{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:04:59Z","timestamp":1790697899632,"version":"4.1.0"},"reference-count":232,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Semmelweis University","award":["2020\u20144.1.1.-TKP2020"],"award-info":[{"award-number":["2020\u20144.1.1.-TKP2020"]}]},{"name":"Semmelweis University","award":["K135076"],"award-info":[{"award-number":["K135076"]}]},{"name":"National Research, Development, and Innovation Office (NKFIH) of Hungary","award":["2020\u20144.1.1.-TKP2020"],"award-info":[{"award-number":["2020\u20144.1.1.-TKP2020"]}]},{"name":"National Research, Development, and Innovation Office (NKFIH) of Hungary","award":["K135076"],"award-info":[{"award-number":["K135076"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>This review discusses the evolving topic of atrial cardiomyopathy concerning valvular heart disease. The pathogenesis of atrial cardiomyopathy involves multiple factors, such as valvular disease leading to atrial structural and functional remodeling due to pressure and volume overload. Atrial enlargement and dysfunction can trigger atrial tachyarrhythmia. The complex interaction between valvular disease and atrial cardiomyopathy creates a vicious cycle of aggravating atrial enlargement, dysfunction, and valvular disease severity. Furthermore, atrial remodeling and arrhythmia can predispose to atrial thrombus formation and stroke. The underlying pathomechanism of atrial myopathy involves molecular, cellular, and subcellular alterations resulting in chronic inflammation, atrial fibrosis, and electrophysiological changes. Atrial dysfunction has emerged as an essential determinant of outcomes in valvular disease and heart failure. Despite its predictive value, the detection of atrial fibrosis and dysfunction is challenging and is not included in the clinical routine. Transthoracic echocardiography and cardiac magnetic resonance imaging are the main diagnostic tools for atrial cardiomyopathy. Recently published data have revealed that both left atrial volumes and functional parameters are independent predictors of cardiovascular events in valvular disease. The integration of atrial function assessment in clinical practice might help in early cardiovascular risk estimation, promoting early therapeutic intervention in valvular disease.<\/jats:p>","DOI":"10.3390\/cells12131796","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T02:28:46Z","timestamp":1688696926000},"page":"1796","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Atrial Cardiomyopathy in Valvular Heart Disease: From Molecular Biology to Clinical Perspectives"],"prefix":"10.3390","volume":"12","author":[{"given":"Andrea \u00c1gnes","family":"Moln\u00e1r","sequence":"first","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"S\u00e1nta","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorottya T\u00edmea","family":"P\u00e1sztor","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9la","family":"Merkely","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/europace\/euac062","article-title":"Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: The 8th AFNET\/EHRA consensus conference","volume":"25","author":"Schnabel","year":"2023","journal-title":"Europace"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1007\/s12265-019-09936-8","article-title":"The Effects of Valvular Heart Disease on Atrial Conduction During Sinus Rhythm","volume":"13","author":"Lanters","year":"2020","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1093\/ehjci\/jeac009","article-title":"Tricuspid regurgitation: Recent advances in understanding pathophysiology, severity grading and outcome","volume":"23","author":"Hahn","year":"2022","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1016\/j.jacc.2019.02.061","article-title":"Atrial Functional Mitral Regurgitation: JACC Review Topic of the Week","volume":"73","author":"Deferm","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.tcm.2014.12.015","article-title":"Atrial remodeling, fibrosis, and atrial fibrillation","volume":"25","author":"Jalife","year":"2015","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1002\/ehf2.14089","article-title":"Atrial cardiomyopathy: From cell to bedside","volume":"9","author":"Li","year":"2022","journal-title":"ESC Heart Fail."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1093\/europace\/euw161","article-title":"EHRA\/HRS\/APHRS\/SOLAECE expert consensus on atrial cardiomyopathies: Definition, characterization, and clinical implication","volume":"18","author":"Goette","year":"2016","journal-title":"Europace"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1177\/01926233221097970","article-title":"Comparison of ANP and BNP Granular Density in Atria of Rats After Physiological and Pathological Hypertrophy","volume":"50","author":"Agostinucci","year":"2022","journal-title":"Toxicol. Pathol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1161\/01.CIR.87.2.464","article-title":"Different secretion patterns of atrial natriuretic peptide and brain natriuretic peptide in patients with congestive heart failure","volume":"87","author":"Yoshimura","year":"1993","journal-title":"Circulation"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1111\/j.1742-4658.2011.08082.x","article-title":"Natriuretic peptide metabolism, clearance and degradation","volume":"278","author":"Potter","year":"2011","journal-title":"FEBS J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.peptides.2018.05.012","article-title":"Atrial and brain natriuretic peptides: Hormones secreted from the heart","volume":"111","author":"Nakagawa","year":"2019","journal-title":"Peptides"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1056\/NEJM199807303390507","article-title":"Natriuretic peptides","volume":"339","author":"Levin","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1161\/01.CIR.90.1.195","article-title":"Localization and mechanism of secretion of B-type natriuretic peptide in comparison with those of A-type natriuretic peptide in normal subjects and patients with heart failure","volume":"90","author":"Yasue","year":"1994","journal-title":"Circulation"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0140-6736(90)90925-U","article-title":"Human brain natriuretic peptide, a novel cardiac hormone","volume":"335","author":"Mukoyama","year":"1990","journal-title":"Lancet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1042\/CS20150469","article-title":"The natriuretic peptides system in the pathophysiology of heart failure: From molecular basis to treatment","volume":"130","author":"Volpe","year":"2016","journal-title":"Clin. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.cardiores.2005.10.001","article-title":"The role of natriuretic peptides in cardioprotection","volume":"69","author":"Nishikimi","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jacep.2017.03.002","article-title":"Molecular and Cellular Mechanisms of Atrial Fibrosis in Atrial Fibrillation","volume":"3","author":"Nattel","year":"2017","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Sygitowicz, G., Maciejak-Jastrz\u0119bska, A., and Sitkiewicz, D. (2021). A Review of the Molecular Mechanisms Underlying Cardiac Fibrosis and Atrial Fibrillation. J. Clin. Med., 10.","DOI":"10.3390\/jcm10194430"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"6312100","DOI":"10.1155\/2022\/6312100","article-title":"Angiotensin II Mediates Cardiomyocyte Hypertrophy in Atrial Cardiomyopathy via Epigenetic Transcriptional Regulation","volume":"2022","author":"Zheng","year":"2022","journal-title":"Comput. Math. Methods Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1089\/ars.2012.4604","article-title":"Angiotensin II-induced production of mitochondrial reactive oxygen species: Potential mechanisms and relevance for cardiovascular disease","volume":"19","author":"Dikalov","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.jacc.2007.09.064","article-title":"Atrial fibrosis: Mechanisms and clinical relevance in atrial fibrillation","volume":"51","author":"Burstein","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4469","DOI":"10.1529\/biophysj.108.136473","article-title":"Electrotonic myofibroblast-to-myocyte coupling increases propensity to reentrant arrhythmias in two-dimensional cardiac monolayers","volume":"95","author":"Zlochiver","year":"2008","journal-title":"Biophys. J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.mayocp.2020.11.005","article-title":"Atrial Fibrillation and Endothelial Dysfunction: A Potential Link?","volume":"96","author":"Corban","year":"2021","journal-title":"Mayo Clin. Proc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/hrt.2007.135277","article-title":"Endothelial dysfunction and pathophysiological correlates in atrial fibrillation","volume":"95","author":"Guazzi","year":"2009","journal-title":"Heart"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1253\/circj.66.583","article-title":"Impaired exercise-induced vasodilatation in chronic atrial fibrillation--role of endothelium-derived nitric oxide","volume":"66","author":"Takahashi","year":"2002","journal-title":"Circ. J."