{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:21:57Z","timestamp":1789582917224,"version":"build-2803163510"},"reference-count":259,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This research received no external funding"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Improvement of insulin secretion by pancreatic \u03b2-cells and preservation of their mass are the current challenges that future antidiabetic drugs should meet for achieving efficient and long-term glycemic control in patients with type 2 diabetes (T2D). The successful development of glucagon-like peptide 1 (GLP-1) analogues, derived from the saliva of a lizard from the Helodermatidae family, has provided the proof of concept that antidiabetic drugs directly targeting pancreatic \u03b2-cells can emerge from venomous animals. The literature reporting on the antidiabetic effects of medicinal plants suggests that they contain some promising active substances such as polyphenols and alkaloids, which could be active as insulin secretagogues and \u03b2-cell protectors. In this review, we discuss the potential of several polyphenols, alkaloids and venom peptides from snake, frogs, scorpions and cone snails. These molecules could contribute to the development of new efficient antidiabetic medicines targeting \u03b2-cells, which would tackle the progression of the disease.<\/jats:p>","DOI":"10.3390\/cells12060940","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T06:48:35Z","timestamp":1679294915000},"page":"940","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Venom Peptides, Polyphenols and Alkaloids: Are They the Next Antidiabetics That Will Preserve \u03b2-Cell Mass and Function in Type 2 Diabetes?"],"prefix":"10.3390","volume":"12","author":[{"given":"Michele","family":"Lodato","sequence":"first","affiliation":[{"name":"University Lille, CNRS, Centrale Lille, University Polytechnique Hauts-de-France, UMR 8520, IEMN, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Plaisance","sequence":"additional","affiliation":[{"name":"University Lille, CNRS, Centrale Lille, University Polytechnique Hauts-de-France, UMR 8520, IEMN, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Pawlowski","sequence":"additional","affiliation":[{"name":"University Lille, CNRS, Centrale Lille, University Polytechnique Hauts-de-France, UMR 8520, IEMN, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Kwapich","sequence":"additional","affiliation":[{"name":"University Lille, CNRS, Centrale Lille, University Polytechnique Hauts-de-France, UMR 8520, IEMN, F-59000 Lille, France"},{"name":"Service de Diab\u00e9tologie et d\u2019Endocrinologie, CH Dunkerque, 59385 Dunkirk, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2821-7079","authenticated-orcid":false,"given":"Alexandre","family":"Barras","sequence":"additional","affiliation":[{"name":"University Lille, CNRS, Centrale Lille, University Polytechnique Hauts-de-France, UMR 8520, IEMN, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeline","family":"Buissart","sequence":"additional","affiliation":[{"name":"University Lille, CNRS, Centrale Lille, University Polytechnique Hauts-de-France, UMR 8520, IEMN, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Dalle","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9nomique Fonctionnelle, Universit\u00e9 de Montpellier, CNRS, INSERM, 34094 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1567-4943","authenticated-orcid":false,"given":"Sabine","family":"Szunerits","sequence":"additional","affiliation":[{"name":"University Lille, CNRS, Centrale Lille, University Polytechnique Hauts-de-France, UMR 8520, IEMN, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8360-7497","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Vicogne","sequence":"additional","affiliation":[{"name":"University Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9795-9888","authenticated-orcid":false,"given":"Rabah","family":"Boukherroub","sequence":"additional","affiliation":[{"name":"University Lille, CNRS, Centrale Lille, University Polytechnique Hauts-de-France, UMR 8520, IEMN, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0752-0343","authenticated-orcid":false,"given":"Amar","family":"Abderrahmani","sequence":"additional","affiliation":[{"name":"University Lille, CNRS, Centrale Lille, University Polytechnique Hauts-de-France, UMR 8520, IEMN, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"key":"ref_1","first-page":"3","article-title":"Between Religion and Science: Some Aspects: Concerning Illness and Healing in Antiquity","volume":"XXIV","author":"Bungau","year":"2015","journal-title":"Transylv. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural Products as Sources of New Drugs over the Nearly Four Decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.11622\/smedj.2017002","article-title":"Frederick Banting (1891\u20131941): Discoverer of Insulin","volume":"58","author":"Tan","year":"2017","journal-title":"Singap. Med. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1007\/s00125-017-4318-z","article-title":"Metformin: Historical Overview","volume":"60","author":"Bailey","year":"2017","journal-title":"Diabetologia"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Drzewoski, J., and Hanefeld, M. (2021). The Current and Potential Therapeutic Use of Metformin\u2014The Good Old Drug. Pharmaceuticals, 14.","DOI":"10.3390\/ph14020122"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1016\/j.bbadis.2016.09.019","article-title":"Metformin, beyond an Insulin Sensitizer, Targeting Heart and Pancreatic \u03b2 Cells","volume":"1863","author":"Yang","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s13300-013-0042-y","article-title":"Sodium Glucose Co-Transporter Type 2 (SGLT2) Inhibitors: Targeting the Kidney to Improve Glycemic Control in Diabetes Mellitus","volume":"4","author":"Bays","year":"2013","journal-title":"Diabetes Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0140-6736(20)31824-9","article-title":"SGLT2 Inhibitors in Patients with Heart Failure with Reduced Ejection Fraction: A Meta-Analysis of the EMPEROR-Reduced and DAPA-HF Trials","volume":"396","author":"Zannad","year":"2020","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0140-6736(22)01429-5","article-title":"SGLT-2 Inhibitors in Patients with Heart Failure: A Comprehensive Meta-Analysis of Five Randomised Controlled Trials","volume":"400","author":"Vaduganathan","year":"2022","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2337\/diaclin.28.1.5","article-title":"Apple Trees to Sodium Glucose Co-Transporter Inhibitors: A Review of SGLT2 Inhibition","volume":"28","author":"White","year":"2010","journal-title":"Clin. Diabetes"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1152\/ajplegacy.1903.10.1.67","article-title":"On the Action of Phlorhizin","volume":"10","author":"Stiles","year":"1903","journal-title":"Am. J. Physiol.-Leg. Content"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Abderrahmani, A., Jacovetti, C., and Regazzi, R. (2022). Lessons from Neonatal \u03b2-Cell Epigenomic for Diabetes Prevention and Treatment. Trends Endocrinol. Metab., S1043-2760(22)00054-6.","DOI":"10.1016\/j.tem.2022.03.002"},{"key":"ref_13","first-page":"2396","article-title":"Metabolic and Cardiovascular Benefits of GLP-1 Agonists, besides the Hypoglycemic Effect (Review)","volume":"20","author":"Iorga","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cmet.2006.10.001","article-title":"GLP-1 Receptor Activation Improves Beta Cell Function and Survival Following Induction of Endoplasmic Reticulum Stress","volume":"4","author":"Yusta","year":"2006","journal-title":"Cell Metab."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1463-1326.2008.00969.x","article-title":"Pancreatic Beta-Cell Mass in European Subjects with Type 2 Diabetes","volume":"10","author":"Rahier","year":"2008","journal-title":"Diabetes Obes. Metab."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2337\/diabetes.52.1.102","article-title":"Beta-Cell Deficit and Increased Beta-Cell Apoptosis in Humans with Type 2 Diabetes","volume":"52","author":"Butler","year":"2003","journal-title":"Diabetes"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"222","DOI":"10.2337\/diab.34.3.222","article-title":"The Effect of Insulin Treatment on Insulin Secretion and Insulin Action in Type II Diabetes Mellitus","volume":"34","author":"Garvey","year":"1985","journal-title":"Diabetes"},{"key":"ref_18","first-page":"G470","article-title":"Actions of Gila Monster Venom on Dispersed Acini from Guinea Pig Pancreas","volume":"242","author":"Raufman","year":"1982","journal-title":"Am. J. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"19650","DOI":"10.1016\/S0021-9258(19)36565-2","article-title":"Exendin-4 Is a High Potency Agonist and Truncated Exendin-(9-39)-Amide an Antagonist at the Glucagon-like Peptide 1-(7-36)-Amide Receptor of Insulin-Secreting Beta-Cells","volume":"268","author":"Fehmann","year":"1993","journal-title":"J. Biol. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Abderrahmani, A., Dalle, S., Szunerits, S., Boukherroub, B., and El Ouaamari, A. (2022). Nanotechnology for Diabetes Management, Royal Society of Chemistry.","DOI":"10.1039\/9781839165498"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"101102","DOI":"10.1016\/j.molmet.2020.101102","article-title":"GLP-1 Receptor Agonists in the Treatment of Type 2 Diabetes\u2013State-of-the-Art","volume":"46","author":"Nauck","year":"2021","journal-title":"Mol. Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1001\/archinte.164.10.1134","article-title":"Trends in Complexity of Diabetes Care in the United States from 1991 to 2000","volume":"164","author":"Grant","year":"2004","journal-title":"Arch. Intern. Med."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"MacLean, C.D., Littenberg, B., and Kennedy, A.G. (2006). Limitations of Diabetes Pharmacotherapy: Results from the Vermont Diabetes Information System Study. BMC Fam. Prac., 7.","DOI":"10.1186\/1471-2296-7-50"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1758-5996-6-110","article-title":"Prediction of Response to GLP-1 Receptor Agonist Therapy in Japanese Patients with Type 2 Diabetes","volume":"6","author":"Imai","year":"2014","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.2337\/dc14-0398","article-title":"Effect of Exenatide, Sitagliptin, or Glimepiride on \u03b2-Cell Secretory Capacity in Early Type 2 Diabetes","volume":"37","author":"Gudipaty","year":"2014","journal-title":"Diabetes Care"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1463-1326.2008.00945.x","article-title":"An Examination of Beta-Cell Function Measures and Their Potential Use for Estimating Beta-Cell Mass","volume":"10","author":"Kahn","year":"2008","journal-title":"Diabetes Obes. Metab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/dmr.5610100104","article-title":"Secondary Failure of Oral Hypoglycaemic Agents: Frequency, Possible Causes, and Management","volume":"10","author":"Pontiroli","year":"1994","journal-title":"Diabetes Metab. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"U.K. Prospective Diabetes Study Group (1995). U.K. Prospective Diabetes Study 16. Overview of 6 Years\u2019 Therapy of Type II Diabetes: A Progressive Disease. Diabetes, 44, 1249\u20131258.","DOI":"10.2337\/diabetes.44.11.1249"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1124\/jpet.105.097501","article-title":"Glibenclamide-Induced Apoptosis Is Specifically Enhanced by Expression of the Sulfonylurea Receptor Isoform SUR1 but Not by Expression of SUR2B or the Mutant SUR1(M1289T)","volume":"316","author":"Hambrock","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1006\/bbrc.2000.2616","article-title":"Sustained Enhancement of Ca(2+) Influx by Glibenclamide Induces Apoptosis in RINm5F Cells","volume":"271","author":"Iwakura","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"840","DOI":"10.5114\/aoms.2015.53304","article-title":"Sulfonylureas and Their Use in Clinical Practice","volume":"11","author":"Sola","year":"2015","journal-title":"Arch. Med. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S2213-8587(18)30025-1","article-title":"Do Sulphonylureas Still Have a Place in Clinical Practice?","volume":"6","author":"Khunti","year":"2018","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.metabol.2006.02.003","article-title":"The Place of Sulfonylureas in the Therapy for Type 2 Diabetes Mellitus","volume":"55","author":"Pulizzi","year":"2006","journal-title":"Metabolism"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1017\/S0007485316000687","article-title":"de Ancient Origin and Recent Range Expansion of the Maize Weevil Sitophilus Zeamais, and Its Genealogical Relationship to the Rice Weevil S. Oryzae","volume":"107","author":"Vinson","year":"2017","journal-title":"Bull. Entomol. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"101212","DOI":"10.1016\/j.molmet.2021.101212","article-title":"Glucose-Induced Insulin Secretion in Isolated Human Islets: Does It Truly Reflect \u03b2-Cell Function in Vivo?","volume":"48","author":"Henquin","year":"2021","journal-title":"Mol. Metab."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4910","DOI":"10.1091\/mbc.e09-04-0284","article-title":"Evidence That Electrostatic Interactions between Vesicle-Associated Membrane Protein 2 and Acidic Phospholipids May Modulate the Fusion of Transport Vesicles with the Plasma Membrane","volume":"20","author":"Williams","year":"2009","journal-title":"Mol. Biol. Cell."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/dom.13001","article-title":"Recent New Insights into the Role of SNARE and Associated Proteins in Insulin Granule Exocytosis","volume":"19","author":"Gaisano","year":"2017","journal-title":"Diabetes Obes. Metab."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1042\/BST0340696","article-title":"Mechanisms Controlling the Expression of the Components of the Exocytotic Apparatus under Physiological and Pathological Conditions","volume":"34","author":"Abderrahmani","year":"2006","journal-title":"Biochem. Soc. Trans."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pharmthera.2017.05.003","article-title":"Mechanisms of the Amplifying Pathway of Insulin Secretion in the \u03b2 Cell","volume":"179","author":"Kalwat","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/bs.apha.2017.03.001","article-title":"Modulation of Ion Channels by Cysteine-Rich Peptides: From Sequence to Structure","volume":"79","author":"Mobli","year":"2017","journal-title":"Adv. Pharmacol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.3389\/fphar.2020.01132","article-title":"From Animal Poisons and Venoms to Medicines: Achievements, Challenges and Perspectives in Drug Discovery","volume":"11","author":"Bordon","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_42","first-page":"11795514211006072","article-title":"Therapeutic Potential of Peptides Derived from Animal Venoms: Current Views and Emerging Drugs for Diabetes","volume":"14","author":"McClean","year":"2021","journal-title":"Clin. Med. Insights Endocrinol. Diabetes"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.toxicon.2019.03.003","article-title":"Elevated Plasma Levels of Hepatocyte Growth Factor in Rats Experimentally Envenomated with Bothrops Jararaca Venom: Role of Snake Venom Metalloproteases","volume":"162","author":"Prezoto","year":"2019","journal-title":"Toxicon"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3389\/fendo.2018.00503","article-title":"The Role of Hepatocyte Growth Factor (HGF) in Insulin Resistance and Diabetes","volume":"9","author":"Oliveira","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.toxicon.2010.12.016","article-title":"The Development of Byetta (Exenatide) from the Venom of the Gila Monster as an Anti-Diabetic Agent","volume":"59","author":"Furman","year":"2012","journal-title":"Toxicon"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.jmb.2019.08.009","article-title":"New Insights into Beta-Cell GLP-1 Receptor and CAMP Signaling","volume":"432","author":"Tomas","year":"2020","journal-title":"J. Mol. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.cellsig.2012.11.009","article-title":"Specific Actions of GLP-1 Receptor Agonists and DPP4 Inhibitors for the Treatment of Pancreatic \u03b2-Cell Impairments in Type 2 Diabetes","volume":"25","author":"Dalle","year":"2013","journal-title":"Cell. Signal."},{"key":"ref_48","first-page":"581","article-title":"Isolation and Structural Characterisation of a Novel 13-Amino Acid Insulin-Releasing Peptide from the Skin Secretion of Agalychnis Calcarifer","volume":"386","author":"Marenah","year":"2005","journal-title":"Diabetologia"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Jones, B., McGlone, E.R., Fang, Z., Pickford, P., Corr\u00eaa, I.R., Oishi, A., Jockers, R., Inoue, A., Kumar, S., and G\u00f6rlitz, F. (2020). Genetic and Biased Agonist-Mediated Reductions in \u03b2-Arrestin Recruitment Prolong CAMP Signalling at Glucagon Family Receptors. J. Biol. Chem.","DOI":"10.1074\/jbc.RA120.016334"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"37744","DOI":"10.1038\/srep37744","article-title":"Monotreme Glucagon-like Peptide-1 in Venom and Gut: One Gene-Two Very Different Functions","volume":"6","author":"He","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/387179a0","article-title":"Truncation of Kir6.2 Produces ATP-Sensitive K+ Channels in the Absence of the Sulphonylurea Receptor","volume":"387","author":"Tucker","year":"1997","journal-title":"Nature"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.2337\/diabetes.52.10.2526","article-title":"Sulfonylureas Rapidly Cross Phospholipid Bilayer Membranes by a Free-Diffusion Mechanism","volume":"52","author":"Kamp","year":"2003","journal-title":"Diabetes"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00125-003-1143-3","article-title":"Sulphonylurea Action Revisited: The Post-Cloning Era","volume":"46","author":"Gribble","year":"2003","journal-title":"Diabetologia"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev.me.31.020180.001401","article-title":"Efficacy and Safety of Oral Hypoglycemic Agents","volume":"31","author":"Seltzer","year":"1980","journal-title":"Annu. Rev. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"125","DOI":"10.7326\/0003-4819-102-1-125","article-title":"The Second-Generation Sulfonylureas: Change or Progress?","volume":"102","author":"Kreisberg","year":"1985","journal-title":"Ann. Intern. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1345\/aph.17360","article-title":"Glimepiride: Role of a New Sulfonylurea in the Treatment of Type 2 Diabetes Mellitus","volume":"32","author":"Campbell","year":"1998","journal-title":"Ann. Pharmacother."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1016\/S0140-6736(01)06715-0","article-title":"Insulinotropic Meglitinide Analogues","volume":"358","author":"Dornhorst","year":"2001","journal-title":"Lancet"},{"key":"ref_58","first-page":"787","article-title":"Mastoparan Increases the Intracellular Free Calcium Concentration in Two Insulin-Secreting Cell Lines by Inhibition of ATP-Sensitive Potassium Channels","volume":"47","author":"Eddlestone","year":"1995","journal-title":"Mol. Pharmacol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.biochi.2014.11.018","article-title":"Beneficial Effects of Tigerinin-1R on Glucose Homeostasis and Beta Cell Function in Mice with Diet-Induced Obesity-Diabetes","volume":"109","author":"Ojo","year":"2015","journal-title":"Biochimie"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.bbrc.2003.09.018","article-title":"Secretory Phospholipase A2 Is Released from Pancreatic \u03b2-Cells and Stimulates Insulin Secretion via Inhibition of ATP-Dependent K+ Channels","volume":"310","author":"Juhl","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1085\/jgp.201812017","article-title":"A Novel High-Affinity Inhibitor against the Human ATP-Sensitive Kir6.2 Channel","volume":"150","author":"Ramu","year":"2018","journal-title":"J. Gen. Physiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e77026","DOI":"10.7554\/eLife.77026","article-title":"Blocking Kir6.2 Channels with SpTx1 Potentiates Glucose-Stimulated Insulin Secretion from Murine Pancreatic \u03b2 Cells and Lowers Blood Glucose in Diabetic Mice","volume":"11","author":"Ramu","year":"2022","journal-title":"Elife"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S2213-8587(14)70213-X","article-title":"Mortality Risk among Sulfonylureas: A Systematic Review and Network Meta-Analysis","volume":"3","author":"Simpson","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.2337\/diabetes.47.7.1053","article-title":"Glucose Augmentation of Mastoparan-Stimulated Insulin Secretion in Rat and Human Pancreatic Islets","volume":"47","author":"Straub","year":"1998","journal-title":"Diabetes"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"23297","DOI":"10.1016\/S0021-9258(19)49462-3","article-title":"Mastoparan Stimulates Exocytosis at a Ca(2+)-Independent Late Site in Stimulus-Secretion Coupling. Studies with the RINm5F Beta-Cell Line","volume":"268","author":"Komatsu","year":"1993","journal-title":"J. Biol. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"4508","DOI":"10.1210\/en.2003-0106","article-title":"Mastoparan-Induced Insulin Secretion from Insulin-Secreting BetaTC3 and INS-1 Cells: Evidence for Its Regulation by Rho Subfamily of G Proteins","volume":"144","author":"Amin","year":"2003","journal-title":"Endocrinology"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.2337\/diabetes.55.04.06.db05-0788","article-title":"Blockers of the Delayed-Rectifier Potassium Current in Pancreatic Beta-Cells Enhance Glucose-Dependent Insulin Secretion","volume":"55","author":"Herrington","year":"2006","journal-title":"Diabetes"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1515\/hsz-2016-0120","article-title":"Molecular Mechanisms Mediating the Beneficial Metabolic Effects of [Arg4]Tigerinin-1R in Mice with Diet-Induced Obesity and Insulin Resistance","volume":"397","author":"Ojo","year":"2016","journal-title":"Biol. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1007\/s00125-003-1159-8","article-title":"Voltage-Dependent K(+) Channels in Pancreatic Beta Cells: Role, Regulation and Potential as Therapeutic Targets","volume":"46","author":"MacDonald","year":"2003","journal-title":"Diabetologia"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Dwenger, M.M., Raph, S.M., Baba, S.P., Moore, J.B., and Nystoriak, M.A. (2022). Diversification of Potassium Currents in Excitable Cells via Kv\u03b2 Proteins. Cells, 11.","DOI":"10.3390\/cells11142230"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e13748","DOI":"10.14814\/phy2.13748","article-title":"Inhibition of BKCa Negatively Alters Cardiovascular Function","volume":"6","author":"Patel","year":"2018","journal-title":"Physiol. Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/emmm.201200218","article-title":"Block of Kv1.7 Potassium Currents Increases Glucose-Stimulated Insulin Secretion","volume":"4","author":"Remedi","year":"2012","journal-title":"EMBO Mol. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1113\/jphysiol.2005.089375","article-title":"Biophysical and Pharmacological Properties of the Voltage-Gated Potassium Current of Human Pancreatic Beta-Cells","volume":"567","author":"Herrington","year":"2005","journal-title":"J. Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.2337\/db07-0991","article-title":"Voltage-Gated Ion Channels in Human Pancreatic Beta-Cells: Electrophysiological Characterization and Role in Insulin Secretion","volume":"57","author":"Braun","year":"2008","journal-title":"Diabetes"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"44938","DOI":"10.1074\/jbc.M205532200","article-title":"Inhibition of Kv2.1 Voltage-Dependent K+Channels in Pancreatic \u03b2-Cells Enhances Glucose-Dependent Insulin Secretion*","volume":"277","author":"MacDonald","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Yacoub, T., Rima, M., Karam, M., Sabatier, J.-M., and Fajloun, Z. (2020). Antimicrobials from Venomous Animals: An Overview. Molecules, 25.","DOI":"10.3390\/molecules25102402"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1006\/bbrc.1998.8159","article-title":"Mechanism of Action of the Antimicrobial Peptide Buforin II: Buforin II Kills Microorganisms by Penetrating the Cell Membrane and Inhibiting Cellular Functions","volume":"244","author":"Park","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nrd1197","article-title":"Therapeutic Potential of Venom Peptides","volume":"2","author":"Lewis","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/sj.jhh.1000428","article-title":"Efficacy of Captopril and Nifedipine in Black and White Patients with Hypertensive Crisis","volume":"11","author":"Damasceno","year":"1997","journal-title":"J. Hum. Hypertens."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/jlcr.3087","article-title":"Multifunctional Targeted Therapy System Based on (99m) Tc\/(177) Lu-Labeled Gold Nanoparticles-Tat(49-57)-Lys(3) -Bombesin Internalized in Nuclei of Prostate Cancer Cells","volume":"56","year":"2013","journal-title":"J. Labelled Comp. Radiopharm."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1096\/fj.03-1459fje","article-title":"Crotamine Is a Novel Cell-Penetrating Protein from the Venom of Rattlesnake Crotalus Durissus Terrificus","volume":"18","author":"Kerkis","year":"2004","journal-title":"FASEB J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.peptides.2017.09.001","article-title":"Peptides from Frog Skin with Potential for Development into Agents for Type 2 Diabetes Therapy","volume":"100","author":"Conlon","year":"2018","journal-title":"Peptides"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Amatya, R., Park, T., Hwang, S., Yang, J., Lee, Y., Cheong, H., Moon, C., Kwak, H.D., Min, K.A., and Shin, M.C. (2020). Drug Delivery Strategies for Enhancing the Therapeutic Efficacy of Toxin-Derived Anti-Diabetic Peptides. Toxins, 12.","DOI":"10.3390\/toxins12050313"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.toxicon.2012.05.027","article-title":"Agelaia MP-I: A Peptide Isolated from the Venom of the Social Wasp, Agelaia Pallipes Pallipes, Enhances Insulin Secretion in Mice Pancreatic Islets","volume":"60","author":"Saidemberg","year":"2012","journal-title":"Toxicon"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/cbdd.12151","article-title":"Insulinotropic Actions of the Frog Skin Host-Defense Peptide Alyteserin-2a: A Structure-Activity Study","volume":"82","author":"Ojo","year":"2013","journal-title":"Chem. Biol. Drug. Des."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s13659-014-0037-z","article-title":"A Novel Insulinotropic Peptide from the Skin Secretions of Amolops Loloensis Frog","volume":"4","author":"Mo","year":"2014","journal-title":"Nat. Prod. Bioprospect."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1073\/pnas.81.6.1822","article-title":"Bombesin Stimulates Insulin Secretion by a Pancreatic Islet Cell Line","volume":"81","author":"Swope","year":"1984","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/0196-9781(83)90019-0","article-title":"Bombesin Stimulates Insulin Secretion and Reduces Food Intake in the Baboon","volume":"4","author":"Woods","year":"1983","journal-title":"Peptides"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0167-0115(82)90136-7","article-title":"Effects of Caerulein and Bombesin on Insulin and Glucagon Secretion from the Isolated, Perfused Rat Pancreas","volume":"3","author":"Martindale","year":"1982","journal-title":"Regul. Pept."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1042\/bj2530193","article-title":"The Biphasic Stimulation of Insulin Secretion by Bombesin Involves Both Cytosolic Free Calcium and Protein Kinase C","volume":"253","author":"Swope","year":"1988","journal-title":"Biochem. J."