{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:55:30Z","timestamp":1790740530090,"version":"4.1.0"},"reference-count":147,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2022R1C1C1006000"],"award-info":[{"award-number":["NRF-2022R1C1C1006000"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2022R1A5A2021216"],"award-info":[{"award-number":["NRF-2022R1A5A2021216"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Non-alcoholic fatty liver disease (NAFLD) refers to a range of conditions in which excess lipids accumulate in the liver, possibly leading to serious hepatic manifestations such as steatohepatitis, fibrosis\/cirrhosis and cancer. Despite its increasing prevalence and significant impact on liver disease-associated mortality worldwide, no medication has been approved for the treatment of NAFLD yet. Liver X receptors \u03b1\/\u03b2 (LXR\u03b1 and LXR\u03b2) are lipid-activated nuclear receptors that serve as master regulators of lipid homeostasis and play pivotal roles in controlling various metabolic processes, including lipid metabolism, inflammation and immune response. Of note, NAFLD progression is characterized by increased accumulation of triglycerides and cholesterol, hepatic de novo lipogenesis, mitochondrial dysfunction and augmented inflammation, all of which are highly attributed to dysregulated LXR signaling. Thus, targeting LXRs may provide promising strategies for the treatment of NAFLD. However, emerging evidence has revealed that modulating the activity of LXRs has various metabolic consequences, as the main functions of LXRs can distinctively vary in a cell type-dependent manner. Therefore, understanding how LXRs in the liver integrate various signaling pathways and regulate metabolic homeostasis from a cellular perspective using recent advances in research may provide new insights into therapeutic strategies for NAFLD and associated metabolic diseases.<\/jats:p>","DOI":"10.3390\/cells12091292","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T12:02:31Z","timestamp":1682942551000},"page":"1292","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Targeting Liver X Receptors for the Treatment of Non-Alcoholic Fatty Liver Disease"],"prefix":"10.3390","volume":"12","author":[{"given":"Hyejin","family":"Kim","sequence":"first","affiliation":[{"name":"College of Pharmacy, Sookmyung Women\u2019s University, Seoul 04310, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaewon","family":"Park","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Sookmyung Women\u2019s University, Seoul 04310, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8472-1846","authenticated-orcid":false,"given":"Tae Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Sookmyung Women\u2019s University, Seoul 04310, Republic of Korea"},{"name":"Drug Information Research Institute, Sookmyung Women\u2019s University, Seoul 04310, Republic of Korea"},{"name":"Muscle Physiome Research Center, Sookmyung Women\u2019s University, Seoul 04310, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/cphy.c130024","article-title":"Energy metabolism in the liver","volume":"4","author":"Rui","year":"2014","journal-title":"Compr. Physiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nrd4280","article-title":"Liver X receptors in lipid metabolism: Opportunities for drug discovery","volume":"13","author":"Hong","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jhep.2011.08.025","article-title":"The interaction of hepatic lipid and glucose metabolism in liver diseases","volume":"56","author":"Bechmann","year":"2012","journal-title":"J. Hepatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.cell.2021.04.015","article-title":"Mechanisms and disease consequences of nonalcoholic fatty liver disease","volume":"184","author":"Loomba","year":"2021","journal-title":"Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"100346","DOI":"10.1016\/j.jhepr.2021.100346","article-title":"New targets for NAFLD","volume":"3","author":"Parlati","year":"2021","journal-title":"JHEP Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: Trends, predictions, risk factors and prevention","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1172\/JCI127502","article-title":"Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice","volume":"130","author":"Orime","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jhep.2018.10.033","article-title":"Non-alcoholic fatty liver disease\u2014A global public health perspective","volume":"70","author":"Younossi","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41575-020-00366-5","article-title":"Nonalcoholic steatohepatitis: The role of peroxisome proliferator-activated receptors","volume":"18","author":"Francque","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1136\/gutjnl-2017-313884","article-title":"Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases","volume":"66","author":"Adams","year":"2017","journal-title":"Gut"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1053\/jhep.2003.50161","article-title":"Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome","volume":"37","author":"Marchesini","year":"2003","journal-title":"Hepatology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMra011775","article-title":"Nonalcoholic fatty liver