{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:48:05Z","timestamp":1790603285823,"version":"4.1.0"},"reference-count":86,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T00:00:00Z","timestamp":1682208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Endometriosis is a chronic disorder of the female reproductive system which afflicts a great number of women worldwide. Histone deacetylases (HDACs) prevent the relaxation of chromatin, thereby positively or negatively modulating gene transcription. The current review aims at studying the impact of histone modifications and their therapeutic targeting in endometriosis. In order to identify relevant studies, a literature review was conducted using the MEDLINE and LIVIVO databases. The current manuscript represents the most comprehensive, up-to-date review of the literature focusing on the particular role of HDACs and their inhibitors in the context of endometriosis. HDAC1, HDAC2, HDAC3, Sirtuin 1, and Sirtuin 3, are the five most studied HDAC enzymes which seem to, at least partly, influence the pathophysiology of endometriosis. Both well-established and novel HDACIs could possibly represent modern, efficacious anti-endometriotic drug agents. Altogether, histone modifications and their therapeutic targeting have been proven to have a strong impact on endometriosis.<\/jats:p>","DOI":"10.3390\/cells12091227","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T01:35:44Z","timestamp":1682300144000},"page":"1227","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The Impact of Histone Modifications in Endometriosis Highlights New Therapeutic Opportunities"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8516-6242","authenticated-orcid":false,"given":"Iason","family":"Psilopatis","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2014Universit\u00e4t zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Bld 10, Goudi, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kleio","family":"Vrettou","sequence":"additional","affiliation":[{"name":"First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Bld 10, Goudi, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian Nima","family":"Fleckenstein","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2014Universit\u00e4t zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"BIH Charit\u00e9 Clinician Scientist Program, Berlin Institute of Health at Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, BIH Biomedical Innovation Academy, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stamatios","family":"Theocharis","sequence":"additional","affiliation":[{"name":"First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Bld 10, Goudi, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,23]]},"reference":[{"key":"ref_1","unstructured":"Tsamantioti, E.S., and Mahdy, H. (2023). StatPearls [Internet], StatPearls Publishing."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s13669-017-0187-1","article-title":"Endometriosis: Epidemiology, Diagnosis and Clinical Management","volume":"6","author":"Parasar","year":"2017","journal-title":"Curr. Obstet. Gynecol. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"590823","DOI":"10.3389\/fncel.2020.590823","article-title":"Pain in Endometriosis","volume":"14","author":"Maddern","year":"2020","journal-title":"Front. Cell Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1055\/a-1033-9588","article-title":"Cycle-related Diarrhea and Dysmenorrhea are Independent Predictors of Peritoneal Endometriosis, Cycle-related Dyschezia is an Independent Predictor of Rectal Involvement","volume":"80","author":"Nicolaus","year":"2020","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Doroftei, B., Maftei, R., Ilie, O.D., Simionescu, G., Anton, E., Armeanu, T., Dabuleanu, A.M., Mihalceanu, E., Condac, C., and Ilea, C. (2021). Transvaginal Ultrasound as a First-Line Approach in Deep Endometriosis: A Pictorial Essay. Diagnostics, 11.","DOI":"10.3390\/diagnostics11030444"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Scioscia, M., Virgilio, B.A., Lagana, A.S., Bernardini, T., Fattizzi, N., Neri, M., and Guerriero, S. (2020). Differential Diagnosis of Endometriosis by Ultrasound: A Rising Challenge. Diagnostics, 10.","DOI":"10.3390\/diagnostics10100848"},{"key":"ref_7","first-page":"15","article-title":"Accuracy of laparoscopic diagnosis of endometriosis","volume":"7","author":"Mettler","year":"2003","journal-title":"JSLS"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"204792","DOI":"10.1155\/2015\/204792","article-title":"An Update on Surgical versus Expectant Management of Ovarian Endometriomas in Infertile Women","volume":"2015","author":"Keyhan","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"ref_9","first-page":"CD001019","article-title":"Oral contraceptives for pain associated with endometriosis","volume":"5","author":"Brown","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_10","first-page":"105","article-title":"Contraception and endometriosis: Challenges, efficacy, and therapeutic importance","volume":"6","author":"Weisberg","year":"2015","journal-title":"Open Access J. Contracept."