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0143-4160(96)90057-3","article-title":"Generation of Repetitive Ca2+ Transients by Bombesin Requires Intracellular Release and Influx of Ca2+ through Voltage-Dependent and Voltage Independent Channels in Single HIT Cells","volume":"19","author":"Leitolf","year":"1996","journal-title":"Cell. Calcium"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"540","DOI":"10.3181\/00379727-182-42377","article-title":"Effect of Bombesin and Gastrin-Releasing Peptide on the Release of Gastric Inhibitory Polypeptide and Insulin in Rats","volume":"182","author":"Greeley","year":"1986","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1055\/s-0030-1254126","article-title":"Brevinin-2-Related Peptide and Its [D4K] Analogue Stimulate Insulin Release In Vitro and Improve Glucose Tolerance in Mice Fed a High Fat Diet","volume":"42","author":"Patterson","year":"2010","journal-title":"Horm. Metab. Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ygcen.2011.03.022","article-title":"Caerulein-and Xenopsin-Related Peptides with Insulin-Releasing Activities from Skin Secretions of the Clawed Frogs, Xenopus Borealis and Xenopus Amieti (Pipidae)","volume":"172","author":"Zahid","year":"2011","journal-title":"Gen. Comp. Endocrinol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0304-4165(99)00211-1","article-title":"Biochemical Characterization of Two Crotamine Isoforms Isolated by a Single Step RP-HPLC from Crotalus Durissus Terrificus (South American Rattlesnake) Venom and Their Action on Insulin Secretion by Pancreatic Islets","volume":"1474","author":"Toyama","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/00006676-200408000-00005","article-title":"Novel Insulin-Releasing Peptides in the Skin of Phyllomedusa trinitatis Frog Include 28 Amino Acid Peptide From Dermaseptin Biv Precursor","volume":"29","author":"Marenah","year":"2004","journal-title":"Pancreas"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1530\/JOE-16-0453","article-title":"Esculentin-2CHa(1-30) and Its Analogues: Stability and Mechanisms of Insulinotropic Action","volume":"232","author":"Vasu","year":"2017","journal-title":"J. Endocrinol."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Ojo, O.O., Srinivasan, D.K., Owolabi, B.O., Vasu, S., Conlon, J.M., Flatt, P.R., and Abdel-Wahab, Y.H.A. (2015). Esculentin-2CHa-Related Peptides Modulate Islet Cell Function and Improve Glucose Tolerance in Mice with Diet-Induced Obesity and Insulin Resistance. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0141549"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00726-015-2107-x","article-title":"In Vitro and in Vivo Insulinotropic Properties of the Multifunctional Frog Skin Peptide Hymenochirin-1B: A Structure-Activity Study","volume":"48","author":"Owolabi","year":"2016","journal-title":"Amino Acids"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s00210-016-1243-5","article-title":"Glucoregulatory, Endocrine and Morphological Effects of [P5K]Hymenochirin-1B in Mice with Diet-Induced Glucose Intolerance and Insulin Resistance","volume":"389","author":"Owolabi","year":"2016","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"256","DOI":"10.2174\/0929866521666141229105757","article-title":"Magainin-Related Peptides Stimulate Insulin-Release and Improve Glucose Tolerance in High Fat Fed Mice","volume":"22","author":"Ojo","year":"2014","journal-title":"Protein Pept. Lett."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/0167-4889(85)90221-6","article-title":"Studies on the Mechanism by Which Melittin Stimulates Insulin Secretion from Isolated Rat Islets of Langerhans","volume":"845","author":"Morgan","year":"1985","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_103","first-page":"295","article-title":"Glucose Dose-Related Influence of Phospholipase C and Melittin on Insulin Release from Perifused Rat Islets","volume":"62","author":"Pace","year":"1988","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.peptides.2009.01.008","article-title":"A Glycine-Leucine-Rich Peptide Structurally Related to the Plasticins from Skin Secretions of the Frog Leptodactylus Laticeps (Leptodactylidae)","volume":"30","author":"Conlon","year":"2009","journal-title":"Peptides"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.peptides.2010.11.002","article-title":"Peptidomic Analysis of Skin Secretions from the Bullfrog Lithobates Catesbeianus (Ranidae) Identifies Multiple Peptides with Potent Insulin-Releasing Activity","volume":"32","author":"Mechkarska","year":"2011","journal-title":"Peptides"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"170472","DOI":"10.1016\/j.peptides.2020.170472","article-title":"Beneficial Actions of the [A14K] Analog of the Frog Skin Peptide PGLa-AM1 in Mice with Obesity and Degenerative Diabetes: A Mechanistic Study","volume":"136","author":"Musale","year":"2021","journal-title":"Peptides"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biochi.2017.04.004","article-title":"Actions of PGLa-AM1 and Its [A14K] and [A20K] Analogues and Their Therapeutic Potential as Anti-Diabetic Agents","volume":"138","author":"Owolabi","year":"2017","journal-title":"Biochimie"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1515\/BC.2008.018","article-title":"Insulin-Releasing Properties of the Frog Skin Peptide Pseudin-2 and Its [Lys18]-Substituted Analogue","volume":"389","author":"Power","year":"2008","journal-title":"Biol. Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"702","DOI":"10.2174\/092986607781483822","article-title":"Insulin Releasing Properties of the Temporin Family of Antimicrobial Peptides","volume":"14","author":"Marenah","year":"2007","journal-title":"Protein Pept. Lett."},{"key":"ref_110","first-page":"437","article-title":"Herbal Medicines for Diabetes Management and Its Secondary Complications","volume":"17","author":"Kumar","year":"2020","journal-title":"Curr. Diabetes Rev."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1006\/pmpp.2000.0287","article-title":"Phenolic-Storing Cells: Keys to Programmed Cell Death and Periderm Formation in Wilt Disease Resistance and in General Defence Responses in Plants?","volume":"57","author":"Beckman","year":"2000","journal-title":"Physiol. Mol. Plant Pathol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2174\/1389201015666140813123843","article-title":"Polyphenols: Well beyond the Antioxidant Capacity: Polyphenol Supplementation and Exercise-Induced Oxidative Stress and Inflammation","volume":"15","author":"Sureda","year":"2014","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.3390\/nu2121231","article-title":"Chemistry and Biochemistry of Dietary Polyphenols","volume":"2","author":"Tsao","year":"2010","journal-title":"Nutrients"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2073S","DOI":"10.1093\/jn\/130.8.2073S","article-title":"Dietary Intake and Bioavailability of Polyphenols","volume":"130","author":"Scalbert","year":"2000","journal-title":"J. Nutr."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Souza, C.R.M., Bezerra, W.P., and Souto, J.T. (2020). Marine Alkaloids with Anti-Inflammatory Activity: Current Knowledge and Future Perspectives. Mar. Drugs, 18.","DOI":"10.3390\/md18030147"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1039\/a900728h","article-title":"Alkaloids from Frog Skin: The Discovery of Epibatidine and the Potential for Developing Novel Non-Opioid Analgesics","volume":"17","author":"Daly","year":"2000","journal-title":"Nat. Prod. Rep."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Heinrich, M., Mah, J., and Amirkia, V. (2021). Alkaloids Used as Medicines: Structural Phytochemistry Meets Biodiversity\u2014An Update and Forward Look. Molecules, 26.","DOI":"10.3390\/molecules26071836"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1083\/jcb.92.2.425","article-title":"Microtubules and Beta Cell Function: Effect of Colchicine on Microtubules and Insulin Secretion in Vitro by Mouse Beta Cells","volume":"92","author":"Boyd","year":"1982","journal-title":"J. Cell. Biol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"30745","DOI":"10.1038\/srep30745","article-title":"Neonatal Treatment with Scopolamine Butylbromide Prevents Metabolic Dysfunction in Male Rats","volume":"6","author":"Malta","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0304-4165(83)90087-9","article-title":"Muscarinic Receptors in Pancreatic Islets of the Rat. Demonstration and Dependence on Long-Term Glucose Environment","volume":"756","author":"Grill","year":"1983","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.cmet.2016.04.009","article-title":"Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes","volume":"23","author":"Tuomi","year":"2016","journal-title":"Cell. Metab."