disease","volume":"346","author":"Angulo","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0016-5085(98)70599-2","article-title":"Steatohepatitis: A tale of two \u201chits\u201d?","volume":"114","author":"Day","year":"1998","journal-title":"Gastroenterology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/j.jcmgh.2021.01.012","article-title":"Transcriptional Regulation of Metabolic Pathways via Lipid-Sensing Nuclear Receptors PPARs, FXR, and LXR in NASH","volume":"11","author":"Cariello","year":"2021","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm3312","article-title":"Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR","volume":"13","author":"Calkin","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jhep.2010.04.008","article-title":"A position statement on NAFLD\/NASH based on the EASL 2009 special conference","volume":"53","author":"Ratziu","year":"2010","journal-title":"J. Hepatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1056\/NEJMoa0907929","article-title":"Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis","volume":"362","author":"Sanyal","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S0140-6736(14)61933-4","article-title":"Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): A multicentre, randomised, placebo-controlled trial","volume":"385","author":"Loomba","year":"2015","journal-title":"Lancet"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/liv.13302","article-title":"Therapies in non-alcoholic steatohepatitis (NASH)","volume":"37","author":"Oseini","year":"2017","journal-title":"Liver Int."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.pharmthera.2017.05.011","article-title":"Targeting nuclear receptors for the treatment of fatty liver disease","volume":"179","author":"Tanaka","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1042\/BST0360891","article-title":"Role of nuclear receptors in the modulation of insulin secretion in lipid-induced insulin resistance","volume":"36","author":"Sugden","year":"2008","journal-title":"Biochem. Soc. Trans."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.cell.2014.03.012","article-title":"Nuclear Receptors, RXR, and the Big Bang","volume":"157","author":"Evans","year":"2014","journal-title":"Cell"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1146\/annurev.med.57.121304.131428","article-title":"Nuclear receptors in lipid metabolism: Targeting the heart of dyslipidemia","volume":"57","author":"Beaven","year":"2006","journal-title":"Annu. Rev. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0092-8674(95)90199-X","article-title":"The nuclear receptor superfamily: The second decade","volume":"83","author":"Mangelsdorf","year":"1995","journal-title":"Cell"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1517\/14728222.7.5.679","article-title":"Nuclear receptors as drug targets: New developments in coregulators, orphan receptors and major therapeutic areas","volume":"7","author":"Sladek","year":"2003","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1152\/physrev.2001.81.3.1269","article-title":"Nuclear hormone receptors and gene expression","volume":"81","author":"Aranda","year":"2001","journal-title":"Physiol. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.2174\/092986706778521878","article-title":"Current pharmacological treatment of nonalcoholic fatty liver","volume":"13","author":"Portincasa","year":"2006","journal-title":"Curr. Med. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"6889533","DOI":"10.1155\/2021\/6889533","article-title":"The Role and Mechanism of Oxidative Stress and Nuclear Receptors in the Development of NAFLD","volume":"2021","author":"Hong","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/nrd1551","article-title":"Principles for modulation of the nuclear receptor superfamily","volume":"3","author":"Gronemeyer","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.tips.2012.03.013","article-title":"Liver X receptor biology and pharmacology: New pathways, challenges and opportunities","volume":"33","author":"Jakobsson","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41580-019-0190-7","article-title":"Mechanisms and regulation of cholesterol homeostasis","volume":"21","author":"Luo","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1172\/JCI27883","article-title":"Liver X receptors as integrators of metabolic and inflammatory signaling","volume":"116","author":"Zelcer","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1365-2796.2012.02529.x","article-title":"LXR\u03b2 activation increases intestinal cholesterol absorption, leading to an atherogenic lipoprotein profile","volume":"272","author":"Hu","year":"2012","journal-title":"J. Intern. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1124\/mol.106.022608","article-title":"Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: Implications for therapeutic targeting","volume":"70","author":"Quinet","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1210\/me.2002-0399","article-title":"Liver X receptors interact with corepressors to regulate gene expression","volume":"17","author":"Hu","year":"2003","journal-title":"Mol. Endocrinol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1111\/bph.15286","article-title":"Screening for liver X receptor modulators: Where are we and for what use?","volume":"178","author":"Fouache","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"7202","DOI":"10.1073\/pnas.97.13.7202","article-title":"The histone deacetylase-3 complex contains nuclear receptor corepressors","volume":"97","author":"Wen","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"11172","DOI":"10.1074\/jbc.M116.726729","article-title":"Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages","volume":"291","author":"Shrestha","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1210\/me.2008-0012","article-title":"Activating signal cointegrator-2 is an essential adaptor to recruit histone H3 lysine 4 methyltransferases MLL3 and MLL4 to the liver X receptors","volume":"22","author":"Lee","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1600-065X.2012.01153.x","article-title":"Liver X receptor and peroxisome proliferator-activated receptor as integrators of lipid homeostasis and immunity","volume":"249","author":"Kidani","year":"2012","journal-title":"Immunol. Rev."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.bbrc.2013.11.077","article-title":"Action mechanisms of Liver X Receptors","volume":"446","author":"Gabbi","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_42","first-page":"7025","article-title":"A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid\/thyroid hormone receptor subfamily","volume":"14","author":"Apfel","year":"1994","journal-title":"Mol. Cell Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1073\/pnas.92.6.2096","article-title":"OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor","volume":"92","author":"Teboul","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1038\/s41467-017-01948-9","article-title":"Dendrogenin A drives LXR to\u2026 trigger leth.hal autophagy in cancers","volume":"8","author":"Segala","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"27816","DOI":"10.1074\/jbc.M603781200","article-title":"Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands","volume":"281","author":"Yang","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1194\/jlr.M072447","article-title":"Fatty acid binding profile of the liver X receptor \u03b1","volume":"58","author":"Bedi","year":"2017","journal-title":"J. Lipid Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"39243","DOI":"10.1074\/jbc.M206170200","article-title":"Fatty acid regulation of liver X receptors (LXR) and peroxisome proliferator-activated receptor alpha (PPARalpha) in HEK293 cells","volume":"277","author":"Pawar","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"27138","DOI":"10.1074\/jbc.M302260200","article-title":"X-ray crystal structure of the liver X receptor beta ligand binding domain: Regulation by a histidine-tryptophan switch","volume":"278","author":"Williams","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4625","DOI":"10.1093\/emboj\/cdg456","article-title":"Crystal structure of the heterodimeric complex of LXRalpha and RXRbeta ligand-binding domains in a fully agonistic conformation","volume":"22","author":"Svensson","year":"2003","journal-title":"EMBO J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"38821","DOI":"10.1074\/jbc.M304842200","article-title":"The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands","volume":"278","author":"Bonn","year":"2003","journal-title":"J Biol. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1124\/dmd.32.1.66","article-title":"CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor","volume":"32","author":"Shenoy","year":"2004","journal-title":"Drug Metab. Dispos."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"7604","DOI":"10.1073\/pnas.112059299","article-title":"Synthetic LXR ligand inhibits the development of atherosclerosis in mice","volume":"99","author":"Joseph","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"166121","DOI":"10.1016\/j.bbadis.2021.166121","article-title":"Liver X receptors and liver physiology","volume":"1867","author":"Schulman","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5419","DOI":"10.1073\/pnas.0830671100","article-title":"Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue","volume":"100","author":"Laffitte","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3412","DOI":"10.1021\/jm901797p","article-title":"Discovery of tertiary sulfonamides as potent liver X receptor antagonists","volume":"53","author":"Zuercher","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Wang, Y., Li, X., and Ren, S. (2020). Cholesterol Metabolites 25-Hydroxycholesterol and 25-Hydroxycholesterol 3-Sulfate Are Potent Paired Regulators: From Discovery to Clinical Usage. Metabolites, 11.","DOI":"10.3390\/metabo11010009"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.metabol.2011.11.014","article-title":"Oxysterol sulfation by cytosolic sulfotransferase suppresses liver X receptor\/sterol regulatory element binding protein-1c signaling pathway and reduces serum and hepatic lipids in mouse models of nonalcoholic fatty liver disease","volume":"61","author":"Bai","year":"2012","journal-title":"Metabolism"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1152\/ajpendo.90555.2008","article-title":"25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR\/SREBP-1 signaling pathway","volume":"295","author":"Ma","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1136\/gutjnl-2016-312431","article-title":"Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease","volume":"66","author":"Rotman","year":"2017","journal-title":"Gut"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s11745-010-3451-y","article-title":"Regulation