{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:23:50Z","timestamp":1768314230387,"version":"3.49.0"},"reference-count":68,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Service R\u00e9gional Vaudois de Transfusion Sanguine","award":["na"],"award-info":[{"award-number":["na"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The hypothesis of the potential impact of the sex of red blood cell (RBC) concentrate (RCC) donors, as well as the sex of the recipients, on the clinical outcome, is still under evaluation. Here, we have evaluated the sex impact on RBC properties using in vitro transfusion models. Using a \u201cflask model\u201d, RBCs from RCCs (representing the donor)\u2014at different storage lengths\u2014were incubated in a sex-matched and sex-mismatched manner with fresh frozen plasma pools (representing the recipient) at 37 \u00b0C, with 5% of CO2 up to 48 h. Standard blood parameters, hemolysis, intracellular ATP, extracellular glucose and lactate were quantified during incubation. Additionally, a \u201cplate model\u201d, coupling hemolysis analysis and morphological study, was carried out in similar conditions in 96-well plates. In both models, RBCs from both sexes hemolyzed significantly less in female-derived plasma. No metabolic or morphological differences were observed between sex-matched and -mismatched conditions, even though ATP was higher in female-derived RBCs during incubations. Female plasma reduced hemolysis of female- as well as male-derived RBCs, which may be related to a sex-dependent plasma composition and\/or sex-related intrinsic RBC properties.<\/jats:p>","DOI":"10.3390\/cells12111454","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T07:00:02Z","timestamp":1684825202000},"page":"1454","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Effect of the Donor\u2019s and Recipient\u2019s Sex on Red Blood Cells Evaluated Using Transfusion Simulations"],"prefix":"10.3390","volume":"12","author":[{"given":"Emmanuel","family":"Laengst","sequence":"first","affiliation":[{"name":"Laboratoire de Recherche sur les Produits Sanguins, Transfusion Interr\u00e9gionale CRS, 1066 Epalinges, Switzerland"},{"name":"Facult\u00e9 de Biologie et de M\u00e9decine, University of Lausanne, 1011 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Crettaz","sequence":"additional","affiliation":[{"name":"Laboratoire de Recherche sur les Produits Sanguins, Transfusion Interr\u00e9gionale CRS, 1066 Epalinges, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2493-8469","authenticated-orcid":false,"given":"Jean-Daniel","family":"Tissot","sequence":"additional","affiliation":[{"name":"Laboratoire de Recherche sur les Produits Sanguins, Transfusion Interr\u00e9gionale CRS, 1066 Epalinges, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9470-0179","authenticated-orcid":false,"given":"Michel","family":"Prudent","sequence":"additional","affiliation":[{"name":"Laboratoire de Recherche sur les Produits Sanguins, Transfusion Interr\u00e9gionale CRS, 1066 Epalinges, Switzerland"},{"name":"Facult\u00e9 de Biologie et de M\u00e9decine, University of Lausanne, 1011 Lausanne, Switzerland"},{"name":"Center for Research and Innovation in Clinical Pharmaceutical Sciences, Institute of Pharmaceutical Sciences of Western Switzerland, University Hospital and University of Lausanne, 1011 Lausanne, Switzerland"},{"name":"Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, 1211 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.3324\/haematol.2016.147645","article-title":"Donor and recipient sex in allogeneic stem cell transplantation: What really matters","volume":"101","author":"Kim","year":"2016","journal-title":"Haematologica"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.semnephrol.2022.04.011","article-title":"Sex and Gender Differences in Kidney Transplantation","volume":"42","author":"Shah","year":"2022","journal-title":"Semin. 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