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Because OCPs are known to increase the risk of Parkinson\u2019s disease (PD), we tested whether chronic low-level intoxication with CLD could reproduce certain key characteristics of Parkinsonism-like neurodegeneration. For that, we used culture systems of mouse midbrain dopamine (DA) neurons and glial cells, together with the nematode C. elegans as an in vivo model organism. We established that CLD kills cultured DA neurons in a concentration- and time-dependent manner while exerting no direct proinflammatory effects on glial cells. DA cell loss was not impacted by the degree of maturation of the culture. The use of fluorogenic probes revealed that CLD neurotoxicity was the consequence of oxidative stress-mediated insults and mitochondrial disturbances. In C. elegans worms, CLD exposure caused a progressive loss of DA neurons associated with locomotor deficits secondary to alterations in food perception. L-DOPA, a molecule used for PD treatment, corrected these deficits. Cholinergic and serotoninergic neuronal cells were also affected by CLD in C. elegans, although to a lesser extent than DA neurons. Noticeably, CLD also promoted the phosphorylation of the aggregation-prone protein tau (but not of \u03b1-synuclein) both in midbrain cell cultures and in a transgenic C. elegans strain expressing a human form of tau in neurons. In summary, our data suggest that CLD is more likely to promote atypical forms of Parkinsonism characterized by tau pathology than classical synucleinopathy-associated PD.<\/jats:p>","DOI":"10.3390\/cells12091336","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T01:32:53Z","timestamp":1683509573000},"page":"1336","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The Pesticide Chlordecone Promotes Parkinsonism-like Neurodegeneration with Tau Lesions in Midbrain Cultures and C. elegans Worms"],"prefix":"10.3390","volume":"12","author":[{"given":"Valeria","family":"Parrales-Macias","sequence":"first","affiliation":[{"name":"Paris Brain Institute\u2014ICM, Inserm, CNRS, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5607-3119","authenticated-orcid":false,"given":"Patrick P.","family":"Michel","sequence":"additional","affiliation":[{"name":"Paris Brain Institute\u2014ICM, Inserm, CNRS, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurore","family":"Tourville","sequence":"additional","affiliation":[{"name":"Paris Brain Institute\u2014ICM, Inserm, CNRS, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Raisman-Vozari","sequence":"additional","affiliation":[{"name":"Paris Brain Institute\u2014ICM, Inserm, CNRS, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Ha\u00efk","sequence":"additional","affiliation":[{"name":"Paris Brain Institute\u2014ICM, Inserm, CNRS, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Hunot","sequence":"additional","affiliation":[{"name":"Paris Brain Institute\u2014ICM, Inserm, CNRS, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9643-4417","authenticated-orcid":false,"given":"Nicolas","family":"Bizat","sequence":"additional","affiliation":[{"name":"Paris Brain Institute\u2014ICM, Inserm, CNRS, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, 75013 Paris, France"},{"name":"Facult\u00e9 de Pharmacie de Paris, Universit\u00e9 de Paris Cit\u00e9, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4084-8674","authenticated-orcid":false,"given":"Annie","family":"Lannuzel","sequence":"additional","affiliation":[{"name":"Paris Brain Institute\u2014ICM, Inserm, CNRS, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, 75013 Paris, France"},{"name":"Centre Hospitalier Universitaire de la Guadeloupe, Service de Neurologie, Facult\u00e9 de M\u00e9decine de l\u2019Universit\u00e9 des Antilles, Centre d\u2019Investigation Clinique (CIC) 1424, 97159 Pointe-\u00e0-Pitre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11356-015-4621-5","article-title":"Chlordecone Exposure and Adverse Effects in French West Indies Populations","volume":"23","author":"Multigner","year":"2016","journal-title":"Environ. 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Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1093\/brain\/awl347","article-title":"Atypical Parkinsonism in Guadeloupe: A Common Risk Factor for Two Closely Related Phenotypes?","volume":"130","author":"Lannuzel","year":"2007","journal-title":"Brain"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1002\/mds.29222","article-title":"Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism","volume":"37","author":"Roze","year":"2022","journal-title":"Mov. Disord."