of hepatocyte lipid metabolism and inflammatory response by 25-hydroxycholesterol and 25-hydroxycholesterol-3-sulfate","volume":"45","author":"Xu","year":"2010","journal-title":"Lipids"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1210\/en.2016-1577","article-title":"Posttranslational Modifications of Lipid-Activated Nuclear Receptors: Focus on Metabolism","volume":"158","author":"Becares","year":"2017","journal-title":"Endocrinology"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.molcel.2007.07.032","article-title":"SIRT1 deacetylates and positively regulates the nuclear receptor LXR","volume":"28","author":"Li","year":"2007","journal-title":"Mol. Cell"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Defour, A., Dessalle, K., Castro Perez, A., Poyot, T., Castells, J., Gallot, Y.S., Durand, C., Euthine, V., Gu, Y., and B\u00e9chet, D. (2012). Sirtuin 1 regulates SREBP-1c expression in a LXR-dependent manner in skeletal muscle. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0043490"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1002\/hep.22887","article-title":"Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones","volume":"49","author":"Hwahng","year":"2009","journal-title":"Hepatology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"8145","DOI":"10.1038\/srep08145","article-title":"Antihyperglycemic mechanism of metformin occurs via the AMPK\/LXR\u03b1\/POMC pathway","volume":"5","author":"Cho","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nature05449","article-title":"The nuclear receptor LXR is a glucose sensor","volume":"445","author":"Mitro","year":"2007","journal-title":"Nature"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1074\/jbc.M109.082685","article-title":"Nuclear receptor liver X receptor is O-GlcNAc-modified in response to glucose","volume":"285","author":"Anthonisen","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1146\/annurev-biochem-060608-102511","article-title":"Cross talk between O-GlcNAcylation and phosphorylation: Roles in signaling, transcription, and chronic disease","volume":"80","author":"Hart","year":"2011","journal-title":"Annu. Rev. Biochem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.molcel.2006.11.022","article-title":"Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma","volume":"25","author":"Ghisletti","year":"2007","journal-title":"Mol. Cell"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1007\/s00125-013-2913-1","article-title":"Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding","volume":"56","author":"Turner","year":"2013","journal-title":"Diabetologia"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.cmet.2015.09.023","article-title":"Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism","volume":"22","author":"Meex","year":"2015","journal-title":"Cell Metab."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1007\/s10620-014-3289-x","article-title":"Expression of liver X receptor correlates with intrahepatic inflammation and fibrosis in patients with nonalcoholic fatty liver disease","volume":"59","author":"Ahn","year":"2014","journal-title":"Dig. Dis. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.cell.2012.02.017","article-title":"Mechanisms for insulin resistance: Common threads and missing links","volume":"148","author":"Samuel","year":"2012","journal-title":"Cell"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1053\/j.gastro.2007.11.037","article-title":"Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis","volume":"134","author":"Zhou","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"11019","DOI":"10.1074\/jbc.M111041200","article-title":"Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors","volume":"277","author":"Joseph","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1101\/gad.850400","article-title":"Role of LXRs in control of lipogenesis","volume":"14","author":"Schultz","year":"2000","journal-title":"Genes Dev."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1101\/gad.844900","article-title":"Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta","volume":"14","author":"Repa","year":"2000","journal-title":"Genes Dev."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/s41574-018-0037-x","article-title":"Liver X receptors in lipid signalling and membrane homeostasis","volume":"14","author":"Wang","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0092-8674(00)81432-4","article-title":"Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha","volume":"93","author":"Peet","year":"1998","journal-title":"Cell"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1007\/s10620-016-4054-0","article-title":"Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease","volume":"61","author":"Softic","year":"2016","journal-title":"Dig. Dis. Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1053\/j.gastro.2013.11.049","article-title":"Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease","volume":"146","author":"Lambert","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1124\/jpet.103.064535","article-title":"Coadministration of a liver X receptor agonist and a peroxisome proliferator activator receptor-alpha agonist in Mice: Effects of nuclear receptor interplay on high-density lipoprotein and triglyceride metabolism in vivo","volume":"309","author":"Beyer","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.cmet.2005.03.001","article-title":"LXRs regulate the balance between fat storage and oxidation","volume":"1","author":"Kalaany","year":"2005","journal-title":"Cell Metab."