},{"key":"ref_26","first-page":"465","article-title":"Associations of big endothelin-1 and C-reactive protein in atrial fibrillation","volume":"13","author":"Zheng","year":"2016","journal-title":"J. Geriatr. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.jacc.2013.10.055","article-title":"Left atrial size and function: Role in prognosis","volume":"63","author":"Hoit","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1007\/s10554-018-1368-3","article-title":"Association with right atrial strain with right atrial pressure: An invasive validation study","volume":"34","author":"Wright","year":"2018","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Moln\u00e1r, A., and Merkely, B. (2022). The Added Value of Atrial Strain Assessment in Clinical Practice. Diagnostics, 12.","DOI":"10.3390\/diagnostics12040982"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1016\/j.jacc.2007.09.021","article-title":"Natriuretic peptides","volume":"50","author":"Daniels","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/ejhf.1494","article-title":"Heart Failure Association of the European Society of Cardiology practical guidance on the use of natriuretic peptide concentrations","volume":"21","author":"Mueller","year":"2019","journal-title":"Eur. J. Heart Fail."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1042\/cs0830437","article-title":"Plasma concentrations and comparisons of brain natriuretic peptide and atrial natriuretic peptide in normal subjects, cardiac transplant recipients and patients with dialysis-independent or dialysis-dependent chronic renal failure","volume":"83","author":"Buckley","year":"1992","journal-title":"Clin. Sci."},{"key":"ref_34","first-page":"832","article-title":"Assay of brain natriuretic peptide (BNP) in human plasma: Evidence for high molecular weight BNP as a major plasma component in heart failure","volume":"76","author":"Yandle","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0022-2143(99)90163-4","article-title":"Review of 10 years of the clinical use of brain natriuretic peptide in cardiology","volume":"134","author":"Valli","year":"1999","journal-title":"J. Lab. Clin. Med."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Fonseca, A.C., and Coelho, P. (2021). Update on Biomarkers Associated to Cardioembolic Stroke: A Narrative Review. Life, 11.","DOI":"10.3390\/life11050448"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.amjcard.2011.06.057","article-title":"Reference limits for N-terminal-pro-B-type natriuretic peptide in healthy individuals (from the Framingham Heart Study)","volume":"108","author":"Fradley","year":"2011","journal-title":"Am. J. Cardiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e009427","DOI":"10.1161\/CIRCHEARTFAILURE.121.009427","article-title":"Reference Ranges for NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) and Risk Factors for Higher NT-proBNP Concentrations in a Large General Population Cohort","volume":"15","author":"Welsh","year":"2022","journal-title":"Circ. Heart Fail."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/ehf2.12150","article-title":"Comparative accuracy of NT-proBNP and MR-proANP for the diagnosis of acute heart failure in dyspnoeic patients","volume":"4","author":"Darche","year":"2017","journal-title":"ESC Heart Fail."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jchf.2016.10.005","article-title":"Atrial Fibrillation in Heart Failure with Preserved Ejection Fraction: Association With Exercise Capacity, Left Ventricular Filling Pressures, Natriuretic Peptides, and Left Atrial Volume","volume":"5","author":"Lam","year":"2017","journal-title":"JACC Heart Fail."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.jacc.2010.02.071","article-title":"Midregional pro-atrial natriuretic peptide and outcome in patients with acute ischemic stroke","volume":"56","author":"Katan","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1177\/0300060518786907","article-title":"Midregional pro-atrial natriuretic peptide, an important member of the natriuretic peptide family: Potential role in diagnosis and prognosis of cardiovascular disease","volume":"46","author":"Idzikowska","year":"2018","journal-title":"J. Int. Med. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1373\/clinchem.2003.021204","article-title":"Immunoluminometric assay for the midregion of pro-atrial natriuretic peptide in human plasma","volume":"50","author":"Morgenthaler","year":"2004","journal-title":"Clin. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1136\/heartjnl-2012-302260","article-title":"Direct comparison of mid-regional pro-atrial natriuretic peptide with N-terminal pro B-type natriuretic peptide in the diagnosis of patients with atrial fibrillation and dyspnoea","volume":"98","author":"Eckstein","year":"2012","journal-title":"Heart"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jchf.2013.02.004","article-title":"Atrial fibrillation impairs the diagnostic performance of cardiac natriuretic peptides in dyspneic patients: Results from the BACH Study (Biomarkers in ACute Heart Failure)","volume":"1","author":"Richards","year":"2013","journal-title":"JACC Heart Fail."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0002-9149(91)90045-M","article-title":"Atrial natriuretic peptide response to cardioversion of atrial flutter and fibrillation and role of associated heart failure","volume":"67","author":"Mookherjee","year":"1991","journal-title":"Am. J. Cardiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.clinbiochem.2011.08.906","article-title":"Mid-regional pro atrial natriuretic peptide allows the accurate identification of patients with atrial fibrillation of short time of onset: A pilot study","volume":"44","author":"Meune","year":"2011","journal-title":"Clin. Biochem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e12277","DOI":"10.1097\/MD.0000000000012277","article-title":"Midregional pro-atrial natriuretic peptide is a superior biomarker to N-terminal pro-B-type natriuretic peptide in the diagnosis of heart failure patients with preserved ejection fraction","volume":"97","author":"Cui","year":"2018","journal-title":"Medicine"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"413","DOI":"10.5603\/CJ.a2022.0012","article-title":"Predictors of left atrial fibrosis in patients with atrial fibrillation referred for catheter ablation","volume":"29","author":"Rossi","year":"2022","journal-title":"Cardiol. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1161\/hc0602.103639","article-title":"Altered expression of ADAMs (A Disintegrin And Metalloproteinase) in fibrillating human atria","volume":"105","author":"Arndt","year":"2002","journal-title":"Circulation"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.yjmcc.2013.11.017","article-title":"Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE\/ADAM-17: A positive feedback mechanism in the RAS","volume":"66","author":"Patel","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3109\/10409231003628015","article-title":"ADAM-17: The enzyme that does it all","volume":"45","author":"Gooz","year":"2010","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1161\/CIRCEP.107.754564","article-title":"Atrial remodeling and atrial fibrillation: Mechanisms and implications","volume":"1","author":"Nattel","year":"2008","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1161\/CIRCRESAHA.114.302226","article-title":"Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression","volume":"114","author":"Heijman","year":"2014","journal-title":"Circ. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12968-021-00820-6","article-title":"Impaired left atrial reservoir and conduit strain in patients with atrial fibrillation and extensive left atrial fibrosis","volume":"23","author":"Hopman","year":"2021","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/01.STR.22.8.983","article-title":"Atrial fibrillation as an independent risk factor for stroke: The Framingham Study","volume":"22","author":"Wolf","year":"1991","journal-title":"Stroke"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"D\u2019Alessandro, E., Winters, J., van Nieuwenhoven, F.A., Schotten, U., and Verheule, S. (2022). The Complex Relation between Atrial Cardiomyopathy and Thrombogenesis. Cells, 11.","DOI":"10.3390\/cells11192963"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0140-6736(09)60040-4","article-title":"Mechanisms of thrombogenesis in atrial fibrillation: Virchow\u2019s triad revisited","volume":"373","author":"Watson","year":"2009","journal-title":"Lancet"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1253\/circj.68.321","article-title":"Expression of the von Willebrand factor in atrial endocardium is increased in atrial fibrillation depending on the extent of structural remodeling","volume":"68","author":"Kumagai","year":"2004","journal-title":"Circ. J."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/hc0902.104353","article-title":"Inflammation and atherosclerosis","volume":"105","author":"Libby","year":"2002","journal-title":"Circulation"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1093\/eurheartj\/ehi350","article-title":"Inflammation in the genesis and perpetuation of atrial fibrillation","volume":"26","author":"Engelmann","year":"2005","journal-title":"Eur. Heart J."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/j.1368-5031.2005.0599b.x","article-title":"The role of inflammation in atrial fibrillation","volume":"59","author":"Boos","year":"2005","journal-title":"Int. J. Clin. Pract."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/eurheartj\/ehi645","article-title":"Is atrial fibrillation an inflammatory disorder?","volume":"27","author":"Boos","year":"2006","journal-title":"Eur. Heart J."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00380-004-0800-x","article-title":"C-reactive protein elevation predicts the occurrence of atrial structural remodeling in patients with paroxysmal atrial fibrillation","volume":"20","author":"Watanabe","year":"2005","journal-title":"Heart Vessel."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ijcard.2005.05.021","article-title":"High-sensitivity C-reactive protein is predictive of successful cardioversion for atrial fibrillation and maintenance of sinus rhythm after conversion","volume":"108","author":"Watanabe","year":"2006","journal-title":"Int. J. Cardiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"581","DOI":"10.2459\/JCM.0b013e3282f3524d","article-title":"C-reactive protein but not atrial dysfunction predicts recurrences of atrial fibrillation after cardioversion in patients with preserved left ventricular function","volume":"9","author":"Lombardi","year":"2008","journal-title":"J. Cardiovasc. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1016\/j.jacc.2006.12.042","article-title":"Association between C-reactive protein and recurrence of atrial fibrillation after successful electrical cardioversion: A meta-analysis","volume":"49","author":"Liu","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","article-title":"2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC","volume":"42","author":"Hindricks","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0735-1097(99)00489-1","article-title":"Stroke with intermittent atrial fibrillation: Incidence and predictors during aspirin therapy. Stroke Prevention in Atrial Fibrillation Investigators","volume":"35","author":"Hart","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"101414","DOI":"10.1016\/j.cpcardiol.2022.101414","article-title":"Mechanism and Prevention of Atrial Remodeling and Their Related Genes in Cardiovascular Disorders","volume":"48","author":"Sandeep","year":"2023","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/ana.24482","article-title":"Electrocardiographic left atrial abnormality and stroke subtype in the atherosclerosis risk in communities study","volume":"78","author":"Kamel","year":"2015","journal-title":"Ann. Neurol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1177\/1747493018799981","article-title":"The AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenic stroke randomized trial: Rationale and methods","volume":"14","author":"Kamel","year":"2019","journal-title":"Int. J. Stroke"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"914360","DOI":"10.3389\/fnagi.2022.914360","article-title":"Atrial cardiopathy and cognitive impairment","volume":"14","author":"Myers","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1161\/STROKEAHA.113.003433","article-title":"Detection of atrial fibrillation after ischemic stroke or transient ischemic attack: A systematic review and meta-analysis","volume":"45","author":"Kishore","year":"2014","journal-title":"Stroke"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1161\/CIRCULATIONAHA.111.029801","article-title":"Prolonged rhythm monitoring for the detection of occult paroxysmal atrial fibrillation in ischemic stroke of unknown cause","volume":"124","author":"Seet","year":"2011","journal-title":"Circulation"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1212\/WNL.0b013e31828f1828","article-title":"Incidence of atrial fibrillation detected by implantable loop recorders in unexplained stroke","volume":"80","author":"Cotter","year":"2013","journal-title":"Neurology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1056\/NEJMoa1313600","article-title":"Cryptogenic stroke and underlying atrial fibrillation","volume":"370","author":"Sanna","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"839398","DOI":"10.3389\/fneur.2022.839398","article-title":"Atrial Cardiopathy and Cryptogenic Stroke","volume":"13","author":"Kato","year":"2022","journal-title":"Front. Neurol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1001\/jama.2009.888","article-title":"Long-term outcomes in individuals with prolonged PR interval or first-degree atrioventricular block","volume":"301","author":"Cheng","year":"2009","journal-title":"JAMA"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1080\/14779072.2017.1355238","article-title":"Atrial cardiopathy: A mechanism of cryptogenic stroke","volume":"15","author":"Yaghi","year":"2017","journal-title":"Expert. Rev. Cardiovasc. Ther."