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S1472-6483(10)61590-8","article-title":"Use of GnRH antagonists in the treatment of endometriosis","volume":"5","author":"Kupker","year":"2002","journal-title":"Reprod Biomed. Online"},{"key":"ref_12","first-page":"CD011031","article-title":"Laparoscopic surgery for endometriosis","volume":"10","author":"Bafort","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"879015","DOI":"10.3389\/fmed.2022.879015","article-title":"New Insights in Pathogenesis of Endometriosis","volume":"9","author":"Signorile","year":"2022","journal-title":"Front. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5420","DOI":"10.1038\/sj.onc.1210610","article-title":"Histone deacetylases and cancer","volume":"26","author":"Glozak","year":"2007","journal-title":"Oncogene"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0079-6468(07)00005-7","article-title":"Histone deacetylase inhibitors: A novel class of anti-cancer agents on its way to the market","volume":"46","author":"Korner","year":"2008","journal-title":"Prog. Med. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1021\/bi00354a035","article-title":"Histone hyperacetylation: Its effects on nucleosome conformation and stability","volume":"25","author":"Ausio","year":"1986","journal-title":"Biochemistry"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nrd772","article-title":"Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer","volume":"1","author":"Johnstone","year":"2002","journal-title":"Nat. Rev. Drug. Discov."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.2174\/1389450110607011553","article-title":"The role of NAD+ dependent histone deacetylases (sirtuins) in ageing","volume":"7","author":"Trapp","year":"2006","journal-title":"Curr. Drug. Targets."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1615\/CritRevOncog.2014012463","article-title":"Deacetylation of chromatin and gene expression regulation: A new target for epigenetic therapy","volume":"20","author":"Olzscha","year":"2015","journal-title":"Crit. Rev. Oncog."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.tem.2013.12.001","article-title":"SIRT1 and other sirtuins in metabolism","volume":"25","author":"Chang","year":"2014","journal-title":"Trends. Endocrinol. Metab."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.molonc.2007.01.001","article-title":"The role of histone deacetylases (HDACs) in human cancer","volume":"1","author":"Ropero","year":"2007","journal-title":"Mol. Oncol."},{"key":"ref_22","first-page":"489","article-title":"Histone deacetylase inhibitors: A novel target of anticancer therapy (review)","volume":"15","author":"Kouraklis","year":"2006","journal-title":"Oncol. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12958-020-00637-5","article-title":"Histone acetylation and the role of histone deacetylases in normal cyclic endometrium","volume":"18","author":"Gujral","year":"2020","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/molehr\/gaq010","article-title":"Epigenetic regulation of endometrium during the menstrual cycle","volume":"16","author":"Munro","year":"2010","journal-title":"Mol. Hum. Reprod."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/humupd\/dmy003","article-title":"Sirtuins in gamete biology and reproductive physiology: Emerging roles and therapeutic potential in female and male infertility","volume":"24","author":"Tatone","year":"2018","journal-title":"Hum. Reprod. Update"},{"key":"ref_26","first-page":"7850688","article-title":"Histone Deacetylase Inhibitors: A Promising Therapeutic Alternative for Endometrial Carcinoma","volume":"2021","author":"Psilopatis","year":"2021","journal-title":"Dis. Mark."},{"key":"ref_27","first-page":"950","article-title":"Targeting histone deacetylases in endometrial cancer: A paradigm-shifting therapeutic strategy?","volume":"22","author":"Garmpis","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Psilopatis, I., Garmpis, N., Garmpi, A., Vrettou, K., Sarantis, P., Koustas, E., Antoniou, E.A., Dimitroulis, D., Kouraklis, G., and Karamouzis, M.V. (2023). The Emerging Role of Histone Deacetylase Inhibitors in Cervical Cancer Therapy. Cancers, 15.","DOI":"10.3390\/cancers15082222"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00404-012-2591-0","article-title":"Aberrant histone acetylation and methylation levels in woman with endometriosis","volume":"287","author":"Xiaomeng","year":"2013","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1177\/1933719113488450","article-title":"The expression of histone deacetylase 1, but not other class I histone deacetylases, is significantly increased in endometriosis","volume":"20","author":"Samartzis","year":"2013","journal-title":"Reprod. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.2147\/IJN.S354314","article-title":"Exosomal lncRNA HOTAIR Promotes the Progression and Angiogenesis of Endometriosis via the miR-761\/HDAC1 Axis and Activation of STAT3-Mediated Inflammation","volume":"17","author":"Zhang","year":"2022","journal-title":"Int. J. Nanomed."