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This study investigated the prognostic impact of circulating \u03b3\u03b4 T-cell alterations using high-dimensional analysis in a cohort of newly diagnosed adult ALL patients (10 B-ALL; 9 Philadelphia+ ALL; 9 T-ALL). Our analysis revealed common alterations in CD8+ T cells and \u03b3\u03b4 T cells of relapsed patients, including accumulation of early stage differentiation and increased expression of BTLA and CD73. We demonstrated that the circulating \u03b3\u03b4 T-cell signature was the most discriminating between relapsed and disease-free groups. In addition, V\u03b42 T-cell alterations strongly discriminated patients by relapse status. Taken together, these data highlight the role of \u0263\u03b4 T cells in adult ALL patients, among whom V\u03b42 T cells may be a pivotal contributor to T-cell immunity in ALL. Our findings provide a strong rationale for further monitoring and potentiating V\u03b42 T cells in ALL, including in the autologous setting.<\/jats:p>","DOI":"10.3390\/cells12131693","type":"journal-article","created":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T01:54:56Z","timestamp":1687485296000},"page":"1693","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prognostic Immune Effector Signature in Adult Acute Lymphoblastic Leukemia Patients Is Dominated by \u03b3\u03b4 T Cells"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2605-4145","authenticated-orcid":false,"given":"Anne-Charlotte","family":"Le Floch","sequence":"first","affiliation":[{"name":"Equipe Immunit\u00e9 et Cancer, Centre de Recherche en Canc\u00e9rologie de Marseille (CRCM), INSERM U1068, CNRS UMR7258, Institut Paoli-Calmettes, Aix-Marseille Universit\u00e9, UM 105, 13009 Marseille, 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