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1161\/STROKEAHA.114.006364","article-title":"P-wave morphology and the risk of incident ischemic stroke in the Multi-Ethnic Study of Atherosclerosis","volume":"45","author":"Kamel","year":"2014","journal-title":"Stroke"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/0735-1097(94)00512-O","article-title":"Incidence of symptomatic atrial fibrillation in patients with paroxysmal supraventricular tachycardia","volume":"25","author":"Hamer","year":"1995","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jacc.2015.05.018","article-title":"Excessive Atrial Ectopy and Short Atrial Runs Increase the Risk of Stroke Beyond Incident Atrial Fibrillation","volume":"66","author":"Larsen","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0022-0736(83)80086-7","article-title":"The effect of left atrial histology and dimension on P wave morphology","volume":"16","author":"Scott","year":"1983","journal-title":"J. Electrocardiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1007\/s00330-022-08598-6","article-title":"The emerging role of atrial strain assessed by cardiac MRI in different cardiovascular settings: An up-to-date review","volume":"32","author":"Cau","year":"2022","journal-title":"Eur. Radiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.jcmg.2012.06.001","article-title":"Assessment of echocardiographic left atrial size: How accurate do we need to be?","volume":"5","author":"Hoit","year":"2012","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1093\/ehjci\/jet239","article-title":"Assessment of left atrial volume and function in patients with permanent atrial fibrillation: Comparison of cardiac magnetic resonance imaging, 320-slice multi-detector computed tomography, and transthoracic echocardiography","volume":"15","author":"Agner","year":"2014","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1161\/CIRCULATIONAHA.115.016795","article-title":"Evaluating the Atrial Myopathy Underlying Atrial Fibrillation: Identifying the Arrhythmogenic and Thrombogenic Substrate","volume":"132","author":"Goldberger","year":"2015","journal-title":"Circulation"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e13771","DOI":"10.1111\/ijcp.13771","article-title":"Atrial fibrillation pattern, left atrial diameter and risk of cardiovascular events and mortality. A prospective multicenter cohort study","volume":"75","author":"Menichelli","year":"2021","journal-title":"Int. J. Clin. Pract."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0735-1097(94)90025-6","article-title":"Prognostic implications of left artial spontaneous echo contrast in nonvalvular atrial fibrillation","volume":"24","author":"Leung","year":"1994","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.amjcard.2013.11.058","article-title":"Impact of increased orifice size and decreased flow velocity of left atrial appendage on stroke in nonvalvular atrial fibrillation","volume":"113","author":"Lee","year":"2014","journal-title":"Am. J. Cardiol."},{"key":"ref_93","first-page":"100190","article-title":"Interatrial septum as a possible source of thromboembolic events","volume":"27","author":"Dudkiewicz","year":"2022","journal-title":"Transl. Res. Anat."},{"key":"ref_94","first-page":"e61240","article-title":"Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure","volume":"180","author":"Merkely","year":"2022","journal-title":"J. Vis. Exp."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.echo.2015.05.015","article-title":"Guidelines for the Echocardiographic Assessment of Atrial Septal Defect and Patent Foramen Ovale: From the American Society of Echocardiography and Society for Cardiac Angiography and Interventions","volume":"28","author":"Silvestry","year":"2015","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ijcard.2016.06.141","article-title":"Atrial septal pouch-Morphological features and clinical considerations","volume":"220","author":"Koziej","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.echo.2021.07.016","article-title":"Patent Foramen Ovale Channel Morphometric Characteristics Associated with Cryptogenic Stroke: The MorPFO Score","volume":"34","author":"Koziej","year":"2021","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"e364","DOI":"10.1161\/STR.0000000000000375","article-title":"2021 Guideline for the Prevention of Stroke in Patients with Stroke and Transient Ischemic Attack: A Guideline from the American Heart Association\/American Stroke Association","volume":"52","author":"Kleindorfer","year":"2021","journal-title":"Stroke"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.echo.2010.02.015","article-title":"Assessment of Myocardial Mechanics Using Speckle Tracking Echocardiography: Fundamentals and Clinical Applications","volume":"23","author":"Geyer","year":"2010","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/ehjci\/jey042","article-title":"Standardization of left atrial, right ventricular, and right atrial deformation imaging using two-dimensional speckle tracking echocardiography: A consensus document of the EACVI\/ASE\/Industry Task Force to standardize deformation imaging","volume":"19","author":"Badano","year":"2018","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/ehjci\/jeab201","article-title":"Normal values and reference ranges for left atrial strain by speckle-tracking echocardiography: The Copenhagen City Heart Study","volume":"23","author":"Nielsen","year":"2021","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.echo.2016.09.007","article-title":"Normal Ranges of Left Atrial Strain by Speckle-Tracking Echocardiography: A Systematic Review and Meta-Analysis","volume":"30","author":"Pathan","year":"2017","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e006077","DOI":"10.1161\/CIRCIMAGING.116.006077","article-title":"Age, Sex, and Blood Pressure-Related Influences on Reference Values of Left Atrial Deformation and Mechanics from a Large-Scale Asian Population","volume":"10","author":"Liao","year":"2017","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1111\/echo.14174","article-title":"In-depth echocardiographic analysis of left atrial function in healthy adults using speckle tracking echocardiography and volumetric analysis","volume":"35","author":"Strachinaru","year":"2018","journal-title":"Echocardiography"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1093\/ehjci\/jey018","article-title":"Echocardiographic reference ranges for normal left atrial function parameters: Results from the EACVI NORRE study","volume":"19","author":"Sugimoto","year":"2018","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"247865","DOI":"10.1155\/2015\/247865","article-title":"The Role of Magnetic Resonance Imaging and Cardiac Computed Tomography in the Assessment of Left Atrial Anatomy, Size, and Function","volume":"2015","author":"Kuchynka","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Fredgart, M.H., Lindholt, J.S., Brandes, A., Steffensen, F.H., Frost, L., Lambrechtsen, J., Karon, M., Busk, M., Urbonaviciene, G., and Egstrup, K. (2022). Association of Left Atrial Size Measured by Non-Contrast Computed Tomography with Cardiovascular Risk Factors-The Danish Cardiovascular Screening Trial (DANCAVAS). Diagnostics, 12.","DOI":"10.3390\/diagnostics12020244"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ijcard.2020.12.029","article-title":"Prognostic importance of left atrial size measured by non-contrast cardiac computed tomography-A DANCAVAS study","volume":"328","author":"Fredgart","year":"2021","journal-title":"Int. J. Cardiol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jcct.2022.01.003","article-title":"Reproducibility of 4D cardiac computed tomography feature tracking myocardial strain and comparison against speckle-tracking echocardiography in patients with severe aortic stenosis","volume":"16","author":"Bernhard","year":"2022","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/ehjci\/jeab166","article-title":"Comparison of left atrial strain measured by feature tracking computed tomography and speckle tracking echocardiography in patients with aortic stenosis","volume":"23","author":"Hirasawa","year":"2021","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1161\/CIRCULATIONAHA.108.811877","article-title":"Detection and quantification of left atrial structural remodeling with delayed-enhancement magnetic resonance imaging in patients with atrial fibrillation","volume":"119","author":"Oakes","year":"2009","journal-title":"Circulation"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1161\/CIRCIMAGING.109.865683","article-title":"Left atrial strain and strain rate in