{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:48:24Z","timestamp":1790196504433,"version":"4.1.0"},"reference-count":68,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Stem cell transplantation has recently demonstrated a significant therapeutic efficacy in various diseases. Multilineage-differentiating stress-enduring (Muse) cells are stress-tolerant endogenous pluripotent stem cells that were first reported in 2010. Muse cells can be found in the peripheral blood, bone marrow and connective tissue of nearly all body organs. Under basal conditions, they constantly move from the bone marrow to peripheral blood to supply various body organs. However, this rate greatly changes even within the same individual based on physical status and the presence of injury or illness. Muse cells can differentiate into all three-germ-layers, producing tissue-compatible cells with few errors, minimal immune rejection and without forming teratomas. They can also endure hostile environments, supporting their survival in damaged\/injured tissues. Additionally, Muse cells express receptors for sphingosine-1-phosphate (S1P), which is a protein produced by damaged\/injured tissues. Through the S1P\u2013S1PR2 axis, circulating Muse cells can preferentially migrate to damaged sites following transplantation. In addition, Muse cells possess a unique immune privilege system, facilitating their use without the need for long-term immunosuppressant treatment or human leucocyte antigen matching. Moreover, they exhibit anti-inflammatory, anti-apoptotic and tissue-protective effects. These characteristics circumvent all challenges experienced with mesenchymal stem cells and induced pluripotent stem cells and encourage the wide application of Muse cells in clinical practice. Indeed, Muse cells have the potential to break through the limitations of current cell-based therapies, and many clinical trials have been conducted, applying intravenously administered Muse cells in stroke, myocardial infarction, neurological disorders and acute respiratory distress syndrome (ARDS) related to novel coronavirus (SARS-CoV-2) infection. Herein, we aim to highlight the unique biological properties of Muse cells and to elucidate the advantageous difference between Muse cells and other types of stem cells. Finally, we shed light on their current therapeutic applications and the major obstacles to their clinical implementation from laboratory to clinic.<\/jats:p>","DOI":"10.3390\/cells12131676","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T02:01:33Z","timestamp":1687312893000},"page":"1676","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Multilineage Differentiating Stress Enduring (Muse) Cells: A New Era of Stem Cell-Based Therapy"],"prefix":"10.3390","volume":"12","author":[{"given":"Raghad F.","family":"Alanazi","sequence":"first","affiliation":[{"name":"Pharm D Program, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basma S.","family":"Alhwity","sequence":"additional","affiliation":[{"name":"Pharm D Program, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghad M.","family":"Almahlawi","sequence":"additional","affiliation":[{"name":"Pharm D Program, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bashayer D.","family":"Alatawi","sequence":"additional","affiliation":[{"name":"Pharm D Program, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8009-3135","authenticated-orcid":false,"given":"Shatha A.","family":"Albalawi","sequence":"additional","affiliation":[{"name":"Pharm D Program, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raneem A.","family":"Albalawi","sequence":"additional","affiliation":[{"name":"Pharm D Program, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaal A.","family":"Albalawi","sequence":"additional","affiliation":[{"name":"Pharm D Program, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed S.","family":"Abdel-Maksoud","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehal","family":"Elsherbiny","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia"},{"name":"Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12015-019-09935-x","article-title":"Advances in Pluripotent Stem Cells: History, Mechanisms, Technologies, and Applications","volume":"16","author":"Liu","year":"2020","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.21037\/sci-2020-001","article-title":"Current State of Stem Cell-Based Therapies: An Overview","volume":"7","author":"Aly","year":"2020","journal-title":"Stem Cell Investig."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13287-019-1165-5","article-title":"Stem Cells: Past, Present, and Future","volume":"10","author":"Zakrzewski","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Dezawa, M. (2018). Muse Cells: Endogenous Reparative Pluripotent Stem Cells, Springer.","DOI":"10.1007\/978-4-431-56847-6"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"8639","DOI":"10.1073\/pnas.0911647107","article-title":"Unique Multipotent Cells in Adult Human Mesenchymal Cell Populations","volume":"107","author":"Kuroda","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"19328","DOI":"10.18632\/oncotarget.25039","article-title":"Stress and Stem Cells: Adult Muse Cells Tolerate Extensive Genotoxic Stimuli Better than Mesenchymal Stromal Cells","volume":"9","author":"Alessio","year":"2018","journal-title":"Oncotarget"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Yamashita, T., Kushida, Y., Abe, K., and Dezawa, M. (2021). Non-Tumorigenic Pluripotent Reparative Muse Cells Provide a New Therapeutic Approach for Neurologic Diseases. 