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1034\/j.1600-079X.2002.02903.x","article-title":"Melatonin Inhibits Insulin Secretion and Decreases PKA Levels without Interfering with Glucose Metabolism in Rat Pancreatic Islets","volume":"33","author":"Picinato","year":"2002","journal-title":"J. Pineal Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1530\/acta.0.0830772","article-title":"The Effect of atropine on the insulin release caused by oral and intravenous glucose in human subjects","volume":"83","author":"Henderson","year":"1976","journal-title":"Eur. J. Endocrinol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.metabol.2004.08.020","article-title":"Evidence for Functional Nicotinic Receptors on Pancreatic Beta Cells","volume":"54","author":"Yoshikawa","year":"2005","journal-title":"Metabolism"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/BF00251017","article-title":"Effect of Increased Pancreatic Islet Norepinephrine, Dopamine and Serotonin Concentration on Insulin Secretion in the Golden Hamster","volume":"18","author":"Zern","year":"1980","journal-title":"Diabetologia"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1210\/endo-92-5-1343","article-title":"Effect of Nicotine and Nicotine Metabolites on Insulin Secretion from Rabbit Pancreas Pieces","volume":"92","author":"Popov","year":"1973","journal-title":"Endocrinology"},{"key":"ref_127","first-page":"156","article-title":"[Effect of nicotine on insulin secretion in the isolated perfused rat pancreas]","volume":"172","author":"Chapal","year":"1978","journal-title":"C. R. Seances Soc. Biol. Fil."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/0014-5793(75)80317-6","article-title":"Quinine-Induced Modifications of Insulin Release and Glucose Metabolism by Isolated Pancreatic Islets","volume":"57","author":"Henquin","year":"1975","journal-title":"FEBS Lett."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/0005-2736(81)90528-9","article-title":"Regulation of Calcium Fluxes in Rat Pancreatic Islets. Quinine Mimics the Dual Effect of Glucose on Calcium Movements","volume":"640","author":"Herchuelz","year":"1981","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1507\/endocrj.EJ17-0543","article-title":"Berberine Inhibits Glucose Oxidation and Insulin Secretion in Rat Islets","volume":"65","author":"Bai","year":"2018","journal-title":"Endocr. J."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"720866","DOI":"10.3389\/fphar.2021.720866","article-title":"Berberine Potentiates Insulin Secretion and Prevents \u03b2-Cell Dysfunction Through the MiR-204\/SIRT1 Signaling Pathway","volume":"12","author":"Lv","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"5616","DOI":"10.1038\/s41467-021-25952-2","article-title":"Berberine Is an Insulin Secretagogue Targeting the KCNH6 Potassium Channel","volume":"12","author":"Zhao","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Suantawee, T., Elazab, S.T., Hsu, W.H., Yao, S., Cheng, H., and Adisakwattana, S. (2017). Cyanidin Stimulates Insulin Secretion and Pancreatic \u03b2-Cell Gene Expression through Activation of l-Type Voltage-Dependent Ca2+ Channels. Nutrients, 9.","DOI":"10.3390\/nu9080814"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ejphar.2013.01.055","article-title":"The Role of Calcium in Intracellular Pathways of Rutin in Rat Pancreatic Islets: Potential Insulin Secretagogue Effect","volume":"702","author":"Kappel","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1074\/jbc.M110.176842","article-title":"Resveratrol Potentiates Glucose-Stimulated Insulin Secretion in INS-1E Beta-Cells and Human Islets through a SIRT1-Dependent Mechanism","volume":"286","author":"Vetterli","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1530\/JOE-14-0335","article-title":"Resveratrol and Curcumin Enhance Pancreatic \u03b2-Cell Function by Inhibiting Phosphodiesterase Activity","volume":"223","author":"Rouse","year":"2014","journal-title":"J. Endocrinol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.2337\/diabetes.55.04.06.db05-1089","article-title":"Genistein Acutely Stimulates Insulin Secretion in Pancreatic Beta-Cells through a CAMP-Dependent Protein Kinase Pathway","volume":"55","author":"Liu","year":"2006","journal-title":"Diabetes"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.lfs.2014.11.010","article-title":"Quercetin and Quercetin-3-O-Glucoside Interact with Different Components of the CAMP Signaling Cascade in Human Retinal Pigment Epithelial Cells","volume":"121","author":"Pavan","year":"2015","journal-title":"Life Sci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1055\/s-2007-1018648","article-title":"Opioid Peptide Effects on Insulin Release and C-AMP in Islets of Langerhans","volume":"15","author":"Green","year":"1983","journal-title":"Horm. Metab. Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ceca.2019.03.009","article-title":"Astragalin Augments Basal Calcium Influx and Insulin Secretion in Rat Pancreatic Islets","volume":"80","author":"Rey","year":"2019","journal-title":"Cell. Calcium"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"C2239","DOI":"10.1152\/ajpcell.00326.2006","article-title":"Dual Regulation of the ATP-Sensitive Potassium Channel by Caffeine","volume":"292","author":"Mao","year":"2007","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1177\/096368979700600107","article-title":"Effects of Caffeine and Acetylcholine on Glucose-Stimulated Insulin Release from Islet Transplants in Mice","volume":"6","author":"Shi","year":"1997","journal-title":"Cell. Transplant."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1093\/ajcn\/78.4.728","article-title":"Coffee Acutely Modifies Gastrointestinal Hormone Secretion and Glucose Tolerance in Humans: Glycemic Effects of Chlorogenic Acid and Caffeine","volume":"78","author":"Johnston","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00394-015-1103-y","article-title":"Ellagic Acid in Emblica Officinalis Exerts Anti-Diabetic Activity through the Action on \u03b2-Cells of Pancreas","volume":"56","author":"Fatima","year":"2017","journal-title":"Eur. J. Nutr."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/978-1-4419-5913-3_55","article-title":"Modeling of ATP-Sensitive Inward Rectifier Potassium Channel 11 and Inhibition Mechanism of the Natural Ligand, Ellagic Acid, Using Molecular Docking","volume":"680","author":"Mathew","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ejphar.2011.08.011","article-title":"Flavonol Kaempferol Improves Chronic Hyperglycemia-Impaired Pancreatic Beta-Cell Viability and Insulin Secretory Function","volume":"670","author":"Zhang","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ejphar.2004.09.008","article-title":"Quinolizidine Alkaloids Isolated from Lupinus Species Enhance Insulin Secretion","volume":"504","author":"Wysocka","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.jep.2012.05.024","article-title":"Nuciferine Stimulates Insulin Secretion from Beta Cells\u2014An in Vitro Comparison with Glibenclamide","volume":"142","author":"Nguyen","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_149","first-page":"278","article-title":"Quercetin Stimulates Insulin Secretion and Reduces the Viability of Rat INS-1 Beta-Cells","volume":"39","author":"Kittl","year":"2016","journal-title":"CPB"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ejphar.2007.04.062","article-title":"Resveratrol Enhances Insulin Secretion by Blocking K(ATP) and K(V) Channels of Beta Cells","volume":"568","author":"Chen","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Lee, D., Kim, Y.-M., Kim, H.W., Choi, Y.-K., Park, B.J., Joo, S.H., and Kang, K.S. (2021). Schisandrin C Affects Glucose-Stimulated Insulin Secretion in Pancreatic \u03b2-Cells and Glucose Uptake in Skeletal Muscle Cells. Molecules, 26.","DOI":"10.3390\/molecules26216509"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/j.1476-5381.1991.tb12472.x","article-title":"Amantadine and Sparteine Inhibit ATP-Regulated K-Currents in the Insulin-Secreting Beta-Cell Line, HIT-T15","volume":"104","author":"Ashcroft","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.biochi.2015.02.003","article-title":"Isolation and Structural Characterization of 2R, 3R Taxifolin 3-O-Rhamnoside from Ethyl Acetate Extract of Hydnocarpus Alpina and Its Hypoglycemic Effect by Attenuating Hepatic Key Enzymes of Glucose Metabolism in Streptozotocin-Induced Diabetic Rats","volume":"111","author":"Balamurugan","year":"2015","journal-title":"Biochimie"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jep.2013.08.043","article-title":"Natural Product Vindoline Stimulates Insulin Secretion and Efficiently Ameliorates Glucose Homeostasis in Diabetic Murine Models","volume":"150","author":"Yao","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.3945\/jn.117.250860","article-title":"S-Equol Activates CAMP Signaling at the Plasma Membrane of INS-1 Pancreatic \u03b2-Cells and Protects against Streptozotocin-Induced Hyperglycemia by Increasing \u03b2-Cell Function in Male Mice","volume":"147","author":"Horiuchi","year":"2017","journal-title":"J. Nutr."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1111\/j.1476-5381.1995.tb13285.x","article-title":"Multiple Effects and Stimulation of Insulin Secretion by the Tyrosine Kinase Inhibitor Genistein in Normal Mouse Islets","volume":"114","author":"Jonas","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1080\/07435809309026682","article-title":"Genistein Augments Cyclic Adenosine 3\u20325\u2032-Monophosphate(CAMP) Accumulation and Insulin Release in MIN6 Cells","volume":"19","author":"Ohno","year":"1993","journal-title":"Endocr. Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.ejphar.2009.06.005","article-title":"Long-Term Exposure to Genistein Improves Insulin Secretory Function of Pancreatic Beta-Cells","volume":"616","author":"Fu","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/BF00421864","article-title":"Effect of Enkephalins and Morphine on Insulin Secretion from Isolated Rat Islets","volume":"19","author":"Green","year":"1980","journal-title":"Diabetologia"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1096\/fj.201601339R","article-title":"Myricetin: A Potent Approach for the Treatment of Type 2 Diabetes as a Natural Class B GPCR Agonist","volume":"31","author":"Li","year":"2017","journal-title":"FASEB J."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jff.2019.02.047","article-title":"CAMP-PKA Dependent ERK1\/2 Activation Is Necessary for Vanillic Acid Potentiated Glucose-Stimulated Insulin Secretion in Pancreatic \u03b2-Cells","volume":"56","author":"Mahendra","year":"2019","journal-title":"J. Funct. Foods"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1126\/science.1104345","article-title":"Type 2 Diabetes-a Matter of Beta-Cell Life and Death?","volume":"307","author":"Rhodes","year":"2005","journal-title":"Science"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cmet.2019.05.006","article-title":"Acceleration of \u03b2 Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes","volume":"30","author":"Andle","year":"2019","journal-title":"Cell. Metab."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.cell.2012.07.029","article-title":"Pancreatic \u03b2-Cell Dedifferentiation As Mechanism Of Diabetic \u03b2-Cell Failure","volume":"150","author":"Talchai","year":"2012","journal-title":"Cell."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Lee, J.-H., and Lee, J. (2022). Endoplasmic Reticulum (ER) Stress and Its Role in Pancreatic \u03b2-Cell Dysfunction and Senescence in Type 2 Diabetes. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23094843"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1089\/ars.2018.7656","article-title":"Contribution of Oxidative Stress and Impaired Biogenesis of Pancreatic \u03b2-Cells to Type 2 Diabetes","volume":"31","year":"2019","journal-title":"Antioxid. Redox Signal."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1007\/s00125-009-1347-2","article-title":"Autophagy in Human Type 2 Diabetes Pancreatic Beta Cells","volume":"52","author":"Masini","year":"2009","journal-title":"Diabetologia"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fendo.2019.00052","article-title":"Modulation of Autophagy Influences the Function and Survival of Human Pancreatic Beta Cells Under Endoplasmic Reticulum Stress Conditions and in Type 2 Diabetes","volume":"10","author":"Bugliani","year":"2019","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Cerf, M.E. (2020). Developmental Programming and Glucolipotoxicity: Insights on Beta Cell Inflammation and Diabetes. Metabolites, 10.","DOI":"10.3390\/metabo10110444"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/j.jmb.2019.09.016","article-title":"Recent Insights Into Mechanisms of \u03b2-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes","volume":"432","author":"Lytrivi","year":"2020","journal-title":"J. Mol. Biol."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Oh, Y.S., and Jun, H.-S. (2017). Effects of Glucagon-Like Peptide-1 on Oxidative Stress and Nrf2 Signaling. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19010026"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.2337\/db16-1009","article-title":"Glucagon-Like Peptide 1 Protects Pancreatic \u03b2-Cells From Death by Increasing Autophagic Flux and Restoring Lysosomal Function","volume":"66","author":"Zummo","year":"2017","journal-title":"Diabetes"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/dom.12790","article-title":"Addition of or Switch to Insulin Therapy in People Treated with Glucagon-like Peptide-1 Receptor Agonists: A Real-World Study in 66 583 Patients","volume":"19","author":"Montvida","year":"2017","journal-title":"Diabetes Obes. Metab."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.2337\/db06-1033","article-title":"Downregulation of GLP-1 and GIP Receptor Expression by Hyperglycemia: Possible Contribution to Impaired Incretin Effects in Diabetes","volume":"56","author":"Xu","year":"2007","journal-title":"Diabetes"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1093\/hmg\/ddu553","article-title":"Selective Disruption of Tcf7l2 in the Pancreatic \u03b2 Cell Impairs Secretory Function and Lowers \u03b2 Cell Mass","volume":"24","author":"Mitchell","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"814854","DOI":"10.1155\/2014\/814854","article-title":"JNK3 Is Required for the Cytoprotective Effect of Exendin 4","volume":"2014","author":"Ezanno","year":"2014","journal-title":"J. Diabetes Res."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1111\/jcmm.13259","article-title":"Liraglutide, a Human Glucagon-like Peptide-1 Analogue, Stimulates AKT-Dependent Survival Signalling and Inhibits Pancreatic \u03b2-Cell Apoptosis","volume":"22","author":"Kapodistria","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/1753-0407.13252","article-title":"Targeting the PI3K\/Akt Signaling Pathway in Pancreatic \u0392-cells to Enhance Their Survival and Function: An Emerging Therapeutic Strategy for Type 1 Diabetes","volume":"14","author":"Camaya","year":"2022","journal-title":"J. Diabetes"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ceb.2007.02.001","article-title":"The JNK Signal Transduction Pathway","volume":"19","author":"Weston","year":"2007","journal-title":"Curr. Opin. Cell. Biol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00018-020-03499-7","article-title":"The Map3k12 (Dlk)\/JNK3 Signaling Pathway Is Required for Pancreatic Beta-Cell Proliferation during Postnatal Development","volume":"78","author":"Tenenbaum","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.2337\/db07-1214","article-title":"Exendin-4 Protects Beta-Cells from Interleukin-1 Beta-Induced Apoptosis by Interfering with the c-Jun NH2-Terminal Kinase Pathway","volume":"57","author":"Ferdaoussi","year":"2008","journal-title":"Diabetes"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1101\/gad.1097103","article-title":"CAMP Promotes Pancreatic Beta-Cell Survival via CREB-Mediated Induction of IRS2","volume":"17","author":"Jhala","year":"2003","journal-title":"Genes. Dev."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1677\/JME-07-0154","article-title":"Anti-Proliferative Effect of pro-Inflammatory Cytokines in Cultured Beta Cells Is Associated with Extracellular Signal-Regulated Kinase 1\/2 Pathway Inhibition: Protective Role of Glucagon-like Peptide -1","volume":"41","author":"Segundo","year":"2008","journal-title":"J. Mol. Endocrinol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.2337\/db05-1618","article-title":"ERK1\/2 Control Phosphorylation and Protein Level of CAMP-Responsive Element-Binding Protein: A Key Role in Glucose-Mediated Pancreatic Beta-Cell Survival","volume":"55","author":"Costes","year":"2006","journal-title":"Diabetes"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1074\/jbc.M109.067207","article-title":"GLP-1 Mediates Antiapoptotic Effect by Phosphorylating Bad through a Beta-Arrestin 1-Mediated ERK1\/2 Activation in Pancreatic Beta-Cells","volume":"285","author":"Quoyer","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.2337\/db16-0084","article-title":"SERCA2 Deficiency Impairs Pancreatic \u03b2-Cell Function in Response to Diet-Induced Obesity","volume":"65","author":"Tong","year":"2016","journal-title":"Diabetes"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3803\/EnM.2017.32.1.1","article-title":"New Potential Targets of Glucagon-Like Peptide 1 Receptor Agonists in Pancreatic \u03b2-Cells and Hepatocytes","volume":"32","author":"Lee","year":"2017","journal-title":"Endocrinol. Metab."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"482","DOI":"10.2337\/diabetes.54.2.482","article-title":"Beta-Cell Pdx1 Expression Is Essential for the Glucoregulatory, Proliferative, and Cytoprotective Actions of Glucagon-like Peptide-1","volume":"54","author":"Li","year":"2005","journal-title":"Diabetes"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1186\/s13287-020-01977-0","article-title":"NKX6.1 Transcription Factor: A Crucial Regulator of Pancreatic \u03b2 Cell Development, Identity, and Proliferation","volume":"11","author":"Aigha","year":"2020","journal-title":"Stem Cell. Res. Ther."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"2146-P","DOI":"10.2337\/db18-2146-P","article-title":"Liraglutide Inhibits Endoplasmic Reticulum Stress in Pancreatic Beta Cells via Regulation of the Homeodomain Transcription Factor Nkx6.1","volume":"67","author":"Li","year":"2018","journal-title":"Diabetes"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.2337\/db05-0825","article-title":"Transcription Factor FoxO1 Mediates Glucagon-like Peptide-1 Effects on Pancreatic Beta-Cell Mass","volume":"55","author":"Buteau","year":"2006","journal-title":"Diabetes"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1172\/JCI200216857","article-title":"The Forkhead Transcription Factor Foxo1 Links Insulin Signaling to Pdx1 Regulation of Pancreatic Beta Cell Growth","volume":"110","author":"Kitamura","year":"2002","journal-title":"J. Clin. Investig."