{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:55:39Z","timestamp":1790790939149,"version":"4.1.0"},"reference-count":62,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,21]],"date-time":"2023-05-21T00:00:00Z","timestamp":1684627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","award":["ANR-18-CE18-0001"],"award-info":[{"award-number":["ANR-18-CE18-0001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Elastic fibers are extracellular macromolecules that provide resilience and elastic recoil to elastic tissues and organs in vertebrates. They are composed of an elastin core surrounded by a mantle of fibrillin-rich microfibrils and are essentially produced during a relatively short period around birth in mammals. Thus, elastic fibers have to resist many physical, chemical, and enzymatic constraints occurring throughout their lives, and their high stability can be attributed to the elastin protein. Various pathologies, called elastinopathies, are linked to an elastin deficiency, such as non-syndromic supravalvular aortic stenosis (SVAS), Williams\u2013Beuren syndrome (WBS), and autosomal dominant cutis laxa (ADCL). To understand these diseases, as well as the aging process related to elastic fiber degradation, and to test potential therapeutic molecules in order to compensate for elastin impairments, different animal models have been proposed. Considering the many advantages of using zebrafish, we here characterize a zebrafish mutant for the elastin a paralog (elnasa12235) with a specific focus on the cardiovascular system and highlight premature heart valve defects at the adult stage.<\/jats:p>","DOI":"10.3390\/cells12101436","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T01:31:46Z","timestamp":1684719106000},"page":"1436","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Characterization of the Zebrafish Elastin a (elnasa12235) Mutant: A New Model of Elastinopathy Leading to Heart Valve Defects"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5756-6695","authenticated-orcid":false,"given":"Marie","family":"Hoareau","sequence":"first","affiliation":[{"name":"Laboratoire de Biologie Tissulaire et Ing\u00e9nierie Th\u00e9rapeutique (LBTI), UMR CNRS 5305, Institut de Biologie et Chimie des Prot\u00e9ines, Universit\u00e9 de Lyon 1, 7 Passage du Vercors, CEDEX 07, F-69367 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na\u00efma","family":"El Kholti","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Tissulaire et Ing\u00e9nierie Th\u00e9rapeutique (LBTI), UMR CNRS 5305, Institut de Biologie et Chimie des Prot\u00e9ines, Universit\u00e9 de Lyon 1, 7 Passage du Vercors, CEDEX 07, F-69367 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6315-2616","authenticated-orcid":false,"given":"Romain","family":"Debret","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Tissulaire et Ing\u00e9nierie Th\u00e9rapeutique (LBTI), UMR CNRS 5305, Institut de Biologie et Chimie des Prot\u00e9ines, Universit\u00e9 de Lyon 1, 7 Passage du Vercors, CEDEX 07, F-69367 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1192-0112","authenticated-orcid":false,"given":"Elise","family":"Lambert","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Tissulaire et Ing\u00e9nierie Th\u00e9rapeutique (LBTI), UMR CNRS 5305, Institut de Biologie et Chimie des Prot\u00e9ines, Universit\u00e9 de Lyon 1, 7 Passage du Vercors, CEDEX 07, F-69367 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.biocel.2008.03.017","article-title":"Tropoelastin","volume":"41","author":"Wise","year":"2009","journal-title":"Int. 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