{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:34:01Z","timestamp":1788968041850,"version":"build-2803163510"},"reference-count":73,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:00:00Z","timestamp":1683763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health","award":["R01-HL089598"],"award-info":[{"award-number":["R01-HL089598"]}]},{"name":"National Institutes of Health","award":["R01-HL147108"],"award-info":[{"award-number":["R01-HL147108"]}]},{"name":"National Institutes of Health","award":["R01-HL153350"],"award-info":[{"award-number":["R01-HL153350"]}]},{"name":"National Institutes of Health","award":["R01-HL160992"],"award-info":[{"award-number":["R01-HL160992"]}]},{"name":"National Institutes of Health","award":["T32-GM136611"],"award-info":[{"award-number":["T32-GM136611"]}]},{"name":"National Institutes of Health","award":["NIH F30-HL156669"],"award-info":[{"award-number":["NIH F30-HL156669"]}]},{"name":"Baylor College of Medicine Medical Scientist Training Program","award":["R01-HL089598"],"award-info":[{"award-number":["R01-HL089598"]}]},{"name":"Baylor College of Medicine Medical Scientist Training Program","award":["R01-HL147108"],"award-info":[{"award-number":["R01-HL147108"]}]},{"name":"Baylor College of Medicine Medical Scientist Training Program","award":["R01-HL153350"],"award-info":[{"award-number":["R01-HL153350"]}]},{"name":"Baylor College of Medicine Medical Scientist Training Program","award":["R01-HL160992"],"award-info":[{"award-number":["R01-HL160992"]}]},{"name":"Baylor College of Medicine Medical Scientist Training Program","award":["T32-GM136611"],"award-info":[{"award-number":["T32-GM136611"]}]},{"name":"Baylor College of Medicine Medical Scientist Training Program","award":["NIH F30-HL156669"],"award-info":[{"award-number":["NIH F30-HL156669"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>This article reviews progress in the field of cardiac genome editing, in particular, its potential utility in treating cardiac arrhythmias. First, we discuss genome editing methods by which DNA can be disrupted, inserted, deleted, or corrected in cardiomyocytes. Second, we provide an overview of in vivo genome editing in preclinical models of heritable and acquired arrhythmias. Third, we discuss recent advancements in cardiac gene transfer, including delivery methods, gene expression optimization, and potential adverse effects associated with therapeutic somatic genome editing. While genome editing for cardiac arrhythmias is still in its infancy, this approach holds great promise, especially for inherited arrhythmia syndromes with a defined genetic defect.<\/jats:p>","DOI":"10.3390\/cells12101363","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T05:05:02Z","timestamp":1683781502000},"page":"1363","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Genome Editing and Cardiac Arrhythmias"],"prefix":"10.3390","volume":"12","author":[{"given":"Oliver M.","family":"Moore","sequence":"first","affiliation":[{"name":"Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX 77030, USA"},{"name":"Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA"},{"name":"Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0015-5339","authenticated-orcid":false,"given":"Kevin S.","family":"Ho","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX 77030, USA"},{"name":"Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juwan S.","family":"Copeland","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaidya","family":"Parthasarathy","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX 77030, USA"},{"name":"Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5044-672X","authenticated-orcid":false,"given":"Xander H. T.","family":"Wehrens","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX 77030, USA"},{"name":"Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA"},{"name":"Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA"},{"name":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA"},{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA"},{"name":"Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA"},{"name":"Center for Space Medicine, Baylor College of Medicine, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: A systematic analysis for the Global Burden of Disease Study 2019","volume":"396","author":"Diseases","year":"2020","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1111\/jce.14429","article-title":"Impact of atrial fibrillation catheter ablation on mortality, stroke, and heart failure hospitalizations: A meta-analysis","volume":"31","author":"Saglietto","year":"2020","journal-title":"J. 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