{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:12:35Z","timestamp":1788883955117,"version":"build-2803163510"},"reference-count":138,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204794"],"award-info":[{"award-number":["82204794"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["202002070917"],"award-info":[{"award-number":["202002070917"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2020Q003"],"award-info":[{"award-number":["2020Q003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical and Health Technology Program of Shandong Province","award":["82204794"],"award-info":[{"award-number":["82204794"]}]},{"name":"Medical and Health Technology Program of Shandong Province","award":["202002070917"],"award-info":[{"award-number":["202002070917"]}]},{"name":"Medical and Health Technology Program of Shandong Province","award":["2020Q003"],"award-info":[{"award-number":["2020Q003"]}]},{"name":"Shandong Province Traditional Chinese Medicine Science and Technology Project","award":["82204794"],"award-info":[{"award-number":["82204794"]}]},{"name":"Shandong Province Traditional Chinese Medicine Science and Technology Project","award":["202002070917"],"award-info":[{"award-number":["202002070917"]}]},{"name":"Shandong Province Traditional Chinese Medicine Science and Technology Project","award":["2020Q003"],"award-info":[{"award-number":["2020Q003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Depression is a common neuropsychiatric disorder with long-term recurrent depressed mood, pain and despair, pessimism and anxiety, and even suicidal tendencies as the main symptoms. Depression usually induces or aggravates the development of other related diseases, such as sleep disorders and endocrine disorders. In today\u2019s society, the incidence of depression is increasing worldwide, and its pathogenesis is complex and generally believed to be related to genetic, psychological, environmental, and biological factors. Current studies have shown the key role of glial cells in the development of depression, and it is noteworthy that some recent evidence suggests that the development of depression may be closely related to viral infections, such as SARS-CoV-2, BoDV-1, ZIKV, HIV, and HHV6, which infect the organism and cause some degree of glial cells, such as astrocytes, oligodendrocytes, and microglia. This can affect the transmission of related proteins, neurotransmitters, and cytokines, which in turn leads to neuroinflammation and depression. Based on the close relationship between viruses and depression, this paper provides an in-depth analysis of the new mechanism of virus-induced depression, which is expected to provide a new perspective on the mechanism of depression and a new idea for the diagnosis of depression in the future.<\/jats:p>","DOI":"10.3390\/cells12131767","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T01:32:18Z","timestamp":1688434338000},"page":"1767","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Exploring New Mechanism of Depression from the Effects of Virus on Nerve Cells"],"prefix":"10.3390","volume":"12","author":[{"given":"Xinxin","family":"Yu","sequence":"first","affiliation":[{"name":"College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzheng","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyuan","family":"Chang","sequence":"additional","affiliation":[{"name":"College of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pufan","family":"Shan","sequence":"additional","affiliation":[{"name":"College of Acupuncture and Tuina, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Nursing, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,3]]},"reference":[{"key":"ref_1","first-page":"804","article-title":"Development of researches on mechanisms of acupuncture underling improvement of depression","volume":"46","author":"Zang","year":"2021","journal-title":"Zhen Ci Yan Jiu"},{"key":"ref_2","first-page":"37","article-title":"Depression: The fourth most common disorder in the world","volume":"30","author":"Yan","year":"2014","journal-title":"New People\u2019s Wkly."},{"key":"ref_3","first-page":"10","article-title":"The etiology and pathogenesis of depression","volume":"12","author":"Chen","year":"2014","journal-title":"China Mod. 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