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1177\/1933719111432870","article-title":"HDAC1 and HDAC2 are differentially expressed in endometriosis","volume":"19","author":"Garcia","year":"2012","journal-title":"Reprod. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"9972","DOI":"10.1111\/jcmm.16835","article-title":"Histone deacetylase HDAC2 silencing prevents endometriosis by activating the HNF4A\/ARID1A axis","volume":"25","author":"Mai","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1080\/01443615.2022.2109955","article-title":"Histone deacetylase 1, Sirtuin 1, and Sirtuin 3 single-nucleotide polymorphisms and the risk of endometriosis in South Indian women","volume":"42","author":"Veena","year":"2022","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"eaaf7533","DOI":"10.1126\/scitranslmed.aaf7533","article-title":"Loss of HDAC3 results in nonreceptive endometrium and female infertility","volume":"11","author":"Kim","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1210\/clinem\/dgab753","article-title":"Role of SIRT1 and Progesterone Resistance in Normal and Abnormal Endometrium","volume":"107","author":"Kim","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"12302","DOI":"10.1038\/s41598-022-16629-x","article-title":"SIRT1 upregulation promotes epithelial-mesenchymal transition by inducing senescence escape in endometriosis","volume":"12","author":"Wang","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/PAI.0000000000000316","article-title":"Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma","volume":"25","author":"Mvunta","year":"2017","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s43032-019-00017-4","article-title":"Differential Expression of KRAS and SIRT1 in Ovarian Cancers with and Without Endometriosis","volume":"27","author":"Teasley","year":"2020","journal-title":"Reprod. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"6765","DOI":"10.1038\/s41598-017-04577-w","article-title":"KRAS Activation and over-expression of SIRT1\/BCL6 Contributes to the Pathogenesis of Endometriosis and Progesterone Resistance","volume":"7","author":"Yoo","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.3390\/cimb43030096","article-title":"Evaluation of BCL6 and SIRT1 as Non-Invasive Diagnostic Markers of Endometriosis","volume":"43","author":"Sansone","year":"2021","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/jog.12252","article-title":"Resveratrol suppresses inflammatory responses in endometrial stromal cells derived from endometriosis: A possible role of the sirtuin 1 pathway","volume":"40","author":"Taguchi","year":"2014","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Gonzalez-Fernandez, R., Martin-Ramirez, R., Rotoli, D., Hernandez, J., Naftolin, F., Martin-Vasallo, P., Palumbo, A., and Avila, J. (2019). Granulosa-Lutein Cell Sirtuin Gene Expression Profiles Differ between Normal Donors and Infertile Women. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010295"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"165756","DOI":"10.1016\/j.bbadis.2020.165756","article-title":"The impact of mitochondrial quality control by Sirtuins on the treatment of type 2 diabetes and diabetic kidney disease","volume":"1866","author":"Xu","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Basis. Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1080\/09513590.2021.1975674","article-title":"A potential role of Sirtuin3 and its target enzyme activities in patients with ovarian endometrioma","volume":"37","author":"Kaleler","year":"2021","journal-title":"Gynecol. Endocrinol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e202101224","DOI":"10.26508\/lsa.202101224","article-title":"Gut microbiota-derived short-chain fatty acids protect against the progression of endometriosis","volume":"4","author":"Chadchan","year":"2021","journal-title":"Life Sci. Alliance"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1093\/humrep\/der203","article-title":"Application of the histone deacetylase inhibitors for the treatment of endometriosis: Histone modifications as pathogenesis and novel therapeutic target","volume":"26","author":"Kawano","year":"2011","journal-title":"Hum. Reprod."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"E1474","DOI":"10.1210\/jc.2013-1608","article-title":"CCAAT\/enhancer-binding protein alpha is epigenetically silenced by histone deacetylation in endometriosis and promotes the pathogenesis of endometriosis","volume":"98","author":"Kawano","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2217\/fon.11.2","article-title":"Rational therapeutic combinations with histone deacetylase inhibitors for the treatment of cancer","volume":"7","author":"Thurn","year":"2011","journal-title":"Future Oncol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/aji.12155","article-title":"Death receptor 6 is epigenetically silenced by histone deacetylation in endometriosis and promotes the pathogenesis of endometriosis","volume":"70","author":"Kai","year":"2013","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1177\/1933719111424453","article-title":"Valproic acid and progestin inhibit lesion growth and reduce hyperalgesia in experimentally induced endometriosis in rats","volume":"19","author":"Liu","year":"2012","journal-title":"Reprod. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1177\/1933719110381928","article-title":"Levo-tetrahydropalmatine retards the growth of ectopic endometrial implants and alleviates generalized hyperalgesia in experimentally induced endometriosis in rats","volume":"18","author":"Zhao","year":"2011","journal-title":"Reprod. Sci."},{"key":"ref_53","first-page":"35","article-title":"Clinical use and applications of histone deacetylase inhibitors in multiple myeloma","volume":"8","author":"Tandon","year":"2016","journal-title":"Clin. Pharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nbt1272","article-title":"Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug","volume":"25","author":"Marks","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Kim, H.I., Seo, S.K., Chon, S.J., Kim, G.H., Lee, I., and Yun, B.H. (2021). Changes in the Expression of TBP-2 in Response to Histone Deacetylase Inhibitor Treatment in Human Endometrial Cells. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031427"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1095\/biolreprod.115.138115","article-title":"Epigenetic Modulation of Collagen 1A1: Therapeutic Implications in Fibrosis and Endometriosis","volume":"94","author":"Zheng","year":"2016","journal-title":"Biol. Reprod."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7164\/antibiotics.29.1","article-title":"A new antifungal antibiotic, trichostatin","volume":"29","author":"Tsuji","year":"1976","journal-title":"J. Antibiot."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1177\/1933719107302913","article-title":"Trichostatin A, a histone deacetylase inhibitor, attenuates invasiveness and reactivates E-cadherin expression in immortalized endometriotic cells","volume":"14","author":"Wu","year":"2007","journal-title":"Reprod. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1016\/j.fertnstert.2008.04.012","article-title":"Peroxisome proliferator-activated receptor-gamma and retinoid X receptor agonists synergistically suppress proliferation of immortalized endometrial stromal cells","volume":"91","author":"Wu","year":"2009","journal-title":"Fertil. Steril."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000279324","article-title":"Constitutive and tumor necrosis factor-alpha-stimulated activation of nuclear factor-kappaB in immortalized endometriotic cells and their suppression by trichostatin A","volume":"70","author":"Wu","year":"2010","journal-title":"Gynecol Obstet Investig."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1177\/1933719117741372","article-title":"Trichostatin A Induces NAG-1 Expression and Apoptosis in Human Endometriotic Stromal Cells","volume":"25","author":"Seo","year":"2018","journal-title":"Reprod. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1093\/humrep\/dep472","article-title":"Trichostatin A, a histone deacetylase inhibitor, reduces lesion growth and hyperalgesia in experimentally induced endometriosis in mice","volume":"25","author":"Lu","year":"2010","journal-title":"Hum. Reprod."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/ja.2011.35","article-title":"Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): A natural product recently approved for cutaneous T-cell lymphoma","volume":"64","author":"VanderMolen","year":"2011","journal-title":"J. Antibiot."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1016\/j.fertnstert.2010.04.052","article-title":"Romidepsin reduces histone deacetylase activity, induces acetylation of histones, inhibits proliferation, and activates apoptosis in immortalized epithelial endometriotic cells","volume":"94","author":"Imesch","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.fertnstert.2010.12.058","article-title":"Inhibition of transcription, expression, and secretion of the vascular epithelial growth factor in human epithelial endometriotic cells by romidepsin","volume":"95","author":"Imesch","year":"2011","journal-title":"Fertil. Steril."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.fertnstert.2013.05.008","article-title":"Histone deacetylase inhibitors down-regulate G-protein-coupled estrogen receptor and the GPER-antagonist G-15 inhibits proliferation in endometriotic cells","volume":"100","author":"Imesch","year":"2013","journal-title":"Fertil. Steril."},{"key":"ref_67","first-page":"296","article-title":"Panobinostat (Farydak): A Novel Option for the Treatment of Relapsed Or Relapsed and Refractory Multiple Myeloma","volume":"41","author":"Moore","year":"2016","journal-title":"Pharm. Ther."