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1093\/brain\/awf086","article-title":"Guadeloupean Parkinsonism: A Cluster of Progressive Supranuclear Palsy-like Tauopathy","volume":"125","author":"Sergeant","year":"2002","journal-title":"Brain"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0306-4522(03)00441-X","article-title":"The Mitochondrial Complex I Inhibitor Annonacin Is Toxic to Mesencephalic Dopaminergic Neurons by Impairment of Energy Metabolism","volume":"121","author":"Lannuzel","year":"2003","journal-title":"Neuroscience"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1002\/mds.22300","article-title":"Atypical Parkinsonism in the Caribbean Island of Guadeloupe: Etiological Role of the Mitochondrial Complex I Inhibitor Annonacin","volume":"23","author":"Lannuzel","year":"2008","journal-title":"Mov. Disord."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"German Federal Institute for Risk Assessment (BfR), Department of Food Safety, Berlin, Germany, Raclariu-Manolica, A.C., Bakhiya, N., and Hirsch-Ernst, K.I. (2020). Risk Assessment Regarding the Use of Annona Muricata in Food Supplements. EFSA J., 18, e181112.","DOI":"10.2903\/j.efsa.2020.e181112"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/s41586-021-04059-0","article-title":"Disruption of Mitochondrial Complex I Induces Progressive Parkinsonism","volume":"599","author":"Zampese","year":"2021","journal-title":"Nature"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1124\/mol.113.087965","article-title":"The Iron-Binding Protein Lactoferrin Protects Vulnerable Dopamine Neurons from Degeneration by Preserving Mitochondrial Calcium Homeostasis","volume":"84","author":"Rousseau","year":"2013","journal-title":"Mol. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Tourville, A., Akbar, D., Corti, O., Prehn, J.H.M., Melki, R., Hunot, S., and Michel, P.P. (2022). Modelling \u03b1-Synuclein Aggregation and Neurodegeneration with Fibril Seeds in Primary Cultures of Mouse Dopaminergic Neurons. Cells, 11.","DOI":"10.3390\/cells11101640"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.4161\/auto.36436","article-title":"Autophagy Modulates SNCA\/\u03b1-Synuclein Release, Thereby Generating a Hostile Microenvironment","volume":"10","author":"Poehler","year":"2014","journal-title":"Autophagy"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1093\/brain\/awab152","article-title":"An in Vivo Caenorhabditis elegans Model for Therapeutic Research in Human Prion Diseases","volume":"144","author":"Bizat","year":"2021","journal-title":"Brain"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5394","DOI":"10.1523\/JNEUROSCI.5831-09.2010","article-title":"Neuron Dysfunction Is Induced by Prion Protein with an Insertional Mutation via a Fyn Kinase and Reversed by Sirtuin Activation in Caenorhabditis Elegans","volume":"30","author":"Bizat","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"105256","DOI":"10.1016\/j.nbd.2021.105256","article-title":"Doxycycline Inhibits \u03b1-Synuclein-Associated Pathologies in Vitro and in Vivo","volume":"151","author":"Parrales","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s13311-012-0109-x","article-title":"A Predictable Worm: Application of Caenorhabditis Elegans for Mechanistic Investigation of Movement Disorders","volume":"9","author":"Dexter","year":"2012","journal-title":"Neurotherapeutics"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Gaeta, A.L., Caldwell, K.A., and Caldwell, G.A. (2019). Found in Translation: The Utility of C. Elegans Alpha-Synuclein Models of Parkinson\u2019s Disease. Brain Sci., 9.","DOI":"10.3390\/brainsci9040073"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/jnc.13532","article-title":"Cellular and Molecular Modifier Pathways in Tauopathies: The Big Picture from Screening Invertebrate Models","volume":"137","author":"Hannan","year":"2016","journal-title":"J. Neurochem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1002\/glia.23032","article-title":"A Simplified Approach for Efficient Isolation of Functional Microglial Cells: Application for Modeling Neuroinflammatory Responses in Vitro","volume":"64","author":"Ouidja","year":"2016","journal-title":"Glia"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1124\/mol.106.022715","article-title":"The Phenotypic Differentiation of Locus Ceruleus Noradrenergic Neurons Mediated by Brain-Derived Neurotrophic Factor Is Enhanced by Corticotropin Releasing Factor through the Activation of a CAMP-Dependent Signaling Pathway","volume":"70","author":"Traver","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Ferreira, E., Almeida, Z.L., Cruz, P.F., Silva E Sousa, M., Ver\u00edssimo, P., and Brito, R.M.M. (2021). Searching for the Best Transthyretin Aggregation Protocol to Study Amyloid Fibril Disruption. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010391"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1002\/glia.23472","article-title":"Microglial Glutamate Release Evoked by \u03b1-Synuclein Aggregates Is Prevented by Dopamine","volume":"66","author":"Hamadat","year":"2018","journal-title":"Glia"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.15252\/embj.201592524","article-title":"Dopamine Signaling Promotes the Xenobiotic Stress Response and Protein Homeostasis","volume":"35","author":"Joshi","year":"2016","journal-title":"EMBO J."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Tourville, A., Viguier, S., Gonz\u00e1lez-Liz\u00e1rraga, F., Tomas-Grau, R.H., Ramirez, P., Brunel, J.-M., Dos Santos Pereira, M., Del-Bel, E., Chehin, R., and Ferri\u00e9, L. (2023). Rescue of Dopamine Neurons from Iron-Dependent Ferroptosis by Doxycycline and Demeclocycline and Their Non-Antibiotic Derivatives. Antioxidants, 12.","DOI":"10.3390\/antiox12030575"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: An Open-Source Platform for Biological-Image Analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"5819","DOI":"10.1242\/dev.126.24.5819","article-title":"Patterning of Dopaminergic Neurotransmitter Identity among Caenorhabditis Elegans Ray Sensory Neurons by a TGFbeta Family Signaling Pathway and a Hox Gene","volume":"126","author":"Lints","year":"1999","journal-title":"Development"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1073\/pnas.042497999","article-title":"Neurotoxin-Induced Degeneration of Dopamine Neurons in Caenorhabditis Elegans","volume":"99","author":"Nass","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"9980","DOI":"10.1073\/pnas.1533448100","article-title":"Neurodegeneration and Defective Neurotransmission in a Caenorhabditis Elegans Model of Tauopathy","volume":"100","author":"Kraemer","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The Genetics of Caenorhabditis Elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Stiernagle, T. (2006). Maintenance of C. Elegans, WormBook.","DOI":"10.1895\/wormbook.1.101.1"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1128\/IAI.70.8.4705-4707.2002","article-title":"Diverse Bacteria Are Pathogens of Caenorhabditis Elegans","volume":"70","author":"Couillault","year":"2002","journal-title":"Infect. Immun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1002\/j.1460-2075.1984.tb01957.x","article-title":"Localization of the Ribosomal Genes in Caenorhabditis Elegans Chromosomes by in Situ Hybridization Using Biotin-Labeled Probes","volume":"3","author":"Albertson","year":"1984","journal-title":"EMBO J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0896-6273(00)81199-X","article-title":"Elegans Locomotory Rate Is Modulated by the Environment through a Dopaminergic Pathway and by Experience through a Serotonergic Pathway","volume":"26","author":"Sawin","year":"2000","journal-title":"Neuron"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/jnc.14041","article-title":"The Noble Gas Xenon Provides Protection and Trophic Stimulation to Midbrain Dopamine Neurons","volume":"142","author":"Lavaur","year":"2017","journal-title":"J. Neurochem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1111\/j.1471-4159.1990.tb01935.x","article-title":"Toxicity of 1-Methyl-4-Phenylpyridinium for Rat Dopaminergic Neurons in Culture: Selectivity and Irreversibility","volume":"54","author":"Michel","year":"1990","journal-title":"J. Neurochem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1113\/jphysiol.2012.228387","article-title":"Quantitative Measurement of Mitochondrial Membrane Potential in Cultured Cells: Calcium-Induced de- and Hyperpolarization of Neuronal Mitochondria","volume":"590","author":"Gerencser","year":"2012","journal-title":"J. Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1046\/j.1471-4159.2000.0751234.x","article-title":"In Alzheimer\u2019s Disease, Heme Oxygenase Is Coincident with Alz50, an Epitope of Tau Induced by 4-Hydroxy-2-Nonenal Modification","volume":"75","author":"Takeda","year":"2000","journal-title":"J. Neurochem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1021\/acschemneuro.2c00356","article-title":"Effects of a New Natural Catechol-O-Methyl Transferase Inhibitor on Two In Vivo Models of Parkinson\u2019s Disease","volume":"13","author":"Harfouche","year":"2022","journal-title":"ACS Chem. Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S0896-6273(02)01093-0","article-title":"Regulation of Body Size and Behavioral State of C. Elegans by Sensory Perception and the EGL-4 CGMP-Dependent Protein Kinase","volume":"36","author":"Fujiwara","year":"2002","journal-title":"Neuron"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Rivard, L., Srinivasan, J., Stone, A., Ochoa, S., Sternberg, P.W., and Loer, C.M. (2010). A Comparison of Experience-Dependent Locomotory Behaviors and Biogenic Amine Neurons in Nematode Relatives of Caenorhabditis Elegans. BMC Neurosci., 11.","DOI":"10.1186\/1471-2202-11-22"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1042\/bj2730127","article-title":"Tau in Alzheimer Neurofibrillary Tangles. N- and C-Terminal Regions Are Differentially Associated with Paired Helical Filaments and the Location of a Putative Abnormal Phosphorylation Site","volume":"273","author":"Brion","year":"1991","journal-title":"Biochem. J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF00227819","article-title":"Monoclonal Antibodies with Selective Specificity for Alzheimer Tau Are Directed against Phosphatase-Sensitive Epitopes","volume":"84","author":"Mercken","year":"1992","journal-title":"Acta Neuropathol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1002\/cbic.201300399","article-title":"Small-Molecule Mechanism of Action Studies in Caenorhabditis Elegans","volume":"14","author":"Zlotkowski","year":"2013","journal-title":"Chembiochem"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1242\/dev.00571","article-title":"Elegans ZAG-1, a Zn-Finger-Homeodomain Protein, Regulates Axonal Development and Neuronal Differentiation","volume":"130","author":"Clark","year":"2003","journal-title":"Development"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/j.1600-0773.1990.tb00861.x","article-title":"Chlordecone inhibits three types of ion channels in a neural cell line","volume":"67","author":"Inoue","year":"1990","journal-title":"Pharmacol. Toxicol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"103","DOI":"10.14802\/jmd.20173","article-title":"Environmental Risk Factors for Progressive Supranuclear Palsy","volume":"14","author":"Park","year":"2021","journal-title":"J. Mov. Disord."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"103698","DOI":"10.1016\/j.etap.2021.103698","article-title":"Characterization and Quantification of Chlordecone Elimination in Ewes","volume":"87","author":"Fourcot","year":"2021","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s00204-022-03231-3","article-title":"Chlordecone: Development of a Physiologically Based Pharmacokinetic Tool to Support Human Health Risks Assessments","volume":"96","author":"Emond","year":"2022","journal-title":"Arch. Toxicol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Omura, D.T., Clark, D.A., Samuel, A.D.T., and Horvitz, H.R. (2012). Dopamine Signaling Is Essential for Precise Rates of Locomotion by C. Elegans. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0038649"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/jat.3426","article-title":"Glucose-Rich Diet Aggravates Monocrotophos-Induced Dopaminergic Neuronal Dysfunction in Caenorhabditis Elegans","volume":"37","author":"Salim","year":"2017","journal-title":"J. Appl. Toxicol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neurobiolaging.2016.11.015","article-title":"Effects of Decreased Dopamine Transporter Levels on Nigrostriatal Neurons and Paraquat\/Maneb Toxicity in Mice","volume":"51","author":"Richter","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1534\/g3.114.010819","article-title":"Dopamine Signaling in C. elegans Is Mediated in Part by HLH-17-Dependent Regulation of Extracellular Dopamine Levels","volume":"4","author":"Felton","year":"2014","journal-title":"G3 (Bethesda)"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3389\/fimmu.2018.00697","article-title":"Brain-Resident Microglia and Blood-Borne Macrophages Orchestrate Central Nervous System Inflammation in Neurodegenerative Disorders and Brain Cancer","volume":"9","author":"Sevenich","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00401-009-0619-8","article-title":"Astrocytes: Biology and Pathology","volume":"119","author":"Sofroniew","year":"2010","journal-title":"Acta Neuropathol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"E7803","DOI":"10.1073\/pnas.1710549114","article-title":"Differential HspBP1 Expression Accounts for the Greater Vulnerability of Neurons than Astrocytes to Misfolded Proteins","volume":"114","author":"Zhao","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2174\/1566524043479185","article-title":"Astrocyte Influences on Ischemic Neuronal Death","volume":"4","author":"Swanson","year":"2004","journal-title":"Curr. Mol. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.2353\/ajpath.2008.080528","article-title":"Chronic Neuron-Specific Tumor Necrosis Factor-Alpha Expression Enhances the Local Inflammatory Environment Ultimately Leading to Neuronal Death in 3xTg-AD Mice","volume":"173","author":"Janelsins","year":"2008","journal-title":"Am. J. Pathol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Acu\u00f1a, L., Hamadat, S., Corbal\u00e1n, N.S., Gonz\u00e1lez-Liz\u00e1rraga, F., Dos-Santos-Pereira, M., Rocca, J., D\u00edaz, J.S., Del-Bel, E., Papy-Garc\u00eda, D., and Cheh\u00edn, R.N. (2019). Rifampicin and Its Derivative Rifampicin Quinone Reduce Microglial Inflammatory Responses and Neurodegeneration Induced In Vitro by \u03b1-Synuclein Fibrillary Aggregates. Cells, 8.","DOI":"10.3390\/cells8080776"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3389\/fcell.2020.00401","article-title":"Selective Targeting of TNF Receptors as a Novel Therapeutic Approach","volume":"8","author":"Fischer","year":"2020","journal-title":"Front. Cell. Dev. Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e14354","DOI":"10.1111\/nmo.14354","article-title":"Comparison of Commercially Available Antibodies for the Detection of Phosphorylated Alpha-Synuclein in Primary Culture of ENS","volume":"34","author":"Oullier","year":"2022","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00401-009-0486-3","article-title":"Mechanisms of Tau-Induced Neurodegeneration","volume":"118","author":"Iqbal","year":"2009","journal-title":"Acta Neuropathol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13024-018-0237-9","article-title":"Pathological Phosphorylation of Tau and TDP-43 by TTBK1 and TTBK2 Drives Neurodegeneration","volume":"13","author":"Taylor","year":"2018","journal-title":"Mol. Neurodegener."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"104947","DOI":"10.1016\/j.nbd.2020.104947","article-title":"Developmental Exposure to the Organochlorine Pesticide Dieldrin Causes Male-Specific Exacerbation of \u03b1-Synuclein-Preformed Fibril-Induced Toxicity and Motor Deficits","volume":"141","author":"Gezer","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1073\/pnas.1414055112","article-title":"SK3 Channel and Mitochondrial ROS Mediate NADPH Oxidase-Independent NETosis Induced by Calcium Influx","volume":"112","author":"Douda","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-1-4939-9027-6_5","article-title":"Measurement of Mitochondrial Membrane Potential with the Fluorescent Dye Tetramethylrhodamine Methyl Ester (TMRM)","volume":"1928","author":"Creed","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1093\/humrep\/17.3.704","article-title":"The Effects of Cryopreservation on Sperm Morphology, Motility and Mitochondrial Function","volume":"17","author":"McClure","year":"2002","journal-title":"Hum. Reprod."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1023\/A:1020727218493","article-title":"Iron-Induced Oxidative Stress Modify Tau Phosphorylation Patterns in Hippocampal Cell Cultures","volume":"16","author":"Zambrano","year":"2003","journal-title":"Biometals"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1093\/hmg\/ddab363","article-title":"Mitochondrial Oxidative Stress Contributes to the Pathological Aggregation and Accumulation of Tau Oligomers in Alzheimer\u2019s Disease","volume":"31","author":"Du","year":"2022","journal-title":"Hum. Mol. Genet."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1172\/JCI127330","article-title":"Oxidative Stress in Vagal Neurons Promotes Parkinsonian Pathology and Intercellular \u03b1-Synuclein Transfer","volume":"129","author":"Musgrove","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.exer.2008.05.018","article-title":"Mitochondrial Function and Redox Control in the Aging Eye: Role of MsrA and Other Repair Systems in Cataract and Macular Degenerations","volume":"88","author":"Brennan","year":"2009","journal-title":"Exp. Eye Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/oxfordjournals.aje.a112572","article-title":"Epidemic kepone poisoning in chemical workers","volume":"107","author":"Cannon","year":"1978","journal-title":"Am. J. Epidemiol."},{"key":"ref_84","first-page":"373","article-title":"Correlation between neurotoxicity and chlordecone (Kepone) levels in brain and plasma in the mouse","volume":"2","author":"Wang","year":"1981","journal-title":"Neurotoxicology"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1289\/ehp.1408407","article-title":"Associations of plasma concentrations of dichlorodiphenyldichloroethylene and polychlorinated biphenyls with prostate cancer: A case-control study in Guadeloupe (French West Indies)","volume":"123","author":"Emeville","year":"2015","journal-title":"Environ. Health Perspect."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/9\/1336\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:30:52Z","timestamp":1760124652000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/9\/1336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,7]]},"references-count":85,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["cells12091336"],"URL":"https:\/\/doi.org\/10.3390\/cells12091336","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,7]]}}}