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This degenerative condition affects the retina and leads to the loss of central vision. The current treatments are focused on the late stage of the disease, but recent studies have highlighted the importance and benefits of preventive treatments and how good dietary habits can reduce the risk of progression to an advanced form of the disease. In this context, we studied whether resveratrol (RSV) or a polyphenolic cocktail, red wine extract (RWE), are able to prevent the initiating events of AMD (i.e., oxidative stress and inflammation) in human ARPE-19 retinal pigment epithelial (RPE) cells and macrophages. This study highlights that RWE and RSV can prevent hydrogen peroxide (H2O2) or 2,2\u2032-Azobis(2-methylpropionamidine) dihydrochloride (AAPH)-induced oxidative stress and can subsequently prevent DNA damage via the inhibition of the ATM (ataxia telangiectasia-mutated)\/Chk2 (checkpoint kinase 2) or Chk1 signaling pathways, respectively. Moreover, ELISA assays show that RWE and RSV can prevent the secretion of proinflammatory cytokines in RPE cells and in human macrophages. Interestingly, RWE exhibits a greater protective impact compared to RSV alone, even though RSV was more concentrated when used alone than in the red wine extract. Our results suggest that RWE and RSV may have potential interest as preventive nutritional supplementations against AMD.<\/jats:p>","DOI":"10.3390\/cells12101408","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T06:00:29Z","timestamp":1684389629000},"page":"1408","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Red Wine Extract Prevents Oxidative Stress and Inflammation in ARPE-19 Retinal Cells"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0038-3809","authenticated-orcid":false,"given":"Clarisse","family":"Cornebise","sequence":"first","affiliation":[{"name":"UFR des Sciences de Sant\u00e9, Universit\u00e9 de Bourgogne, 21000 Dijon, France"},{"name":"INSERM Research Center U1231\u2014Cancer and Adaptive Immune Response Team, Bioactive Molecules and Health Research Group, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maude","family":"Perus","sequence":"additional","affiliation":[{"name":"UFR des Sciences de Sant\u00e9, Universit\u00e9 de Bourgogne, 21000 Dijon, France"},{"name":"INSERM Research Center U1231\u2014Cancer and Adaptive Immune Response Team, Bioactive Molecules and Health Research Group, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5549-1992","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Hermetet","sequence":"additional","affiliation":[{"name":"UFR des Sciences de Sant\u00e9, Universit\u00e9 de Bourgogne, 21000 Dijon, France"},{"name":"INSERM Research Center U1231\u2014Cancer and Adaptive Immune Response Team, Bioactive Molecules and Health Research Group, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1359-4114","authenticated-orcid":false,"given":"Josep","family":"Valls-Fonayet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bordeaux, Bordeaux Sciences Agro, Bordeaux INP, INRAE, OENO, UMR 1366, ISVV, 33140 Villenave d\u2019Ornon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5308-8697","authenticated-orcid":false,"given":"Tristan","family":"Richard","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bordeaux, Bordeaux Sciences Agro, Bordeaux INP, INRAE, OENO, UMR 1366, ISVV, 33140 Villenave d\u2019Ornon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Aires","sequence":"additional","affiliation":[{"name":"UFR des Sciences de Sant\u00e9, Universit\u00e9 de Bourgogne, 21000 Dijon, France"},{"name":"INSERM Research Center U1231\u2014Cancer and Adaptive Immune Response Team, Bioactive Molecules and Health Research Group, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Delmas","sequence":"additional","affiliation":[{"name":"UFR des Sciences de Sant\u00e9, Universit\u00e9 de Bourgogne, 21000 Dijon, France"},{"name":"INSERM Research Center U1231\u2014Cancer and Adaptive Immune Response Team, Bioactive Molecules and Health Research Group, 21000 Dijon, France"},{"name":"Centre de Lutte Contre le Cancer Georges Fran\u00e7ois Leclerc Center, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1001\/archopht.122.4.564","article-title":"Prevalence of age-related macular degeneration in the United States","volume":"122","author":"Friedman","year":"2004","journal-title":"Arch. 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