{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:52:48Z","timestamp":1780339968365,"version":"3.54.1"},"reference-count":142,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bundesministerium f\u00fcr Bildung und Forschung (BMBF) funded ERA-NET program: Psi-Alc","award":["FKZ: 01EW1908"],"award-info":[{"award-number":["FKZ: 01EW1908"]}]},{"name":"Bundesministerium f\u00fcr Bildung und Forschung (BMBF) funded ERA-NET program: Psi-Alc","award":["FKZ: 01ZX1909A"],"award-info":[{"award-number":["FKZ: 01ZX1909A"]}]},{"name":"Bundesministerium f\u00fcr Bildung und Forschung (BMBF) funded ERA-NET program: Psi-Alc","award":["ME 5279\/3-1"],"award-info":[{"award-number":["ME 5279\/3-1"]}]},{"name":"Bundesministerium f\u00fcr Bildung und Forschung (BMBF) funded ERA-NET program: Psi-Alc","award":["402170461\u2013RR 265"],"award-info":[{"award-number":["402170461\u2013RR 265"]}]},{"name":"Bundesministerium f\u00fcr Bildung und Forschung (BMBF) funded ERA-NET program: Psi-Alc","award":["668863-SyBil-AA"],"award-info":[{"award-number":["668863-SyBil-AA"]}]},{"name":"BMBF-funded SysMedSUDs consortium","award":["FKZ: 01EW1908"],"award-info":[{"award-number":["FKZ: 01EW1908"]}]},{"name":"BMBF-funded SysMedSUDs consortium","award":["FKZ: 01ZX1909A"],"award-info":[{"award-number":["FKZ: 01ZX1909A"]}]},{"name":"BMBF-funded SysMedSUDs consortium","award":["ME 5279\/3-1"],"award-info":[{"award-number":["ME 5279\/3-1"]}]},{"name":"BMBF-funded SysMedSUDs consortium","award":["402170461\u2013RR 265"],"award-info":[{"award-number":["402170461\u2013RR 265"]}]},{"name":"BMBF-funded SysMedSUDs consortium","award":["668863-SyBil-AA"],"award-info":[{"award-number":["668863-SyBil-AA"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FKZ: 01EW1908"],"award-info":[{"award-number":["FKZ: 01EW1908"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FKZ: 01ZX1909A"],"award-info":[{"award-number":["FKZ: 01ZX1909A"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ME 5279\/3-1"],"award-info":[{"award-number":["ME 5279\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["402170461\u2013RR 265"],"award-info":[{"award-number":["402170461\u2013RR 265"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["668863-SyBil-AA"],"award-info":[{"award-number":["668863-SyBil-AA"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union\u2019s Horizon 2020","award":["FKZ: 01EW1908"],"award-info":[{"award-number":["FKZ: 01EW1908"]}]},{"name":"European Union\u2019s Horizon 2020","award":["FKZ: 01ZX1909A"],"award-info":[{"award-number":["FKZ: 01ZX1909A"]}]},{"name":"European Union\u2019s Horizon 2020","award":["ME 5279\/3-1"],"award-info":[{"award-number":["ME 5279\/3-1"]}]},{"name":"European Union\u2019s Horizon 2020","award":["402170461\u2013RR 265"],"award-info":[{"award-number":["402170461\u2013RR 265"]}]},{"name":"European Union\u2019s Horizon 2020","award":["668863-SyBil-AA"],"award-info":[{"award-number":["668863-SyBil-AA"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Alcohol abuse is a leading risk factor for the public health burden worldwide. Approved pharmacotherapies have demonstrated limited effectiveness over the last few decades in treating alcohol use disorders (AUD). New therapeutic approaches are therefore urgently needed. Historical and recent clinical trials using psychedelics in conjunction with psychotherapy demonstrated encouraging results in reducing heavy drinking in AUD patients, with psilocybin being the most promising candidate. While psychedelics are known to induce changes in gene expression and neuroplasticity, we still lack crucial information about how this specifically counteracts the alterations that occur in neuronal circuits throughout the course of addiction. This review synthesizes well-established knowledge from addiction research about pathophysiological mechanisms related to the metabotropic glutamate receptor 2 (mGlu2), with findings and theories on how mGlu2 connects to the major signaling pathways induced by psychedelics via serotonin 2A receptors (2AR). We provide literature evidence that mGlu2 and 2AR are able to regulate each other\u2019s downstream signaling pathways, either through monovalent crosstalk or through the formation of a 2AR-mGlu2 heteromer, and highlight epigenetic mechanisms by which 2ARs can modulate mGlu2 expression. Lastly, we discuss how these pathways might be targeted therapeutically to restore mGlu2 function in AUD patients, thereby reducing the propensity to relapse.<\/jats:p>","DOI":"10.3390\/cells12060963","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T07:46:43Z","timestamp":1679471203000},"page":"963","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Psychedelic Targeting of Metabotropic Glutamate Receptor 2 and Its Implications for the Treatment of Alcoholism"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1215-4264","authenticated-orcid":false,"given":"Kevin","family":"Domanegg","sequence":"first","affiliation":[{"name":"Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 69115 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5903-6521","authenticated-orcid":false,"given":"Wolfgang H.","family":"Sommer","sequence":"additional","affiliation":[{"name":"Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 69115 Heidelberg, Germany"},{"name":"Bethanien Hospital for Psychiatry, Psychosomatics, and