{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:14:13Z","timestamp":1791396853085,"version":"4.3.3"},"reference-count":65,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["R01AG056614"],"award-info":[{"award-number":["R01AG056614"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD), which was first identified more than a century ago, has become a pandemic that exacts enormous social burden and economic tolls as no measure of combating devastated AD is currently available. Growing etiopathological, genetic, and biochemical data indicate that AD is a heterogeneous, polygenic, multifactorial, and complex disease. However, its exact etiopathology remains to be determined. Numerous experimental data show that cerebral iron and copper dyshomeostasis contribute to A\u03b2 amyloidosis and tauopathy, two neuropathological hallmarks of AD. Moreover, increasing experimental evidence suggests ferroptosis, an iron-dependent and nonapoptotic form of cell death, may be involved in the neurodegenerative process in the AD brain. Thus, the anti-ferroptosis approach may be an efficacious therapeutic strategy for AD patients. Furthermore, it remains to be further determined whether cuproptosis, a copper-dependent and distinct form of regulated cell death, also plays a contributing role in AD neurodegeneration. We hope this concise review of recent experimental studies of oxidative stress-mediated ferroptosis and cuproptosis in AD may spur further investigations on this timely and essential line of research.<\/jats:p>","DOI":"10.3390\/cells12101369","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T02:36:59Z","timestamp":1683859019000},"page":"1369","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["A Concise Review on Oxidative Stress-Mediated Ferroptosis and Cuproptosis in Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4811-1901","authenticated-orcid":false,"given":"Xudong","family":"Huang","sequence":"first","affiliation":[{"name":"Neurochemistry Laboratory, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,12]]},"reference":[{"key":"ref_1","first-page":"1129","article-title":"\u00dcber einen eigenartigen schweren ErkrankungsprozeB der Hirnrinde","volume":"23","author":"Alzheimer","year":"1906","journal-title":"Neurol. Cent."},{"key":"ref_2","first-page":"146","article-title":"\u00dcber eine eigenartige Erkrankung der Hirnrinde","volume":"64","author":"Alzheimer","year":"1907","journal-title":"Allg. Z. Fur Psychiatr. Und Psych. Gerichtl. Medizin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1196\/annals.1306.012","article-title":"Redox-active metals, oxidative stress, and Alzheimer\u2019s disease pathology","volume":"1012","author":"Huang","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_4","unstructured":"WHO (2023, May 04). Dementia. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dementia."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"(2023). 2023 Alzheimer\u2019s disease facts and figures. Alzheimers Dement, 19, 1598\u20131695.","DOI":"10.1002\/alz.13016"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.90.5.1977","article-title":"Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease","volume":"90","author":"Strittmatter","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u2019s disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/325733a0","article-title":"The precursor of Alzheimer\u2019s disease amyloid A4 protein resembles a cell-surface receptor","volume":"325","author":"Kang","year":"1987","journal-title":"Nature"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/S0140-6736(87)91754-5","article-title":"Chromosome 21q21 sublocalisation of gene encoding beta-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer disease and Down syndrome","volume":"1","author":"Robakis","year":"1987","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1126\/science.2949367","article-title":"Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus","volume":"235","author":"Tanzi","year":"1987","journal-title":"Science"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/375754a0","article-title":"Cloning of a gene bearing missense mutations in early-onset familial Alzheimer\u2019s disease","volume":"375","author":"Sherrington","year":"1995","journal-title":"Nature"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.7638622","article-title":"Candidate gene for the chromosome 1 familial Alzheimer\u2019s disease locus","volume":"269","author":"Wasco","year":"1995","journal-title":"Science"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0006-291X(84)80190-4","article-title":"Alzheimer\u2019s disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein","volume":"120","author":"Glenner","year":"1984","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1073\/pnas.82.12.4245","article-title":"Amyloid plaque core protein in Alzheimer disease and Down syndrome","volume":"82","author":"Masters","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7107","DOI":"10.1007\/s12035-018-0914-2","article-title":"Role of Amyloid Precursor Protein (APP) and Its Derivatives in the Biology and Cell Fate Specification of Neural Stem Cells","volume":"55","author":"Coronel","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease: Progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature19323","article-title":"The antibody aducanumab reduces Abeta plaques in Alzheimer\u2019s disease","volume":"537","author":"Sevigny","year":"2016","journal-title":"Nature"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa2212948","article-title":"Lecanemab in Early Alzheimer\u2019s Disease","volume":"388","author":"Swanson","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.radcr.2022.10.023","article-title":"Subcortical signal alteration of corticospinal tracts. A radiologic manifestation of