{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:00:28Z","timestamp":1787500828197,"version":"build-2736575974"},"reference-count":64,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,5,7]],"date-time":"2023-05-07T00:00:00Z","timestamp":1683417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Salud Carlos III (ISCIII)","award":["PI19\/01007"],"award-info":[{"award-number":["PI19\/01007"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["DTS21\/00130"],"award-info":[{"award-number":["DTS21\/00130"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["r B054\/12"],"award-info":[{"award-number":["r B054\/12"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["MS19\/00092"],"award-info":[{"award-number":["MS19\/00092"]}]},{"name":"Fondo Europeo de Desarrollo Regional (Feder)","award":["PI19\/01007"],"award-info":[{"award-number":["PI19\/01007"]}]},{"name":"Fondo Europeo de Desarrollo Regional (Feder)","award":["DTS21\/00130"],"award-info":[{"award-number":["DTS21\/00130"]}]},{"name":"Fondo Europeo de Desarrollo Regional (Feder)","award":["r B054\/12"],"award-info":[{"award-number":["r B054\/12"]}]},{"name":"Fondo Europeo de Desarrollo Regional (Feder)","award":["MS19\/00092"],"award-info":[{"award-number":["MS19\/00092"]}]},{"name":"CIBER-BBN","award":["PI19\/01007"],"award-info":[{"award-number":["PI19\/01007"]}]},{"name":"CIBER-BBN","award":["DTS21\/00130"],"award-info":[{"award-number":["DTS21\/00130"]}]},{"name":"CIBER-BBN","award":["r B054\/12"],"award-info":[{"award-number":["r B054\/12"]}]},{"name":"CIBER-BBN","award":["MS19\/00092"],"award-info":[{"award-number":["MS19\/00092"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["PI19\/01007"],"award-info":[{"award-number":["PI19\/01007"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["DTS21\/00130"],"award-info":[{"award-number":["DTS21\/00130"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["r B054\/12"],"award-info":[{"award-number":["r B054\/12"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["MS19\/00092"],"award-info":[{"award-number":["MS19\/00092"]}]},{"name":"Aragon Government","award":["PI19\/01007"],"award-info":[{"award-number":["PI19\/01007"]}]},{"name":"Aragon Government","award":["DTS21\/00130"],"award-info":[{"award-number":["DTS21\/00130"]}]},{"name":"Aragon Government","award":["r B054\/12"],"award-info":[{"award-number":["r B054\/12"]}]},{"name":"Aragon Government","award":["MS19\/00092"],"award-info":[{"award-number":["MS19\/00092"]}]},{"name":"Miguel Servet Program","award":["PI19\/01007"],"award-info":[{"award-number":["PI19\/01007"]}]},{"name":"Miguel Servet Program","award":["DTS21\/00130"],"award-info":[{"award-number":["DTS21\/00130"]}]},{"name":"Miguel Servet Program","award":["r B054\/12"],"award-info":[{"award-number":["r B054\/12"]}]},{"name":"Miguel Servet Program","award":["MS19\/00092"],"award-info":[{"award-number":["MS19\/00092"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The induction of pluripotency by enforced expression of different sets of genes in somatic cells has been achieved with reprogramming technologies first described by Yamanaka\u2019s group. Methodologies for generating induced pluripotent stem cells are as varied as the combinations of genes used. It has previously been reported that the adenoviral E1a gene can induce the expression of two of the Yamanaka factors (c-Myc and Oct-4) and epigenetic changes. Here, we demonstrate that the E1a-12S over-expression is sufficient to induce pluripotent-like characteristics closely to epiblast stem cells in mouse embryonic fibroblasts through the activation of the pluripotency gene regulatory network. These findings provide not only empirical evidence that the expression of one single factor is sufficient for partial reprogramming but also a potential mechanistic explanation for how viral infection could lead to neoplasia if they are surrounded by the appropriate environment or the right medium, as happens with the tumorogenic niche.<\/jats:p>","DOI":"10.3390\/cells12091338","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T01:32:53Z","timestamp":1683509573000},"page":"1338","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The E1a Adenoviral Gene Upregulates the Yamanaka Factors to Induce Partial Cellular Reprogramming"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2293-363X","authenticated-orcid":false,"given":"Gracia","family":"Mendoza","sequence":"first","affiliation":[{"name":"Instituto Aragon\u00e9s de Ciencias de la Salud (IACS), 50009 Zaragoza, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Arag\u00f3n), 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5630-6645","authenticated-orcid":false,"given":"Rebeca","family":"Gonz\u00e1lez-Pastor","sequence":"additional","affiliation":[{"name":"Instituto Aragon\u00e9s de Ciencias de la Salud (IACS), 50009 Zaragoza, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica (CENBIO), Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Quito 170527, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2108-658X","authenticated-orcid":false,"given":"Juan Miguel","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London W12 ONN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Altamira","family":"Arce-Cerezo","sequence":"additional","affiliation":[{"name":"Centro de Biotecnolog\u00eda Animal y de Terapia G\u00e9nica (CBATEG), Universidad Aut\u00f3noma de Barcelona, 08193 Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2124-7657","authenticated-orcid":false,"given":"Miguel","family":"Quintanilla","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Instituto de Investigaciones Biom\u00e9dicas \u2018Alberto Sols\u2019, Universidad Aut\u00f3noma de Madrid (UAM), (UAM-CSIC), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5030-6687","authenticated-orcid":false,"given":"Gema","family":"Moreno-Bueno","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Instituto de Investigaciones Biom\u00e9dicas \u2018Alberto Sols\u2019, Universidad Aut\u00f3noma de Madrid (UAM), (UAM-CSIC), 28029 Madrid, Spain"},{"name":"Fundaci\u00f3n MD Anderson Internacional, 28033 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red, Instituto de Salud Carlos III, Red de C\u00e1ncer (CIBERONC) and Red de Nanomedicina y Nanomateriales (CIBER-BBN), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pujol","sequence":"additional","affiliation":[{"name":"Centro de Biotecnolog\u00eda Animal y de Terapia G\u00e9nica (CBATEG), Universidad Aut\u00f3noma de Barcelona, 08193 Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Belmar-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Instituto Aragon\u00e9s de Ciencias de la Salud (IACS), 50009 Zaragoza, Spain"},{"name":"OncoGenomics Lab, Universidad Privada San Juan Bautista, Lima 15038, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"de Martino","sequence":"additional","affiliation":[{"name":"Instituto Aragon\u00e9s de Ciencias de la Salud (IACS), 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efr\u00e9n","family":"Riu","sequence":"additional","affiliation":[{"name":"Centro de Biotecnolog\u00eda Animal y de Terapia G\u00e9nica (CBATEG), Universidad Aut\u00f3noma de Barcelona, 08193 Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan A.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London W12 ONN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2890-7846","authenticated-orcid":false,"given":"Pilar","family":"Martin-Duque","sequence":"additional","affiliation":[{"name":"Instituto Aragon\u00e9s de Ciencias de la Salud 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