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1073\/pnas.1017884108","article-title":"Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity","volume":"108","author":"Archer","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1002\/hep.31423","article-title":"Liver X Receptor Alpha Activation Inhibits Autophagy and Lipophagy in Hepatocytes by Dysregulating Autophagy-Related 4B Cysteine Peptidase and Rab-8B, Reducing Mitochondrial Fuel Oxidation","volume":"73","author":"Kim","year":"2021","journal-title":"Hepatology"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"4104","DOI":"10.1210\/en.2009-0676","article-title":"Activation of liver X receptor regulates substrate oxidation in white adipocytes","volume":"150","author":"Stenson","year":"2009","journal-title":"Endocrinology"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/383728a0","article-title":"An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha","volume":"383","author":"Janowski","year":"1996","journal-title":"Nature"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1074\/jbc.272.6.3137","article-title":"Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway","volume":"272","author":"Lehmann","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1172\/JCI9794","article-title":"Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice","volume":"107","author":"Alberti","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"15565","DOI":"10.1074\/jbc.M301311200","article-title":"Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8","volume":"278","author":"Yu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"43018","DOI":"10.1074\/jbc.M107823200","article-title":"Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta","volume":"276","author":"Zhang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1161\/ATVBAHA.109.195693","article-title":"Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo","volume":"30","author":"Yasuda","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"18793","DOI":"10.1074\/jbc.M109927200","article-title":"Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta","volume":"277","author":"Repa","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1172\/JCI24594","article-title":"Liver X receptors alpha and beta regulate renin expression in vivo","volume":"115","author":"Morello","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"8513","DOI":"10.1073\/pnas.100519097","article-title":"LXRalpha functions as a cAMP-responsive transcriptional regulator of gene expression","volume":"97","author":"Tamura","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1194\/jlr.M500080-JLR200","article-title":"The human ABCG1 gene: Identification of LXR response elements that modulate expression in macrophages and liver","volume":"46","author":"Sabol","year":"2005","journal-title":"J. Lipid Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"14700","DOI":"10.1074\/jbc.275.19.14700","article-title":"Human white\/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols","volume":"275","author":"Venkateswaran","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1194\/jlr.M010686","article-title":"Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: Identification of ARL7 as a direct target","volume":"52","author":"Hong","year":"2011","journal-title":"J. Lipid Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1128\/MCB.23.6.2182-2191.2003","article-title":"The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions","volume":"23","author":"Laffitte","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1172\/JCI8573","article-title":"Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element","volume":"105","author":"Luo","year":"2000","journal-title":"J. Clin. Investig."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1128\/MCB.01716-12","article-title":"IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor","volume":"33","author":"Scotti","year":"2013","journal-title":"Mol. Cell Biol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"19720","DOI":"10.1074\/jbc.M110.123729","article-title":"The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2","volume":"285","author":"Hong","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1126\/science.1168974","article-title":"LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor","volume":"325","author":"Zelcer","year":"2009","journal-title":"Science"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.cmet.2016.07.016","article-title":"Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils","volume":"24","author":"Kirchgessner","year":"2016","journal-title":"Cell Metab."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.cmet.2014.10.001","article-title":"The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice","volume":"20","author":"Hong","year":"2014","journal-title":"Cell Metab."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1042\/BJ20060914","article-title":"SREBP-2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR","volume":"400","author":"Wong","year":"2006","journal-title":"Biochem. J."