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of Nrf2 in Oxidative Stress and Toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.freeradbiomed.2016.03.002","article-title":"Glucagon-like Peptide-1 Improves Beta-Cell Antioxidant Capacity via Extracellular Regulated Kinases Pathway and Nrf2 Translocation","volume":"95","author":"Goya","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Nishimura, W., Iwasa, H., and Tumurkhuu, M. (2022). Role of the Transcription Factor MAFA in the Maintenance of Pancreatic \u03b2-Cells. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23094478"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.2337\/db09-0685","article-title":"Glucagon-Like Peptide-1 Agonists Protect Pancreatic \u03b2-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB","volume":"58","author":"Cunha","year":"2009","journal-title":"Diabetes"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"7448","DOI":"10.1128\/MCB.23.21.7448-7459.2003","article-title":"XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response","volume":"23","author":"Lee","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"4735","DOI":"10.1074\/jbc.M117.805069","article-title":"Estrogen Receptor \u03b1 Protects Pancreatic \u03b2-Cells from Apoptosis by Preserving Mitochondrial Function and Suppressing Endoplasmic Reticulum Stress","volume":"293","author":"Zhou","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"100598","DOI":"10.1016\/j.xcrm.2022.100598","article-title":"Efficacy of Glucagon-like Peptide-1 and Estrogen Dual Agonist in Pancreatic Islets Protection and Pre-Clinical Models of Insulin-Deficient Diabetes","volume":"3","author":"Fuselier","year":"2022","journal-title":"Cell. Rep. Med."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1210\/en.2011-0259","article-title":"Glucagon-Like Peptide-1 Enhances Glucokinase Activity in Pancreatic \u03b2-Cells through the Association of Epac2 with Rim2 and Rab3A","volume":"153","author":"Park","year":"2012","journal-title":"Endocrinology"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.biochi.2021.10.017","article-title":"Pancreatic Islet Cells Disarray, Apoptosis, and Proliferation in Obese Mice. The Role of Semaglutide Treatment","volume":"193","author":"Marinho","year":"2022","journal-title":"Biochimie"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1111\/j.1463-1326.2010.01299.x","article-title":"The Role of Peroxisome Proliferator-Activated Receptor Gamma in Pancreatic Beta Cell Function and Survival: Therapeutic Implications for the Treatment of Type 2 Diabetes Mellitus","volume":"12","author":"Gupta","year":"2010","journal-title":"Diabetes Obes. Metab."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.tem.2017.11.007","article-title":"AMPK and Friends: Central Regulators of \u03b2 Cell Biology","volume":"29","author":"Rourke","year":"2018","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"646113","DOI":"10.3389\/fcell.2021.646113","article-title":"GLP-1-Induced AMPK Activation Inhibits PARP-1 and Promotes LXR-Mediated ABCA1 Expression to Protect Pancreatic \u03b2-Cells Against Cholesterol-Induced Toxicity Through Cholesterol Efflux","volume":"9","author":"Li","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1007\/s00125-004-1379-6","article-title":"Glucagon-like Peptide-1 Prevents Beta Cell Glucolipotoxicity","volume":"47","author":"Buteau","year":"2004","journal-title":"Diabetologia"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"e3065","DOI":"10.1002\/psc.3065","article-title":"Assessment of the Potential of Temporin Peptides from the Frog Rana Temporaria (Ranidae) as Anti-Diabetic Agents","volume":"24","author":"Musale","year":"2018","journal-title":"J. Pept. Sci."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1007\/s00726-017-2469-3","article-title":"Anti-Diabetic Actions of Esculentin-2CHa(1-30) and Its Stable Analogues in a Diet-Induced Model of Obesity-Diabetes","volume":"49","author":"Vasu","year":"2017","journal-title":"Amino Acids"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ejphar.2014.07.057","article-title":"Phytoestrogens and Their Effects","volume":"741","author":"Sirotkin","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1159\/000320570","article-title":"Reference Profile Correlation Reveals Estrogen-like Trancriptional Activity of Curcumin","volume":"26","author":"Bachmeier","year":"2010","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3889\/oamjms.2019.086","article-title":"Phytoestrogens and Their Health Effect","volume":"7","author":"Desmawati","year":"2019","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"9232","DOI":"10.1073\/pnas.0602956103","article-title":"Estrogens Protect Pancreatic \u03b2-Cells from Apoptosis and Prevent Insulin-Deficient Diabetes Mellitus in Mice","volume":"103","author":"Chu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3945\/ajcn.115.117440","article-title":"Administration of Resveratrol for 5 Wk Has No Effect on Glucagon-like Peptide 1 Secretion, Gastric Emptying, or Glycemic Control in Type 2 Diabetes: A Randomized Controlled Trial","volume":"103","author":"Thazhath","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jnutbio.2017.07.013","article-title":"Apple and Blackcurrant Polyphenol-Rich Drinks Decrease Postprandial Glucose, Insulin and Incretin Response to a High-Carbohydrate Meal in Healthy Men and Women","volume":"49","author":"Stone","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1007\/s11010-021-04106-4","article-title":"Black Chokeberry Aronia Melanocarpa Extract Reduces Blood Pressure, Glycemia and Lipid Profile in Patients with Metabolic Syndrome: A Prospective Controlled Trial","volume":"476","author":"Tasic","year":"2021","journal-title":"Mol. Cell. Biochem."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"E1119","DOI":"10.1152\/ajpendo.00629.2020","article-title":"Effects of Totum-63 on Glucose Homeostasis and Postprandial Glycemia: A Translational Study","volume":"320","author":"Chavanelle","year":"2021","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/ptr.6272","article-title":"Ascophyllum Nodosum and Fucus Vesiculosus on Glycemic Status and on Endothelial Damage Markers in Dysglicemic Patients","volume":"33","author":"Derosa","year":"2019","journal-title":"Phytother. Res."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1055\/s-0044-101752","article-title":"Effects of Curcuminoids Plus Piperine on Glycemic, Hepatic and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo-Controlled Trial","volume":"68","author":"Panahi","year":"2018","journal-title":"Drug. Res. (Stuttg)"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"110984","DOI":"10.1016\/j.biopha.2020.110984","article-title":"Therapeutic Effect of Berberine on Metabolic Diseases: Both Pharmacological Data and Clinical Evidence","volume":"133","author":"Xu","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s13258-022-01250-z","article-title":"Berberine Protects against Palmitate Induced Beta Cell Injury via Promoting Mitophagy","volume":"44","author":"Li","year":"2022","journal-title":"Genes Genomics"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.metabol.2008.01.013","article-title":"Efficacy of Berberine in Patients with Type 2 Diabetes Mellitus","volume":"57","author":"Yin","year":"2008","journal-title":"Metabolism"},{"key":"ref_221","doi-asserted-by":"crossref","unstructured":"Moon, J.M., Ratliff, K.M., Hagele, A.M., Stecker, R.A., Mumford, P.W., and Kerksick, C.M. (2021). Absorption Kinetics of Berberine and Dihydroberberine and Their Impact on Glycemia: A Randomized, Controlled, Crossover Pilot Trial. Nutrients, 14.","DOI":"10.3390\/nu14010124"},{"key":"ref_222","first-page":"370","article-title":"Curcumin Ameliorates HO-Induced Injury through SIRT1-PERK-CHOP Pathway in Pancreatic Beta Cells","volume":"54","author":"Cao","year":"2022","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1007\/s10495-015-1150-0","article-title":"Curcumin Attenuates Palmitate-Induced Apoptosis in MIN6 Pancreatic \u03b2-Cells through PI3K\/Akt\/FoxO1 and Mitochondrial Survival Pathways","volume":"20","author":"Hao","year":"2015","journal-title":"Apoptosis"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"9817","DOI":"10.1021\/jf902618v","article-title":"Epigallocatechin Gallate (EGCG) and Rutin Suppress the Glucotoxicity through Activating IRS2 and AMPK Signaling in Rat Pancreatic Beta Cells","volume":"57","author":"Cai","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3945\/jn.109.118216","article-title":"Dietary Anthocyanin-Rich Bilberry Extract Ameliorates Hyperglycemia and Insulin Sensitivity via Activation of AMP-Activated Protein Kinase in Diabetic Mice","volume":"140","author":"Takikawa","year":"2010","journal-title":"J. Nutr."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1002\/mnfr.200800526","article-title":"The Anti-Diabetic Effect of Anthocyanins in Streptozotocin-Induced Diabetic Rats through Glucose Transporter 4 Regulation and Prevention of Insulin Resistance and Pancreatic Apoptosis","volume":"53","author":"Nizamutdinova","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_227","unstructured":"(2019). Delphinidin-Induced Autophagy Protects Pancreatic <bold>\u03b2<\/Bold> Cells against Apoptosis Resulting from High-Glucose Stress via AMPK Signaling Pathway. ABBS, 1242\u20131249."