{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T11:35:01Z","timestamp":1789212901043,"version":"build-2803163510"},"reference-count":85,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"HHU Open Access Fund and the Faculty of Medicine of HHU D\u00fcsseldorf"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>In mammals, the circadian system controls various physiological processes to maintain metabolism, behavior, and immune function during a daily 24 h cycle. Although driven by a cell-autonomous core clock in the hypothalamus, rhythmic activities are entrained to external cues, such as environmental lighting conditions. Exposure to artificial light at night (ALAN) can cause circadian disruption and thus is linked to an increased occurrence of civilization diseases in modern society. Moreover, alterations of circadian rhythms and dysregulation of immune responses, including inflammasome activation, are common attributes of neurodegenerative diseases, including Alzheimer\u2019, Parkinson\u2019s, and Huntington\u2019s disease. Although there is evidence that the inflammasome in the hippocampus is activated by stress, the direct effect of circadian disruption on inflammasome activation remains poorly understood. In the present study, we aimed to analyze whether exposure to constant light (LL) affects inflammasome activation in the mouse hippocampus. In addition to decreased circadian power and reduced locomotor activity, we found cleaved caspase 1 significantly elevated in the hippocampus of mice exposed to LL. However, we did not find hallmarks of inflammasome priming or cleavage of pro-interleukins. These findings suggest that acute circadian disruption leads to an assembled \u201cready to start\u201d inflammasome, which may turn the brain more vulnerable to additional aversive stimuli.<\/jats:p>","DOI":"10.3390\/cells12141836","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T01:52:25Z","timestamp":1689213145000},"page":"1836","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Acute Circadian Disruption Due to Constant Light Promotes Caspase 1 Activation in the Mouse Hippocampus"],"prefix":"10.3390","volume":"12","author":[{"given":"Pikria","family":"Ketelauri","sequence":"first","affiliation":[{"name":"Institute of Anatomy II, Medical Faculty, Heinrich-Heine-University (HHU), 40225 D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Scharov","sequence":"additional","affiliation":[{"name":"Institute of Anatomy II, Medical Faculty, Heinrich-Heine-University (HHU), 40225 D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5088-3118","authenticated-orcid":false,"given":"Charlotte","family":"von Gall","sequence":"additional","affiliation":[{"name":"Institute of Anatomy II, Medical Faculty, Heinrich-Heine-University (HHU), 40225 D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Johann","sequence":"additional","affiliation":[{"name":"Institute of Anatomy II, Medical Faculty, Heinrich-Heine-University (HHU), 40225 D\u00fcsseldorf, Germany"},{"name":"Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf (UKE), Martinistra\u00dfe 52, 20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1189\/jlb.3RU1015-451R","article-title":"A matter of time: Study of circadian clocks and their role in inflammation","volume":"99","author":"Carter","year":"2016","journal-title":"J. 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