ARIA: A case report","volume":"18","author":"Sotoudeh","year":"2023","journal-title":"Radiol. Case Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1007\/s10571-017-0574-1","article-title":"Tau Proteins and Tauopathies in Alzheimer\u2019s Disease","volume":"38","author":"Chong","year":"2018","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"103487","DOI":"10.1016\/j.drudis.2023.103487","article-title":"Hyperphosphorylated tau (p-tau) and drug discovery in the context of Alzheimer\u2019s disease and related tauopathies","volume":"28","author":"Moore","year":"2023","journal-title":"Drug Discov. Today"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1038\/s41591-019-0611-3","article-title":"Resistance to autosomal dominant Alzheimer\u2019s disease in an APOE3 Christchurch homozygote: A case report","volume":"25","author":"Lopera","year":"2019","journal-title":"Nat. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00401-022-02467-8","article-title":"Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer\u2019s dementia","volume":"144","author":"Sanchez","year":"2022","journal-title":"Acta Neuropathol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Peng, Y., Chang, X., and Lang, M. (2021). Iron Homeostasis Disorder and Alzheimer\u2019s Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222212442"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"7609","DOI":"10.1021\/bi990438f","article-title":"The A beta peptide of Alzheimer\u2019s disease directly produces hydrogen peroxide through metal ion reduction","volume":"38","author":"Huang","year":"1999","journal-title":"Biochemistry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jsb.2005.12.011","article-title":"Metal exposure and Alzheimer\u2019s pathogenesis","volume":"155","author":"Liu","year":"2006","journal-title":"J. Struct. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"20140165","DOI":"10.1098\/rsif.2014.0165","article-title":"Ferrous iron formation following the co-aggregation of ferric iron and the Alzheimer\u2019s disease peptide beta-amyloid (1-42)","volume":"11","author":"Everett","year":"2014","journal-title":"J. R. Soc. Interface"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1021\/ic402406g","article-title":"Evidence of redox-active iron formation following aggregation of ferrihydrite and the Alzheimer\u2019s disease peptide beta-amyloid","volume":"53","author":"Everett","year":"2014","journal-title":"Inorg. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.chembiol.2017.07.014","article-title":"Iron Biochemistry is Correlated with Amyloid Plaque Morphology in an Established Mouse Model of Alzheimer\u2019s Disease","volume":"24","author":"Telling","year":"2017","journal-title":"Cell Chem. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"11782","DOI":"10.1039\/C7NR06794A","article-title":"Nanoscale synchrotron X-ray speciation of iron and calcium compounds in amyloid plaque cores from Alzheimer\u2019s disease subjects","volume":"10","author":"Everett","year":"2018","journal-title":"Nanoscale"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"10332","DOI":"10.1038\/s41598-020-67117-z","article-title":"Iron stored in ferritin is chemically reduced in the presence of aggregating Abeta(1\u201342)","volume":"10","author":"Everett","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"eabf6707","DOI":"10.1126\/sciadv.abf6707","article-title":"Biogenic metallic elements in the human brain?","volume":"7","author":"Everett","year":"2021","journal-title":"Sci. Adv."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"10797","DOI":"10.1073\/pnas.1605941113","article-title":"Magnetite pollution nanoparticles in the human brain","volume":"113","author":"Maher","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Reichert, C.O., de Freitas, F.A., Sampaio-Silva, J., Rokita-Rosa, L., Barros, P.L., Levy, D., and Bydlowski, S.P. (2020). Ferroptosis Mechanisms Involved in Neurodegenerative Diseases. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228765"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.freeradbiomed.2018.09.033","article-title":"Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration","volume":"133","author":"Masaldan","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3622","DOI":"10.1111\/bph.14567","article-title":"Treating Alzheimer\u2019s disease by targeting iron","volume":"176","author":"Nikseresht","year":"2019","journal-title":"Br. J. Pharm."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.1007\/s12035-018-1403-3","article-title":"Ferroptosis and Its Role in Diverse Brain Diseases","volume":"56","author":"Weiland","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1002\/alz.12282","article-title":"Regional brain iron associated with deterioration in Alzheimer\u2019s disease: A large cohort study and theoretical significance","volume":"17","author":"Ayton","year":"2021","journal-title":"Alzheimers Dement"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1038\/s41380-019-0375-7","article-title":"Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology","volume":"25","author":"Ayton","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"101494","DOI":"10.1016\/j.redox.2020.101494","article-title":"Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine\/glutamate antiporter in Alzheimer\u2019s disease: Evidence of ferroptosis","volume":"32","author":"Ashraf","year":"2020","journal-title":"Redox Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"101947","DOI":"10.1016\/j.redox.2021.101947","article-title":"NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer\u2019s diseases","volume":"41","author":"Park","year":"2021","journal-title":"Redox Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1038\/s41418-020-00685-9","article-title":"Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer\u2019s disease","volume":"28","author":"Bao","year":"2021","journal-title":"Cell Death Differ."