patients with paroxysmal and persistent atrial fibrillation: Relationship to left atrial structural remodeling detected by delayed-enhancement MRI","volume":"3","author":"Kuppahally","year":"2010","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1001\/jama.2014.3","article-title":"Association of atrial tissue fibrosis identified by delayed enhancement MRI and atrial fibrillation catheter ablation: The DECAAF study","volume":"311","author":"Marrouche","year":"2014","journal-title":"JAMA"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.jacbts.2019.05.005","article-title":"Atrial Myopathy","volume":"4","author":"Shen","year":"2019","journal-title":"JACC Basic Transl. Sci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1001\/jama.2022.8831","article-title":"Effect of MRI-Guided Fibrosis Ablation vs. Conventional Catheter Ablation on Atrial Arrhythmia Recurrence in Patients With Persistent Atrial Fibrillation: The DECAAF II Randomized Clinical Trial","volume":"327","author":"Marrouche","year":"2022","journal-title":"JAMA"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/RLI.0000000000000219","article-title":"Left Atrial 4-Dimensional Flow Magnetic Resonance Imaging: Stasis and Velocity Mapping in Patients With Atrial Fibrillation","volume":"51","author":"Markl","year":"2016","journal-title":"Investig. Radiol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12968-014-0060-6","article-title":"Quantification of left atrial strain and strain rate using Cardiovascular Magnetic Resonance myocardial feature tracking: A feasibility study","volume":"16","author":"Kowallick","year":"2014","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_118","first-page":"446","article-title":"Normal left atrial strain and strain rate using cardiac magnetic resonance feature tracking in healthy volunteers","volume":"21","author":"Truong","year":"2020","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"43","author":"Vahanian","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1161\/01.CIR.102.4.470","article-title":"Left ventricular hypertrophy: Pathogenesis, detection, and prognosis","volume":"102","author":"Lorell","year":"2000","journal-title":"Circulation"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","article-title":"Mechanisms of physiological and pathological cardiac hypertrophy","volume":"15","author":"Nakamura","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"e001685","DOI":"10.1136\/openhrt-2021-001685","article-title":"Early reduction of left atrial function predicts adverse clinical outcomes in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement","volume":"8","author":"Sabatino","year":"2021","journal-title":"Open Heart"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"101979","DOI":"10.1155\/2013\/101979","article-title":"Regulation of tissue fibrosis by the biomechanical environment","volume":"2013","author":"Carver","year":"2013","journal-title":"BioMed Res. Int."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/echo.14258","article-title":"Left atrial strain and distensibility in relation to left ventricular dysfunction and prognosis in aortic stenosis","volume":"36","author":"Meimoun","year":"2019","journal-title":"Echocardiography"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"oeac023","DOI":"10.1093\/ehjopen\/oeac023","article-title":"Prognostic value of left atrial strain in patients with congenital aortic stenosis","volume":"2","author":"Mutluer","year":"2022","journal-title":"Eur. Heart J. Open."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1056\/NEJMoa1008232","article-title":"Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery","volume":"363","author":"Leon","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1161\/CIRCINTERVENTIONS.112.000124","article-title":"Atrial fibrillation and aortic stenosis: Impact on clinical outcomes among patients undergoing transcatheter aortic valve implantation","volume":"6","author":"Stortecky","year":"2013","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/ejechocard\/jer006","article-title":"Left atrial function and remodelling in aortic stenosis","volume":"12","author":"Magne","year":"2011","journal-title":"Eur. J. Echocardiogr."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.echo.2022.10.011","article-title":"Prognostic Value of Left Atrial Strain in Aortic Stenosis: A Competing Risk Analysis","volume":"36","author":"Tan","year":"2023","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1093\/ehjci\/jev230","article-title":"Prognostic value of left atrial reservoir function in patients with severe aortic stenosis: A 2D speckle-tracking echocardiographic study","volume":"17","author":"Galli","year":"2016","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1161\/01.CIR.0000060533.79248.0C","article-title":"Increased plasma natriuretic peptide levels reflect symptom onset in aortic stenosis","volume":"107","author":"Gerber","year":"2003","journal-title":"Circulation"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S1388-9842(00)00074-X","article-title":"Plasma N-terminal pro BNP and cardiotrophin-1 are elevated in aortic stenosis","volume":"3","author":"Talwar","year":"2001","journal-title":"Eur. J. Heart Fail."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"e011036","DOI":"10.1161\/JAHA.118.011036","article-title":"Characteristics and Prognosis of Patients with Moderate Aortic Stenosis and Preserved Left Ventricular Ejection Fraction","volume":"8","author":"Delesalle","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1161\/01.CIR.0000126825.50903.18","article-title":"Natriuretic peptides predict symptom-free survival and postoperative outcome in severe aortic stenosis","volume":"109","author":"Klaar","year":"2004","journal-title":"Circulation"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1007\/s10554-021-02175-6","article-title":"Incremental prognostic role of left atrial reservoir strain in asymptomatic patients with moderate aortic stenosis","volume":"37","author":"Sonaglioni","year":"2021","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1056\/NEJMoa1910555","article-title":"Five-Year Outcomes of Transcatheter or Surgical Aortic-Valve Replacement","volume":"382","author":"Makkar","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1056\/NEJMoa1700456","article-title":"Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients","volume":"376","author":"Reardon","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_138","first-page":"E341","article-title":"Short-term decrease of left atrial size predicts clinical outcome in patients with severe aortic stenosis undergoing TAVR","volume":"96","author":"Murray","year":"2020","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Anastasius, M., Ro, R., Gavalas, M., Patel, N., Prandi, F.R., Tang, G.H.L., Krishnamoorthy, P., Sharma, S.K., Kini, A., and Lerakis, S. (2022). The Effect of TAVR on Left Ventricular and Left Atrial Mechanics in Patients with Aortic Stenosis. J. Cardiovasc. Dev. Dis., 9.","DOI":"10.3390\/jcdd9020035"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1007\/s10554-013-0265-z","article-title":"Left atrial remodelling in patients undergoing transcatheter aortic valve implantation: A speckle-tracking prospective, longitudinal study","volume":"29","author":"Cameli","year":"2013","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1159\/000514665","article-title":"The Prognostic Value of Left Atrial Global Longitudinal Strain and Left Atrial Phasic Volumes in Patients Undergoing Transcatheter Valve Implantation for Severe Aortic Stenosis","volume":"146","author":"Weber","year":"2021","journal-title":"Cardiology"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1111\/echo.12808","article-title":"Effects of transcatheter aortic valve implantation on left ventricular and left atrial morphology and function","volume":"32","author":"Padalino","year":"2015","journal-title":"Echocardiography"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.echo.2012.10.002","article-title":"Short-term