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nature17674","article-title":"Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis","volume":"534","author":"Sallam","year":"2016","journal-title":"Nature"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"e28766","DOI":"10.7554\/eLife.28766","article-title":"Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP","volume":"6","author":"Zhang","year":"2017","journal-title":"eLife"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nm820","article-title":"Reciprocal regulation of inflammation and lipid metabolism by liver X receptors","volume":"9","author":"Joseph","year":"2003","journal-title":"Nat. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1161\/01.RES.0000163630.86796.17","article-title":"Liver x receptor agonists inhibit cytokine-induced osteopontin expression in macrophages through interference with activator protein-1 signaling pathways","volume":"96","author":"Ogawa","year":"2005","journal-title":"Circ. Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1111\/j.1742-4658.2005.04599.x","article-title":"Liver X receptor agonists inhibit tissue factor expression in macrophages","volume":"272","author":"Terasaka","year":"2005","journal-title":"FEBS J."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1161\/01.RES.0000252878.34269.06","article-title":"A nuclear receptor corepressor-dependent pathway mediates suppression of cytokine-induced C-reactive protein gene expression by liver X receptor","volume":"99","author":"Blaschke","year":"2006","journal-title":"Circ. Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1101\/gad.545110","article-title":"GPS2-dependent corepressor\/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response","volume":"24","author":"Venteclef","year":"2010","journal-title":"Genes Dev."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ajpath.2011.03.019","article-title":"Suppression of chronic damage in renal allografts by Liver X receptor (LXR) activation relevant contribution of macrophage LXR\u03b1","volume":"179","author":"Kiss","year":"2011","journal-title":"Am. J. Pathol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S1097-2765(03)00384-8","article-title":"Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism","volume":"12","author":"Castrillo","year":"2003","journal-title":"Mol. Cell"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1016\/j.celrep.2018.11.100","article-title":"LXR Suppresses Inflammatory Gene Expression and Neutrophil Migration through cis-Repression and Cholesterol Efflux","volume":"25","author":"Thomas","year":"2018","journal-title":"Cell Rep."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"e08009","DOI":"10.7554\/eLife.08009","article-title":"LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling","volume":"4","author":"Ito","year":"2015","journal-title":"eLife"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"17813","DOI":"10.1073\/pnas.0407749101","article-title":"Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis","volume":"101","author":"Valledor","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cell.2004.09.032","article-title":"LXR-dependent gene expression is important for macrophage survival and the innate immune response","volume":"119","author":"Joseph","year":"2004","journal-title":"Cell"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1172\/JCI35288","article-title":"Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice","volume":"119","author":"Korf","year":"2009","journal-title":"J. Clin. Investig."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.4049\/jimmunol.180.5.3305","article-title":"Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense","volume":"180","author":"Smoak","year":"2008","journal-title":"J. Immunol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"31882","DOI":"10.1074\/jbc.M703278200","article-title":"Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses","volume":"282","author":"Birrell","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/SHK.0b013e3181a47f85","article-title":"Liver X receptor agonist GW3965 dose-dependently regulates lps-mediated liver injury and modulates posttranscriptional TNF-alpha production and p38 mitogen-activated protein kinase activation in liver macrophages","volume":"32","author":"Wang","year":"2009","journal-title":"Shock"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1016\/j.freeradbiomed.2010.09.001","article-title":"Inhibition of liver X receptor-\u03b1-dependent hepatic steatosis by isoliquiritigenin, a licorice antioxidant flavonoid, as mediated by JNK1 inhibition","volume":"49","author":"Kim","year":"2010","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1073\/pnas.0630588100","article-title":"Triglyceride accumulation protects against fatty acid-induced lipotoxicity","volume":"100","author":"Listenberger","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1053\/j.gastro.2011.09.049","article-title":"A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells","volume":"142","author":"Teratani","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/hep.26604","article-title":"Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice","volume":"59","author":"Tomita","year":"2014","journal-title":"Hepatology"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1053\/j.gastro.2010.11.053","article-title":"Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease","volume":"140","author":"Beaven","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.cmet.2020.03.010","article-title":"Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis","volume":"31","author":"Wang","year":"2020","journal-title":"Cell Metab."