Psychotherapy Greifswald, 17489 Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5103-0731","authenticated-orcid":false,"given":"Marcus W.","family":"Meinhardt","sequence":"additional","affiliation":[{"name":"Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 69115 Heidelberg, Germany"},{"name":"Department of Molecular Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 69115 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/S0140-6736(10)61462-6","article-title":"Drug Harms in the UK: A Multicriteria Decision Analysis","volume":"376","author":"Nutt","year":"2010","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s40273-021-01031-8","article-title":"What Are the Economic Costs to Society Attributable to Alcohol Use? A Systematic Review and Modelling Study","volume":"39","author":"Manthey","year":"2021","journal-title":"Pharmacoeconomics"},{"key":"ref_3","unstructured":"World Health Organization (2018). Global Status Report on Alcohol and Health 2018, WHO. Available online: https:\/\/www.who.int\/publications\/i\/item\/9789241565639."},{"key":"ref_4","unstructured":"Ritchie, H., and Roser, M. (2018). Our World Data, Available online: https:\/\/ourworldindata.org\/alcohol-consumption."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Rehm, J., Allamani, A., Elekes, Z., Jakubczyk, A., Manthey, J., Probst, C., Struzzo, P., della Vedova, R., Gual, A., and Wojnar, M. (2015). Alcohol Dependence and Treatment Utilization in Europe\u2014A Representative Cross-Sectional Study in Primary Care. BMC Fam. Pract, 16.","DOI":"10.1186\/s12875-015-0308-8"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/adb.12646","article-title":"Alcohol Dependence and Very High Risk Level of Alcohol Consumption: A Life-Threatening and Debilitating Disease","volume":"23","author":"Rehm","year":"2018","journal-title":"Addict. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"eaax4043","DOI":"10.1126\/sciadv.aax4043","article-title":"Advances in the Science and Treatment of Alcohol Use Disorder","volume":"5","author":"Witkiewitz","year":"2019","journal-title":"Sci. Adv."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1177\/0269881113495320","article-title":"Reduced-Risk Drinking as a Viable Treatment Goal in Problematic Alcohol Use and Alcohol Dependence","volume":"27","year":"2013","journal-title":"J. Psychopharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/164_2017_79","article-title":"Advances in Pharmacotherapy Development: Human Clinical Studies","volume":"248","author":"Litten","year":"2018","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41398-019-0591-6","article-title":"Developing Neuroscience-Based Treatments for Alcohol Addiction: A Matter of Choice?","volume":"9","author":"Heilig","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"100025","DOI":"10.1016\/j.addicn.2022.100025","article-title":"Classic and Non-classic Psychedelics for Substance Use Disorder: A Review of Their Historic, Past and Current Research","volume":"3","author":"Mendes","year":"2022","journal-title":"Addict. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1176\/appi.ajp.2019.19010035","article-title":"Psychedelics and Psychedelic-Assisted Psychotherapy","volume":"177","author":"Reiff","year":"2020","journal-title":"Am. J. Psychiatry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1177\/0269881112439253","article-title":"Lysergic Acid Diethylamide (LSD) for Alcoholism: Meta-Analysis of Randomized Controlled Trials","volume":"26","author":"Krebs","year":"2012","journal-title":"J. Psychopharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1177\/0269881114565144","article-title":"Psilocybin-Assisted Treatment for Alcohol Dependence: A Proof-of-Concept Study","volume":"29","author":"Bogenschutz","year":"2015","journal-title":"J. Psychopharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1001\/jamapsychiatry.2022.2096","article-title":"Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients with Alcohol Use Disorder: A Randomized Clinical Trial","volume":"79","author":"Bogenschutz","year":"2022","journal-title":"JAMA Psychiatry"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"104793","DOI":"10.1016\/j.neubiorev.2022.104793","article-title":"Pharmacological, Neural, and Psychological Mechanisms Underlying Psychedelics: A Critical Review","volume":"140","author":"Yaden","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1097\/00001756-199812010-00024","article-title":"Psilocybin Induces Schizophrenia-like Psychosis in Humans via a Serotonin-2 Agonist Action","volume":"9","author":"Vollenweider","year":"1998","journal-title":"Neuroreport"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"16S","DOI":"10.1016\/S0893-133X(98)00135-3","article-title":"Serotonin and Hallucinogens","volume":"21","author":"Aghajanian","year":"1999","journal-title":"Neuropsychopharmacology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1038\/s41386-019-0324-9","article-title":"Psychedelic Effects of Psilocybin Correlate with Serotonin 2A Receptor Occupancy and Plasma Psilocin Levels","volume":"44","author":"Madsen","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.neuropharm.2011.01.017","article-title":"Multiple Receptors Contribute to the Behavioral Effects of Indoleamine