effects of transcatheter aortic valve implantation on left atrial mechanics and left ventricular diastolic function","volume":"26","author":"Spethmann","year":"2013","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Lisi, M., Pastore, M.C., Fiorio, A., Cameli, M., Mandoli, G.E., Righini, F.M., Cavigli, L., D\u2019Ascenzi, F., Focardi, M., and Rubboli, A. (2022). Left Atrial Remodeling in Response to Aortic Valve Replacement: Pathophysiology and Myocardial Strain Analysis. Life, 12.","DOI":"10.3390\/life12122074"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.amjcard.2019.04.029","article-title":"Usefulness of Longitudinal Strain to Assess Remodeling of Right and Left Cardiac Chambers Following Transcatheter Aortic Valve Implantation","volume":"124","author":"Medvedofsky","year":"2019","journal-title":"Am. J. Cardiol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.cjca.2017.04.005","article-title":"Left Atrial Phasic Function and Its Association with Atrial Fibrillation in Patients After Transcatheter Aortic Valve Implantation","volume":"33","author":"Poulin","year":"2017","journal-title":"Can. J. Cardiol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/0003-4975(93)90894-N","article-title":"Hazards of postoperative atrial arrhythmias","volume":"56","author":"Creswell","year":"1993","journal-title":"Ann. Thorac. Surg."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/j.jcin.2021.05.026","article-title":"Postoperative Atrial Fibrillation or Flutter Following Transcatheter or Surgical Aortic Valve Replacement: PARTNER 3 Trial","volume":"14","author":"Shahim","year":"2021","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s10554-013-0323-6","article-title":"Pre-operative left atrial strain predicts post-operative atrial fibrillation in patients undergoing aortic valve replacement for aortic stenosis","volume":"30","author":"Cameli","year":"2014","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1016\/j.jcin.2018.08.018","article-title":"A Stitch in Time: Biomarker-Guided Timing of Aortic Valve Replacement for Severe Aortic Stenosis?","volume":"11","author":"Januzzi","year":"2018","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.cjco.2021.04.006","article-title":"Quality-of-Life Outcomes After Transcatheter Aortic Valve Implantation in a \u201cReal World\u201d Population: Insights from a Prospective Canadian Database","volume":"3","author":"Lauck","year":"2021","journal-title":"CJC Open"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0195-668X(03)00201-X","article-title":"A prospective survey of patients with valvular heart disease in Europe: The Euro Heart Survey on Valvular Heart Disease","volume":"24","author":"Iung","year":"2003","journal-title":"Eur. Heart J."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/S0140-6736(16)00558-4","article-title":"Mitral valve disease--current management and future challenges","volume":"387","author":"Nishimura","year":"2016","journal-title":"Lancet"},{"key":"ref_154","first-page":"e201703","article-title":"Primary mitral valve regurgitation: Update and review","volume":"2017","author":"Apostolidou","year":"2017","journal-title":"Glob. Cardiol. Sci. Pract."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.jcmg.2019.01.040","article-title":"Subtypes of Atrial Functional Mitral Regurgitation: Imaging Insights into Their Mechanisms and Therapeutic Implications","volume":"13","author":"Kagiyama","year":"2020","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1007\/s10741-021-10100-1","article-title":"Speckle tracking echocardiography in primary mitral regurgitation: Should we reconsider the time for intervention?","volume":"27","author":"Pastore","year":"2022","journal-title":"Heart Fail. Rev."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.carpath.2009.12.005","article-title":"Atrial myocardial nox2 containing NADPH oxidase activity contribution to oxidative stress in mitral regurgitation: Potential mechanism for atrial remodeling","volume":"20","author":"Chang","year":"2011","journal-title":"Cardiovasc. Pathol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1172\/JCI118280","article-title":"Stretch-induced programmed myocyte cell death","volume":"96","author":"Cheng","year":"1995","journal-title":"J. Clin. Investig."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1161\/01.CIR.104.2.174","article-title":"Impaired myofibrillar energetics and oxidative injury during human atrial fibrillation","volume":"104","author":"Mihm","year":"2001","journal-title":"Circulation"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1161\/hh1701.096615","article-title":"Reactive oxygen species mediate amplitude-dependent hypertrophic and apoptotic responses to mechanical stretch in cardiac myocytes","volume":"89","author":"Pimentel","year":"2001","journal-title":"Circ. Res."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.carpath.2007.07.008","article-title":"Dedifferentiation of atrial cardiomyocytes in cardiac valve disease: Unrelated to atrial fibrillation","volume":"17","author":"Chen","year":"2008","journal-title":"Cardiovasc. Pathol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1161\/01.CIR.96.9.3157","article-title":"Structural changes of atrial myocardium due to sustained atrial fibrillation in the goat","volume":"96","author":"Ausma","year":"1997","journal-title":"Circulation"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1540-8175.2010.01329.x","article-title":"Chronic mitral regurgitation: Left atrial deformation analysis by two-dimensional speckle tracking echocardiography","volume":"28","author":"Cameli","year":"2011","journal-title":"Echocardiography"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1016\/S0735-1097(03)00486-8","article-title":"Plasma natriuretic peptide levels increase with symptoms and severity of mitral regurgitation","volume":"41","author":"Sutton","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1161\/01.CIR.0000164269.80908.9D","article-title":"B-type natriuretic peptide in organic mitral regurgitation: Determinants and impact on outcome","volume":"111","author":"Detaint","year":"2005","journal-title":"Circulation"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.amjcard.2012.10.049","article-title":"Usefulness of atrial deformation analysis to predict left atrial fibrosis and endocardial thickness in patients undergoing mitral valve operations for severe mitral regurgitation secondary to mitral valve prolapse","volume":"111","author":"Cameli","year":"2013","journal-title":"Am. J. Cardiol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.jacc.2021.12.029","article-title":"Restoring Sinus Rhythm Reverses Cardiac Remodeling and Reduces Valvular Regurgitation in Patients With Atrial Fibrillation","volume":"79","author":"Lang","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/S0735-1097(01)01540-6","article-title":"Initial energy setting, outcome and efficiency in direct current cardioversion of atrial fibrillation and flutter","volume":"38","author":"Gallagher","year":"2001","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"e006553","DOI":"10.1161\/CIRCIMAGING.117.006553","article-title":"Impact of the MitraClip Procedure on Left Atrial Strain and Strain Rate","volume":"11","author":"Singh","year":"2018","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_170","first-page":"309","article-title":"Left Atrial and Left Ventricular Function and Remodeling Following Percutaneous Mitral Valve Repair","volume":"25","author":"Rammos","year":"2016","journal-title":"J. Heart Valve Dis."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.cardfail.2017.12.008","article-title":"Effects of Transcatheter Mitral Valve Repair with MitraClip on Left Ventricular and Atrial Hemodynamic Load and Myocardial Wall Stress","volume":"24","author":"Kamperidis","year":"2018","journal-title":"J. Card. Fail."