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1210\/en.2016-1194","article-title":"TGF-beta Induces Endometriotic Progression via a Noncanonical, KLF11-Mediated Mechanism","volume":"157","author":"Correa","year":"2016","journal-title":"Endocrinology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1038\/s41598-022-06883-4","article-title":"Effectiveness of Gamma Oryzanol on prevention of surgical induced endometriosis development in rat model","volume":"12","author":"Eisalou","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"116277","DOI":"10.1016\/j.jep.2023.116277","article-title":"Bushen Wenyang Huayu Decoction inhibits autophagy by regulating the SIRT1-FoXO-1 pathway in endometriosis rats","volume":"308","author":"Li","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"153050","DOI":"10.1016\/j.tox.2021.153050","article-title":"Iron overload inhibits cell proliferation and promotes autophagy via PARP1\/SIRT1 signaling in endometriosis and adenomyosis","volume":"465","author":"Zhou","year":"2022","journal-title":"Toxicology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"a026831","DOI":"10.1101\/cshperspect.a026831","article-title":"HDACs and HDAC Inhibitors in Cancer Development and Therapy","volume":"6","author":"Li","year":"2016","journal-title":"Cold Spring Harb. Perspect Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4068\/cmj.2016.52.1.1","article-title":"HDAC and HDAC Inhibitor: From Cancer to Cardiovascular Diseases","volume":"52","author":"Yoon","year":"2016","journal-title":"Chonnam. Med. J."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Garmpis, N., Damaskos, C., Dimitroulis, D., Kouraklis, G., Garmpi, A., Sarantis, P., Koustas, E., Patsouras, A., Psilopatis, I., and Antoniou, E.A. (2022). Clinical Significance of the Histone Deacetylase 2 (HDAC-2) Expression in Human Breast Cancer. J. Pers. Med., 12.","DOI":"10.3390\/jpm12101672"},{"key":"ref_75","first-page":"592868","article-title":"Histone Deacetylase Inhibitors as Therapeutic Interventions on Cervical Cancer Induced by Human Papillomavirus","volume":"8","author":"Deberaldini","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"948217","DOI":"10.3389\/fchem.2022.948217","article-title":"Potential of histone deacetylase inhibitors in the control and regulation of prostate, breast and ovarian cancer","volume":"10","author":"Pramanik","year":"2022","journal-title":"Front. Chem."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Olaniyi, K.S., Bashir, A.M., Areloegbe, S.E., Sabinari, I.W., Akintayo, C.O., Oniyide, A.A., and Aturamu, A. (2022). Short chain fatty acid, acetate restores ovarian function in experimentally induced PCOS rat model. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0272124"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"512","DOI":"10.2741\/4603","article-title":"Histone deacetylase: A potential therapeutic target for ovarian dysfunction","volume":"23","author":"Sunita","year":"2018","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Psilopatis, I., Karniadakis, I., Danos, K.S., Vrettou, K., Michaelidou, K., Mavridis, K., Agelaki, S., and Theocharis, S. (2022). May EPH\/Ephrin Targeting Revolutionize Lung Cancer Treatment?. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010093"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Psilopatis, I., Kokkali, S., Palamaris, K., Digklia, A., Vrettou, K., and Theocharis, S. (2022). Organoids: A New Chapter in Sarcoma Diagnosis and Treatment. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911271"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Psilopatis, I., Pergaris, A., Vrettou, K., Theocharis, S., and Troungos, C. (2022). Thymic Epithelial Neoplasms: Focusing on the Epigenetic Alterations. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23074045"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Psilopatis, I., Pergaris, A., Vrettou, K., Tsourouflis, G., and Theocharis, S. (2022). The EPH\/Ephrin System in Gynecological Cancers: Focusing on the Roots of Carcinogenesis for Better Patient Management. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23063249"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Psilopatis, I., Souferi-Chronopoulou, E., Vrettou, K., Troungos, C., and Theocharis, S. (2022). EPH\/Ephrin-Targeting Treatment in Breast Cancer: A New Chapter in Breast Cancer Therapy. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232315275"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Psilopatis, I., Sykaras, A.G., Mandrakis, G., Vrettou, K., and Theocharis, S. (2022). Patient-Derived Organoids: The Beginning of a New Era in Ovarian Cancer Disease Modeling and Drug Sensitivity Testing. Biomedicines, 11.","DOI":"10.3390\/biomedicines11010001"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Psilopatis, I., Vrettou, K., Fleckenstein, F.N., and Theocharis, S. (2023). The Role of Peroxisome Proliferator-Activated Receptors in Preeclampsia. Cells, 12.","DOI":"10.3390\/cells12040647"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"947","DOI":"10.2147\/PPA.S45710","article-title":"Understanding benefits and addressing misperceptions and barriers to intrauterine device access among populations in the United States","volume":"8","author":"Yoost","year":"2014","journal-title":"Patient Prefer. 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