Hallucinogens","volume":"61","author":"Halberstadt","year":"2011","journal-title":"Neuropharmacology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.euroneuro.2016.01.005","article-title":"Modulatory Effect of the 5-HT1A Agonist Buspirone and the Mixed Non-Hallucinogenic 5-HT1A\/2A Agonist Ergotamine on Psilocybin-Induced Psychedelic Experience","volume":"26","author":"Pokorny","year":"2016","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41386-022-01446-7","article-title":"Schrooms against Booze: Potential of Mycotherapy for the Treatment of AUD","volume":"48","author":"Meinhardt","year":"2023","journal-title":"Neuropsychopharmacology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.neulet.2011.01.046","article-title":"Metabotropic Glutamate MGlu2 Receptor Is Necessary for the Pharmacological and Behavioral Effects Induced by Hallucinogenic 5-HT2A Receptor Agonists","volume":"493","author":"Moreno","year":"2011","journal-title":"Neurosci. Lett."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nature06612","article-title":"Identification of a Serotonin\/Glutamate Receptor Complex Implicated in Psychosis","volume":"452","author":"Ang","year":"2008","journal-title":"Nature"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.neubiorev.2017.02.024","article-title":"Metabotropic and Ionotropic Glutamate Receptors as Potential Targets for the Treatment of Alcohol Use Disorder","volume":"77","author":"Goodwani","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.3389\/fphar.2022.985954","article-title":"MGlu2 Mechanism-Based Interventions to Treat Alcohol Relapse","volume":"13","author":"Vengeliene","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1038\/s41386-020-00950-y","article-title":"Addiction as a Brain Disease Revised: Why It Still Matters, and the Need for Consilience","volume":"46","author":"Heilig","year":"2021","journal-title":"Neuropsychopharmacology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0140-6736(19)31775-1","article-title":"Alcohol Use Disorders","volume":"394","author":"Carvalho","year":"2019","journal-title":"Lancet"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/sj.npp.1301564","article-title":"Drug Addiction as a Pathology of Staged Neuroplasticity","volume":"33","author":"Kalivas","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bcp.2007.06.039","article-title":"Glutamatergic Substrates of Drug Addiction and Alcoholism","volume":"75","author":"Gass","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.coph.2020.09.005","article-title":"Glutamate Receptors and Metaplasticity in Addiction","volume":"56","author":"Chiamulera","year":"2021","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s00213-013-3226-2","article-title":"Glutamatergic Targets for New Alcohol Medications","volume":"229","author":"Holmes","year":"2013","journal-title":"Psychopharmacology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejphar.2010.01.030","article-title":"Group II Metabotropic Glutamate Receptors (MGlu2\/3) in Drug Addiction","volume":"639","author":"Moussawi","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1523\/JNEUROSCI.4062-12.2013","article-title":"Rescue of Infralimbic MGluR2 Deficit Restores Control Over Drug-Seeking Behavior in Alcohol Dependence","volume":"33","author":"Meinhardt","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"16963","DOI":"10.1073\/pnas.1309839110","article-title":"Loss of Metabotropic Glutamate Receptor 2 Escalates Alcohol Consumption","volume":"110","author":"Zhou","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.neuropharm.2016.03.020","article-title":"Prevalence and Influence of Cys407* Grm2 Mutation in Hannover-Derived Wistar Rats: MGlu2 Receptor Loss Links to Alcohol Intake, Risk Taking and Emotional Behaviour","volume":"115","author":"Wood","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1111\/acer.13488","article-title":"Reduced Levels of MGlu2 Receptors within the Prelimbic Cortex Are Not Associated with Elevated Glutamate Transmission or High Alcohol Drinking","volume":"41","author":"Ding","year":"2017","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/adb.12187","article-title":"Postdependent State in Rats as a Model for Medication Development in Alcoholism","volume":"20","author":"Meinhardt","year":"2015","journal-title":"Addict. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1126\/sciadv.abh2399","article-title":"Psilocybin Targets a Common Molecular Mechanism for Cognitive Impairment and Increased Craving in Alcoholism","volume":"7","author":"Meinhardt","year":"2021","journal-title":"Sci. Adv."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00702-014-1180-8","article-title":"Glutamate as a Neurotransmitter in the Healthy Brain","volume":"121","author":"Zhou","year":"2014","journal-title":"J. Neural Transm."