title":"Ageing Res. Rev."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ghir.2008.05.005","article-title":"Role of the GH\/IGF-1 axis in lifespan and healthspan: Lessons from animal models","volume":"18","author":"Berryman","year":"2008","journal-title":"Growth Horm. IGF Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cmet.2013.12.008","article-title":"Fasting: Molecular mechanisms and clinical applications","volume":"19","author":"Longo","year":"2014","journal-title":"Cell Metab."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1385\/JMN:15:2:99","article-title":"Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats","volume":"15","author":"Lee","year":"2000","journal-title":"J. Mol. Neurosci."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1046\/j.0022-3042.2001.00747.x","article-title":"Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice","volume":"80","author":"Lee","year":"2002","journal-title":"J. Neurochem."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.cmet.2015.05.012","article-title":"A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance, and healthspan","volume":"22","author":"Brandhorst","year":"2015","journal-title":"Cell Metab."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.stem.2014.04.014","article-title":"Prolonged fasting reduces IGF-1\/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression","volume":"14","author":"Cheng","year":"2014","journal-title":"Cell Stem Cell"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/emboj.2011.459","article-title":"Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors","volume":"31","author":"Ng","year":"2012","journal-title":"EMBO J."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.stem.2015.03.003","article-title":"The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling","volume":"16","author":"Wang","year":"2015","journal-title":"Cell Stem Cell"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/ng.710","article-title":"Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells","volume":"42","author":"Loewer","year":"2010","journal-title":"Nat. Genet."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.cmet.2020.01.002","article-title":"Reducing hypothalamic stem cell senescence protects against aging-associated physiological decline","volume":"31","author":"Xiao","year":"2020","journal-title":"Cell Metab."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1007\/s00429-014-0786-9","article-title":"Differential distribution of Y-box-binding protein 1 and cold shock domain protein A in developing and adult human brain","volume":"220","author":"Bernstein","year":"2015","journal-title":"Brain Struct. Funct."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"7702","DOI":"10.1074\/jbc.M413353200","article-title":"Transcription factor YB-1 mediates DNA polymerase \u03b1 gene expression","volume":"280","author":"Yilmaz","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1093\/nar\/29.5.1200","article-title":"Y box-binding protein-1 binds preferentially to single-stranded nucleic acids and exhibits 3\u2032\u2192 5\u2032 exonuclease activity","volume":"29","author":"Izumi","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1111\/gtc.12093","article-title":"YB 1 binds to and represses the p16 tumor suppressor gene","volume":"18","author":"Kotake","year":"2013","journal-title":"Genes Cells"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.brainres.2011.11.021","article-title":"Theaflavin, a black tea polyphenol, protects nigral dopaminergic neurons against chronic MPTP\/probenecid induced Parkinson\u2019s disease","volume":"1433","author":"Anandhan","year":"2012","journal-title":"Brain Res."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.cell.2008.09.017","article-title":"Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression","volume":"135","author":"Nishino","year":"2008","journal-title":"Cell"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0959-437X(02)00013-8","article-title":"Tumor suppression by Ink4a\u2013Arf: Progress and puzzles","volume":"13","author":"Lowe","year":"2003","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature05091","article-title":"Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing","volume":"443","author":"Molofsky","year":"2006","journal-title":"Nature"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1073\/pnas.0908750107","article-title":"MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling","volume":"107","author":"Zhao","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"e00924","DOI":"10.7554\/eLife.00924","article-title":"A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties","volume":"2","author":"Nishino","year":"2013","journal-title":"Elife"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3389\/fgene.2015.00087","article-title":"Non-coding RNA in neural function, disease, and aging","volume":"6","author":"Szafranski","year":"2015","journal-title":"Front. Genet."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Spinelli, M., Natale, F., Rinaudo, M., Leone, L., Mezzogori, D., Fusco, S., and Grassi, C. (2020). Neural Stem Cell-Derived Exosomes Revert HFD-Dependent Memory Impairment via CREB-BDNF Signalling. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21238994"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s12015-011-9266-2","article-title":"Current challenges for the advancement of neural stem cell biology and transplantation research","volume":"8","author":"Reekmans","year":"2012","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nrm3448","article-title":"Induced pluripotent stem cells: The new patient?","volume":"13","author":"Bellin","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/5\/769\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:44:13Z","timestamp":1760121853000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/5\/769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,28]]},"references-count":173,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["cells12050769"],"URL":"https:\/\/doi.org\/10.3390\/cells12050769","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,28]]}}}