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.3892\/mmr.2014.3078","article-title":"Cyanidin-3-Glucoside Isolated from Mulberry Fruits Protects Pancreatic \u03b2-Cells against Glucotoxicity-Induced Apoptosis","volume":"11","author":"Lee","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3892\/ijmm.2014.2013","article-title":"Cyanidin-3-Glucoside Isolated from Mulberry Fruit Protects Pancreatic \u03b2-Cells against Oxidative Stress-Induced Apoptosis","volume":"35","author":"Lee","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1515\/znc-2017-0172","article-title":"Cyanidin-3-Rutinoside Protects INS-1 Pancreatic \u03b2 Cells against High Glucose-Induced Glucotoxicity by Apoptosis","volume":"73","author":"Choi","year":"2018","journal-title":"Z. Naturforsch. C"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1248\/bpb.35.121","article-title":"Apigenin Attenuates 2-Deoxy-D-Ribose-Induced Oxidative Cell Damage in HIT-T15 Pancreatic \u03b2-Cells","volume":"35","author":"Suh","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/mpa.0b013e31811ed0d2","article-title":"Flavonoids Protect against Cytokine-Induced Pancreatic Beta-Cell Damage through Suppression of Nuclear Factor KappaB Activation","volume":"35","author":"Kim","year":"2007","journal-title":"Pancreas"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1007\/s11626-017-0135-4","article-title":"Apigenin Attenuates Streptozotocin-Induced Pancreatic \u03b2 Cell Damage by Its Protective Effects on Cellular Antioxidant Defense","volume":"53","author":"Wang","year":"2017","journal-title":"In Vitro Cell. Dev.Biol.-Anim."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/j.1476-5381.2010.00910.x","article-title":"Quercetin Potentiates Insulin Secretion and Protects INS-1 Pancreatic \u03b2-Cells against Oxidative Damage via the ERK1\/2 Pathway","volume":"161","author":"Youl","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"292","DOI":"10.7555\/JBR.28.20130170","article-title":"Luteolin Prevents Uric Acid-Induced Pancreatic \u03b2-Cell Dysfunction","volume":"28","author":"Ding","year":"2014","journal-title":"J. Biomed. Res."},{"key":"ref_236","doi-asserted-by":"crossref","unstructured":"Ojo, O.A., Grant, S., Amanze, J.C., Oni, A.I., Ojo, A.B., Elebiyo, T.C., Obafemi, T.O., Ayokunle, D.I., and Ogunlakin, A.D. (2022). Annona Muricata L. Peel Extract Inhibits Carbohydrate Metabolizing Enzymes and Reduces Pancreatic \u03b2-Cells, Inflammation, and Apoptosis via Upregulation of PI3K\/AKT Genes. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0276984"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cyto.2012.04.011","article-title":"Flavonoids Protect Pancreatic Beta-Cells from Cytokines Mediated Apoptosis through the Activation of PI3-Kinase Pathway","volume":"59","author":"Lin","year":"2012","journal-title":"Cytokine"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"192","DOI":"10.4093\/dmj.2018.0052","article-title":"Myricetin Protects Against High Glucose-Induced \u03b2-Cell Apoptosis by Attenuating Endoplasmic Reticulum Stress via Inactivation of Cyclin-Dependent Kinase 5","volume":"43","author":"Karunakaran","year":"2019","journal-title":"Diabetes Metab. J."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1089\/jmf.2011.2033","article-title":"Myricetin Protects against Cytokine-Induced Cell Death in RIN-M5f \u03b2 Cells","volume":"15","author":"Ding","year":"2012","journal-title":"J. Med. Food"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1210\/en.2009-1294","article-title":"Genistein Induces Pancreatic Beta-Cell Proliferation through Activation of Multiple Signaling Pathways and Prevents Insulin-Deficient Diabetes in Mice","volume":"151","author":"Fu","year":"2010","journal-title":"Endocrinology"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1080\/10286020.2012.657180","article-title":"In Vivo Recovery Effect of Silibinin Treatment on Streptozotocin-Induced Diabetic Mice Is Associated with the Modulations of Sirt-1 Expression and Autophagy in Pancreatic \u03b2-Cell","volume":"14","author":"Wang","year":"2012","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11010-018-3414-9","article-title":"Silibinin Ameliorates Amylin-Induced Pancreatic \u03b2-Cell Apoptosis Partly via Upregulation of GLP-1R\/PKA Pathway","volume":"452","author":"Yang","year":"2019","journal-title":"Mol. Cell. Biochem."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.3892\/ijmm.2014.1883","article-title":"Silibinin Protects \u03b2 Cells from Glucotoxicity through Regulation of the Insig-1\/SREBP-1c Pathway","volume":"34","author":"Chen","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.numecd.2020.04.011","article-title":"Significant Reduction of Apoptosis Induced via Hypoxia and Oxidative Stress in Isolated Human Islet by Resveratrol","volume":"30","author":"Keshtkar","year":"2020","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.diabres.2012.02.029","article-title":"The Protective Effect of Resveratrol on Islet Insulin Secretion and Morphology in Mice on a High-Fat Diet","volume":"97","author":"Zhang","year":"2012","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/j.bbadis.2012.08.009","article-title":"Activation of SIRT1 Protects Pancreatic \u03b2-Cells against Palmitate-Induced Dysfunction","volume":"1822","author":"Wu","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_247","unstructured":"Magliano, D.J., and Boyko, E.J. (2021). IDF Diabetes Atlas 10th Edition Scientific Committee IDF Diabetes Atlas; IDF Diabetes Atlas, International Diabetes Federation. [10th ed.]."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1111\/bph.13622","article-title":"The Potential Health Effects of Dietary Phytoestrogens","volume":"174","author":"Rietjens","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.pharmthera.2011.02.004","article-title":"Polyphenols as Small Molecular Inhibitors of Signaling Cascades in Carcinogenesis","volume":"130","author":"Kang","year":"2011","journal-title":"Pharmacol. Ther."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2174\/1570163816666190808120843","article-title":"Targeting Small Molecule Tyrosine Kinases by Polyphenols: New Move Towards Anti-Tumor Drug Discovery","volume":"17","author":"Sakle","year":"2020","journal-title":"Curr. Drug. Discov. Technol."},{"key":"ref_251","doi-asserted-by":"crossref","unstructured":"Wang, Y., Alkhalidy, H., and Liu, D. (2021). The Emerging Role of Polyphenols in the Management of Type 2 Diabetes. Molecules, 26.","DOI":"10.3390\/molecules26030703"},{"key":"ref_252","doi-asserted-by":"crossref","unstructured":"Corb Aron, R.A., Abid, A., Vesa, C.M., Nechifor, A.C., Behl, T., Ghitea, T.C., Munteanu, M.A., Fratila, O., Andronie-Cioara, F.L., and Toma, M.M. (2021). Recognizing the Benefits of Pre-\/Probiotics in Metabolic Syndrome and Type 2 Diabetes Mellitus Considering the Influence of Akkermansia Muciniphila as a Key Gut Bacterium. Microorganisms, 9.","DOI":"10.3390\/microorganisms9030618"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1080\/19490976.2016.1142036","article-title":"Triggering Akkermansia with Dietary Polyphenols: A New Weapon to Combat the Metabolic Syndrome?","volume":"7","author":"Pilon","year":"2016","journal-title":"Gut Microbes"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1080\/09168451.2018.1444467","article-title":"Flavonoid Metabolism: The Interaction of Metabolites and Gut Microbiota","volume":"82","author":"Murota","year":"2018","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_255","doi-asserted-by":"crossref","unstructured":"Renaud, J., and Martinoli, M.-G. (2019). Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20081883"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.tifs.2010.08.003","article-title":"Encapsulation of Polyphenols\u2014A Review","volume":"21","author":"Fang","year":"2010","journal-title":"Trends Food Sci. Technol."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1039\/C9CS00886A","article-title":"The Impact of Chemical Engineering and Technological Advances on Managing Diabetes: Present and Future Concepts","volume":"50","author":"Szunerits","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ijpharm.2009.05.054","article-title":"Formulation and Characterization of Polyphenol-Loaded Lipid Nanocapsules","volume":"379","author":"Barras","year":"2009","journal-title":"Int. J. Pharm."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/dom.13005","article-title":"A Review of Methods for Measuring \u03b2-Cell Function: Design Considerations from the Restoring Insulin Secretion (RISE) Consortium","volume":"20","author":"Hannon","year":"2018","journal-title":"Diabetes Obes. Metab."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/6\/940\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:59:00Z","timestamp":1760122740000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/6\/940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,20]]},"references-count":259,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["cells12060940"],"URL":"https:\/\/doi.org\/10.3390\/cells12060940","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,20]]}}}