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.celrep.2018.12.094","article-title":"Impaired LXR\u03b1 Phosphorylation Attenuates Progression of Fatty Liver Disease","volume":"26","author":"Becares","year":"2019","journal-title":"Cell Rep."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1194\/jlr.M093229","article-title":"Elevated oxysterol levels in human and mouse livers reflect nonalcoholic steatohepatitis","volume":"60","author":"Raselli","year":"2019","journal-title":"J. Lipid Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1007\/s00535-012-0585-0","article-title":"Increased serum liver X receptor ligand oxysterols in patients with non-alcoholic fatty liver disease","volume":"47","author":"Ikegami","year":"2012","journal-title":"J. Gastroenterol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"100051","DOI":"10.1016\/j.jlr.2021.100051","article-title":"4\u03b2-Hydroxycholesterol is a prolipogenic factor that promotes SREBP1c expression and activity through the liver X receptor","volume":"62","author":"Moldavski","year":"2021","journal-title":"J. Lipid Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/oby.22130","article-title":"27-Hydroxycholesterol Inhibits Sterol Regulatory Element-Binding Protein 1 Activation and Hepatic Lipid Accumulation in Mice","volume":"26","author":"Li","year":"2018","journal-title":"Obesity"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"52772","DOI":"10.1074\/jbc.M410302200","article-title":"Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs","volume":"279","author":"Adams","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"101102","DOI":"10.1016\/j.isci.2020.101102","article-title":"High Glucose Induces Lipid Accumulation via 25-Hydroxycholesterol DNA-CpG Methylation","volume":"23","author":"Wang","year":"2020","journal-title":"iScience"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1172\/JCI59817","article-title":"Liver LXR\u03b1 expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice","volume":"122","author":"Zhang","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1021\/jm100034x","article-title":"Identification of phenylsulfone-substituted quinoxaline (WYE-672) as a tissue selective liver X-receptor (LXR) agonist","volume":"53","author":"Hu","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1016\/j.bmcl.2009.01.109","article-title":"Discovery of tetrahydro-cyclopenta[b]indole as selective LXRs modulator","volume":"19","author":"Ratni","year":"2009","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1124\/jpet.108.142687","article-title":"Antiatherosclerotic effects of a novel synthetic tissue-selective steroidal liver X receptor agonist in low-density lipoprotein receptor-deficient mice","volume":"327","author":"Peng","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.1021\/jm500442z","article-title":"The medicinal chemistry of liver X receptor (LXR) modulators","volume":"57","author":"Tice","year":"2014","journal-title":"J. Med. Chem."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"E4680","DOI":"10.1073\/pnas.1714518115","article-title":"Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages","volume":"115","author":"Muse","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1177\/0091270009335768","article-title":"Safety, pharmacokinetics, and pharmacodynamics of single doses of LXR-623, a novel liver X-receptor agonist, in healthy participants","volume":"49","author":"Katz","year":"2009","journal-title":"J. Clin. Pharmacol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1194\/jlr.M900037-JLR200","article-title":"LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse","volume":"50","author":"Quinet","year":"2009","journal-title":"J. Lipid Res."},{"key":"ref_145","unstructured":"(2023, March 30). Placebo-Controlled, Ascending, Multiple-Dose Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of BMS-779788 in Healthy Subjects, Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00836602."},{"key":"ref_146","unstructured":"(2023, March 30). A Randomized, Placebo-Controlled, Multiple Ascending Dose Study To Assess The Safety, Pharmacokinetics and Pharmacodynamics Of CS-8080 In Healthy Volunteers, Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00796575."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2017.07.010","article-title":"The Challenges and Promise of Targeting the Liver X Receptors for Treatment of Inflammatory Disease","volume":"181","author":"Fessler","year":"2018","journal-title":"Pharmacol. Ther."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/9\/1292\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:27:46Z","timestamp":1760124466000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/9\/1292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,1]]},"references-count":147,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["cells12091292"],"URL":"https:\/\/doi.org\/10.3390\/cells12091292","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,1]]}}}