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J. Transplant."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"9875","DOI":"10.1073\/pnas.1100816108","article-title":"Multilineage-Differentiating Stress-Enduring (Muse) Cells Are a Primary Source of Induced Pluripotent Stem Cells in Human Fibroblasts","volume":"108","author":"Wakao","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.12.033","article-title":"Mobilization of Pluripotent Multilineage-Differentiating Stress-Enduring Cells in Ischemic Stroke","volume":"25","author":"Hori","year":"2016","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1253\/circj.CJ-17-0552","article-title":"Mobilized Muse Cells After Acute Myocardial Infarction Predict Cardiac Function and Remodeling in the Chronic Phase","volume":"82","author":"Tanaka","year":"2018","journal-title":"Circ. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1089\/scd.2013.0473","article-title":"Human Adipose Tissue Possesses a Unique Population of Pluripotent Stem Cells with Nontumorigenic and Low Telomerase Activities: Potential Implications in Regenerative Medicine","volume":"23","author":"Ogura","year":"2014","journal-title":"Stem Cells Dev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-4-431-56847-6_1","article-title":"The Muse Cell Discovery, Thanks to Wine and Science","volume":"1103","author":"Dezawa","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1463258","DOI":"10.1155\/2016\/1463258","article-title":"Muse Cells: Nontumorigenic Pluripotent Stem Cells Present in Adult Tissues-A Paradigm Shift in Tissue Regeneration and Evolution","volume":"2016","author":"Simerman","year":"2016","journal-title":"Stem Cells Int."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1186\/s13287-022-03126-1","article-title":"Muse Cells: Ushering in a New Era of Stem Cell-Based Therapy for Stroke","volume":"13","author":"Li","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/s13287-017-0674-3","article-title":"Pluripotent Nontumorigenic Multilineage Differentiating Stress Enduring Cells (Muse Cells): A Seven-Year Retrospective","volume":"8","author":"Fisch","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1089\/cell.2015.0085","article-title":"Muse Cells, a New Type of Pluripotent Stem Cell Derived from Human Fibroblasts","volume":"18","author":"Liu","year":"2016","journal-title":"Cell. Reprogram."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.reth.2020.04.011","article-title":"Regenerative Potential of Pluripotent Nontumorgenetic Stem Cells: Multilineage Differentiating Stress Enduring Cells (Muse Cells)","volume":"15","author":"Cao","year":"2020","journal-title":"Regen. Ther."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/978-4-431-56847-6_3","article-title":"Muse Cells Are Endogenous Reparative Stem Cells","volume":"1103","author":"Kushida","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"963689720923574","DOI":"10.1177\/0963689720923574","article-title":"A Novel Type of Stem Cells Double-Positive for SSEA-3 and CD45 in Human Peripheral Blood","volume":"29","author":"Sato","year":"2020","journal-title":"Cell Transplant."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1161\/CIRCRESAHA.117.311648","article-title":"S1P-S1PR2 Axis Mediates Homing of Muse Cells into Damaged Heart for Long-Lasting Tissue Repair and Functional Recovery After Acute Myocardial Infarction","volume":"122","author":"Yamada","year":"2018","journal-title":"Circ. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"821","DOI":"10.3727\/096368916X693662","article-title":"Muse Cells, Nontumorigenic Pluripotent-Like Stem Cells, Have Liver Regeneration Capacity Through Specific Homing and Cell Replacement in a Mouse Model of Liver Fibrosis","volume":"26","author":"Iseki","year":"2017","journal-title":"Cell Transplant."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1177\/0963689717721514","article-title":"Cardiotrophic Growth Factor-Driven Induction of Human Muse Cells into Cardiomyocyte-Like Phenotype","volume":"27","author":"Amin","year":"2018","journal-title":"Cell Transplant."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/978-4-431-56847-6_18","article-title":"Future of Muse Cells","volume":"Volume 1103","author":"Dezawa","year":"2018","journal-title":"Muse Cells"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-4-431-56847-6_4","article-title":"Protocols for Isolation and Evaluation of Muse Cells","volume":"Volume 1103","author":"Dezawa","year":"2018","journal-title":"Muse Cells"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1253\/circj.CJ-20-0307","article-title":"Safety and Efficacy of Human Muse Cell-Based Product for Acute Myocardial Infarction in a First-in-Human Trial","volume":"84","author":"Noda","year":"2020","journal-title":"Circ. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/978-4-431-56847-6_8","article-title":"Acute Myocardial Infarction, Cardioprotection, and Muse Cells","volume":"Volume 1103","author":"Dezawa","year":"2018","journal-title":"Muse Cells"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1161\/STROKEAHA.120.030618","article-title":"Cell-Based Therapy for Stroke: Musing with Muse Cells","volume":"51","author":"Park","year":"2020","journal-title":"Stroke"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41572-019-0118-8","article-title":"Ischaemic Stroke","volume":"5","author":"Campbell","year":"2019","journal-title":"Nat. Rev. Dis. Primer"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s13287-018-0913-2","article-title":"Neural Stem Cell Therapy for Subacute and Chronic Ischemic Stroke","volume":"9","author":"Boese","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/stem.2206","article-title":"Transplantation of Unique Subpopulation of Fibroblasts, Muse Cells, Ameliorates Experimental Stroke Possibly via Robust Neuronal Differentiation","volume":"34","author":"Uchida","year":"2016","journal-title":"Stem Cells"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Yamauchi, T., Kuroda, Y., Morita, T., Shichinohe, H., Houkin, K., Dezawa, M., and Kuroda, S. (2015). Therapeutic Effects of Human Multilineage-Differentiating Stress Enduring (MUSE) Cell Transplantation into Infarct Brain of Mice. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0116009"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1161\/STROKEAHA.116.014950","article-title":"Human Muse Cells Reconstruct Neuronal Circuitry in Subacute Lacunar Stroke Model","volume":"48","author":"Uchida","year":"2017","journal-title":"Stroke"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1161\/STROKEAHA.119.026589","article-title":"Intravenously Transplanted Human Multilineage-Differentiating Stress-Enduring Cells Afford Brain Repair in a Mouse Lacunar Stroke Model","volume":"51","author":"Abe","year":"2020","journal-title":"Stroke"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00221-016-4818-y","article-title":"Neuro-Regeneration Therapy Using Human Muse Cells Is Highly Effective in a Mouse Intracerebral Hemorrhage Model","volume":"235","author":"Shimamura","year":"2017","journal-title":"Exp. Brain Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1001\/jama.283.22.2941","article-title":"Relationship of Symptom-Onset-to-Balloon Time and Door-to-Balloon Time with Mortality in Patients Undergoing Angioplasty for Acute Myocardial Infarction","volume":"283","author":"Cannon","year":"2000","journal-title":"JAMA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jjcc.2021.10.030","article-title":"Stem Cell Therapy for Acute Myocardial Infarction\u2014Focusing on the Comparison between Muse Cells and Mesenchymal Stem Cells","volume":"80","author":"Yamada","year":"2022","journal-title":"J. Cardiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1182\/blood-2005-06-2211","article-title":"Reconstitution of the Functional Human Hematopoietic Microenvironment Derived from Human Mesenchymal Stem Cells in the Murine Bone Marrow Compartment","volume":"107","author":"Muguruma","year":"2006","journal-title":"Blood"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/sctm.17-0210","article-title":"Concise Review: Rational Use of Mesenchymal Stem Cells in the Treatment of Ischemic Heart Disease","volume":"7","author":"Ward","year":"2018","journal-title":"Stem Cells Transl. Med."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Yamada, Y., Minatoguchi, S., Baba, S., Shibata, S., Takashima, S., Wakao, S., Okura, H., Dezawa, M., and Minatoguchi, S. (2022). Human Muse Cells Reduce Myocardial Infarct Size and Improve Cardiac Function without Causing Arrythmias in a Swine Model of Acute Myocardial Infarction. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0265347"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"566858","DOI":"10.3389\/fnins.2020.566858","article-title":"Amyotrophic Lateral Sclerosis: A Neurodegenerative Motor Neuron Disease with Ocular Involvement","volume":"14","author":"Rojas","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"17102","DOI":"10.1038\/s41598-020-74216-4","article-title":"Therapeutic Benefit of Muse Cells in a Mouse Model of Amyotrophic Lateral Sclerosis","volume":"10","author":"Yamashita","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1177\/0271678X20972656","article-title":"Intravenously Delivered Multilineage-Differentiating Stress Enduring Cells Dampen Excessive Glutamate Metabolism and Microglial Activation in Experimental Perinatal Hypoxic Ischemic Encephalopathy","volume":"41","author":"Suzuki","year":"2021","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3389\/fendo.2017.00343","article-title":"T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes","volume":"8","author":"Burrack","year":"2017","journal-title":"Front. Endocrinol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-4-431-56847-6_6","article-title":"Immunomodulatory Properties and Potential Therapeutic Benefits of Muse Cells Administration in Diabetes","volume":"1103","author":"Perone","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"146","DOI":"10.5966\/sctm.2014-0181","article-title":"Therapeutic Potential of Adipose-Derived SSEA-3-Positive Muse Cells for Treating Diabetic Skin Ulcers","volume":"4","author":"Kinoshita","year":"2015","journal-title":"Stem Cells Transl. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3389\/fncel.2016.00098","article-title":"Inflammogenesis of Secondary Spinal Cord Injury","volume":"10","author":"Anwar","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Anjum, A., Yazid, M.D., Fauzi Daud, M., Idris, J., Ng, A.M.H., Selvi Naicker, A., Ismail, O.H.R., Athi Kumar, R.K., and Lokanathan, Y. (2020). Spinal Cord Injury: Pathophysiology, Multimolecular Interactions, and Underlying Recovery Mechanisms. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21207533"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bbrc.2021.06.070","article-title":"Human Muse Cells-Derived Neural Precursor Cells as the Novel Seed Cells for the Repair of Spinal Cord Injury","volume":"568","author":"Chen","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"648","DOI":"10.3171\/2020.7.SPINE20293","article-title":"Association of Intravenous Administration of Human Muse Cells with Deficit Amelioration in a Rat Model of Spinal Cord Injury","volume":"34","author":"Kajitani","year":"2021","journal-title":"J. Neurosurg. Spine"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/cbin.11255","article-title":"Study of the Protective Effect on Damaged Intestinal Epithelial Cells of Rat Multilineage-Differentiating Stress-Enduring (Muse) Cells","volume":"44","author":"Sun","year":"2020","journal-title":"Cell Biol. Int."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1177\/0963689718761657","article-title":"Human Multilineage-Differentiating Stress-Enduring Cells Exert Pleiotropic Effects to Ameliorate Acute Lung Ischemia-Reperfusion Injury in a Rat Model","volume":"27","author":"Yabuki","year":"2018","journal-title":"Cell Transplant."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1055\/s-0038-1676089","article-title":"Interstitial Cystitis\/Bladder Pain Syndrome","volume":"36","author":"Marcu","year":"2018","journal-title":"Semin. Reprod. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1007\/s00192-018-3592-8","article-title":"Bladder Wall Injection of Mesenchymal Stem Cells Ameliorates Bladder Inflammation, Overactivity, and Nociception in a Chemically Induced Interstitial Cystitis-like Rat Model","volume":"29","author":"Furuta","year":"2018","journal-title":"Int. Urogynecol. J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s00192-022-05166-w","article-title":"Effects of Human Muse Cells on Bladder Inflammation, Overactivity, and Nociception in a Chemically Induced Hunner-Type Interstitial Cystitis-like Rat Model","volume":"33","author":"Furuta","year":"2022","journal-title":"Int. Urogynecol. J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1053\/j.gastro.2018.11.082","article-title":"Acute Pancreatitis: A Multifaceted Set of Organelle and Cellular Interactions","volume":"156","author":"Habtezion","year":"2019","journal-title":"Gastroenterology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00595-021-02382-7","article-title":"Intravenous Injection of Human Multilineage-Differentiating Stress-Enduring Cells Alleviates Mouse Severe Acute Pancreatitis without Immunosuppressants","volume":"52","author":"Fukase","year":"2022","journal-title":"Surg. Today"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s11748-015-0576-1","article-title":"PPAR-\u03b3 Agonist Attenuates Inflammation in Aortic Aneurysm Patients","volume":"63","author":"Motoki","year":"2015","journal-title":"Gen. Thorac. Cardiovasc. Surg."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/978-4-431-56847-6_15","article-title":"Muse Cells and Aortic Aneurysm","volume":"Volume 1103","author":"Dezawa","year":"2018","journal-title":"Muse Cells"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1016\/j.jtcvs.2018.01.098","article-title":"Intravenously Injected Human Multilineage-Differentiating Stress-Enduring Cells Selectively Engraft into Mouse Aortic Aneurysms and Attenuate Dilatation by Differentiating into Multiple Cell Types","volume":"155","author":"Hosoyama","year":"2018","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/j.1478-3231.2011.02530.x","article-title":"Use of Hepatocyte and Stem Cells for Treatment of Post-Resectional Liver Failure: Are We There Yet?","volume":"31","author":"Ezzat","year":"2011","journal-title":"Liver Int."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1007\/s00595-020-02117-0","article-title":"The Evaluation of the Safety and Efficacy of Intravenously Administered Allogeneic Multilineage-Differentiating Stress-Enduring Cells in a Swine Hepatectomy Model","volume":"51","author":"Iseki","year":"2021","journal-title":"Surg. Today"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/978-4-431-56847-6_11","article-title":"Application of Muse Cell Therapy for Kidney Diseases","volume":"1103","author":"Uchida","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1681\/ASN.2016070775","article-title":"Beneficial Effects of Systemically Administered Human Muse Cells in Adriamycin Nephropathy","volume":"28","author":"Uchida","year":"2017","journal-title":"J. Am. Soc. Nephrol. JASN"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e528","DOI":"10.1111\/jdv.17201","article-title":"Intravenous Allogeneic Multilineage-Differentiating Stress-Enduring Cells in Adults with Dystrophic Epidermolysis Bullosa: A Phase 1\/2 Open-Label Study","volume":"35","author":"Fujita","year":"2021","journal-title":"J. Eur. Acad. Dermatol. Venereol. 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