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/ccd.28775","article-title":"Left atrial global function in chronic heart failure patients with functional mitral regurgitation after MitraClip","volume":"96","author":"Fasell","year":"2020","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.amjcard.2018.06.031","article-title":"Changes in Left Atrial Function After Transcutaneous Mitral Valve Repair","volume":"122","author":"Avenatti","year":"2018","journal-title":"Am. J. Cardiol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1111\/echo.15470","article-title":"Effect of mitral valve transcatheter edge-to-edge repair on indices of left atrial performance in chronic mitral regurgitation","volume":"39","author":"Biersmith","year":"2022","journal-title":"Echocardiography"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1111\/echo.13288","article-title":"Left atrial remodeling in patients undergoing percutaneous mitral valve repair with the MitraClip system: An advanced echocardiography study","volume":"33","author":"Toprak","year":"2016","journal-title":"Echocardiography"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1111\/echo.12222","article-title":"Left atrial longitudinal strain parameters predict postoperative persistent atrial fibrillation following mitral valve surgery: A speckle tracking echocardiography study","volume":"30","author":"Candan","year":"2013","journal-title":"Echocardiography"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1093\/ehjci\/jeac058","article-title":"Prognostic value of left atrial reservoir function in patients with severe primary mitral regurgitation undergoing mitral valve repair","volume":"24","author":"Stassen","year":"2022","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_178","first-page":"17","article-title":"Left atrial deformation: Useful index for early detection of cardiac damage in chronic mitral regurgitation","volume":"17","author":"Cameli","year":"2017","journal-title":"Int. J. Cardiol. Heart Vasc."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.echo.2013.05.019","article-title":"Left atrial function by two-dimensional speckle-tracking echocardiography in patients with severe organic mitral regurgitation: Association with guidelines-based surgical indication and postoperative (long-term) survival","volume":"26","author":"Debonnaire","year":"2013","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.echo.2018.03.011","article-title":"Left Atrial Function Is Associated with Earlier Need for Cardiac Surgery in Moderate to Severe Mitral Regurgitation: Usefulness in Targeting for Early Surgery","volume":"31","author":"Ring","year":"2018","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1161\/CIRCIMAGING.108.813071","article-title":"Left atrial function in diastolic heart failure","volume":"2","author":"Kurt","year":"2009","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1161\/01.CIR.100.4.427","article-title":"Left atrial relaxation and left ventricular systolic function determine left atrial reservoir function","volume":"100","author":"Barbier","year":"1999","journal-title":"Circulation"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/eurheartj\/ehac504","article-title":"Valvular heart disease: Shifting the focus to the myocardium","volume":"44","author":"Delgado","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4103\/jcecho.jcecho_13_21","article-title":"The Role of the Left Atrial Strain Parameters on Grading of Aortic Regurgitation","volume":"31","author":"Kalkan","year":"2021","journal-title":"J. Cardiovasc. Echogr."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/0735-1097(91)90870-F","article-title":"Mechanisms for left ventricular systolic dysfunction in aortic regurgitation: Importance for predicting the functional response to aortic valve replacement","volume":"17","author":"Starling","year":"1991","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1111\/echo.13368","article-title":"Left atrium function by 2D speckle tracking in aortic valve disease","volume":"33","author":"Eugenia","year":"2016","journal-title":"Echocardiography"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s12574-022-00577-6","article-title":"Prognostic value of diastolic function parameters in significant aortic regurgitation: The role of the left atrial strain","volume":"20","author":"Zamorano","year":"2022","journal-title":"J. Echocardiogr."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0002-9149(03)00849-X","article-title":"Associations between plasma natriuretic peptide levels, symptoms, and left ventricular function in patients with chronic aortic regurgitation","volume":"92","author":"Gerber","year":"2003","journal-title":"Am. J. Cardiol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/jce.13024","article-title":"Histopathological Study of Left and Right Atria in Isolated Rheumatic Mitral Stenosis with and without Atrial Fibrillation","volume":"27","author":"Shenthar","year":"2016","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1136\/hrt.2003.015347","article-title":"Fibrosis in left atrial tissue of patients with atrial fibrillation with and without underlying mitral valve disease","volume":"90","author":"Boldt","year":"2004","journal-title":"Heart"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.echo.2021.12.010","article-title":"Left Atrial Deformation Imaging and Atrial Fibrillation in Patients with Rheumatic Mitral Stenosis","volume":"35","author":"Stassen","year":"2022","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1056\/NEJM198204293061703","article-title":"Epidemiologic features of chronic atrial fibrillation: The Framingham study","volume":"306","author":"Kannel","year":"1982","journal-title":"N. Engl. J. Med."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.cardiores.2005.04.016","article-title":"Matrix metalloproteinases and atrial remodeling in patients with mitral valve disease and atrial fibrillation","volume":"67","author":"Willems","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.4022\/jafib.2143","article-title":"Prevalence and Factors Associated with Atrial Fibrillation Among Patients with Rheumatic Heart Disease","volume":"12","author":"Dhungana","year":"2019","journal-title":"J. Atr. Fibrillation"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.echo.2012.11.016","article-title":"Two-dimensional atrial systolic strain imaging predicts atrial fibrillation at 4-year follow-up in asymptomatic rheumatic mitral stenosis","volume":"26","author":"Ancona","year":"2013","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1007\/s10554-021-02509-4","article-title":"Left atrium reservoir function is central in patients with rheumatic mitral stenosis","volume":"38","author":"Bouchahda","year":"2021","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/echo.13770","article-title":"Atrial deformation correlated with functional capacity in mitral stenosis patients","volume":"35","author":"Chien","year":"2018","journal-title":"Echocardiography"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4103\/jcecho.jcecho_80_21","article-title":"Severe Rheumatic Mitral Stenosis, Worse Left Atrial Mechanics is Closely Associated with Echo Criteria for Intervention","volume":"32","author":"Vriz","year":"2022","journal-title":"J. Cardiovasc. Echogr."