{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:12:19Z","timestamp":1792033939216,"version":"4.4.0"},"reference-count":63,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016991","name":"Universidad de Guadalajara","doi-asserted-by":"publisher","award":["269639-PROSNI"],"award-info":[{"award-number":["269639-PROSNI"]}],"id":[{"id":"10.13039\/100016991","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016991","name":"Universidad de Guadalajara","doi-asserted-by":"publisher","award":["PROINPEP 2021"],"award-info":[{"award-number":["PROINPEP 2021"]}],"id":[{"id":"10.13039\/100016991","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016991","name":"Universidad de Guadalajara","doi-asserted-by":"publisher","award":["2019-552265"],"award-info":[{"award-number":["2019-552265"]}],"id":[{"id":"10.13039\/100016991","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016991","name":"Universidad de Guadalajara","doi-asserted-by":"publisher","award":["269639-PROSNI"],"award-info":[{"award-number":["269639-PROSNI"]}],"id":[{"id":"10.13039\/100016991","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016991","name":"Universidad de Guadalajara","doi-asserted-by":"publisher","award":["PROINPEP 2021"],"award-info":[{"award-number":["PROINPEP 2021"]}],"id":[{"id":"10.13039\/100016991","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016991","name":"Universidad de Guadalajara","doi-asserted-by":"publisher","award":["2019-552265"],"award-info":[{"award-number":["2019-552265"]}],"id":[{"id":"10.13039\/100016991","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"CONACyT-Mexico Grant Ciencia de Frontera","doi-asserted-by":"publisher","award":["269639-PROSNI"],"award-info":[{"award-number":["269639-PROSNI"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"CONACyT-Mexico Grant Ciencia de Frontera","doi-asserted-by":"publisher","award":["PROINPEP 2021"],"award-info":[{"award-number":["PROINPEP 2021"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"CONACyT-Mexico Grant Ciencia de Frontera","doi-asserted-by":"publisher","award":["2019-552265"],"award-info":[{"award-number":["2019-552265"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>During embryonic and fetal development, the cerebellum undergoes several histological changes that require a specific microenvironment. Pleiotrophin (PTN) has been related to cerebral and cerebellar cortex ontogenesis in different species. PTN signaling includes PTPRZ1, ALK, and NRP-1 receptors, which are implicated in cell differentiation, migration, and proliferation. However, its involvement in human cerebellar development has not been described so far. Therefore, we investigated whether PTN and its receptors were expressed in the human cerebellar cortex during fetal and early neonatal development. The expression profile of PTN and its receptors was analyzed using an immunohistochemical method. PTN, PTPRZ1, and NRP-1 were expressed from week 17 to the postnatal stage, with variable expression among granule cell precursors, glial cells, and Purkinje cells. ALK was only expressed during week 31. These results suggest that, in the fetal and neonatal human cerebellum, PTN is involved in cell communication through granule cell precursors, Bergmann glia, and Purkinje cells via PTPRZ1, NRP-1, and ALK signaling. This communication could be involved in cell proliferation and cellular migration. Overall, the present study represents the first characterization of PTN, PTPRZ1, ALK, and NRP-1 expression in human tissues, suggesting their involvement in cerebellar cortex development.<\/jats:p>","DOI":"10.3390\/cells12131733","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:33:07Z","timestamp":1687912387000},"page":"1733","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Pleiotrophin and the Expression of Its Receptors during Development of the Human Cerebellar Cortex"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2843-7821","authenticated-orcid":false,"given":"Margarita Belem","family":"Santana-Bejarano","sequence":"first","affiliation":[{"name":"Laboratorio de Patolog\u00eda Diagn\u00f3stica e Inmunohistoqu\u00edmica, Centro de Investigaci\u00f3n y Diagn\u00f3stico en Patolog\u00eda, Departamento de Microbiolog\u00eda y Patolog\u00eda, CUCS, Universidad de Guadalajara, Guadalajara 44340, Mexico"},{"name":"Doctorado en Ciencias en Biolog\u00eda Molecular en Medicina, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Romina","family":"Grosso-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Laboratorio de Patolog\u00eda Diagn\u00f3stica e Inmunohistoqu\u00edmica, Centro de Investigaci\u00f3n y Diagn\u00f3stico en Patolog\u00eda, Departamento de Microbiolog\u00eda y Patolog\u00eda, CUCS, Universidad de Guadalajara, Guadalajara 44340, Mexico"},{"name":"Departamento de Anatom\u00eda Patol\u00f3gica, Centro M\u00e9dico Nacional de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Graciela","family":"Puebla-Mora","sequence":"additional","affiliation":[{"name":"Laboratorio de Patolog\u00eda Diagn\u00f3stica e Inmunohistoqu\u00edmica, Centro de Investigaci\u00f3n y Diagn\u00f3stico en Patolog\u00eda, Departamento de Microbiolog\u00eda y Patolog\u00eda, CUCS, Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Guadalupe","family":"Mart\u00ednez-Silva","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda Patol\u00f3gica, Centro M\u00e9dico Nacional de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9692-8521","authenticated-orcid":false,"given":"Mario","family":"Nava-Villalba","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n y Diagn\u00f3stico en Patolog\u00eda, Departamento de Microbiolog\u00eda y Patolog\u00eda, CUCS, Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5662-9076","authenticated-orcid":false,"given":"Ana Laura","family":"M\u00e1rquez-Aguirre","sequence":"additional","affiliation":[{"name":"Unidad de Biotecnolog\u00eda M\u00e9dica y Farmac\u00e9utica, Centro de Investigaci\u00f3n y Asistencia en Tecnolog\u00eda y Dise\u00f1o del Estado de Jalisco A.C. (CIATEJ), Guadalajara 44270, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7443-2514","authenticated-orcid":false,"given":"Daniel","family":"Ortu\u00f1o-Sahag\u00fan","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuroinmunobiolog\u00eda Molecular, Instituto de Investigaci\u00f3n en Ciencias Biom\u00e9dicas (IICB), CUCS, Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6779-1017","authenticated-orcid":false,"given":"Marisol","family":"God\u00ednez-Rub\u00ed","sequence":"additional","affiliation":[{"name":"Laboratorio de Patolog\u00eda Diagn\u00f3stica e Inmunohistoqu\u00edmica, Centro de Investigaci\u00f3n y Diagn\u00f3stico en Patolog\u00eda, Departamento de Microbiolog\u00eda y Patolog\u00eda, CUCS, Universidad de Guadalajara, Guadalajara 44340, Mexico"},{"name":"Departamento de Morfolog\u00eda, CUCS, Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Haldipur, P., Bharti, U., Alberti, C., Sarkar, C., Gulati, G., Iyengar, S., Gressens, P., and Mani, S. 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