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrn2356","article-title":"Metaplasticity: Tuning Synapses and Networks for Plasticity","volume":"9","author":"Abraham","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.neuron.2018.05.018","article-title":"Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert","volume":"98","author":"Reiner","year":"2018","journal-title":"Neuron"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"108275","DOI":"10.1016\/j.pharmthera.2022.108275","article-title":"Targeting MGluR2\/3 for Treatment of Neurodegenerative and Neuropsychiatric Diseases","volume":"239","author":"Li","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2174\/187152708784083821","article-title":"Ionotropic Glutamate Receptors & CNS Disorders","volume":"7","author":"Bowie","year":"2008","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev.pharmtox.011008.145533","article-title":"Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease","volume":"50","author":"Niswender","year":"2010","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"ar66","DOI":"10.1091\/mbc.E21-10-0484","article-title":"Subsynaptic Mobility of Presynaptic MGluR Types Is Differentially Regulated by Intra- and Extracellular Interactions","volume":"33","author":"Berger","year":"2022","journal-title":"Mol. Biol. Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/0306-4522(95)00533-1","article-title":"The Metabotropic Glutamate Receptors, MGLUR2 and MGLUR3, Show Unique Postsynaptic, Presynaptic and Glial Localizations","volume":"71","author":"Petralia","year":"1996","journal-title":"Neuroscience"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"13734","DOI":"10.1096\/fj.201901543R","article-title":"Localization of Group II and III Metabotropic Glutamate Receptors at Pre- and Postsynaptic Sites of Inner Hair Cell Ribbon Synapses","volume":"33","author":"Klotz","year":"2019","journal-title":"FASEB J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"ra5","DOI":"10.1126\/scisignal.aab0467","article-title":"Allosteric Signaling through an MGlu2 and 5-HT2A Heteromeric Receptor Complex and Its Potential Contribution to Schizophrenia","volume":"9","author":"Moreno","year":"2016","journal-title":"Sci. Signal."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1093\/cercor\/bhx005","article-title":"MGluR2 versus MGluR3 Metabotropic Glutamate Receptors in Primate Dorsolateral Prefrontal Cortex: Postsynaptic MGluR3 Strengthen Working Memory Networks","volume":"28","author":"Jin","year":"2018","journal-title":"Cereb. Cortex"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"108799","DOI":"10.1016\/j.neuropharm.2021.108799","article-title":"Membrane Trafficking and Positioning of MGluRs at Presynaptic and Postsynaptic Sites of Excitatory Synapses","volume":"200","author":"Scheefhals","year":"2021","journal-title":"Neuropharmacology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fnana.2022.849937","article-title":"Glutamate Metabotropic Receptor Type 3 (MGlu3) Localization in the Rat Prelimbic Medial Prefrontal Cortex","volume":"16","author":"Woo","year":"2022","journal-title":"Front. Neuroanat."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0896-6273(92)90118-W","article-title":"A Family of Metabotropic Glutamate Receptors","volume":"8","author":"Tanabe","year":"1992","journal-title":"Neuron"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1085\/jgp.109.4.477","article-title":"Positive and Negative Coupling of the Metabotropic Glutamate Receptors to a G Protein\u2013Activated K+ Channel, GIRK, in Xenopus Oocytes","volume":"109","author":"Sharon","year":"1997","journal-title":"J. Gen. Physiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"7067","DOI":"10.1523\/JNEUROSCI.14-11-07067.1994","article-title":"The Metabotropic Glutamate Receptor Types 2\/3 Inhibit L-Type Calcium Channels via a Pertussis Toxin-Sensitive G-Protein in Cultured Cerebellar Granule Cells","volume":"14","author":"Chavis","year":"1994","journal-title":"J. Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1113\/jphysiol.2003.056812","article-title":"Group II Metabotropic Glutamate Receptors Enhance NMDA Receptor Currents via a Protein Kinase C-Dependent Mechanism in Pyramidal Neurones of Rat Prefrontal Cortex","volume":"554","author":"Tyszkiewicz","year":"2004","journal-title":"J. Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"srep00926","DOI":"10.1038\/srep00926","article-title":"Group II Metabotropic Glutamate Receptors Modify N-Methyl-D-Aspartate Receptors via Src Kinase","volume":"3","author":"Trepanier","year":"2013","journal-title":"Sci. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1038\/npp.2011.12","article-title":"Group II Metabotropic Glutamate Receptor Agonist Ameliorates MK801-Induced Dysfunction of NMDA Receptors via the Akt\/GSK-3\u03b2 Pathway in Adult Rat Prefrontal Cortex","volume":"36","author":"Xi","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"11521","DOI":"10.1523\/JNEUROSCI.1519-16.2016","article-title":"Activation of Group II Metabotropic Glutamate Receptors Promotes LTP Induction at Schaffer Collateral-CA1 Pyramidal Cell Synapses by Priming NMDA Receptors","volume":"36","author":"Rosenberg","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3935","DOI":"10.1113\/jphysiol.2013.255075","article-title":"SNARE Proteins Are Essential in the Potentiation of NMDA Receptors by Group II Metabotropic Glutamate Receptors","volume":"591","author":"Cheng","year":"2013","journal-title":"J. Physiol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Wang, M.J., Li, Y.C., Snyder, M.A., Wang, H., Li, F., and Gao, W.J. (2013). Group II Metabotropic Glutamate Receptor Agonist LY379268 Regulates AMPA Receptor Trafficking in Prefrontal Cortical Neurons. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0061787"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1038\/npp.2016.107","article-title":"The MGluR2 Positive Allosteric Modulator, AZD8529, and Cue-Induced Relapse to Alcohol Seeking in Rats","volume":"41","author":"Augier","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.bbr.2006.03.032","article-title":"The Metabotropic Glutamate 2\/3 Receptor Agonist LY404039 Reduces Alcohol-Seeking but Not Alcohol Self-Administration in Alcohol-Preferring (P) Rats","volume":"171","author":"Rodd","year":"2006","journal-title":"Behav. Brain Res."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Ray, T.S. (2010). Psychedelics and the Human Receptorome. PLoS ONE, 5.","DOI":"10.1371\/annotation\/e580a864-cf13-40c2-9bd9-b9687a6f0fe4"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1124\/pr.115.011478","article-title":"Psychedelics","volume":"68","author":"Nichols","year":"2016","journal-title":"Pharmacol. Rev."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41583-020-0367-2","article-title":"Psychedelic Drugs: Neurobiology and Potential for Treatment of Psychiatric Disorders","volume":"21","author":"Vollenweider","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/YCO.0000000000000467","article-title":"How Do Psychedelics Work?","volume":"32","year":"2019","journal-title":"Curr. Opin. Psychiatry"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.neuron.2007.01.008","article-title":"Hallucinogens Recruit Specific Cortical 5-HT2A Receptor-Mediated Signaling Pathways to Affect Behavior","volume":"53","author":"Weisstaub","year":"2007","journal-title":"Neuron"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1126\/science.adf0435","article-title":"Psychedelics Promote Neuroplasticity through the Activation of Intracellular 5-HT2A Receptors","volume":"379","author":"Vargas","year":"2023","journal-title":"Science"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1124\/pr.118.015552","article-title":"International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-Hydroxytryptamine; Pharmacology and Function","volume":"73","author":"Barnes","year":"2021","journal-title":"Pharmacol. Rev."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1177\/0269881120959614","article-title":"Transcriptional Regulation in the Rat Prefrontal Cortex and Hippocampus after a Single Administration of Psilocybin","volume":"35","author":"Jefsen","year":"2020","journal-title":"J. Psychopharmacol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1523\/JNEUROSCI.17-08-02785.1997","article-title":"5-HT(2A) Receptor-Mediated Regulation of Brain-Derived Neurotrophic Factor MRNA in the Hippocampus and the Neocortex","volume":"17","author":"Vaidya","year":"1997","journal-title":"J. Neurosci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.neuint.2009.06.013","article-title":"BDNF Downregulates 5-HT2A Receptor Protein Levels in Hippocampal Cultures","volume":"55","author":"Trajkovska","year":"2009","journal-title":"Neurochem. Int."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0091-3057(02)00844-4","article-title":"Modulation of DOI-Induced Increases in Cortical BDNF Expression by Group II MGlu Receptors","volume":"73","author":"Gewirtz","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fnbeh.2017.00035","article-title":"The Role of Early Growth Response 1 (EGR1) in Brain Plasticity and Neuropsychiatric Disorders","volume":"11","author":"Duclot","year":"2017","journal-title":"Front. Behav. Neurosci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e65228","DOI":"10.7554\/eLife.65228","article-title":"Egr2 Induction in Spiny Projection Neurons of the Ventrolateral Striatum Contributes to Cocaine Place Preference in Mice","volume":"10","author":"Mukherjee","year":"2021","journal-title":"eLife"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1124\/mol.112.084582","article-title":"Repressive Epigenetic Changes at the MGlu2 Promoter in Frontal Cortex of 5-HT2A Knockout Mice","volume":"83","author":"Kurita","year":"2013","journal-title":"Mol. Pharmacol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.106.104463","article-title":"Functional Selectivity and Classical Concepts of Quantitative Pharmacology","volume":"320","author":"Urban","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_79","first-page":"123","article-title":"Serotonin 2A (5-HT2A) Receptor Function: Ligand-Dependent Mechanisms and Pathways","volume":"6","author":"Raote","year":"2007","journal-title":"Serotonin Recept. Neurobiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/j.neuropharm.2007.03.013","article-title":"Role of Gq Protein in Behavioral Effects of the Hallucinogenic Drug 1-(2,5-Dimethoxy-4-Iodophenyl)-2-Aminopropane","volume":"52","author":"Garcia","year":"2007","journal-title":"Neuropharmacology"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/dta.1333","article-title":"Head-Twitch Response in Rodents Induced by the Hallucinogen 2,5-Dimethoxy-4-Iodoamphetamine: A Comprehensive History, a Re-Evaluation of Mechanisms, and Its Utility as a Model","volume":"4","author":"Canal","year":"2012","journal-title":"Drug Test. Anal."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/j.cell.2019.04.044","article-title":"Illuminating G-Protein-Coupling Selectivity of GPCRs","volume":"177","author":"Inoue","year":"2019","journal-title":"Cell"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/j.cell.2020.08.024","article-title":"Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor","volume":"182","author":"Kim","year":"2020","journal-title":"Cell"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.bbrc.2020.08.022","article-title":"Differential Signaling Signatures Evoked by DOI versus Lisuride Stimulation of the 5-HT2A Receptor","volume":"531","author":"Banerjee","year":"2020","journal-title":"Biochem. Biophys Res. Commun."