{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:21:09Z","timestamp":1787498469015,"version":"build-2736575974"},"reference-count":102,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T00:00:00Z","timestamp":1680652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"Keenan Center Accelerator Award, Ohio Third Frontier","doi-asserted-by":"publisher","award":["R01HL136232"],"award-info":[{"award-number":["R01HL136232"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"Keenan Center Accelerator Award, Ohio Third Frontier","doi-asserted-by":"publisher","award":["R01HL157232"],"award-info":[{"award-number":["R01HL157232"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"Keenan Center Accelerator Award, Ohio Third Frontier","doi-asserted-by":"publisher","award":["GR12574"],"award-info":[{"award-number":["GR12574"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Myocardial Infarction (MI) occurs due to a blockage in the coronary artery resulting in ischemia and necrosis of cardiomyocytes in the left ventricular heart muscle. The dying cardiac tissue is replaced with fibrous scar tissue, causing a decrease in myocardial contractility and thus affecting the functional capacity of the myocardium. Treatments, such as stent placements, cardiac bypasses, or transplants are beneficial but with many limitations, and may decrease the overall life expectancy due to related complications. In recent years, with the advent of human induced pluripotent stem cells (hiPSCs), newer avenues using cell-based approaches for the treatment of MI have emerged as a potential for cardiac regeneration. While hiPSCs and their derived differentiated cells are promising candidates, their translatability for clinical applications has been hindered due to poor preclinical reproducibility. Various preclinical animal models for MI, ranging from mice to non-human primates, have been adopted in cardiovascular research to mimic MI in humans. Therefore, a comprehensive literature review was essential to elucidate the factors affecting the reproducibility and translatability of large animal models. In this review article, we have discussed different animal models available for studying stem-cell transplantation in cardiovascular applications, mainly focusing on the highly translatable porcine MI model.<\/jats:p>","DOI":"10.3390\/cells12071090","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T01:10:27Z","timestamp":1680743427000},"page":"1090","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Preclinical Large Animal Porcine Models for Cardiac Regeneration and Its Clinical Translation: Role of hiPSC-Derived Cardiomyocytes"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1931-6470","authenticated-orcid":false,"given":"Divya","family":"Sridharan","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nooruddin","family":"Pracha","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schaza Javed","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA"},{"name":"Department of Internal Medicine, Northeast Georgia Medical Center, Gainesville, GA 30501, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salmman","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA"},{"name":"Lake Erie College of Osteopathic Medicine (LECOM), Erie, PA 16509, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anam J.","family":"Dewani","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA"},{"name":"Department of Chemistry & Biochemistry, The University of Toledo, Toledo, OH 43606, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Baseeruddin","family":"Alvi","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhamad","family":"Mergaye","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzair","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3430-374X","authenticated-orcid":false,"given":"Mahmood","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA"},{"name":"Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jjcc.2020.03.013","article-title":"Heart regeneration using pluripotent stem cells","volume":"76","author":"Kadota","year":"2020","journal-title":"J. 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