{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T10:35:01Z","timestamp":1771670101601,"version":"3.50.1"},"reference-count":41,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:00:00Z","timestamp":1688515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deutsche Forschungsgemeinschaft (German Research Foundation, DFG)","award":["239283807\u2014TRR-152 (P23, P15)"],"award-info":[{"award-number":["239283807\u2014TRR-152 (P23, P15)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Magnesium is an essential mediator of a vast number of critical enzymatic cellular reactions in the human body. Some clinical epidemiological studies suggest that hypomagnesemia accounts for declines in insulin secretion in patients with type 2 diabetes (T2D); however, the results of various experimental studies do not support this notion. To address this discrepancy, we assessed the short- and long-term effects of hypomagnesemia on \u03b2-cell function and insulin secretion in primary mouse islets of Langerhans and in a mouse model of hypomagnesemia known as Trpm6\u039417 \/fl;Villin1-Cre mice. We found that lowering the extracellular Mg2+ concentration from 1.2 mM to either 0.6 or 0.1 mM remarkably increased glucose-induced insulin secretion (GIIS) in primary islets isolated from C57BL\/6 mice. Similarly, both the plasma insulin levels and GIIS rose in isolated islets of Trpm6\u039417 \/fl;Villin1-Cre mice. We attribute these rises to augmented increases in intracellular Ca2+ oscillations in pancreatic \u03b2-cells. However, the glycemic metabolic profile was not impaired in Trpm6\u039417 \/fl;Villin1-Cre mice, suggesting that chronic hypomagnesemia does not lead to insulin resistance. Collectively, the results of this study suggest that neither acute nor chronic Mg2+ deficiency suppresses glucose-induced rises in insulin secretion. Even though hypomagnesemia can be symptomatic of T2D, such deficiency may not account for declines in insulin release in this disease.<\/jats:p>","DOI":"10.3390\/cells12131790","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:34:30Z","timestamp":1688603670000},"page":"1790","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Chronic Mg2+ Deficiency Does Not Impair Insulin Secretion in Mice"],"prefix":"10.3390","volume":"12","author":[{"given":"Noushafarin","family":"Khajavi","sequence":"first","affiliation":[{"name":"Walther Straub Institute of Pharmacology and Toxicology, LMU Munich, 80539 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klea","family":"Ri\u00e7ku","sequence":"additional","affiliation":[{"name":"Walther Straub Institute of Pharmacology and Toxicology, LMU Munich, 80539 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale C. F.","family":"Schreier","sequence":"additional","affiliation":[{"name":"Walther Straub Institute of Pharmacology and Toxicology, LMU Munich, 80539 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Gentz","sequence":"additional","affiliation":[{"name":"Walther Straub Institute of Pharmacology and Toxicology, LMU Munich, 80539 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1722-4919","authenticated-orcid":false,"given":"Philipp","family":"Beyerle","sequence":"additional","affiliation":[{"name":"Walther Straub Institute of Pharmacology and Toxicology, LMU Munich, 80539 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Cruz","sequence":"additional","affiliation":[{"name":"Walther Straub Institute of Pharmacology and Toxicology, LMU Munich, 80539 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Breit","sequence":"additional","affiliation":[{"name":"Walther Straub Institute of Pharmacology and Toxicology, LMU Munich, 80539 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter S.","family":"Reinach","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Wenzhou Medical University, Wenzhou 325015, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Gudermann","sequence":"additional","affiliation":[{"name":"Walther Straub Institute of Pharmacology and Toxicology, LMU Munich, 80539 Munich, Germany"},{"name":"German Center for Lung Research, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,5]]},"reference":[{"key":"ref_1","first-page":"307","article-title":"Type 2 diabetes control and complications and their relation to serum magnesium level","volume":"18","author":"Alswat","year":"2022","journal-title":"Arch. 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