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"7124","DOI":"10.1523\/JNEUROSCI.1090-09.2009","article-title":"PSD-95 Is Essential for Hallucinogen and Atypical Antipsychotic Drug Actions at Serotonin Receptors","volume":"29","author":"Abbas","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"12122","DOI":"10.1523\/JNEUROSCI.0131-13.2013","article-title":"Phosphorylation of Threonine-19 of PSD-95 by GSK-3\u03b2 Is Required for PSD-95 Mobilization and Long-Term Depression","volume":"33","author":"Nelson","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1038\/sj.npp.1300439","article-title":"In Vivo Regulation of Glycogen Synthase Kinase-3\u03b2 (GSK3\u03b2) by Serotonergic Activity in Mouse Brain","volume":"29","author":"Li","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3389\/fnmol.2011.00031","article-title":"Glycogen Synthase Kinase-3 Is an Intermediate Modulator of Serotonin Neurotransmission","volume":"4","author":"Polter","year":"2011","journal-title":"Front. Mol. Neurosci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1073\/pnas.0708862105","article-title":"Agonist-Directed Signaling of the Serotonin 2A Receptor Depends on \u03b2-Arrestin-2 Interactions in Vivo","volume":"105","author":"Schmid","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"13513","DOI":"10.1523\/JNEUROSCI.1665-10.2010","article-title":"Serotonin, But Not N-Methyltryptamines, Activates the Serotonin 2A Receptor Via a \u03b2-Arrestin2\/Src\/Akt Signaling Complex In Vivo","volume":"30","author":"Schmid","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1021\/acschemneuro.2c00170","article-title":"Tolerance and Cross-Tolerance among Psychedelic and Nonpsychedelic 5-HT2A Receptor Agonists in Mice","volume":"13","author":"Jaster","year":"2022","journal-title":"ACS Chem. Neurosci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"17690","DOI":"10.1038\/s41598-021-96736-3","article-title":"LSD-Stimulated Behaviors in Mice Require \u03b2-Arrestin 2 but Not \u03b2-Arrestin 1","volume":"11","author":"Rodriguiz","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1074\/mcp.M113.036558","article-title":"Quantitative Phosphoproteomics Unravels Biased Phosphorylation of Serotonin 2A Receptor at Ser280 by Hallucinogenic versus Nonhallucinogenic Agonists","volume":"13","author":"Karaki","year":"2014","journal-title":"Mol. Cell. Proteom."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.neuropharm.2013.02.005","article-title":"The Two Faces of the Pharmacological Interaction of MGlu2 and 5-HT2A-Relevance of Receptor Heterocomplexes and Interaction through Functional Brain Pathways","volume":"70","author":"Delille","year":"2013","journal-title":"Neuropharmacology"},{"key":"ref_95","first-page":"76","article-title":"Physiological Antagonism between 5-Hydroxytryptamine2A and Group II Metabotropic Glutamate Receptors in Prefrontal Cortex","volume":"292","author":"Marek","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0028-3908(97)00051-8","article-title":"Serotonin Induces Excitatory Postsynaptic Potentials in Apical Dendrites of Neocortical Pyramidal Cells","volume":"36","author":"Aghajanian","year":"1997","journal-title":"Neuropharmacology"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1016\/j.neuropharm.2012.01.010","article-title":"Heterocomplex Formation of 5-HT2A-MGlu2 and Its Relevance for Cellular Signaling Cascades","volume":"62","author":"Delille","year":"2012","journal-title":"Neuropharmacology"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/7854_2017_480","article-title":"Interactions of Hallucinogens with the Glutamatergic System: Permissive Network Effects Mediated through Cortical Layer V Pyramidal Neurons","volume":"Volume 36","author":"Marek","year":"2018","journal-title":"Current Topics in Behavioral Neurosciences"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0893-133X(00)00136-6","article-title":"Behavioral Evidence for Interactions between a Hallucinogenic Drug and Group II Metabotropic Glutamate Receptors","volume":"23","author":"Gewirtz","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0091-3057(02)00845-6","article-title":"Group II MGlu Receptor Agonists Inhibit Behavioural and Electrophysiological Effects of DOI in Mice","volume":"73","author":"Klodzinska","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1124\/mol.107.035170","article-title":"A Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 2 Blocks a Hallucinogenic Drug Model of Psychosis","volume":"72","author":"Benneyworth","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Taddeucci, A., Olivero, G., Roggeri, A., Milanese, C., Di Giorgio, F.P., Grilli, M., Marchi, M., Garrone, B., and Pittaluga, A. (2022). Presynaptic 5-HT2A-mGlu2\/3 Receptor\u2013Receptor Crosstalk in the Prefrontal Cortex: Metamodulation of Glutamate Exocytosis. Cells, 11.","DOI":"10.3390\/cells11193035"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.neuropharm.2018.02.030","article-title":"5-HT2A-MGlu2\/3 Receptor