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/s41419-020-03020-9","article-title":"Intracellular amyloid toxicity induces oxytosis\/ferroptosis regulated cell death","volume":"11","author":"Huang","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1038\/s41418-022-01003-1","article-title":"Selective ferroptosis vulnerability due to familial Alzheimer\u2019s disease presenilin mutations","volume":"29","author":"Greenough","year":"2022","journal-title":"Cell Death Differ."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"12087","DOI":"10.1039\/D1FO01471D","article-title":"Plasmalogens improve swimming performance by modulating the expression of genes involved in amino acid and lipid metabolism, oxidative stress, and ferroptosis in an Alzheimer\u2019s disease zebrafish model","volume":"12","author":"Feng","year":"2021","journal-title":"Food Funct."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"108002","DOI":"10.1016\/j.intimp.2021.108002","article-title":"Tetrahydroxy stilbene glycoside ameliorates Alzheimer\u2019s disease in APP\/PS1 mice via glutathione peroxidase related ferroptosis","volume":"99","author":"Gao","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.freeradbiomed.2021.11.003","article-title":"Profiling the chemical nature of anti-oxytotic\/ferroptotic compounds with phenotypic screening","volume":"177","author":"Liang","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s10020-022-00442-3","article-title":"Eriodictyol ameliorates cognitive dysfunction in APP\/PS1 mice by inhibiting ferroptosis via vitamin D receptor-mediated Nrf2 activation","volume":"28","author":"Li","year":"2022","journal-title":"Mol. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.7150\/ijbs.69714","article-title":"Forsythoside A Mitigates Alzheimer\u2019s-like Pathology by Inhibiting Ferroptosis-mediated Neuroinflammation via Nrf2\/GPX4 Axis Activation","volume":"18","author":"Wang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"6983","DOI":"10.1007\/s12035-022-03014-y","article-title":"Senegenin Rescues PC12 Cells with Oxidative Damage Through Inhibition of Ferroptosis","volume":"59","author":"Zhang","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1080\/15376516.2022.2053254","article-title":"Deferoxamine ameliorated Al(mal)3-induced neuronal ferroptosis in adult rats by chelating brain iron to attenuate oxidative damage","volume":"32","author":"Zhu","year":"2022","journal-title":"Toxicol. Mech. Methods"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Patel, R., and Aschner, M. (2021). Commonalities between Copper Neurotoxicity and Alzheimer\u2019s Disease. Toxics, 9.","DOI":"10.3390\/toxics9010004"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.1038\/s41380-022-01802-5","article-title":"Brain copper may protect from cognitive decline and Alzheimer\u2019s disease pathology: A community-based study","volume":"27","author":"Agarwal","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s43188-020-00043-4","article-title":"Chronic copper exposure leads to hippocampus oxidative stress and impaired learning and memory in male and female rats","volume":"36","author":"Lamtai","year":"2020","journal-title":"Toxicol. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3389\/fnagi.2017.00300","article-title":"Serum Copper, Zinc, and Iron Levels in Patients with Alzheimer\u2019s Disease: A Meta-Analysis of Case-Control Studies","volume":"9","author":"Li","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"37111","DOI":"10.1074\/jbc.274.52.37111","article-title":"Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction","volume":"274","author":"Huang","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"14771","DOI":"10.1073\/pnas.1302212110","article-title":"Low levels of copper disrupt brain amyloid-beta homeostasis by altering its production and clearance","volume":"110","author":"Singh","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s41392-022-01229-y","article-title":"Copper homeostasis and cuproptosis in health and disease","volume":"7","author":"Chen","year":"2022","journal-title":"Signal Transduct Target"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"932676","DOI":"10.3389\/fnagi.2022.932676","article-title":"Identification and immunological characterization of cuproptosis-related molecular clusters in Alzheimer\u2019s disease","volume":"14","author":"Lai","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Zhou, Q., Lu, L., Su, Y., Shi, W., Zhang, H., Liu, R., Pu, Y., and Yin, L. (2023). Copper Induces Cognitive Impairment in Mice via Modulation of Cuproptosis and CREB Signaling. Nutrients, 15.","DOI":"10.3390\/nu15040972"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1064639","DOI":"10.3389\/fneur.2022.1064639","article-title":"Diagnostic models and predictive drugs associated with cuproptosis hub genes in Alzheimer\u2019s disease","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Neurol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Pilozzi, A., Yu, Z., Carreras, I., Cormier, K., Hartley, D., Rogers, J., Dedeoglu, A., and Huang, X. (2020). A Preliminary Study of Cu Exposure Effects upon Alzheimer\u2019s Amyloid Pathology. Biomolecules, 10.","DOI":"10.3390\/biom10030408"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/10\/1369\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:33:26Z","timestamp":1760124806000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/10\/1369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,12]]},"references-count":65,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["cells12101369"],"URL":"https:\/\/doi.org\/10.3390\/cells12101369","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,12]]}}}