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1540-8175.2005.04085.x","article-title":"Serum N-terminal pro-BNP levels correlate with symptoms and echocardiographic findings in patients with mitral stenosis","volume":"22","author":"Kaya","year":"2005","journal-title":"Echocardiography"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1016\/j.jacc.2014.02.536","article-title":"2014 AHA\/ACC guideline for the management of patients with valvular heart disease: A report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"63","author":"Nishimura","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jcmg.2018.06.014","article-title":"Burden of Tricuspid Regurgitation in Patients Diagnosed in the Community Setting","volume":"12","author":"Topilsky","year":"2019","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: A population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jacc.2019.11.013","article-title":"Atrial Failure as a Clinical Entity: JACC Review Topic of the Week","volume":"75","author":"Bisbal","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1022755","DOI":"10.3389\/fcvm.2022.1022755","article-title":"The atrial secondary tricuspid regurgitation is associated to more favorable outcome than the ventricular phenotype","volume":"9","author":"Gavazzoni","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"836441","DOI":"10.3389\/fcvm.2022.836441","article-title":"Functional Tricuspid Regurgitation: Behind the Scenes of a Long-Time Neglected Disease","volume":"9","author":"Vinciguerra","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1093\/ehjci\/jeaa194","article-title":"Tricuspid valve geometry and right heart remodelling: Insights into the mechanism of atrial functional tricuspid regurgitation","volume":"21","author":"Utsunomiya","year":"2020","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.echo.2021.01.004","article-title":"The Pathophysiological Link between Right Atrial Remodeling and Functional Tricuspid Regurgitation in Patients with Atrial Fibrillation: A Three-Dimensional Echocardiography Study","volume":"34","author":"Guta","year":"2021","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.echo.2019.08.016","article-title":"Functional Regurgitation of Atrioventricular Valves and Atrial Fibrillation: An Elusive Pathophysiological Link Deserving Further Attention","volume":"33","author":"Muraru","year":"2020","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_209","first-page":"315","article-title":"Severe tricuspid regurgitation in the aged: Atrial remodeling associated with long-standing atrial fibrillation","volume":"48","author":"Yamasaki","year":"2006","journal-title":"J. Cardiol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12947-021-00264-z","article-title":"The role of left atrial strain in patients with functional tricuspid regurgitation before and after annuloplasty: A long-term follow-up study","volume":"19","author":"Meng","year":"2021","journal-title":"Cardiovasc. Ultrasound"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1007\/s10554-015-0663-5","article-title":"The relationship between tricuspid regurgitation severity and right atrial mechanics: A speckle tracking echocardiography study","volume":"31","author":"Teixeira","year":"2015","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12933-020-01071-y","article-title":"SGLT2i: Beyond the glucose-lowering effect","volume":"19","author":"Ni","year":"2020","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1056\/NEJMoa1911303","article-title":"Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction","volume":"381","author":"McMurray","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1056\/NEJMoa2022190","article-title":"Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure","volume":"383","author":"Packer","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1001\/jama.2020.1906","article-title":"Effect of Dapagliflozin on Worsening Heart Failure and Cardiovascular Death in Patients with Heart Failure with and Without Diabetes","volume":"323","author":"Petrie","year":"2020","journal-title":"JAMA"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"e145","DOI":"10.1097\/FJC.0000000000001183","article-title":"Association of SGLT2 Inhibitors with Risk of Atrial Fibrillation and Stroke in Patients with and Without Type 2 Diabetes: A Systemic Review and Meta-Analysis of Randomized Controlled Trials","volume":"79","author":"Zheng","year":"2022","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.freeradbiomed.2017.01.035","article-title":"Dapagliflozin, a selective SGLT2 Inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts","volume":"104","author":"Lee","year":"2017","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12933-019-0816-2","article-title":"SGLT2 inhibition with empagliflozin attenuates myocardial oxidative stress and fibrosis in diabetic mice heart","volume":"18","author":"Li","year":"2019","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"e017483","DOI":"10.1161\/JAHA.119.017483","article-title":"Canagliflozin Suppresses Atrial Remodeling in a Canine Atrial Fibrillation Model","volume":"10","author":"Nishinarita","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ejphar.2003.12.016","article-title":"Involvement of Na+\/H+ exchanger in hypoxia\/re-oxygenation-induced neonatal rat cardiomyocyte apoptosis","volume":"486","author":"Sun","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/cvr\/cvu045","article-title":"Epicardial adipose tissue and atrial fibrillation","volume":"102","author":"Hatem","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"H129","DOI":"10.1152\/ajpheart.00565.2021","article-title":"Epicardial adipose tissue as a mediator of cardiac arrhythmias","volume":"322","author":"Patel","year":"2022","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12933-021-01237-2","article-title":"Effect of empagliflozin on ectopic fat stores and myocardial energetics in type 2 diabetes: The EMPACEF study","volume":"20","author":"Gaborit","year":"2021","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Masson, W., Lavalle-Cobo, A., and Nogueira, J.P. (2021). Effect of SGLT2-Inhibitors on Epicardial Adipose Tissue: A Meta-Analysis. Cells, 10.","DOI":"10.3390\/cells10082150"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"106322","DOI":"10.1016\/j.ejps.2022.106322","article-title":"Sodium-glucose co-transporter-2 inhibitors and epicardial adiposity","volume":"180","author":"Yaribeygi","year":"2023","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Szekeres, Z., Toth, K., and Szabados, E. (2021). The Effects of SGLT2 Inhibitors on Lipid Metabolism. Metabolites, 11.","DOI":"10.3390\/metabo11020087"},{"key":"ref_227","doi-asserted-by":"crossref","unstructured":"Llorens-Cebri\u00e0, C., Molina-Van den Bosch, M., Vergara, A., Jacobs-Cach\u00e1, C., and Soler, M.J. (2022). Antioxidant Roles of SGLT2 Inhibitors in the Kidney. Biomolecules, 12.","DOI":"10.3390\/biom12010143"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"6656","DOI":"10.1074\/jbc.M113.519256","article-title":"The mineralocorticoid receptor promotes fibrotic remodeling in atrial fibrillation","volume":"289","author":"Lavall","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1016\/j.ijcard.2013.08.022","article-title":"Impact of aldosterone antagonists on the substrate for atrial fibrillation: Aldosterone promotes oxidative stress and atrial structural\/electrical remodeling","volume":"168","author":"Mayyas","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1093\/europace\/euv366","article-title":"Mineralocorticoid receptor antagonists and atrial fibrillation: A meta-analysis","volume":"18","author":"Liu","year":"2016","journal-title":"Europace"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ijcard.2016.12.029","article-title":"Aldosterone Pathway Blockade to Prevent Atrial Fibrillation: A Systematic Review and Meta-Analysis","volume":"231","author":"Neefs","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1097\/CCM.0b013e31825b8be2","article-title":"Angiotensin-converting enzyme inhibition or mineralocorticoid receptor blockade do not affect prevalence of atrial fibrillation in patients undergoing cardiac surgery","volume":"40","author":"Pretorius","year":"2012","journal-title":"Crit. Care Med."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/13\/1796\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:07:21Z","timestamp":1760126841000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/13\/1796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,6]]},"references-count":232,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["cells12131796"],"URL":"https:\/\/doi.org\/10.3390\/cells12131796","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,6]]}}}