Complex in Rat Spinal Cord Glutamatergic Nerve Endings: A 5-HT2A to MGlu2\/3 Signalling to Amplify Presynaptic Mechanism of Auto-Control of Glutamate Exocytosis","volume":"133","author":"Olivero","year":"2018","journal-title":"Neuropharmacology"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3389\/fphar.2018.00208","article-title":"Metabotropic Glutamate2 Receptors Play a Key Role in Modulating Head Twitches Induced by a Serotonergic Hallucinogen in Mice","volume":"9","author":"Benvenga","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1007\/s00213-018-5015-4","article-title":"Role of MGlu2 in the 5-HT 2A Receptor-Dependent Antipsychotic Activity of Clozapine in Mice","volume":"235","author":"Hideshima","year":"2018","journal-title":"Psychopharmacology"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.pnpbp.2007.07.009","article-title":"AMPA Receptor Involvement in 5-Hydroxytryptamine2A Receptor-Mediated Pre-Frontal Cortical Excitatory Synaptic Currents and DOI-Induced Head Shakes","volume":"32","author":"Zhang","year":"2008","journal-title":"Prog. Neuropsycho-Pharmacol. Biol. Psychiatry"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.cell.2011.09.055","article-title":"Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs","volume":"147","author":"Fribourg","year":"2011","journal-title":"Cell"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1124\/pr.113.008052","article-title":"G Protein-Coupled Receptor Oligomerization Revisited: Functional and Pharmacological Perspectives","volume":"66","author":"Devi","year":"2014","journal-title":"Pharmacol. Rev."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1152\/physiol.00028.2008","article-title":"Heterodimers and Receptor Mosaics of Different Types of G-Protein-Coupled Receptors","volume":"23","author":"Fuxe","year":"2008","journal-title":"Physiology"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"636","DOI":"10.2174\/187152710793361586","article-title":"Heteromerization of G Protein-Coupled Receptors: Relevance to Neurological Disorders and Neurotherapeutics","volume":"9","author":"Albizu","year":"2012","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.tips.2018.10.007","article-title":"A2AR-D2R Heteroreceptor Complexes in Cocaine Reward and Addiction","volume":"39","author":"Wydra","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev-pharmtox-011613-135952","article-title":"G Protein-Coupled Receptor Heteromers","volume":"56","author":"Gomes","year":"2016","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"BSR20160547","DOI":"10.1042\/BSR20160547","article-title":"Methods Used to Study the Oligomeric Structure of G-Protein-Coupled Receptors","volume":"37","author":"Guo","year":"2017","journal-title":"Biosci. Rep."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"44301","DOI":"10.1074\/jbc.M112.413161","article-title":"Identification of Three Residues Essential for 5-Hydroxytryptamine 2A-Metabotropic Glutamate 2 (5-HT2A\u00b7mGlu2) Receptor Heteromerization and Its Psychoactive Behavioral Function","volume":"287","author":"Moreno","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1038\/emboj.2009.177","article-title":"Crosstalk between GABAB and MGlu1a Receptors Reveals New Insight into GPCR Signal Integration","volume":"28","author":"Rives","year":"2009","journal-title":"EMBO J."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.pbb.2018.09.007","article-title":"Chronic Methamphetamine Self-Administration Dysregulates 5-HT2A and MGlu2 Receptor Expression in the Rat Prefrontal and Perirhinal Cortex: Comparison to Chronic Phencyclidine and MK-801","volume":"175","author":"Zaniewska","year":"2018","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-Due\u00f1as, V., G\u00f3mez-Soler, M., Valle-Le\u00f3n, M., Watanabe, M., Ferrer, I., and Ciruela, F. (2019). Revealing Adenosine A2A-Dopamine D2 Receptor Heteromers in Parkinson\u2019s Disease Post-Mortem Brain through a New AlphaScreen-Based Assay. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20143600"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"eaaw3122","DOI":"10.1126\/scisignal.aaw3122","article-title":"Interclass GPCR Heteromerization Affects Localization and Trafficking","volume":"13","author":"Toneatti","year":"2020","journal-title":"Sci. Signal."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1021\/acschemneuro.6b00409","article-title":"Growing Evidence for Heterogeneous Synaptic Localization of 5-HT2A Receptors","volume":"8","author":"Berthoux","year":"2017","journal-title":"ACS Chem. Neurosci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"E1382","DOI":"10.1073\/pnas.1525586113","article-title":"Presynaptic Serotonin 2A Receptors Modulate Thalamocortical Plasticity and Associative Learning","volume":"113","author":"Barre","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.pneurobio.2018.10.001","article-title":"Role of Glutamatergic System and Mesocorticolimbic Circuits in Alcohol Dependence","volume":"171","author":"Alasmari","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bbr.2014.04.007","article-title":"The Role of Serotonin in Drug Use and Addiction","volume":"277","author":"Homberg","year":"2015","journal-title":"Behav. Brain Res."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Domi, E., Barchiesi, R., and Barbier, E. (2023). Epigenetic Dysregulation in Alcohol-Associated Behaviors: Preclinical and Clinical Evidence. Curr. Top Behav. Neurosci., Online ahead of print.","DOI":"10.1007\/7854_2022_410"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/nn.3181","article-title":"HDAC2 Regulates Atypical Antipsychotic Responses through the Modulation of MGlu2 Promoter Activity","volume":"15","author":"Kurita","year":"2012","journal-title":"Nat. Neurosci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41386-018-0143-4","article-title":"Chronic Clozapine Treatment Restrains via HDAC2 the Performance of MGlu2 Receptor Agonism in a Rodent Model of Antipsychotic Activity","volume":"44","author":"Ibi","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/nn.4616","article-title":"Antipsychotic-Induced Hdac2 Transcription via NF-\u039aB Leads to Synaptic and Cognitive Side Effects","volume":"20","author":"Ibi","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/embr.201337983","article-title":"The I\u03baB Kinase Complex in NF-\u039aB Regulation and Beyond","volume":"15","author":"Hinz","year":"2014","journal-title":"EMBO Rep."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.neuroscience.2018.07.010","article-title":"HDAC2-Dependent Antipsychotic-like Effects of Chronic Treatment with the HDAC Inhibitor SAHA in Mice","volume":"388","author":"Ibi","year":"2018","journal-title":"Neuroscience"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"109836","DOI":"10.1016\/j.celrep.2021.109836","article-title":"Prolonged Epigenomic and Synaptic Plasticity Alterations Following Single Exposure to a Psychedelic in Mice","volume":"37","author":"Zhu","year":"2021","journal-title":"Cell Rep."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/jnc.15534","article-title":"Lysergic Acid Diethylamide Induces Increased Signalling Entropy in Rats\u2019 Prefrontal Cortex","volume":"162","author":"Savino","year":"2022","journal-title":"J. Neurochem."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S2215-0366(16)00104-8","article-title":"Neurobiology of Addiction: A Neurocircuitry Analysis","volume":"3","author":"Koob","year":"2016","journal-title":"Lancet Psychiatry"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/13543776.2019.1637421","article-title":"MGluR2 Positive Allosteric Modulators: An Updated Patent Review (2013\u20132018)","volume":"29","author":"Trabanco","year":"2019","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"8297","DOI":"10.1523\/JNEUROSCI.1889-07.2007","article-title":"The Use of Knock-Out Mice Unravels Distinct Roles for MGlu2 and MGlu3 Metabotropic Glutamate Receptors in Mechanisms of Neurodegeneration\/Neuroprotection","volume":"27","author":"Corti","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.tips.2016.01.008","article-title":"Drug Tolerance: A Known Unknown in Translational Neuroscience","volume":"37","author":"Bespalov","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"e13229","DOI":"10.1111\/adb.13229","article-title":"Classic Psychedelics and Alcohol Use Disorders: A Systematic Review of Human and Animal Studies","volume":"27","year":"2022","journal-title":"Addict. Biol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/acps.13249","article-title":"Therapeutic Effects of Classic Serotonergic Psychedelics: A Systematic Review of Modern-Era Clinical Studies","volume":"143","author":"Andersen","year":"2021","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_137","first-page":"129","article-title":"Therapeutic Effect of Psilocybin in Addiction: A Systematic Review","volume":"14","author":"Fuentes","year":"2023","journal-title":"Front. Psychiatry"},{"key":"ref_138","unstructured":"(2023, March 21). Available online: https:\/\/www.unodc.org\/pdf\/convention_1971_en.pdf."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neuropharm.2018.05.012","article-title":"The Abuse Potential of Medical Psilocybin According to the 8 Factors of the Controlled Substances Act","volume":"142","author":"Johnson","year":"2018","journal-title":"Neuropharmacology"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1080\/17512433.2018.1511424","article-title":"Efficacy, Tolerability, and Safety of Serotonergic Psychedelics for the Management of Mood, Anxiety, and Substance-Use Disorders: A Systematic Review of Systematic Reviews","volume":"11","author":"Bouso","year":"2018","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1177\/02698811211069100","article-title":"Adverse Effects of Psychedelics: From Anecdotes and Misinformation to Systematic Science","volume":"36","author":"Schlag","year":"2022","journal-title":"Br. Assoc. Psychopharmacol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/cpt.2821","article-title":"Pharmacokinetics and Pharmacodynamics of Oral Psilocybin Administration in Healthy Participants","volume":"113","author":"Holze","year":"2022","journal-title":"Clin. Pharmacol. Ther."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/6\/963\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:00:37Z","timestamp":1760122837000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/6\/963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,22]]},"references-count":142,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["cells12060963"],"URL":"https:\/\/doi.org\/10.3390\/cells12060963","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,22]]}}}